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Article ; Online: Impact of Noninvasive Respiratory Support in Patients With COVID-19 Requiring V-V ECMO.

Ahmad, Qamar / Green, Adam / Chandel, Abhimanyu / Lantry, James / Desai, Mehul / Simou, Jikerkhoun / Osborn, Erik / Singh, Ramesh / Puri, Nitin / Moran, Patrick / Dalton, Heidi / Speir, Alan / King, Christopher

ASAIO journal (American Society for Artificial Internal Organs : 1992)

2022 Volume 68, Issue 2, Page(s) 171–177

Abstract: ... unknown. We reviewed data of patients with coronavirus disease 2019 (COVID-19) treated with V-V ECMO ...

Abstract	The impact of the duration of noninvasive respiratory support (RS) including high-flow nasal cannula and noninvasive ventilation before the initiation of extracorporeal membrane oxygenation (ECMO) is unknown. We reviewed data of patients with coronavirus disease 2019 (COVID-19) treated with V-V ECMO at two high-volume tertiary care centers. Survival analysis was used to compare the effect of duration of RS on liberation from ECMO. A total of 78 patients required ECMO and the median duration of RS and invasive mechanical ventilation (IMV) before ECMO was 2 days (interquartile range [IQR]: 0, 6) and 2.5 days (IQR: 1, 5), respectively. The median duration of ECMO support was 24 days (IQR: 11, 73) and 59.0% (N = 46) remained alive at the time of censure. Patients that received RS for ≥3 days were significantly less likely to be liberated from ECMO (HR: 0.46; 95% CI: 0.26-0.83), IMV (HR: 0.42; 95% CI: 0.20-0.89) or be discharged from the hospital (HR: 0.52; 95% CI: 0.27-0.99) compared to patients that received RS for <3 days. There was no difference in hospital mortality between the groups (HR: 1.12; 95% CI: 0.56-2.26). These relationships persisted after adjustment for age, gender, and duration of IMV. Prolonged duration of RS before ECMO may result in lung injury and worse subsequent outcomes.
MeSH term(s)	COVID-19 ; Extracorporeal Membrane Oxygenation/adverse effects ; Humans ; Respiration, Artificial ; Retrospective Studies ; SARS-CoV-2 ; Treatment Outcome
Language	English
Publishing date	2022-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	759982-1
ISSN	1538-943X ; 0162-1432 ; 1058-2916
ISSN (online)	1538-943X
ISSN	0162-1432 ; 1058-2916
DOI	10.1097/MAT.0000000000001626
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Zs.B 2435: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article: Relationship of Serum Apolipoprotein A-V Levels, Oxidative Stress and Inflammatory Biomarkers with Hypertriglyceridemia in Type 2 Diabetes Mellitus.

Sharma, Devesh / Garg, Seema / Mehndiratta, Mohit / V Madhu, S / Puri, Dinesh

International journal of endocrinology and metabolism

2017 Volume 15, Issue 2, Page(s) e44805

Abstract: ... the risk of incident cardiovascular disease (CVD) substantially. In recent years, apolipoprotein A-V (Apo ... A-V protein) has attracted considerably as a modulator of circulating TG levels.: Objectives ... The study was conducted in order to evaluate the levels of Apo A - V proteins and markers of inflammation ...

