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  1. Article: Synthesis of 2,3,4-Trisubstituted Thiochromanes using an Organocatalytic Enantioselective Tandem Michael-Henry Reaction.

    Dodda, Rajasekhar / Goldman, Joshua J / Mandal, Tanmay / Zhao, Cong-Gui / Broker, Grant A / Tiekink, Edward R T

    Advanced synthesis & catalysis

    2009  Volume 350, Issue 4, Page(s) 537–541

    Abstract: ... catalyzed tandem Michael addition-Henry reaction between 2-mercaptobenzaldehydes and β-nitrostyrenes. Good ...

    Abstract Enantioenriched 2,3,4-trisubstituted thiochromanes have been synthesized by using a cupreine-catalyzed tandem Michael addition-Henry reaction between 2-mercaptobenzaldehydes and β-nitrostyrenes. Good diastereoselectivities and enantioselectivities were obtained for the title compounds, which may be further improved through a single recrystallization (up to 98% de and> 99% ee).
    Language English
    Publishing date 2009-10-12
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2041384-1
    ISSN 1615-4169 ; 1615-4150
    ISSN (online) 1615-4169
    ISSN 1615-4150
    DOI 10.1002/adsc.200700331
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  2. Article ; Online: Genes, in context

    Goldman, Michael A

    Science (New York, N.Y.)

    2024  Volume 384, Issue 6691, Page(s) 40

    Abstract: As biologists have long known, the genome is only one piece in the puzzle of life. ...

    Abstract As biologists have long known, the genome is only one piece in the puzzle of life.
    MeSH term(s) Biology
    Language English
    Publishing date 2024-04-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ado0262
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    Zs.A 27: Show issues Location:
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  3. Article ; Online: Pandemics and their lessons

    Goldman, Michael A

    Science (New York, N.Y.)

    2023  Volume 381, Issue 6665, Page(s) 1418

    Abstract: Distrust and xenophobia have long been stumbling blocks during public health crises. ...

    Abstract Distrust and xenophobia have long been stumbling blocks during public health crises.
    Language English
    Publishing date 2023-09-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.adj8933
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  4. Article ; Online: Autonomy Is Desired, Entrustment Is What Matters.

    Goldman, Michael P / Auerbach, Marc A

    Hospital pediatrics

    2023  Volume 13, Issue 6, Page(s) e150–e152

    MeSH term(s) Humans ; Internship and Residency ; Clinical Competence
    Language English
    Publishing date 2023-05-06
    Publishing country United States
    Document type Editorial ; Comment
    ISSN 2154-1671
    ISSN (online) 2154-1671
    DOI 10.1542/hpeds.2023-007205
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  5. Article ; Online: Management of the Difficult Airway.

    Miller, Kelsey A / Goldman, Michael P / Nagler, Joshua

    Pediatric emergency care

    2023  Volume 39, Issue 3, Page(s) 192–200

    Abstract: Abstract: Airway management is a fundamental component of care during resuscitation of critically ill and injured children. In addition to predicted anatomic and physiologic differences in children compared with adults, certain conditions can predict ... ...

    Abstract Abstract: Airway management is a fundamental component of care during resuscitation of critically ill and injured children. In addition to predicted anatomic and physiologic differences in children compared with adults, certain conditions can predict potential difficulty during pediatric airway management. This review presents approaches to identifying pediatric patients in whom airway management is more likely to be difficult, and discusses strategies to address such challenges. These strategies include optimization of effective bag-mask ventilation, alternative approaches to laryngoscopy, use of adjunct airway devices, modifications to rapid sequence intubation, and performance of surgical airways in children. The importance of considering systems of care in preparing for potentially difficult pediatric airways is also discussed.
    MeSH term(s) Adult ; Humans ; Child ; Intubation, Intratracheal ; Airway Management ; Laryngoscopy ; Resuscitation ; Critical Illness
    Language English
    Publishing date 2023-02-16
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 632588-9
    ISSN 1535-1815 ; 0749-5161
    ISSN (online) 1535-1815
    ISSN 0749-5161
    DOI 10.1097/PEC.0000000000002916
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  6. Article ; Online: Foreword

    Ian Goldman

    Journal of MultiDisciplinary Evaluation, Vol 19, Iss

    2023  Volume 44

    Abstract: ... we would like to pay tribute to Michael Harnar, Bagele Chilisa, and Nicky Bowman for their dedicated work ...

