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Article ; Online: Neuronal Transcriptome from

Liu, Elaine Y / Russ, Jenny / Lee, Edward B

Free neuropathology

2020 Volume 1

Abstract: A hexanucleotide ... ...

Abstract	A hexanucleotide G
Language	English
Publishing date	2020-08-21
Publishing country	Germany
Document type	Journal Article
ISSN	2699-4445
ISSN (online)	2699-4445
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Variation in Nevada primary care clinicians' use of urine drug testing to mitigate opioid harm.

Hartzell, Sarah Y T / Keller, Michelle S / Albertson, Elaine Michelle / Liu, Yan / Larson, Madalyn / Friedman, Sarah

Journal of substance use and addiction treatment

2023 Volume 145, Page(s) 208940

Abstract: Introduction: The prescription opioid epidemic led to federal, state, and health system guidelines and policies aimed at mitigating opioid misuse, including presumptive urine drug testing (UDT). This study identifies whether a difference exists in UDT ... ...

Abstract	Introduction: The prescription opioid epidemic led to federal, state, and health system guidelines and policies aimed at mitigating opioid misuse, including presumptive urine drug testing (UDT). This study identifies whether a difference exists in UDT use among different primary care medical license types. Methods: The study used January 2017-April 2018 Nevada Medicaid pharmacy and professional claims data to examine presumptive UDTs. We examined correlations between UDTs and clinician characteristics (medical license type, urban/rural status, care setting) along with clinician-level measures of patient mix characteristics (proportions of patients with behavioral health diagnoses, early refills). Adjusted odds ratios (AORs) and predicted probabilities (PPs) from a logistic regression with a binomial distribution are reported. The analysis included 677 primary care clinicians (medical doctors [MD], physician assistants [PA], nurse practitioners [NP]). Results: Of those in the study, 85.1 % of clinicians did not order any presumptive UDTs. NPs had the highest proportion of UDT use (21.2 % of NPs), followed by PAs (20.0 % of PAs), and MDs (11.4 % of MDs). Adjusted analyses showed that being a PA or NP was associated with higher odds of UDT (PA: AOR: 3.6; 95 % CI: 3.1-4.1; NP: AOR: 2.5; 95 % CI: 2.2-2.8) compared to being an MD. PAs had the highest PP for ordering UDTs (2.1 %, 95 % CI: 0.5 %-8.4 %). Among clinicians who ordered UDTs, midlevel clinicians had higher mean and median UDT use (PA and NP mean: 24.3 % vs. MDs: 19.4 %; PA and NP median: 17.7 % vs. MDs: 12.5 %). Conclusion: In Nevada Medicaid, UDTs are concentrated among 15 % of primary care clinicians who are frequently non-MDs. More research should include PAs and NPs when examining clinician variation in mitigating opioid misuse.
MeSH term(s)	United States/epidemiology ; Humans ; Analgesics, Opioid/adverse effects ; Nevada/epidemiology ; Substance Abuse Detection ; Opioid-Related Disorders/diagnosis ; Primary Health Care
Chemical Substances	Analgesics, Opioid
Language	English
Publishing date	2023-01-07
Publishing country	United States
Document type	Journal Article
ISSN	2949-8759
ISSN (online)	2949-8759
DOI	10.1016/j.josat.2022.208940
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Article ; Online: High-titer post-vaccine COVID-19 convalescent plasma for immunocompromised patients during the first omicron surge.

Tayyar, Ralph / Wong, Lisa Kanata / Dahlen, Alex / Shu, Elaine / Pandey, Suchitra / Liu, Anne Y

Transplant infectious disease : an official journal of the Transplantation Society

2023 Volume 25, Issue 2, Page(s) e14055

Abstract: Background: Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID-19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. ... ...

