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Book ; Online: Idea univerzity z české perspektivy

Balík, Stanislav / Dvořák, Petr / Fiala, Petr / Floss, Pavel / Horák, Petr / Jirsa, Jakub / Lach, Jiří / Macháček, Jiří / Machula, Tomáš / Munzar, Dominik / Noble, Ivana / Sokol, Jan / Soukup, Daniel / Šimáčková, Kateřina / Hanuš, Jiří / Hanuš, Jiří

Rozhovory s Jiřím Hanušem

(Masaryk University Conversations ; 1)

2021

Series title	Masaryk University Conversations ; 1
Keywords	Philosophy & theory of education ; History of education ; Organization & management of education ; the idea of university, education, history, status of universities, perception of universities and education
Language	0\|c
Size	1 electronic resource (213 pages)
Publisher	Masaryk University Press
Document type	Book ; Online
Note	Czech ; Open Access
HBZ-ID	HT021610948
ISBN	9788021097629 ; 8021097620
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article: Capture threshold of bipolar and unipolar pacing of left ventricle via coronary sinus branch: longitudinal study.

Stritecky, Jakub / Kremlacek, Jan / Hanus, Josef / Haman, Ludek / Stritecka, Hana / Simka, Jakub / Parizek, Petr

Frontiers in cardiovascular medicine

2023 Volume 10, Page(s) 1096538

Abstract: Introduction: The aim of this paper is to first monitor the changes in the capture threshold of endovascularly placed leads for left ventricle pacing, second to compare the pacing configurations, and third to verify the effect of Steroid elution for ... ...

Abstract	Introduction: The aim of this paper is to first monitor the changes in the capture threshold of endovascularly placed leads for left ventricle pacing, second to compare the pacing configurations, and third to verify the effect of Steroid elution for endovascular leads. Sample and method: The study included 202 consecutive single centre patients implanted with the Quartet™ lead (St. Jude Medical). The capture threshold and related lead parameters were tested during implantation, on the day of the patient's discharge, and 3, 9, and 15 months after implantation. The electrical energy corresponding to the threshold values for inducing ventricular contraction was recorded for subgroups of patients with bipolar and pseudo-unipolar pacing vectors and electrodes equipped with and without a slow-eluting steroids. The best setting for the resynchronization effect was generally chosen. Capture threshold was taken as a selection criterion only if there were multiple options with (expected) similar resynchronization effect. Results and discussion: The measurements showed that the ratio of threshold energies of UNI vs. BI was 5× higher (
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2023.1096538
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The effect of curcumin encapsulation into yeast glucan particles on antioxidant enzyme expression

Treml, Jakub / Šalamúnová, Petra / Hanuš, Jaroslav / Hošek, Jan

Food & function

2021 Volume 12, Issue 5, Page(s) 1954–1957

Abstract: Glucan particles (GPs) from Saccharomyces cerevisiae consist mainly of β-1,3-d-glucan. Curcumin is a phenolic compound of plant origin. A 24 h incubation with a mixture of GPs and curcumin increased the expression of the Nrf2 protein and increased the ... ...

Abstract	Glucan particles (GPs) from Saccharomyces cerevisiae consist mainly of β-1,3-d-glucan. Curcumin is a phenolic compound of plant origin. A 24 h incubation with a mixture of GPs and curcumin increased the expression of the Nrf2 protein and increased the activation of the Nrf2-ARE system significantly.
MeSH term(s)	Antioxidants/chemistry ; Antioxidants/metabolism ; Antioxidants/pharmacology ; Curcumin/chemistry ; Curcumin/pharmacology ; Drug Compounding ; Glucans/chemistry ; Hep G2 Cells ; Humans ; NF-E2-Related Factor 2/metabolism ; Oxidative Stress/drug effects ; Saccharomyces cerevisiae/chemistry ; THP-1 Cells
Chemical Substances	Antioxidants ; Glucans ; NF-E2-Related Factor 2 ; NFE2L2 protein, human ; Curcumin (IT942ZTH98)
Language	English
Publishing date	2021-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2612033-1
ISSN	2042-650X ; 2042-6496
ISSN (online)	2042-650X
ISSN	2042-6496
DOI	10.1039/d0fo03237a
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Laser-Treated MXene as an Electrochemical Agent to Boost Properties of Semitransparent Photoelectrode Based on Titania Nanotubes.

