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  1. Article: A Vernalization Response in a Winter Safflower (

    Cullerne, Darren P / Fjellheim, Siri / Spriggs, Andrew / Eamens, Andrew L / Trevaskis, Ben / Wood, Craig C

    Frontiers in plant science

    2021  Volume 12, Page(s) 639014

    Abstract: Safflower ( ...

    Abstract Safflower (
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711035-7
    ISSN 1664-462X
    ISSN 1664-462X
    DOI 10.3389/fpls.2021.639014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Assessment of the impact of direct in vitro PFAS treatment on mouse spermatozoa.

    Calvert, Leah / Martin, Jacinta H / Anderson, Amanda L / Bernstein, Ilana R / Burke, Nathan D / De Iuliis, Geoffry N / Eamens, Andrew L / Dun, Matthew D / Turner, Brett D / Roman, Shaun D / Green, Mark P / Nixon, Brett

    Reproduction & fertility

    2024  Volume 5, Issue 1

    MeSH term(s) Male ; Mice ; Animals ; Testicular Neoplasms/veterinary ; Semen Analysis/veterinary ; Reactive Oxygen Species/pharmacology ; Semen ; Spermatozoa/physiology ; DNA/pharmacology ; Fluorocarbons/toxicity ; Rodent Diseases ; Neoplasms, Germ Cell and Embryonal
    Chemical Substances Reactive Oxygen Species ; DNA (9007-49-2) ; Fluorocarbons
    Language English
    Publishing date 2024-03-08
    Publishing country England
    Document type Journal Article
    ISSN 2633-8386
    ISSN (online) 2633-8386
    DOI 10.1530/RAF-23-0087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Miniature Inverted-Repeat Transposable Elements: Small DNA Transposons That Have Contributed to Plant

    Pegler, Joseph L / Oultram, Jackson M J / Mann, Christopher W G / Carroll, Bernard J / Grof, Christopher P L / Eamens, Andrew L

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 5

    Abstract: Angiosperms form the largest phylum within the Plantae kingdom and show remarkable genetic variation due to the considerable difference in the nuclear genome size of each species. Transposable elements (TEs), mobile DNA sequences that can amplify and ... ...

    Abstract Angiosperms form the largest phylum within the Plantae kingdom and show remarkable genetic variation due to the considerable difference in the nuclear genome size of each species. Transposable elements (TEs), mobile DNA sequences that can amplify and change their chromosome position, account for much of the difference in nuclear genome size between individual angiosperm species. Considering the dramatic consequences of TE movement, including the complete loss of gene function, it is unsurprising that the angiosperms have developed elegant molecular strategies to control TE amplification and movement. Specifically, the RNA-directed DNA methylation (RdDM) pathway, directed by the repeat-associated small-interfering RNA (rasiRNA) class of small regulatory RNA, forms the primary line of defense to control TE activity in the angiosperms. However, the miniature inverted-repeat transposable element (MITE) species of TE has at times avoided the repressive effects imposed by the rasiRNA-directed RdDM pathway. MITE proliferation in angiosperm nuclear genomes is due to their preference to transpose within gene-rich regions, a pattern of transposition that has enabled MITEs to gain further transcriptional activity. The sequence-based properties of a MITE results in the synthesis of a noncoding RNA (ncRNA), which, after transcription, folds to form a structure that closely resembles those of the precursor transcripts of the microRNA (miRNA) class of small regulatory RNA. This shared folding structure results in a MITE-derived miRNA being processed from the MITE-transcribed ncRNA, and post-maturation, the MITE-derived miRNA can be used by the core protein machinery of the miRNA pathway to regulate the expression of protein-coding genes that harbor homologous MITE insertions. Here, we outline the considerable contribution that the MITE species of TE have made to expanding the miRNA repertoire of the angiosperms.
    Language English
    Publishing date 2023-03-01
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12051101
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  4. Article ; Online: RNA-Based Control of Fungal Pathogens in Plants.

    Mann, Christopher W G / Sawyer, Anne / Gardiner, Donald M / Mitter, Neena / Carroll, Bernard J / Eamens, Andrew L

    International journal of molecular sciences

    2023  Volume 24, Issue 15

    Abstract: Our duty to conserve global natural ecosystems is increasingly in conflict with our need to feed an expanding population. The use of conventional pesticides not only damages the environment and vulnerable biodiversity but can also still fail to prevent ... ...