Abstract	Background: Transplant and hematologic malignancy patients have high Coronavirus disease 2019 (COVID-19) mortality and impaired vaccination responses. Omicron variant evades several monoclonal antibodies previously used in immunocompromised patients. Polyclonal COVID-19 convalescent plasma (CCP) may provide broader neutralizing capacity against new variants at high titers. Vaccination increases severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) titer in convalescent donors. Methods: We conducted a retrospective chart review of hospitalized immunocompromised patients with COVID-19 who received high-titer CCP during the first omicron surge, collected from vaccinated donors within 6 months of pre-omicron COVID-19. Data on safety and outcomes were extracted. Results: A total of 44 immunocompromised patients were included, 59.1% with solid organ transplant, 22.7% with hematopoietic cell transplant, 11.4% with hematologic malignancy, and 6.8% with autoimmune disease. Overall, 95% of CCP units transfused were from recently recovered and vaccinated donors and had SARS-CoV-2 antibody results 8- to 37-fold higher than the Food and Drug Administration's cutoff for high-titer CCP. There were two mild transfusion reactions. A total of 30-day mortality was 4.5%. There were no differences in 100-day mortality by underlying diagnosis, levels of immunosuppression, and timing of CCP administration. Patients with higher immunosuppression had significantly higher mean World Health Organization clinical progression scores at 30-day post-CCP compared to those with lower immunosuppression. Conclusions: CCP is a safe, globally available treatment for immunocompromised patients with COVID-19. Mortality was lower in our cohort than that of COVID-19 patients with similar immunocompromising conditions. Post-vaccine CCP with very high titers should be prioritized for study in immunocompromised patients. Post-vaccine CCP has the potential to keep pace with new variants by overcoming mutations at sufficiently high titer.
MeSH term(s)	Humans ; COVID-19/therapy ; SARS-CoV-2 ; Hematopoietic Stem Cell Transplantation ; Retrospective Studies ; COVID-19 Serotherapy ; Immunocompromised Host ; Vaccines ; Antibodies, Viral ; Hematologic Neoplasms/therapy ; Antibodies, Neutralizing
Chemical Substances	Vaccines ; Antibodies, Viral ; Antibodies, Neutralizing
Language	English
Publishing date	2023-03-16
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	1476094-0
ISSN	1399-3062 ; 1398-2273
ISSN (online)	1399-3062
ISSN	1398-2273
DOI	10.1111/tid.14055
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Article: Educating the Next Generation of Cancer Researchers: Evaluation of A Cancer Research Partnership Training Program.

Zhu, Lin / Dodd, S J / Chen, Yuku / Kaminsky, Emily R / Liu, Zhiqing Elaine / Ma, Grace X / Ogunwobi, Olorunseun O / Fang, Carolyn Y

medRxiv : the preprint server for health sciences

2023

Abstract: African American, American Indian and Alaska Native, Hispanic (or Latinx), Native Hawaiian, and other Pacific Islander groups are underrepresented in the biomedical workforce, which is one of the barriers to addressing cancer disparities among minority ... ...

Abstract	African American, American Indian and Alaska Native, Hispanic (or Latinx), Native Hawaiian, and other Pacific Islander groups are underrepresented in the biomedical workforce, which is one of the barriers to addressing cancer disparities among minority populations. The creation of a more inclusive biomedical workforce dedicated to reducing the burden of cancer health disparities requires structured, mentored research and cancer-related research exposure during the earlier stages of training. The Summer Cancer Research Institute (SCRI), a multicomponent 8-week intensive summer program funded under the Partnership between a Minority Serving Institute and a National Institutes of Health-designated Comprehensive Cancer Center. This study assessed whether students who participated in the SCRI Program report greater knowledge and interest in pursuing careers in cancer-related fields than their counterparts who did not participate in SCRI. Successes, challenges, and solutions in providing training in cancer and cancer health disparities research to improve diversity in the biomedical fields were also discussed.
Language	English
Publishing date	2023-05-16
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.15.23289973
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Correction: Preclinical safety and biodistribution of CRISPR targeting SIV in non-human primates.

Gene therapy

2024

Language	English
Publishing date	2024-01-12
Publishing country	England
Document type	Published Erratum
ZDB-ID	1191036-7
ISSN	1476-5462 ; 0969-7128
ISSN (online)	1476-5462
ISSN	0969-7128
DOI	10.1038/s41434-023-00438-6
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Zs.A 3991: Show issues

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Article ; Online: Educating the next generation of cancer researchers: Evaluation of a cancer research partnership training program.

Zhu, Lin / Dodd, S J / Chen, Yuku / Kaminsky, Emily R / Liu, Zhiqing Elaine / Ma, Grace X / Ogunwobi, Olorunseun O / Fang, Carolyn Y

PloS one

2023 Volume 18, Issue 10, Page(s) e0286279

Abstract	African American, American Indian and Alaska Native, Hispanic (or Latinx), Native Hawaiian, and other Pacific Islander groups are underrepresented in the biomedical workforce, which is one of the barriers to addressing cancer disparities among minority populations. The creation of a more inclusive biomedical workforce dedicated to reducing the burden of cancer health disparities requires structured, mentored research and cancer-related research exposure during the earlier stages of training. The Summer Cancer Research Institute (SCRI) is a multicomponent 8-week intensive summer program funded under the Partnership between a Minority Serving Institute and a National Institutes of Health-designated Comprehensive Cancer Center. In this survey study, we found that students who participated in the SCRI Program reported greater knowledge and interest in pursuing careers in cancer-related fields than their counterparts who did not participate in SCRI. Successes, challenges, and solutions in providing training in cancer and cancer health disparities research to improve diversity in the biomedical fields were also discussed.
MeSH term(s)	Humans ; Biomedical Research/education ; Minority Groups/education ; Mentors ; Hawaii ; Workforce ; Neoplasms/therapy
Language	English
Publishing date	2023-10-04
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0286279
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Sustaining Independent Careers in Vision Research: Demographics and Success in Second R01 Attainment Among Clinician-Scientists from 1985 to 2019.