Abstract	Background: Serum levels of triglycerides (TGs) are often found to be raised in type 2 diabetes mellitus (T2DM). TG levels ≥ 2.2 mM, systemic inflammation and oxidative stress (OS) are known to increase the risk of incident cardiovascular disease (CVD) substantially. In recent years, apolipoprotein A-V (Apo A-V protein) has attracted considerably as a modulator of circulating TG levels. Objectives: The study was conducted in order to evaluate the levels of Apo A - V proteins and markers of inflammation and OS in patients of T2DM with and without hypertriglyceridemia (HTG) and also to assess correlation between them. Methods: T2DM patients were categorized into two groups of 40 participants, according to criteria for risk of CVD: group 1/ controls (TG ≤ 1.65 mM, n = 40) and group 2/ cases (TG ≥ 2.2 mM, n = 40). Despite the routine investigations, serum levels of Apo A-V, interleukin-6 (IL-6) and Insulin were estimated using ELISA, free fatty acids (FFA) with fluorometric assay and malondialdehyde (MDA) was measured using a spectrophotometer. Comparison of levels and correlation between variables was carried out with appropriate statistical tools. Results: Serum Apo A-V protein levels were found significantly lower (P = 0.04) and MDA was significantly higher (P = 0.049) in cases. MDA correlated with TG levels positively (P = 0.000) and negatively with high density lipoproteins (HDL) (P = 0.000). However Apo A-V protein levels did not correlate with TG levels (P = 0.819, r = -0.027), IL-6 (r = 0.135, P = 0.269), FFA (r = 0.128, P = 0.277) and MDA (r = -0.217, P = 0.073). IL-6 levels significantly and positively correlated with HOMA-IR (r = 0.327, P = 0.004) in the all patients. Conclusions: In patients of T2DM, low levels of Apo A-V are associated with HTG, indicating that Apo A-V is linked with TG metabolism. Burden of oxidative stress is greater in HTG of T2DM as is evident from MDA levels and its correlation with TG levels. Since oxidative stress is an important patho-physiological basis which increases the risk of CVD in patients of T2DM with HTG. Further studies are required in order to explore the possible role of Apo A-V in TG metabolism in diabetes.
Language	English
Publishing date	2017-04-22
Publishing country	Iran
Document type	Journal Article
ZDB-ID	2744447-8
ISSN	1726-9148 ; 1726-913X
ISSN (online)	1726-9148
ISSN	1726-913X
DOI	10.5812/ijem.44805
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Article ; Online: Kinetic Spinodal Instabilities in the Mott Transition in V_{2}O_{3}: Evidence from Hysteresis Scaling and Dissipative Phase Ordering.

Bar, Tapas / Choudhary, Sujeet Kumar / Ashraf, Md Arsalan / Sujith, K S / Puri, Sanjay / Raj, Satyabrata / Bansal, Bhavtosh

Physical review letters

2018 Volume 121, Issue 4, Page(s) 45701

Abstract: ... that the depth of supercooling and superheating in vanadium sesquioxide (V_{2}O_{3}) shifts with the temperature ...

Abstract	We present the first systematic observation of scaling of thermal hysteresis with the temperature scanning rate around an abrupt thermodynamic transition in correlated electron systems. We show that the depth of supercooling and superheating in vanadium sesquioxide (V_{2}O_{3}) shifts with the temperature quench rates. The dynamic scaling exponent is close to the mean field prediction of 2/3. These observations, combined with the purely dissipative continuous ordering seen in "quench-and-hold" experiments, indicate departures from classical nucleation theory toward a barrier-free phase ordering associated with critical dynamics. Observation of critical-like features and scaling in a thermally induced abrupt phase transition suggests that the presence of a spinodal-like instability is not just an artifact of the mean field theories but can also exist in the transformation kinetics of real systems, surviving fluctuations.
Language	English
Publishing date	2018-07-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.121.045701
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Article ; Online: Discussion.

Puri, Varun

The Journal of thoracic and cardiovascular surgery

2023 Volume 167, Issue 1, Page(s) 363–364

Language	English
Publishing date	2023-09-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	3104-5
ISSN	1097-685X ; 0022-5223
ISSN (online)	1097-685X
ISSN	0022-5223
DOI	10.1016/j.jtcvs.2023.07.048
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Article ; Online: Phosphorous Chloride-Antimony(V) Chloride-Alkyl Chloride Complexes

Sneh Lata, M S Saini, S N Dubey and D M Puri

Proceedings of Indian National Science Academy, Vol 46, Iss 4A (2015)

2015

Abstract: Phosphorous Chloride-Antimony(V) Chloride-Alkyl Chloride Complexes ...

Abstract	Phosphorous Chloride-Antimony(V) Chloride-Alkyl Chloride Complexes
Keywords	Science ; Q
Language	English
Publishing date	2015-02-01T00:00:00Z
Publisher	Indian National Science Academy
Document type	Article ; Online
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Article ; Online: Bioinformatics-driven identification of prognostic biomarkers in kidney renal clear cell carcinoma.