    Abstract This special edition of JMDE is a watershed for the International Evaluation Academy - the first science output, and on such an important topic. The collaboration with JMDE has been outstanding, and we would like to pay tribute to Michael Harnar, Bagele Chilisa, and Nicky Bowman for their dedicated work shepherding this edition. We hope this can be an important contribution to rethinking how evaluation can be fit for purpose in a world of polycrises, where the traditional Western growth models have led us to the brink of catastrophe. We need different ways of looking at the world, and learning from indigenous and decolonized approaches will be key in us garnering the wisdom to learn and transform how we use evaluation in the service of humanity and Nature, rather than for continued exploitation and despoilation. We hope this will be the first of many collaborations with the Journal. We wish you all fruitful reading and engagement.
    Keywords Education ; L ; Social Sciences ; H
    Language English
    Publishing date 2023-07-01T00:00:00Z
    Publisher The Evaluation Center at Western Michigan University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Plant-based and Early Time-restricted Eating for Prevention and Treatment of Type 2 Diabetes in Adults: A Narrative Review.

    Goldman, David M / Warbeck, Cassandra B / Waterfall, Thomas J / Sud, Adam / Quarshie, Michael / Craddock, Joel C

    Canadian journal of diabetes

    2024  

    Abstract: Type 2 diabetes (T2D) is a significant public health challenge for which effective lifestyle interventions are needed. A growing body of evidence supports the use of both plant-based eating patterns and early time-restricted eating (eTRE) for the ... ...

    Abstract Type 2 diabetes (T2D) is a significant public health challenge for which effective lifestyle interventions are needed. A growing body of evidence supports the use of both plant-based eating patterns and early time-restricted eating (eTRE) for the prevention and treatment of T2D, but research has not yet explored the potential of these dietary strategies in combination. In this narrative review we assessed the evidence by which plant-based diets, in conjunction with eTRE, could support T2D care. The electronic databases MEDLINE and the Web of Science were searched for relevant articles published throughout the last decade. Observational research has shown that healthy plant-based eating patterns and eTRE are associated with reductions in T2D risk. Interventional trials demonstrated that plant-based diets promote improvements in glycated hemoglobin, insulin resistance, glycemic control, and cardiometabolic risk factors. These changes may be mediated, in part, by reductions in oxidative stress, dietary acid load, and hepatocellular and intramyocellular lipids. The eTRE strategies were also shown to improve insulin resistance and glycemic control, and mechanisms of action included enhanced regulation of circadian rhythm and increased metabolic flexibility. Integrating these dietary strategies may produce additive benefits, mediated by reduced visceral adiposity and beneficial shifts in gut microbiota composition. However, potential barriers to concurrent implementation of these interventions may exist, including social challenges, scheduling constraints, and tolerance. Prospective trials are needed to examine their acceptability and clinical effects.
    Language English
    Publishing date 2024-03-19
    Publishing country Canada
    Document type Journal Article ; Review
    ISSN 2352-3840
    ISSN (online) 2352-3840
    DOI 10.1016/j.jcjd.2024.03.002
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  8. Article ; Online: Changes in Physician Work Hours and Implications for Workforce Capacity, 2001 to 2021-Reply.

    Goldman, Anna L / Barnett, Michael L

    JAMA internal medicine

    2023  Volume 183, Issue 7, Page(s) 744

    MeSH term(s) Humans ; Physicians ; Workforce
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2023.1166
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  9. Article: DDX3X and DDX3Y constitutively form nano-sized RNA-protein clusters that foster enzymatic activity.

