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  1. Article: Immediate Effect of Baricitinib on Arthritis and Biological Disease-Modifying Antirheumatic Drug-Induced Psoriasis-Like Skin Lesions in Two Patients with Rheumatoid Arthritis.

    Tada, Yoshifumi / Ono, Nobuyuki / Koarada, Syuichi

    Case reports in rheumatology

    2021  Volume 2021, Page(s) 8876847

    Abstract: Biological disease-modifying antirheumatic drugs (bDMARDs) are very effective for treating rheumatoid arthritis (RA). However, they sometimes induce adverse events such as psoriasis-like skin lesions. We describe psoriasis-like skin lesions that ... ...

    Abstract Biological disease-modifying antirheumatic drugs (bDMARDs) are very effective for treating rheumatoid arthritis (RA). However, they sometimes induce adverse events such as psoriasis-like skin lesions. We describe psoriasis-like skin lesions that developed simultaneously with an RA flare in patient 1 during treatment with abatacept and in patient 2 soon after starting certolizumab pegol. The skin lesions persisted in patient 2 despite stopping certolizumab. Baricitinib was initiated because of RA flare and resulted in immediate beneficial effects on arthritis as well as skin lesions. The RA went into remission in both patients, and the psoriasis-like skin lesions disappeared within four weeks (patient 1) and three months (patient 2).
    Language English
    Publishing date 2021-02-05
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2666708-3
    ISSN 2090-6897 ; 2090-6889
    ISSN (online) 2090-6897
    ISSN 2090-6889
    DOI 10.1155/2021/8876847
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Placental transfer of tocilizumab in a patient with rheumatoid arthritis.

    Tada, Yoshifumi / Sakai, Mariko / Nakao, Yoshinobu / Maruyama, Akihito / Ono, Nobuyuki / Koarada, Syuichi

    Rheumatology (Oxford, England)

    2019  Volume 58, Issue 9, Page(s) 1694–1695

    MeSH term(s) Adult ; Antibodies, Monoclonal, Humanized/pharmacokinetics ; Antirheumatic Agents/pharmacokinetics ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Infant, Newborn ; Maternal-Fetal Exchange ; Pregnancy ; Pregnancy Complications/drug therapy ; Pregnancy Outcome ; Prenatal Exposure Delayed Effects
    Chemical Substances Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; tocilizumab (I031V2H011)
    Language English
    Publishing date 2019-09-10
    Publishing country England
    Document type Case Reports ; Letter
    ZDB-ID 1464822-2
    ISSN 1462-0332 ; 1462-0324
    ISSN (online) 1462-0332
    ISSN 1462-0324
    DOI 10.1093/rheumatology/kez155
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: RP105-Negative B Cells in Systemic Lupus Erythematosus

    Syuichi Koarada / Yoshifumi Tada

    Clinical and Developmental Immunology, Vol

    2012  Volume 2012

    Keywords Immunologic diseases. Allergy ; RC581-607 ; Specialties of internal medicine ; RC581-951 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Allergy and Immunology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Hindawi Publishing Corporation
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: RP105-negative B cells in systemic lupus erythematosus.

    Koarada, Syuichi / Tada, Yoshifumi

    Clinical & developmental immunology

    2011  Volume 2012, Page(s) 259186

    Abstract: Systemic lupus erythematosus (SLE) is a multisystem disease characterized by B cells producing autoantibodies against nuclear proteins and DNA, especially anti-double-strand DNA (dsDNA) antibodies. RP105 (CD180), the toll-like receptor- (TLR-) associated ...

    Abstract Systemic lupus erythematosus (SLE) is a multisystem disease characterized by B cells producing autoantibodies against nuclear proteins and DNA, especially anti-double-strand DNA (dsDNA) antibodies. RP105 (CD180), the toll-like receptor- (TLR-) associated molecule, is expressed on normal B cells. However, RP105-negative B cells increase in peripheral blood from patients with active SLE. RP105 may regulate B-cell activation, and RP105-negative B cells produce autoantibodies and take part in pathophysiology of SLE. It is possible that targeting RP105-negative B cells is one of the treatments of SLE. In this paper, we discuss the RP105 biology and clinical significance in SLE.
    MeSH term(s) Animals ; Antibodies, Monoclonal, Murine-Derived/therapeutic use ; Antigens, CD/analysis ; Antigens, CD/physiology ; Autoantibodies/biosynthesis ; Autoantibodies/immunology ; B-Lymphocyte Subsets/immunology ; Disease Models, Animal ; Humans ; Immunophenotyping ; Immunotherapy/methods ; Lupus Erythematosus, Systemic/immunology ; Lymphocyte Activation ; Mice ; Rheumatic Diseases/immunology ; Rituximab ; Toll-Like Receptors/immunology
    Chemical Substances Antibodies, Monoclonal, Murine-Derived ; Antigens, CD ; Autoantibodies ; CD180 protein, human ; Toll-Like Receptors ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2011-09-15
    Publishing country Egypt
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2119646-1
    ISSN 1740-2530 ; 1740-2522
    ISSN (online) 1740-2530
    ISSN 1740-2522
    DOI 10.1155/2012/259186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinical features of elderly-onset Adult-onset Still's disease.