Verma, Varinder Madhav / Puri, Sanjeev / Puri, Veena

Frontiers in nephrology

2024 Volume 4, Page(s) 1349859

Abstract: Renal cell carcinoma (RCC), particularly the clear cell subtype (ccRCC), poses a significant global health concern due to its increasing prevalence and resistance to conventional therapies. Early detection of ccRCC remains challenging, resulting in poor ... ...

Abstract	Renal cell carcinoma (RCC), particularly the clear cell subtype (ccRCC), poses a significant global health concern due to its increasing prevalence and resistance to conventional therapies. Early detection of ccRCC remains challenging, resulting in poor patient survival rates. In this study, we employed a bioinformatic approach to identify potential prognostic biomarkers for kidney renal clear cell carcinoma (KIRC). By analyzing RNA sequencing data from the TCGA-KIRC project, differentially expressed genes (DEGs) associated with ccRCC were identified. Pathway analysis utilizing the Qiagen Ingenuity Pathway Analysis (IPA) tool elucidated key pathways and genes involved in ccRCC dysregulation. Prognostic value assessment was conducted through survival analysis, including Cox univariate proportional hazards (PH) modeling and Kaplan-Meier plotting. This analysis unveiled several promising biomarkers, such as
Language	English
Publishing date	2024-04-04
Publishing country	Switzerland
Document type	Journal Article
ISSN	2813-0626
ISSN (online)	2813-0626
DOI	10.3389/fneph.2024.1349859
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Article: The role of endoscopic treatment in the management of grade v primary vesicoureteral reflux.

Menezes, Maria N / Puri, Prem

European urology

2007 Volume 52, Issue 5, Page(s) 1505–1509

Abstract: ... II-IV vesicoureteral reflux (VUR), its role in the management of grade V reflux has been questioned ... In this study we reviewed our 21-yr experience of endoscopic treatment in children with grade V primary VUR ... treatment for primary grade V reflux from 1984 to 2004. VUR was unilateral in 39 patients and bilateral ...

Abstract	Objectives: Although endoscopic treatment provides a high rate of success in children with grades II-IV vesicoureteral reflux (VUR), its role in the management of grade V reflux has been questioned. In this study we reviewed our 21-yr experience of endoscopic treatment in children with grade V primary VUR. Methods: We retrospectively reviewed the medical records of 132 children who underwent endoscopic treatment for primary grade V reflux from 1984 to 2004. VUR was unilateral in 39 patients and bilateral in 34, and 59 patients had ipsilateral grade V reflux with a lower grade of VUR on the contralateral side. Endoscopic treatment was performed in a total of 166 grade V ureters; polytetrafluoroethylene was used from 1984 to 2000 and dextranomer/hyaluronic acid from 2001 to 2004. Median follow-up was 12.2 yr and mean follow-up was 13.4 yr. Results: VUR was completely resolved after first injection in 88 (53%) ureters and downgraded to grade I or II in 26 (15.7%). VUR resolved after a second and third injection in 36 (21.7%) and 10 (6%) of ureters, respectively. Endoscopic treatment failed to correct VUR in 6 (3.6%) ureters, requiring ureteral reimplantation in 5 and nephrectomy in 1. Thirteen patients developed urinary tract infections during the follow-up period, and on investigation 9 ureters (5.4%) had recurrence of VUR. No injection or morbidity related to tissue-augmenting substances was noted in any patient. Conclusion: Endoscopic treatment should be the first-line of treatment in management of grade V vesicoureteral reflux.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Cystoscopy/methods ; Dextrans/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Hyaluronic Acid/administration & dosage ; Infant ; Injections ; Male ; Polytetrafluoroethylene/administration & dosage ; Prosthesis Implantation/methods ; Retrospective Studies ; Severity of Illness Index ; Time Factors ; Treatment Outcome ; Urinary Bladder ; Urodynamics ; Urography ; Vesico-Ureteral Reflux/diagnosis ; Vesico-Ureteral Reflux/physiopathology ; Vesico-Ureteral Reflux/surgery
Chemical Substances	Dextrans ; dextranomer-hyaluronic acid copolymer ; Polytetrafluoroethylene (9002-84-0) ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2007-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	193790-x
ISSN	1421-993X ; 0302-2838
ISSN (online)	1421-993X
ISSN	0302-2838
DOI	10.1016/j.eururo.2007.04.082
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Zs.A 1247: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Endoscopic treatment of primary grade V vesicoureteral reflux using hyaluronic acid copolymer (DX/HA).