    Yanas, Amber / Shweta, Him / Owens, Michael C / Liu, Kathy Fange / Goldman, Yale E

    bioRxiv : the preprint server for biology

    2023  

    Abstract: DEAD-box helicases, which are crucial for many aspects of RNA metabolism, often contain intrinsically disordered regions (IDRs), whose functions remain unclear. Using multiparameter confocal microscopy, we reveal that sex chromosome-encoded homologous ... ...

    Abstract DEAD-box helicases, which are crucial for many aspects of RNA metabolism, often contain intrinsically disordered regions (IDRs), whose functions remain unclear. Using multiparameter confocal microscopy, we reveal that sex chromosome-encoded homologous RNA helicases, DDX3X and DDX3Y, form nano-sized RNA-protein clusters (RPCs) that foster their catalytic activities
    Language English
    Publishing date 2023-11-29
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.29.569239
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  10. Article ; Online: Changes in Physician Work Hours and Implications for Workforce Capacity and Work-Life Balance, 2001-2021.

    Goldman, Anna L / Barnett, Michael L

    JAMA internal medicine

    2023  Volume 183, Issue 2, Page(s) 106–114

    Abstract: Importance: Physician work hours are an underexplored facet of the physician workforce that can inform policy for the rapidly changing health care labor market.: Objective: To examine trends in individual physician work hours and their contribution ... ...

    Abstract Importance: Physician work hours are an underexplored facet of the physician workforce that can inform policy for the rapidly changing health care labor market.
    Objective: To examine trends in individual physician work hours and their contribution to clinical workforce changes over a 20-year period.
    Design, setting, and participants: This cross-sectional study focused on active US physicians between January 2001 and December 2021 who were included in the Current Population Survey. Outcomes for physicians, advanced practice professionals (APPs), and nonphysician holders of doctoral degrees were compared, and generalized linear models were used to estimate differences in time trends for weekly work hours across subgroups.
    Main outcomes and measures: Physician and APP workforce size, defined as the number of active clinicians, 3-year moving averages of weekly work hours by individual physicians, and weekly hours contributed by the physician and APP workforce per 100 000 US residents.
    Results: A total of 87 297 monthly surveys of physicians from 17 599 unique households were included in the analysis. The number of active physicians grew 32.9% from 2001 to 2021, peaking in 2019 at 989 684, then falling 6.7% to 923 419 by 2021, with disproportionate loss of physicians in rural areas. Average weekly work hours for individual physicians declined by 7.6% (95% CI, -9.1% to -6.1%), from 52.6 to 48.6 hours per week from 2001 to 2021. The downward trend was driven by decreasing hours among male physicians, particularly fathers (11.9% decline in work hours), rural physicians (-9.7%), and physicians aged 45 to 54 years (-9.8%). Physician mothers were the only examined subgroup to experience a statistically significant increase in work hours (3.0%). Total weekly hours contributed by the physician workforce per 10 000 US residents increased by 7.0%, from 13 006 hours in 2001 to 2003 to 13 920 hours in 2019 to 2021, compared with 16.6% growth in the US population over that time period. Weekly hours contributed by the APP workforce per 100 000 US residents grew 71.2% from 2010 through 2012 to 2019 through 2021.
    Conclusions and relevance: This cross-sectional study showed that physician work hours consistently declined in the past 20 years, such that physician workforce hours per capita lagged behind US population growth. This trend was offset by rapid growth in hours contributed by the APP workforce. The gap in physician work hours between men and women narrowed considerably, with diverging potential implications for gender equity. Increasing physician retirement combined with a drop in active physicians during the COVID-19 pandemic may further slow growth in physician workforce hours per capita in the US.
    MeSH term(s) Humans ; Male ; Female ; United States ; Work-Life Balance ; Cross-Sectional Studies ; Pandemics ; COVID-19 ; Physicians ; Workforce ; Surveys and Questionnaires
    Language English
    Publishing date 2023-01-30
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2699338-7
    ISSN 2168-6114 ; 2168-6106
    ISSN (online) 2168-6114
    ISSN 2168-6106
    DOI 10.1001/jamainternmed.2022.5792
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