Kouao, Dujearic-Stephane / Grochowska, Katarzyna / Stranak, Vitezslav / Sezemsky, Petr / Gumieniak, Justyna / Kramek, Agnieszka / Karczewski, Jakub / Coy, Emerson / Hanus, Jan / Kylian, Ondrej / Sawczak, Mirosław / Siuzdak, Katarzyna

ACS nano

2024 Volume 18, Issue 14, Page(s) 10165–10183

Abstract: In this study, ... ...

Abstract	In this study, Ti
Language	English
Publishing date	2024-03-27
Publishing country	United States
Document type	Journal Article
ISSN	1936-086X
ISSN (online)	1936-086X
DOI	10.1021/acsnano.4c00092
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Radiometric and Atmospheric Corrections of Multispectral μMCA Camera for UAV Spectroscopy

Robert Minařík / Jakub Langhammer / Jan Hanuš

Remote Sensing, Vol 11, Iss 20, p

2019 Volume 2428

Abstract: This study presents a complex empirical image-based radiometric calibration method for a Tetracam μMCA multispectral frame camera. The workflow is based on a laboratory investigation of the camera’s radiometric properties combined with vicarious ... ...

Abstract	This study presents a complex empirical image-based radiometric calibration method for a Tetracam μMCA multispectral frame camera. The workflow is based on a laboratory investigation of the camera’s radiometric properties combined with vicarious atmospheric correction using an empirical line. The effect of the correction is demonstrated on out-of-laboratory field campaign data. The dark signal noise behaviour was investigated based on the exposure time and ambient temperature. The vignette effect coupled with nonuniform quantum efficiency was studied with respect to changing exposure times and illuminations to simulate field campaign conditions. The efficiency of the proposed correction workflow was validated by comparing the reflectance values that were extracted from a fully corrected image and the raw data of the reference spectroscopy measurement using three control targets. The Normalized Root Mean Square Errors (NRMSE) of all separate bands ranged from 0.24 to 2.10%, resulting in a significant improvement of the NRMSE compared to the raw data. The results of a field experiment demonstrated that the proposed correction workflow significantly improves the quality of multispectral imagery. The workflow was designed to be applicable to the out-of-laboratory conditions of UAV imaging campaigns in variable natural conditions and other types of multiarray imaging systems.
Keywords	uav ; multispectral sensor ; tetracam μmca ; radiometric corrections ; atmospheric corrections ; spectroscopy ; Science ; Q
Language	English
Publishing date	2019-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Radiometric and Atmospheric Corrections of Multispectral μMCA Camera for UAV Spectroscopy

Minařík, Robert / Langhammer, Jakub / Hanuš, Jan

Remote Sensing. 2019 Oct. 19, v. 11, no. 20

2019

Abstract	This study presents a complex empirical image-based radiometric calibration method for a Tetracam μMCA multispectral frame camera. The workflow is based on a laboratory investigation of the camera’s radiometric properties combined with vicarious atmospheric correction using an empirical line. The effect of the correction is demonstrated on out-of-laboratory field campaign data. The dark signal noise behaviour was investigated based on the exposure time and ambient temperature. The vignette effect coupled with nonuniform quantum efficiency was studied with respect to changing exposure times and illuminations to simulate field campaign conditions. The efficiency of the proposed correction workflow was validated by comparing the reflectance values that were extracted from a fully corrected image and the raw data of the reference spectroscopy measurement using three control targets. The Normalized Root Mean Square Errors (NRMSE) of all separate bands ranged from 0.24 to 2.10%, resulting in a significant improvement of the NRMSE compared to the raw data. The results of a field experiment demonstrated that the proposed correction workflow significantly improves the quality of multispectral imagery. The workflow was designed to be applicable to the out-of-laboratory conditions of UAV imaging campaigns in variable natural conditions and other types of multiarray imaging systems.
Keywords	ambient temperature ; cameras ; exposure duration ; field experimentation ; image analysis ; multispectral imagery ; radiometry ; reflectance ; remote sensing ; spectroscopy ; unmanned aerial vehicles
Language	English
Dates of publication	2019-1019
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2513863-7
ISSN	2072-4292
ISSN	2072-4292
DOI	10.3390/rs11202428
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Missorting of plasma miRNAs in aging and Alzheimer's disease.