Hunziker, Manuela / Mohanan, Nochiparambil / D'Asta, Federica / Puri, Prem

Pediatric surgery international

2010 Volume 26, Issue 10, Page(s) 977–979

Abstract: ... to recommend ureteral reimplantation as the treatment of choice in the management of grade V VUR. The purpose ... in the treatment of grade V reflux.: Materials and methods: During 2001-2009, 56 children (35 males, 21 females ... with primary grade V VUR underwent endoscopic treatment using DX/HA. Their ages ranged from 4 months to 11 ...

Abstract	Purpose: Since DX/HA was approved by the Food and Drug Administration in 2001 as an acceptable tissue-augmenting substance for subureteral injection, endoscopic treatment has become increasingly popular for treating vesicoureteral reflux (VUR). However, most paediatric urologists still continue to recommend ureteral reimplantation as the treatment of choice in the management of grade V VUR. The purpose of this study was to prospectively evaluate the effectiveness of endoscopic subureteral injection of DX/HA in the treatment of grade V reflux. Materials and methods: During 2001-2009, 56 children (35 males, 21 females) with primary grade V VUR underwent endoscopic treatment using DX/HA. Their ages ranged from 4 months to 11 years. Forty-nine patients had unilateral grade V VUR, and seven had bilateral grade V (63 refluxing ureters including 17 duplex systems). Renal scarring on dimercaptosuccinic acid was observed in 39 kidneys (mild scarring 13, moderate scarring 14 and severe scarring 12). In all patients, endoscopic injection was made after inserting the needle within the wide ureteral orifice. Renal ultrasound and voiding cystourethrogram was performed 3 months after the endoscopic treatment. If VUR had not resolved, the patient was considered for further endoscopic treatment. After the VUR was resolved, children were followed with renal ultrasound at 1 year and every 2 years thereafter. Results: The VUR completely resolved after first injection of DX/HA in 33 (52.4%) ureters and downgraded to grade I VUR in 7 (11.1%) ureters. 19 (30.2%) ureters required a second injection, and 4 (6.3%) ureters required a third injection to resolve VUR. No children in this series needed reimplantation of ureters or presented with ureteral obstruction during follow-up. Conclusion: Endoscopic treatment with DX/HA is effective in eradicating grade V primary reflux. This simple and minimally invasive treatment should be offered to all parents of children with grade V VUR as an alternative to ureteral reimplantation.
MeSH term(s)	Child ; Child, Preschool ; Endoscopy/methods ; Female ; Follow-Up Studies ; Humans ; Hyaluronic Acid/administration & dosage ; Infant ; Injections ; Male ; Prospective Studies ; Prosthesis Implantation/methods ; Radionuclide Imaging ; Time Factors ; Treatment Outcome ; Urography ; Urologic Surgical Procedures/methods ; Vesico-Ureteral Reflux/diagnostic imaging ; Vesico-Ureteral Reflux/surgery
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2010-07-13
Publishing country	Germany
Document type	Comparative Study ; Journal Article
ZDB-ID	632773-4
ISSN	1437-9813 ; 0179-0358
ISSN (online)	1437-9813
ISSN	0179-0358
DOI	10.1007/s00383-010-2650-1
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Article ; Online: A point mutation, E95D, in the mumps virus V protein disengages STAT3 targeting from STAT1 targeting.

Puri, Mamta / Lemon, Ken / Duprex, W Paul / Rima, Bertus K / Horvath, Curt M

Journal of virology

2009 Volume 83, Issue 13, Page(s) 6347–6356

Abstract: Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein ... transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon ... activated STAT1 or STAT2 protein, mumps virus V protein is unique in its ability to also target STAT3 ...

