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  1. Article ; Online: Advances in research strategies and approaches for toxicity testing of environmental exposures.

    Wang, Huihui / Zhang, Qiang / Pi, Jingbo

    Toxicology and applied pharmacology

    2023  Volume 460, Page(s) 116363

    MeSH term(s) Research Design ; Environmental Exposure ; Environmental Pollutants/toxicity ; Risk Assessment
    Chemical Substances Environmental Pollutants
    Language English
    Publishing date 2023-01-07
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2023.116363
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  2. Article: The Role and Mechanism of Retinol and Its Transformation Product, Retinoic Acid, in Modulating Oxidative Stress-Induced Damage to the Duck Intestinal Epithelial Barrier In Vitro.

    Zhang, Li / Tang, Rui / Wu, Yan / Liang, Zhenhua / Liu, Jingbo / Pi, Jinsong / Zhang, Hao

    Animals : an open access journal from MDPI

    2023  Volume 13, Issue 19

    Abstract: This study aimed to investigate the effects and mechanisms of retinol and retinoic acid on primary duck intestinal epithelial cells under oxidative stress induced by ... ...

    Abstract This study aimed to investigate the effects and mechanisms of retinol and retinoic acid on primary duck intestinal epithelial cells under oxidative stress induced by H
    Language English
    Publishing date 2023-10-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani13193098
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  3. Article ; Online: Pb-Induced Eryptosis May Provoke Thrombosis Prior to Hemolysis.

    Jin, Qiushuo / Yao, Chunyang / Bian, Yiying / Pi, Jingbo

    International journal of molecular sciences

    2022  Volume 23, Issue 13

    Abstract: Lead (Pb) is a common metal, which can be toxic to the human body via the pollution of water or food, and can cause anemia and other diseases. However, what happens before hemolysis and anemia caused by Pb poisoning is unclear. Here, we demonstrated Pb ... ...

    Abstract Lead (Pb) is a common metal, which can be toxic to the human body via the pollution of water or food, and can cause anemia and other diseases. However, what happens before hemolysis and anemia caused by Pb poisoning is unclear. Here, we demonstrated Pb can cause procoagulant activity of erythroid cells leading to thrombosis before hemolysis. In freshly isolated human erythroid cells, we observed that Pb resulted in hemolysis in both concentration- and time-dependent manners, but that no lysis occurred in Pb-exposed erythroid cells (≤20 μM for 1 h). Pb treatment did not cause shape changes at up to 0.5 h incubation but at 1 h incubation echinocyte and echino-spherocyte shape changes were observed, indicating that Pb can exaggerate a concentration- and time-dependent trend of shape changes in erythroid cells. After Pb treatment, ROS-independent eryptosis was shown with no increase of reactive oxygen species (ROS), but with an increase of [Ca
    MeSH term(s) Anemia ; Animals ; Calcium ; Eryptosis ; Erythrocytes ; Hemolysis ; Lead/toxicity ; Mice ; Phosphatidylserines ; Reactive Oxygen Species ; Thrombosis/etiology
    Chemical Substances Phosphatidylserines ; Reactive Oxygen Species ; Lead (2P299V784P) ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23137008
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  4. Article ; Online: Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway.

    Liu, Shengnan / Pi, Jingbo / Zhang, Qiang

    Redox biology

    2022  Volume 54, Page(s) 102389

    Abstract: The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ... ...

    Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely was it looked at from a quantitative signaling perspective. Signal amplification, i.e., ultrasensitivity, is crucially important for robust induction of antioxidant genes to appropriate levels that can adequately counteract the stresses. In this review article, we examined a number of well-known molecular events in the KEAP1-NRF2-ARE pathway from a quantitative perspective with a focus on how signal amplification can be achieved. We illustrated, by using a series of mathematical models, that redox-regulated protein sequestration, stabilization, translation, nuclear trafficking, DNA promoter binding, and transcriptional induction - which are embedded in the molecular network comprising KEAP1, NRF2, sMaf, p62, and BACH1 - may generate highly ultrasensitive NRF2 activation and antioxidant gene induction. The emergence and degree of ultrasensitivity depend on the strengths of protein-protein and protein-DNA interaction and protein abundances. A unique, quantitative understanding of signal amplification in the KEAP1-NRF2-ARE pathway will help to identify sensitive targets for the prevention and therapeutics of oxidative stress-related diseases and develop quantitative adverse outcome pathway models to facilitate the health risk assessment of oxidative chemicals.
    MeSH term(s) Antioxidants/metabolism ; Kelch-Like ECH-Associated Protein 1/genetics ; Kelch-Like ECH-Associated Protein 1/metabolism ; NF-E2-Related Factor 2/genetics ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress ; Signal Transduction
    Chemical Substances Antioxidants ; Kelch-Like ECH-Associated Protein 1 ; NF-E2-Related Factor 2
    Language English
    Publishing date 2022-06-30
    Publishing country Netherlands
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2701011-9
    ISSN 2213-2317 ; 2213-2317
    ISSN (online) 2213-2317
    ISSN 2213-2317
    DOI 10.1016/j.redox.2022.102389
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  5. Article ; Online: Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway

    Shengnan Liu / Jingbo Pi / Qiang Zhang

    Redox Biology, Vol 54, Iss , Pp 102389- (2022)

    2022  

    Abstract: The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely ... ...