    Abstract Our duty to conserve global natural ecosystems is increasingly in conflict with our need to feed an expanding population. The use of conventional pesticides not only damages the environment and vulnerable biodiversity but can also still fail to prevent crop losses of 20-40% due to pests and pathogens. There is a growing call for more ecologically sustainable pathogen control measures. RNA-based biopesticides offer an eco-friendly alternative to the use of conventional fungicides for crop protection. The genetic modification (GM) of crops remains controversial in many countries, though expression of transgenes inducing pathogen-specific RNA interference (RNAi) has been proven effective against many agronomically important fungal pathogens. The topical application of pathogen-specific RNAi-inducing sprays is a more responsive, GM-free approach to conventional RNAi transgene-based crop protection. The specific targeting of essential pathogen genes, the development of RNAi-nanoparticle carrier spray formulations, and the possible structural modifications to the RNA molecules themselves are crucial to the success of this novel technology. Here, we outline the current understanding of gene silencing pathways in plants and fungi and summarize the pioneering and recent work exploring RNA-based biopesticides for crop protection against fungal pathogens, with a focus on spray-induced gene silencing (SIGS). Further, we discuss factors that could affect the success of RNA-based control strategies, including RNA uptake, stability, amplification, and movement within and between the plant host and pathogen, as well as the cost and design of RNA pesticides.
    MeSH term(s) Biological Control Agents ; Ecosystem ; RNA Interference ; RNA, Small Interfering/genetics ; Crops, Agricultural/genetics ; Pesticides ; Plant Diseases/genetics ; Plant Diseases/prevention & control ; Plant Diseases/microbiology
    Chemical Substances Biological Control Agents ; RNA, Small Interfering ; Pesticides
    Language English
    Publishing date 2023-08-03
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241512391
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  5. Article ; Online: The Plant microRNA Pathway: The Production and Action Stages.

    Pegler, Joseph L / Grof, Christopher P L / Eamens, Andrew L

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1932, Page(s) 15–39

    Abstract: Plant microRNAs are an endogenous class of small regulatory RNA central to the posttranscriptional regulation of gene expression in plant development and environmental stress adaptation or in response to pathogen challenge. The plant microRNA pathway is ... ...

    Abstract Plant microRNAs are an endogenous class of small regulatory RNA central to the posttranscriptional regulation of gene expression in plant development and environmental stress adaptation or in response to pathogen challenge. The plant microRNA pathway is readily separated into two distinct stages: (1) the production stage, which is localized to the plant cell nucleus and where the microRNA small RNA is processed from a double-stranded RNA precursor transcript, and (2) the action stage, which is localized to the plant cell cytoplasm and where the mature microRNA small RNA is loaded into an effector complex and is used by the complex as a sequence specificity guide to direct expression repression of target genes harboring highly complementary microRNA target sequences. Historical research indicated that the plant microRNA pathway was a highly structured, almost linear pathway requiring a small set of core machinery proteins. However, contemporary research has demonstrated that the plant microRNA pathway is highly dynamic, and to allow for this flexibility, a large and highly functionally diverse set of machinery proteins is now known to be required. For example, recent research has shown that plant microRNAs can regulate target gene expression via a translational repression mechanism of RNA silencing in addition to the standard messenger RNA cleavage-based mechanism of RNA silencing: a mode of RNA silencing originally assigned to all plant microRNAs. Using Arabidopsis thaliana as our model system, here we report on both the core and auxiliary sets of machinery proteins now known to be required for both microRNA production and microRNA action in plants.
    MeSH term(s) Animals ; Arabidopsis/genetics ; Gene Expression Regulation, Plant/genetics ; MicroRNAs/genetics ; RNA Interference/physiology ; RNA, Messenger/genetics ; RNA, Plant/genetics
    Chemical Substances MicroRNAs ; RNA, Messenger ; RNA, Plant
    Language English
    Publishing date 2019-01-30
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-9042-9_2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The contribution of epididymosomes to the sperm small RNA profile.

    Trigg, Natalie A / Eamens, Andrew L / Nixon, Brett

    Reproduction (Cambridge, England)

    2019  Volume 157, Issue 6, Page(s) R209–R223

    Abstract: It is now well established that mature spermatozoa harbour a rich and diverse profile of small non-protein-coding regulatory RNAs (sRNAs). There is also growing appreciation that this sRNA profile displays considerable plasticity, being altered in ... ...