Čarna, Maria / Novotny, Jan S / Dragišić, Neda / Slavik, Hanuš / Sheardova, Kateřina / Geda, Yonas E / Vyhnalek, Martin / Laczo, Jan / Hort, Jakub / Mao, Zixu / Rissman, Robert A / Hajduch, Marian / Dammer, Eric B / Stokin, Gorazd B

Journal of neurochemistry

2023 Volume 165, Issue 2, Page(s) 149–161

Abstract: The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs ... ...

Abstract	The observation that aging is regulated by microRNAs (miRNA) and at the same time represents the greatest risk factor for Alzheimer's disease (AD), prompted us to examine the circulating miRNA network in AD beyond aging. We here show that plasma miRNAs in aging are downregulated and predicted to be preferentially targeted to the extracellular vesicle (EV) content. In AD, miRNAs are further downregulated, display altered proportions of motifs relevant to their loading into EVs and secretion propensity, and are forecast to be found exclusively in EVs. The circulating miRNA network in AD, therefore, reflects pathological exacerbation of the aging process whereby physiological suppression of AD pathology by miRNAs becomes insufficient.
MeSH term(s)	Humans ; MicroRNAs/genetics ; Alzheimer Disease/genetics ; Extracellular Vesicles ; Aging/genetics
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80158-6
ISSN	1471-4159 ; 0022-3042 ; 1474-1644
ISSN (online)	1471-4159
ISSN	0022-3042 ; 1474-1644
DOI	10.1111/jnc.15801
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Incorporating natural anti-inflammatory compounds into yeast glucan particles increases their bioactivity in vitro.

Šalamúnová, Petra / Cupalová, Lucie / Majerská, Monika / Treml, Jakub / Ruphuy, Gabriela / Šmejkal, Karel / Štěpánek, František / Hanuš, Jaroslav / Hošek, Jan

International journal of biological macromolecules

2020 Volume 169, Page(s) 443–451

Abstract: Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating ... ...

Abstract	Yeast glucan particles (GPs) are promising agents for the delivery of biologically active compounds as drugs. GPs possess their own biological activities and can act synergistically with their cargo. This study aimed to determine how incorporating artemisinin, ellagic acid, (-)-epigallocatechin gallate, morusin, or trans-resveratrol into GPs affects their anti-inflammatory and antioxidant potential in vitro. Two different methods - slurry evaporation and spray drying - were used to prepare composites (GPs + bioactive compound) and the anti-inflammatory and antioxidative properties of the resultant products were compared. Several of the natural compounds showed the beneficial effects of being combined with GPs. The materials prepared by spray drying showed greater activity than those made using a rotary evaporator. Natural compounds incorporated into yeast GPs showed greater anti-inflammatory potential in vitro than simple suspensions of these compounds as demonstrated by their inhibition of the activity of transcription factors NF-κB/AP-1 and the secretion of the pro-inflammatory cytokine TNF-α.
MeSH term(s)	Anti-Inflammatory Agents/pharmacology ; Antioxidants/pharmacology ; Artemisinins/pharmacology ; Catechin/analogs & derivatives ; Catechin/chemistry ; Catechin/pharmacology ; Cytokines ; Ellagic Acid/chemistry ; Ellagic Acid/pharmacology ; Flavonoids/chemistry ; Flavonoids/pharmacology ; Glucans/chemistry ; Glucans/pharmacology ; Monocytes/drug effects ; NF-kappa B ; Resveratrol/chemistry ; Resveratrol/pharmacology ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae Proteins
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants ; Artemisinins ; Cytokines ; Flavonoids ; Glucans ; NF-kappa B ; Saccharomyces cerevisiae Proteins ; Ellagic Acid (19YRN3ZS9P) ; morusin (62596-29-6) ; Catechin (8R1V1STN48) ; artemisinin (9RMU91N5K2) ; epigallocatechin gallate (BQM438CTEL) ; Resveratrol (Q369O8926L)
Language	English
Publishing date	2020-12-16
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2020.12.107
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Current therapeutic developments in atrophic age-related macular degeneration.