    Abstract The KEAP1-NRF2-ARE signaling pathway plays a central role in mediating the adaptive cellular stress response to oxidative and electrophilic chemicals. This canonical pathway has been extensively studied and reviewed in the past two decades, but rarely was it looked at from a quantitative signaling perspective. Signal amplification, i.e., ultrasensitivity, is crucially important for robust induction of antioxidant genes to appropriate levels that can adequately counteract the stresses. In this review article, we examined a number of well-known molecular events in the KEAP1-NRF2-ARE pathway from a quantitative perspective with a focus on how signal amplification can be achieved. We illustrated, by using a series of mathematical models, that redox-regulated protein sequestration, stabilization, translation, nuclear trafficking, DNA promoter binding, and transcriptional induction – which are embedded in the molecular network comprising KEAP1, NRF2, sMaf, p62, and BACH1 – may generate highly ultrasensitive NRF2 activation and antioxidant gene induction. The emergence and degree of ultrasensitivity depend on the strengths of protein-protein and protein-DNA interaction and protein abundances. A unique, quantitative understanding of signal amplification in the KEAP1-NRF2-ARE pathway will help to identify sensitive targets for the prevention and therapeutics of oxidative stress-related diseases and develop quantitative adverse outcome pathway models to facilitate the health risk assessment of oxidative chemicals.
    Keywords Oxidative stress ; KEAP1 ; NRF2 ; ARE ; Ultrasensitivity ; Signal amplification ; Medicine (General) ; R5-920 ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2022-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Pb-Induced Eryptosis May Provoke Thrombosis Prior to Hemolysis

    Qiushuo Jin / Chunyang Yao / Yiying Bian / Jingbo Pi

    International Journal of Molecular Sciences, Vol 23, Iss 7008, p

    2022  Volume 7008

    Abstract: Lead (Pb) is a common metal, which can be toxic to the human body via the pollution of water or food, and can cause anemia and other diseases. However, what happens before hemolysis and anemia caused by Pb poisoning is unclear. Here, we demonstrated Pb ... ...

    Abstract Lead (Pb) is a common metal, which can be toxic to the human body via the pollution of water or food, and can cause anemia and other diseases. However, what happens before hemolysis and anemia caused by Pb poisoning is unclear. Here, we demonstrated Pb can cause procoagulant activity of erythroid cells leading to thrombosis before hemolysis. In freshly isolated human erythroid cells, we observed that Pb resulted in hemolysis in both concentration- and time-dependent manners, but that no lysis occurred in Pb-exposed erythroid cells (≤20 μM for 1 h). Pb treatment did not cause shape changes at up to 0.5 h incubation but at 1 h incubation echinocyte and echino-spherocyte shape changes were observed, indicating that Pb can exaggerate a concentration- and time-dependent trend of shape changes in erythroid cells. After Pb treatment, ROS-independent eryptosis was shown with no increase of reactive oxygen species (ROS), but with an increase of [Ca 2+ ] i and caspase 3 activity. With a thrombosis mouse model, we observed increased thrombus by Pb treatment (0 or 25 mg/kg). In brief, prior to hemolysis, we demonstrated Pb can cause ROS-independent but [Ca 2+ ] i -dependent eryptosis, which might provoke thrombosis.
    Keywords lead (Pb) ; ROS-independent ; intracellular calcium level ; eryptosis ; shape changes ; venous thrombosis mice model ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: MiR-106a-5p by Targeting

    Zhang, Li / Luo, Xiang / Tang, Rui / Wu, Yan / Liang, Zhenhua / Liu, Jingbo / Pi, Jinsong / Zhang, Hao

    Animals : an open access journal from MDPI

    2024  Volume 14, Issue 7

    Abstract: Under caged stress conditions, severe disruptions in duck intestinal barrier function, which adversely affect economic performance, have been observed. MiRNAs play a crucial role in cellular processes, but the mechanisms underlying their involvement in ... ...