Abstract	Mumps virus, like other paramyxoviruses in the Rubulavirus genus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leading to the destruction of cellular signal transducer and activator of transcription (STAT) proteins. While many V proteins target the interferon-activated STAT1 or STAT2 protein, mumps virus V protein is unique in its ability to also target STAT3 for ubiquitin modification and proteasome-mediated degradation. Here we report that a single amino acid substitution in the mumps virus V protein, E95D, results in defective STAT3 targeting while maintaining the ability to target STAT1. Results indicate that the E95D mutation disrupts the ability of the V protein to associate with STAT3. A recombinant mumps virus carrying the E95D mutation in its P and V proteins replicates normally in cultured cells but fails to induce targeting of STAT3. Infection with the recombinant virus results in the differential regulation of a number of cellular genes compared to wild-type mumps virus and increases cell death in infected cells, producing a large-plaque phenotype.
MeSH term(s)	Amino Acid Substitution ; Animals ; Chlorocebus aethiops ; Gene Expression Regulation ; Host-Pathogen Interactions ; Humans ; Mice ; Mumps/virology ; Mumps virus/genetics ; Mumps virus/metabolism ; Mutagenesis, Site-Directed ; Oligonucleotide Array Sequence Analysis ; Point Mutation ; STAT1 Transcription Factor/metabolism ; STAT3 Transcription Factor/metabolism ; Vero Cells ; Viral Proteins/genetics ; Viral Proteins/metabolism
Chemical Substances	STAT1 Transcription Factor ; STAT1 protein, human ; STAT3 Transcription Factor ; STAT3 protein, human ; Viral Proteins
Language	English
Publishing date	2009-04-22
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80174-4
ISSN	1098-5514 ; 0022-538X
ISSN (online)	1098-5514
ISSN	0022-538X
DOI	10.1128/JVI.00596-09
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Article: Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1.

Lu, Lenette L / Puri, Mamta / Horvath, Curt M / Sen, Ganes C

The Journal of biological chemistry

2008 Volume 283, Issue 21, Page(s) 14269–14276

Abstract: V accessory proteins from Paramyxoviruses are important in viral evasion ... of interferon regulatory factor 3 (IRF3)-mediated gene induction, we identified select paramyxoviral V proteins that inhibited ... that interaction between V and the IRF3/7 kinases, TRAF family member-associated NFkappaB activator (TANK)-binding ...

Abstract	V accessory proteins from Paramyxoviruses are important in viral evasion of the innate immune response. Here, using a cell survival assay that identifies both inhibitors and activators of interferon regulatory factor 3 (IRF3)-mediated gene induction, we identified select paramyxoviral V proteins that inhibited double-stranded RNA-mediated signaling; these are encoded by mumps virus (MuV), human parainfluenza virus 2 (hPIV2), and parainfluenza virus 5 (PIV5), all members of the genus Rubulavirus. We showed that interaction between V and the IRF3/7 kinases, TRAF family member-associated NFkappaB activator (TANK)-binding kinase 1 (TBK1)/inhibitor of kappaB kinase epsilon (IKKe), was essential for this inhibition. Indeed, V proteins were phosphorylated directly by TBK1/IKKe, and this, intriguingly, resulted in lowering of the cellular level of V. Thus, it appears that V mimics IRF3 in both its phosphorylation by TBK1/IKKe and its subsequent degradation. Finally, a PIV5 mutant encoding a V protein that could not inhibit IKKe was much more susceptible to the antiviral effects of double-stranded RNA than the wild-type virus. Because many innate immune response signaling pathways, including those initiated by TLR3, TLR4, RIG-I, MDA5, and DNA-dependent activator of IRFs (DAI), use TBK1/IKKe as the terminal kinases to activate IRFs, rubulaviral V proteins have the potential to inhibit all of them.
MeSH term(s)	Animals ; Cell Line ; Chlorocebus aethiops ; Gene Expression Regulation ; Humans ; I-kappa B Kinase/metabolism ; Interferon Regulatory Factor-3/antagonists & inhibitors ; Interferon Regulatory Factor-3/genetics ; Interferon Regulatory Factor-3/metabolism ; Paramyxoviridae/genetics ; Paramyxoviridae/metabolism ; Phosphorylation ; Protein Binding ; Protein-Serine-Threonine Kinases/metabolism ; Signal Transduction ; Substrate Specificity ; Toll-Like Receptor 3/metabolism ; Transcriptional Activation ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication
Chemical Substances	Interferon Regulatory Factor-3 ; Toll-Like Receptor 3 ; Viral Proteins ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; I-kappa B Kinase (EC 2.7.11.10)
Language	English
Publishing date	2008-03-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1074/jbc.M710089200
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