    Abstract It is now well established that mature spermatozoa harbour a rich and diverse profile of small non-protein-coding regulatory RNAs (sRNAs). There is also growing appreciation that this sRNA profile displays considerable plasticity, being altered in response to paternal exposure to a variety of environmental stressors. Coupled with evidence that upon delivery to the oocyte at the moment of fertilisation, sperm-borne sRNAs are able to influence both early embryonic development and the subsequent health of the offspring, there is now interest in both the timing and degree of change in the composition of the sRNA cargo of sperm. Models in which such epigenetic changes are linked to the spermatogenic cycle are seemingly incompatible with the lack of overt phenotypic changes in the spermatozoa of affected males. Rather, there is mounting consensus that such changes are imposed on sperm during their transit and storage within the epididymis, a protracted developmental window that takes place over several weeks. Notably, since spermatozoa are rendered transcriptionally and translationally silent during their development in the testes, it is most likely that the epididymis-documented alterations to the sperm sRNA profile are driven extrinsically, with a leading candidate being epididymosomes: small membrane enclosed extracellular vesicles that encapsulate a complex macromolecular cargo of proteins and RNAs, including the sRNAs. Here, we review the role of epididymosome-sperm communication in contributing to the establishment of the sperm sRNA profile during their epididymal transit.
    MeSH term(s) Animals ; Cell-Derived Microparticles/genetics ; Cell-Derived Microparticles/metabolism ; Epididymis/metabolism ; Epididymis/physiology ; Humans ; Male ; RNA, Small Untranslated/genetics ; Spermatogenesis ; Spermatozoa/metabolism ; Spermatozoa/physiology ; Transcriptome
    Chemical Substances RNA, Small Untranslated
    Language English
    Publishing date 2019-02-19
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2034501-X
    ISSN 1741-7899 ; 1470-1626 ; 1476-3990
    ISSN (online) 1741-7899
    ISSN 1470-1626 ; 1476-3990
    DOI 10.1530/REP-18-0480
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.362: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Genetic Variants Associated with Long-Terminal Repeats Can Diagnostically Classify

    Oultram, Jackson M J / Pegler, Joseph L / Symons, Greg M / Bowser, Timothy A / Eamens, Andrew L / Grof, Christopher P L / Korbie, Darren J

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: ... Cannabis ... ...

    Abstract Cannabis sativa
    Language English
    Publishing date 2022-11-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232314531
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  8. Article: DEFECTIVE EMBRYO AND MERISTEMS1

    Matthew, Louisa / Reyes, Melquiades E C / Mann, Christopher W G / McDowall, Alasdair W / Eamens, Andrew L / Carroll, Bernard J

    Plants (Basel, Switzerland)

    2022  Volume 11, Issue 19

    Abstract: Most flowering plant species contain at least two copies of ... ...

    Abstract Most flowering plant species contain at least two copies of the
    Language English
    Publishing date 2022-09-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants11192545
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  9. Article: MicroRNA-Mediated Responses to Cadmium Stress in

    Pegler, Joseph L / Oultram, Jackson M J / Nguyen, Duc Quan / Grof, Christopher P L / Eamens, Andrew L

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 1

    Abstract: In recent decades, the presence of cadmium (Cd) in the environment has increased significantly due to anthropogenic activities. Cd is taken up from the soil by plant roots for its subsequent translocation to shoots. However, Cd is a non-essential heavy ... ...

    Abstract In recent decades, the presence of cadmium (Cd) in the environment has increased significantly due to anthropogenic activities. Cd is taken up from the soil by plant roots for its subsequent translocation to shoots. However, Cd is a non-essential heavy metal and is therefore toxic to plants when it over-accumulates. MicroRNA (miRNA)-directed gene expression regulation is central to the response of a plant to Cd stress. Here, we document the miRNA-directed response of wild-type
    Language English
    Publishing date 2021-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10010130
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  10. Article: Molecular Manipulation of the miR396 and miR399 Expression Modules Alters the Response of

    Pegler, Joseph L / Nguyen, Duc Quan / Oultram, Jackson M J / Grof, Christopher P L / Eamens, Andrew L

    Plants (Basel, Switzerland)

    2021  Volume 10, Issue 12

    Abstract: In plant cells, the molecular and metabolic processes of nucleic acid synthesis, phospholipid production, coenzyme activation and the generation of the vast amount of chemical energy required to drive these processes relies on an adequate supply of the ... ...

    Abstract In plant cells, the molecular and metabolic processes of nucleic acid synthesis, phospholipid production, coenzyme activation and the generation of the vast amount of chemical energy required to drive these processes relies on an adequate supply of the essential macronutrient, phosphorous (P). The requirement of an appropriate level of P in plant cells is evidenced by the intricately linked molecular mechanisms of P sensing, signaling and transport. One such mechanism is the posttranscriptional regulation of the P response pathway by the highly conserved plant microRNA (miRNA), miR399. In addition to miR399, numerous other plant miRNAs are also required to respond to environmental stress, including miR396. Here, we exposed
    Language English
    Publishing date 2021-11-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants10122570
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