    Abstract Under caged stress conditions, severe disruptions in duck intestinal barrier function, which adversely affect economic performance, have been observed. MiRNAs play a crucial role in cellular processes, but the mechanisms underlying their involvement in repairing oxidative stress-induced damage to duck intestinal barriers have not been elucidated. We performed miRNA-seq and protein tandem mass tagging (TMT) sequencing and identified differentially expressed miRNAs and proteins in oxidative stress-treated ducks. Dual-luciferase reporter vector experiments, RT-qPCR, and Western blotting revealed the regulatory role of apla-miR-106a-5p/MAP3K2 in intestinal barrier damage repair. The results showed that oxidative stress led to shortened villi and deepened crypts, impairing intestinal immune function. Significant downregulation of apla-miR-106a-5p was revealed by miRNA-seq, and the inhibition of its expression not only enhanced cell viability but also improved intestinal barrier function. TMT protein sequencing revealed MAP3K2 upregulation in caged-stressed duck intestines, and software analysis confirmed
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606558-7
    ISSN 2076-2615
    ISSN 2076-2615
    DOI 10.3390/ani14071037
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  8. Article ; Online: Arsenic as an environmental toxicant and a therapeutic agent: Foe and friend.

    Xu, Yuanyuan / Tokar, Erik J / Pi, Jingbo

    Toxicology and applied pharmacology

    2021  Volume 415, Page(s) 115438

    MeSH term(s) Animals ; Antineoplastic Agents/adverse effects ; Arsenic/adverse effects ; Arsenic Poisoning/etiology ; Arsenic Poisoning/genetics ; Arsenic Poisoning/metabolism ; Arsenic Poisoning/pathology ; Cell Transformation, Neoplastic/chemically induced ; Cell Transformation, Neoplastic/genetics ; Cell Transformation, Neoplastic/metabolism ; Cell Transformation, Neoplastic/pathology ; DNA Damage ; Epigenesis, Genetic/drug effects ; Gene Expression Regulation, Neoplastic ; Humans ; Neoplasms/chemically induced ; Neoplasms/genetics ; Neoplasms/metabolism ; Neoplasms/pathology ; Nervous System/drug effects ; Nervous System/metabolism ; Nervous System/pathology ; Patient Safety ; Risk Assessment ; Risk Factors
    Chemical Substances Antineoplastic Agents ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2021-02-04
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 204477-8
    ISSN 1096-0333 ; 0041-008X
    ISSN (online) 1096-0333
    ISSN 0041-008X
    DOI 10.1016/j.taap.2021.115438
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    In stock of ZB MED Cologne/Königswinter

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  9. Article ; Online: The Role and Mechanism of Retinol and Its Transformation Product, Retinoic Acid, in Modulating Oxidative Stress-Induced Damage to the Duck Intestinal Epithelial Barrier In Vitro

    Li Zhang / Rui Tang / Yan Wu / Zhenhua Liang / Jingbo Liu / Jinsong Pi / Hao Zhang

    Animals, Vol 13, Iss 3098, p

    2023  Volume 3098

    Abstract: This study aimed to investigate the effects and mechanisms of retinol and retinoic acid on primary duck intestinal epithelial cells under oxidative stress induced by H 2 O 2 . Different ratios of retinol and retinoic acid were used for treatment. The ... ...

    Abstract This study aimed to investigate the effects and mechanisms of retinol and retinoic acid on primary duck intestinal epithelial cells under oxidative stress induced by H 2 O 2 . Different ratios of retinol and retinoic acid were used for treatment. The study evaluated the cell morphology, viability, antioxidative capacity, and barrier function of cells. The expression of genes related to oxidative stress and the intestinal barrier was analyzed. The main findings demonstrated that the treated duck intestinal epithelial cells exhibited increased viability, increased antioxidative capacity, and improved intestinal barrier function compared to the control group. High retinoic acid treatment improved viability and gene expression, while high retinol increased antioxidative indicators and promoted intestinal barrier repair. Transcriptome analysis revealed the effects of treatments on cytokine interactions, retinol metabolism, PPAR signaling, and cell adhesion. In conclusion, this study highlights the potential of retinol and retinoic acid in protecting and improving intestinal cell health under oxidative stress, providing valuable insights for future research.
    Keywords retinol ; retinoic acid ; duck intestinal epithelial cell ; oxidative stress ; mechanism ; Veterinary medicine ; SF600-1100 ; Zoology ; QL1-991
    Subject code 610
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms.

    Yang, Yang / Liu, Zhiyuan / Wu, Jinzhi / Bao, Simeng / Wang, Yanshuai / Li, Jiliang / Song, Tao / Sun, Yongxin / Pi, Jingbo

    Antioxidants (Basel, Switzerland)

    2023  Volume 12, Issue 12

    Abstract: Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antioxidants and ... ...

    Abstract Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antioxidants and reactive oxygen species (ROS) levels, especially the cytoplasmic and mitochondrial ROS during osteoclastogenesis in vitro. In the current study, we found that the absence of
    Language English
    Publishing date 2023-12-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704216-9
    ISSN 2076-3921
    ISSN 2076-3921
    DOI 10.3390/antiox12122094
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