Liu, Elaine A / Wang, Sophia Y / Rao, Rajesh C

Translational vision science & technology

2020 Volume 9, Issue 12, Page(s) 32

Abstract: Purpose: To evaluate the success of ophthalmology and optometry clinician-scientists in obtaining a second R01 (renewal or new) and factors associated with this success, including gender, clinical specialty, degree, institution, and bench versus non- ... ...

Abstract	Purpose: To evaluate the success of ophthalmology and optometry clinician-scientists in obtaining a second R01 (renewal or new) and factors associated with this success, including gender, clinical specialty, degree, institution, and bench versus non-bench research. Methods: First-time National Eye Institute (NEI) R01 awardee data from 1985 to 2014 ( Results: Overall, from 1985 to 2014, 62.8% of ophthalmology or optometry clinician-scientists were awarded a second R01; at 5 years after receipt of the first R01 (the typical length of an R01), only 3.9% received their second R01. None of the factors examined (temporal cohort, gender, clinical specialty, degree, institution, or bench vs. non-bench research) was significantly associated with successful attainment of a second R01. Conclusions: We found an overall success rate of 62.8% for receiving a second R01, but 5 years after the first R01 an attainment rate for a second R01 of only ∼4%. Translational relevance: Our study provides insight on significant leaks in the clinician-scientist pipeline and raises questions of how stakeholders should support this important group of individuals at the intersection of clinical medicine and biomedical research.
MeSH term(s)	Awards and Prizes ; Biomedical Research ; Demography ; Humans ; National Institutes of Health (U.S.) ; Physicians ; United States
Language	English
Publishing date	2020-11-25
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2674602-5
ISSN	2164-2591
ISSN	2164-2591
DOI	10.1167/tvst.9.12.32
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Article ; Online: Catheter ablation of typical atrial flutter improves cardiac chamber size and function.

Jou, Stephanie / Liu, Qi / Gulsen, Mert R / Biviano, Angelo / Wan, Elaine Y / Dizon, Jose / Saluja, Deepak / Garan, Hasan / Yarmohammadi, Hirad

Journal of cardiovascular electrophysiology

2023 Volume 35, Issue 1, Page(s) 130–135

Abstract: Introduction: Cavo-tricuspid isthmus (CTI) dependent atrial flutter (AFL) is one of the most common atrial arrhythmias involving the right atrium (RA) for which radiofrequency catheter ablation has been widely used as a therapy of choice. However, there ...

Abstract	Introduction: Cavo-tricuspid isthmus (CTI) dependent atrial flutter (AFL) is one of the most common atrial arrhythmias involving the right atrium (RA) for which radiofrequency catheter ablation has been widely used as a therapy of choice. However, there is limited data on the effect of this intervention on cardiac size and function. Methods: A retrospective study was conducted on 468 patients who underwent ablation for CTI dependent typical AFL at a single institution between 2010 and 2019. After excluding patients with congenital or rheumatic heart disease, heart transplant recipients, or those without baseline echocardiogram, a total of 130 patients were included in the analysis. Echocardiographic data were analyzed at baseline before ablation, and at early follow-up within 1-year postablation. Follow-up echocardiographic data was available for 55 patients. Results: Of the 55 patients with CTI-AFL, the mean age was 64.2 ± 14.8 years old with 14.5% (n = 8) female. The average left ventricular ejection fraction (LVEF) significantly improved on follow-up echo (40.2 ± 16.9 to 50.4 ± 14.9%, p < .0001), of which 50% of patients had an improvement in LVEF of at least 10%. There was a significant reduction in left atrial volume index (82.74 ± 28.5 to 72.96 ± 28 mL/m Conclusions: Patients who underwent CTI dependent AFL ablation showed an improvement in cardiac size and function at follow-up evaluation. While long-term results are still unknown, these findings indicate that restoration of sinus rhythm in patients with typical AFL is associated with improvement in atrial size and left ventricular function.
MeSH term(s)	Humans ; Female ; Middle Aged ; Aged ; Atrial Flutter/diagnostic imaging ; Atrial Flutter/surgery ; Retrospective Studies ; Stroke Volume ; Ventricular Function, Left ; Catheter Ablation/adverse effects ; Catheter Ablation/methods ; Treatment Outcome
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1025989-2
ISSN	1540-8167 ; 1045-3873
ISSN (online)	1540-8167
ISSN	1045-3873
DOI	10.1111/jce.16134
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Zs.A 2863: Show issues

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Article: Tissue Characteristics of Endometrial Carcinoma Analyzed by Quantitative Synthetic MRI and Diffusion-Weighted Imaging.