    Maruyama, Akihito / Kokuzawa, Ayako / Yamauchi, Yusuke / Kirino, Yohei / Nagai, Hideto / Inoue, Yasushi / Ota, Toshiyuki / Chifu, Yutaka / Inokuchi, Satomi / Koarada, Syuichi / Ohta, Akihide / Iwamoto, Masahiro / Tada, Yoshifumi

    Modern rheumatology

    2020  Volume 31, Issue 4, Page(s) 862–868

    Abstract: Objectives: To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).: Methods: Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according ... ...

    Abstract Objectives: To clarify the characteristics of patients with elderly-onset Adult-onset Still's disease (AOSD).
    Methods: Patients were classified into elderly-onset (>60 years: 47 patients) and younger-onset (≤60 years: 95 patients) groups according to their age at diagnosis of AOSD. Clinical features, treatments, and prognosis were compared between the elderly-onset and younger-onset groups.
    Results: In the elderly-onset group, compared with the younger-onset group, typical skin rashes were less frequent (21.3% vs 58.9%, respectively;
    Conclusions: Our results demonstrated that elderly-onset AOSD patients had several characteristics that differed from younger-onset AOSD patients, including less typical skin lesions, more AOSD-related complications, higher ferritin levels, and poorer prognoses.
    MeSH term(s) Adult ; Age Factors ; Age of Onset ; Aged ; Female ; Humans ; Male ; Middle Aged ; Prognosis ; Still's Disease, Adult-Onset/diagnosis ; Still's Disease, Adult-Onset/pathology
    Language English
    Publishing date 2020-10-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.1080/14397595.2020.1829340
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Successful golimumab therapy in four patients with refractory Takayasu's arteritis.

    Suematsu, Rie / Tashiro, Satoko / Ono, Nobuyuki / Koarada, Syuichi / Ohta, Akihide / Tada, Yoshifumi

    Modern rheumatology

    2016  Volume 28, Issue 4, Page(s) 712–715

    Abstract: Recent studies suggested that anti-TNF-α biological therapies are effective in treating Takayasu's arteritis (TA) refractory to conventional immunosuppressive therapy. However, the efficacy of golimumab (GLM) for TA therapy is unknown. We report four ... ...

    Abstract Recent studies suggested that anti-TNF-α biological therapies are effective in treating Takayasu's arteritis (TA) refractory to conventional immunosuppressive therapy. However, the efficacy of golimumab (GLM) for TA therapy is unknown. We report four women with TA who were successfully treated with GLM. GLM was prescribed as induction therapy for three patients and as maintenance therapy for one patient. GLM showed therapeutic value and might be useful, together with other anti-TNF-α agents, in treating TA.
    MeSH term(s) Adult ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/therapeutic use ; Female ; Humans ; Immunosuppressive Agents/administration & dosage ; Immunosuppressive Agents/therapeutic use ; Takayasu Arteritis/drug therapy ; Takayasu Arteritis/pathology
    Chemical Substances Antibodies, Monoclonal ; Immunosuppressive Agents ; golimumab (91X1KLU43E)
    Language English
    Publishing date 2016-03-21
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2078157-X
    ISSN 1439-7609 ; 1439-7595
    ISSN (online) 1439-7609
    ISSN 1439-7595
    DOI 10.3109/14397595.2015.1134393
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Erythema nodosum-like lesions in Behçet's disease: a clinicopathological study of 26 cases.

    Misago, Noriyuki / Tada, Yoshifumi / Koarada, Syuichi / Narisawa, Yutaka

    Acta dermato-venereologica

    2012  Volume 92, Issue 6, Page(s) 681–686

    Abstract: The histopathological features of erythema nodosum-like lesions remain controversial with regard to whether they resemble those of conventional erythema nodosum. We reviewed the clinicopathological features of erythema nodosum-like lesions in 26 patients ...