Hanus, Jakub / Zhao, Fangkun / Wang, Shusheng

The British journal of ophthalmology

2016 Volume 100, Issue 1, Page(s) 122–127

Abstract: Age-related macular degeneration (AMD), a degenerative disorder of the central retina, is the leading cause of irreversible blindness in the elderly. The underlying mechanism of the advanced form of dry AMD, also named geographic atrophy (GA) or atrophic ...

Abstract	Age-related macular degeneration (AMD), a degenerative disorder of the central retina, is the leading cause of irreversible blindness in the elderly. The underlying mechanism of the advanced form of dry AMD, also named geographic atrophy (GA) or atrophic AMD, remains unclear. Consequently, no cure is available for dry AMD or GA. The only prevention option currently available is the Age-Related Eye Disease Study (AREDS) formulation, which has been demonstrated to slow down the progression of dry AMD. This review summarises recent advances in therapy for dry AMD and GA. Building on the new understanding of the disease and recent technological breakthroughs, numerous ongoing clinical trials have the goal of meeting the need to cure AMD. Therapeutic agents are being developed to target the key features of the disease, including inhibiting the complement pathway and other inflammatory pathways, reducing oxidative stress and protecting retinal pigment epithelial (RPE) cells, inhibiting lipofuscin and visual cycle, regenerating RPE cells from stem cells and restoring choroidal blood flow. Some of these therapeutic options, especially the stem cell-based therapy, hold great promise, which brings great hope for this devastating blinding disease.
MeSH term(s)	Anti-Inflammatory Agents/therapeutic use ; Antioxidants/therapeutic use ; Geographic Atrophy/etiology ; Geographic Atrophy/therapy ; Humans ; Immunotherapy/methods ; Stem Cell Transplantation
Chemical Substances	Anti-Inflammatory Agents ; Antioxidants
Language	English
Publishing date	2016-01
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80078-8
ISSN	1468-2079 ; 0007-1161
ISSN (online)	1468-2079
ISSN	0007-1161
DOI	10.1136/bjophthalmol-2015-306972
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: E-Cigarette Aerosol Exposure Induces Reactive Oxygen Species, DNA Damage, and Cell Death in Vascular Endothelial Cells.

Anderson, Chastain / Majeste, Andrew / Hanus, Jakub / Wang, Shusheng

Toxicological sciences : an official journal of the Society of Toxicology

2016 Volume 154, Issue 2, Page(s) 332–340

Abstract: Cigarette smoking remains one of the leading causes of preventable death worldwide. Vascular cell death and dysfunction is a central or exacerbating component in the majority of cigarette smoking related pathologies. The recent development of the ... ...

Abstract	Cigarette smoking remains one of the leading causes of preventable death worldwide. Vascular cell death and dysfunction is a central or exacerbating component in the majority of cigarette smoking related pathologies. The recent development of the electronic nicotine delivery systems known as e-cigarettes provides an alternative to conventional cigarette smoking; however, the potential vascular health risks of e-cigarette use remain unclear. This study evaluates the effects of e-cigarette aerosol extract (EAE) and conventional cigarette smoke extract (CSE) on human umbilical vein endothelial cells (HUVECs). A laboratory apparatus was designed to produce extracts from e-cigarettes and conventional cigarettes according to established protocols for cigarette smoking. EAE or conventional CSE was applied to human vascular endothelial cells for 4-72 h, dependent on the assay. Treated cells were assayed for reactive oxygen species, DNA damage, cell viability, and markers of programmed cell death pathways. Additionally, the anti-oxidants α-tocopherol and n-acetyl-l-cysteine were used to attempt to rescue e-cigarette induced cell death. Our results indicate that e-cigarette aerosol is capable of inducing reactive oxygen species, causing DNA damage, and significantly reducing cell viability in a concentration dependent fashion. Immunofluorescent and flow cytometry analysis indicate that both the apoptosis and programmed necrosis pathways are triggered by e-cigarette aerosol treatment. Additionally, anti-oxidant treatment provides a partial rescue of the induced cell death, indicating that reactive oxygen species play a causal role in e-cigarette induced cytotoxicity.
Language	English
Publishing date	2016-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	1420885-4
ISSN	1096-0929 ; 1096-6080
ISSN (online)	1096-0929
ISSN	1096-6080
DOI	10.1093/toxsci/kfw166
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