Wang, Yiang / He, Mengge / Cao, Peng / Ip, Philip P C / Lin, Chien-Yuan / Liu, Weiyin / Lee, Chia-Wei / Lee, Elaine Y P

Diagnostics (Basel, Switzerland)

2022 Volume 12, Issue 12

Abstract: Background: This study investigates the association of T1, T2, proton density (PD) and the apparent diffusion coefficient (ADC) with histopathologic features of endometrial carcinoma (EC).: Methods: One hundred and nine EC patients were prospectively ...

Abstract	Background: This study investigates the association of T1, T2, proton density (PD) and the apparent diffusion coefficient (ADC) with histopathologic features of endometrial carcinoma (EC). Methods: One hundred and nine EC patients were prospectively enrolled from August 2019 to December 2020. Synthetic magnetic resonance imaging (MRI) was acquired through one acquisition, in addition to diffusion-weighted imaging (DWI) and other conventional sequences using 1.5T MRI. T1, T2, PD derived from synthetic MRI and ADC derived from DWI were compared among different histopathologic features, namely the depth of myometrial invasion (MI), tumor grade, cervical stromal invasion (CSI) and lymphovascular invasion (LVSI) of EC by the Mann-Whitney U test. Classification models based on the significant MRI metrics were constructed with their respective receiver operating characteristic (ROC) curves, and their micro-averaged ROC was used to evaluate the overall performance of these significant MRI metrics in determining aggressive histopathologic features of EC. Results: EC with MI had significantly lower T2, PD and ADC than those without MI ( Conclusions: Synthetic MRI provided quantitative metrics to characterize EC with one single acquisition. Low T2, PD and ADC were associated with aggressive histopathologic features of EC, offering excellent performance in determining aggressive histopathologic features of EC.
Language	English
Publishing date	2022-11-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics12122956
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Article: Incidence and Predictors for Oncologic Etiologies in Chinese Children with Pituitary Stalk Thickening.

Li, Mario W T / Poon, Sarah W Y / Cheung, Claudia / Wong, Chris K C / Shing, Matthew M K / Chow, Terry T W / Lee, Samantha L K / Pang, Gloria S W / Kwan, Elaine Y W / Poon, Grace W K / Yau, Ho-Chung / Tung, Joanna Y L / Liu, Anthony P Y

Cancers

2023 Volume 15, Issue 15

Abstract: Background: With the increasing use of magnetic resonance imaging (MRI) in the evaluation of children with endocrine disorders, pituitary stalk thickening (PST) poses a clinical conundrum due to the potential for underlying neoplasms and challenges in ... ...

Abstract	Background: With the increasing use of magnetic resonance imaging (MRI) in the evaluation of children with endocrine disorders, pituitary stalk thickening (PST) poses a clinical conundrum due to the potential for underlying neoplasms and challenges in obtaining a tissue biopsy. The existing literature suggests Langerhans cell histiocytosis (LCH) to be the commonest (16%) oncologic cause for PST, followed by germ cell tumors (GCTs, 13%) (CCLG 2021). As the cancer epidemiology varies according to ethnicity, we present herein the incidence and predictors for oncologic etiologies in Hong Kong Chinese children with PST. Methods: Based on a territory-wide electronic database, we reviewed patients aged < 19 years who presented to three referral centers with endocrinopathies between 2010 and 2022. Records for patients who underwent at least one MRI brain/pituitary were examined ( Results: Twenty-eight patients (M:F = 10:18) were identified. The median age at diagnosis of PST was 10.9 years (range: 3.8-16.5), with central diabetes insipidus (CDI) and growth hormone deficiency (GHD) being the most frequent presenting endocrine disorders. At a median follow-up of 4.8 years, oncologic diagnoses were made in 14 patients (50%), including 13 GCTs (46%; germinoma = 11, non-germinoma = 2) and one LCH (4%). Among patients with GCTs, 10 were diagnosed based on histology, two by abnormal tumor markers and one by a combination of histology and tumor markers. Three patients with germinoma were initially misdiagnosed as hypophysitis/LCH. The cumulative incidence of oncologic diagnoses was significantly higher in boys and patients with PST at presentation ≥6.5 mm, CDI or ≥2 pituitary hormone deficiencies at presentation and evolving hypopituitarism (all Conclusions: A higher rate of GCTs was observed in Chinese children with endocrinopathy and isolated PST. The predictors identified in this study may guide healthcare providers in Asia in clinical decision making. Serial measurement of tumor markers is essential in management.
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15153935
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