    Abstract The histopathological features of erythema nodosum-like lesions remain controversial with regard to whether they resemble those of conventional erythema nodosum. We reviewed the clinicopathological features of erythema nodosum-like lesions in 26 patients with Behçet's disease and evaluated the clinical characteristics of Behçet's disease in these patients. The results suggest that: (i) the clinico-pathological features of 27% of the erythema nodosum-like lesions in Behçet's disease are indistinguishable from those of conventional erythema nodosum; (ii) the other 73% of the erythema nodosum-like lesions are histopathologically characterized by the presence of vasculitis (venulitis or phlebitis); (iii) the clinical features of erythema nodosum-like lesions with vasculitis show heterogeneity; (iv) the presence of the erythema nodosum type lesion may be an indicator of the mildness of Behçet's disease; and (v) the presence of severe vasculitis, especially phlebitis, in erythema nodosum-like lesions may be an indicator of the involvement of the gastrointestinal tract in Behçet's disease.
    MeSH term(s) Adult ; Aged ; Behcet Syndrome/complications ; Behcet Syndrome/pathology ; Biopsy ; Erythema Nodosum/etiology ; Erythema Nodosum/pathology ; Female ; Humans ; Male ; Middle Aged ; Phlebitis/etiology ; Phlebitis/pathology ; Severity of Illness Index ; Skin/pathology
    Language English
    Publishing date 2012-11
    Publishing country Sweden
    Document type Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-1349
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Are the 2016 EULAR/ACR/PRINTO classification criteria for macrophage activation syndrome applicable to patients with adult-onset Still's disease?

    Tada, Yoshifumi / Inokuchi, Satomi / Maruyama, Akihito / Suematsu, Rie / Sakai, Mariko / Sadanaga, Yuri / Ono, Nobuyuki / Arinobu, Yojiro / Koarada, Syuichi

    Rheumatology international

    2018  Volume 39, Issue 1, Page(s) 97–104

    Abstract: The objectives of this study are to determine whether the 2016 European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organization classification criteria for macrophage activation syndrome (MAS) ... ...

    Abstract The objectives of this study are to determine whether the 2016 European League Against Rheumatism/American College of Rheumatology/Paediatric Rheumatology International Trials Organization classification criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (SJIA) can be used to identify MAS in patients with adult-onset Still's disease (AOSD). Using laboratory data from 76 AOSD patients with and without MAS, we analyzed the ability of the collective and individual constitutive elements of the 2016 MAS in SJIA criteria and additional laboratory measures to discriminate between AOSD patients with (n = 16) and without (n = 60) MAS. Cutoff values to determine the sensitivity, specificity, and predictive values were calculated from receiver operating characteristic curves, and modified classification criteria for MAS in AOSD were evaluated. The 2016 MAS in SJIA classification criteria had an overall sensitivity of 100%, specificity of 70.0%, positive predictive value of 47.1%, and negative predictive value of 100% to discriminate between AOSD patients with and without MAS based on laboratory data. Among the individual criteria, the sensitivity of triglycerides (46.7%) and the specificity of ferritin (15.0%) for MAS in AOSD were particularly low. The sensitivity and specificity for classifying MAS in AOSD patients were increased to 100 and 93%, respectively, by excluding triglycerides and changing the cutoff values for other criteria in the 2016 MAS in SJIA classification. The 2016 classification criteria for MAS in SJIA had higher sensitivity but lower specificity to identify MAS in AOSD patients compared with SJIA patients.
    MeSH term(s) Adult ; Arthritis, Juvenile/complications ; Female ; Humans ; Macrophage Activation Syndrome/classification ; Macrophage Activation Syndrome/complications ; Macrophage Activation Syndrome/diagnosis ; Male ; Retrospective Studies ; Rheumatology ; Sensitivity and Specificity ; Still's Disease, Adult-Onset/complications
    Language English
    Publishing date 2018-07-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 8286-7
    ISSN 1437-160X ; 0172-8172
    ISSN (online) 1437-160X
    ISSN 0172-8172
    DOI 10.1007/s00296-018-4114-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Persistent expression of CXCR5 on plasmablasts in IgG4-related disease.

    Koarada, Syuichi / Tashiro, Satoko / Tokuda, Yukiko / Ono, Yukihide / Sadanaga, Yuri / Suematsu, Rie / Ono, Nobuyuki / Ohta, Akihide / Tada, Yoshifumi

    Annals of the rheumatic diseases

    2015  Volume 74, Issue 4, Page(s) e32

    MeSH term(s) Autoimmune Diseases/diagnosis ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Plasma Cells/cytology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2014-207207
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Subsets of RP105-negative plasmablasts in IgG4-related disease.

    Koarada, Syuichi / Tashiro, Satoko / Tokuda, Yukiko / Ono, Yukihide / Sadanaga, Yuri / Suematsu, Rie / Ono, Nobuyuki / Ohta, Akihide / Tada, Yoshifumi

    Annals of the rheumatic diseases

    2014  Volume 73, Issue 10, Page(s) e65

    MeSH term(s) Autoimmune Diseases/diagnosis ; Female ; Humans ; Immunoglobulin G/blood ; Male ; Plasma Cells/cytology
    Chemical Substances Immunoglobulin G
    Language English
    Publishing date 2014-10
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 7090-7
    ISSN 1468-2060 ; 0003-4967
    ISSN (online) 1468-2060
    ISSN 0003-4967
    DOI 10.1136/annrheumdis-2014-206179
    Database MEDical Literature Analysis and Retrieval System OnLINE

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