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Article: Giant bullous emphysema successfully treated with percutaneous drainage followed by resection: A case complicated by lung cancer diagnosed by intraoperative biopsy.

Hasegawa, Sachie / Yokoyama, Mako / Inui, Toshihide / Ishikawa, Hiroaki / Watanabe, Hiroko / Kimura, Masaki / Yoshida, Susumu / Sakamoto, Tohru

Respirology case reports

2024 Volume 12, Issue 3, Page(s) e01329

Abstract: We present a case of bilateral giant bullous emphysema (GBE) with rapidly progressive dyspnea. The dyspnea was thought to be due to tension bullae caused by the check valve mechanism in COVID-19 bronchitis. Multiple nodules were also detected on both ... ...

Abstract	We present a case of bilateral giant bullous emphysema (GBE) with rapidly progressive dyspnea. The dyspnea was thought to be due to tension bullae caused by the check valve mechanism in COVID-19 bronchitis. Multiple nodules were also detected on both sides of the lung. As the patient had poor pulmonary reserve for surgical bullectomy, we first performed percutaneous intracavitary drainage. Prior to this procedure, we placed a chest tube in the thoracic cavity to avoid tension pneumothorax. As a result, the patient's remaining lung expanded and respiratory status improved, allowing him to undergo surgical bullectomy. Intraoperatively, needle biopsy of the lung nodule was directly performed, which led to a diagnosis of adenocarcinoma. Despite multiple distant metastases, the patient's general condition improved postoperatively, and chemotherapy was successfully initiated.
Language	English
Publishing date	2024-03-25
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.1329
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Article ; Online: Apigenin Alleviates Endoplasmic Reticulum Stress-Mediated Apoptosis in INS-1 β-Cells.

Ihim, Stella Amarachi / Kaneko, Yukiko K / Yamamoto, Moe / Yamaguchi, Momoka / Kimura, Toshihide / Ishikawa, Tomohisa

Biological & pharmaceutical bulletin

2023 Volume 46, Issue 4, Page(s) 630–635

Abstract: The improvement of type 2 diabetes mellitus induced by naturally occurring polyphenols, known as flavonoids, has received considerable attention. However, there is a dearth of information regarding the effect of the trihydroxyflavone apigenin on ... ...

Abstract	The improvement of type 2 diabetes mellitus induced by naturally occurring polyphenols, known as flavonoids, has received considerable attention. However, there is a dearth of information regarding the effect of the trihydroxyflavone apigenin on pancreatic β-cell function. In the present study, the anti-diabetic effect of apigenin on pancreatic β-cell insulin secretion, apoptosis, and the mechanism underlying its anti-diabetic effects, were investigated in the INS-ID β-cell line. The results showed that apigenin concentration-dependently facilitated 11.1-mM glucose-induced insulin secretion, which peaked at 30 µM. Apigenin also concentration-dependently inhibited the expression of endoplasmic reticulum (ER) stress signaling proteins, CCAAT/enhancer binding protein (C/EBP) homologous protein (CHOP) and cleaved caspase-3, which was elevated by thapsigargin in INS-1D cells, with peak suppression at 30 µM. This was strongly correlated with the results of flow cytometric analysis of annexin V/propidium iodide (PI) staining and DNA fragmentation analysis. Moreover, the increased expression of thioredoxin-interacting protein (TXNIP) induced by thapsigargin was remarkably reduced by apigenin in a concentration-dependent manner. These results suggest that apigenin is an attractive candidate with remarkable and potent anti-diabetic effects on β-cells, which are mediated by facilitating glucose-stimulated insulin secretion and preventing ER stress-mediated β-cell apoptosis, the latter of which may be possibly mediated by reduced expression of CHOP and TXNIP, thereby promoting β-cell survival and function.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 2/metabolism ; Apigenin/pharmacology ; Thapsigargin/metabolism ; Thapsigargin/pharmacology ; Insulin-Secreting Cells ; Apoptosis ; Endoplasmic Reticulum Stress ; Glucose/metabolism ; Transcription Factor CHOP/metabolism
Chemical Substances	Apigenin (7V515PI7F6) ; Thapsigargin (67526-95-8) ; Glucose (IY9XDZ35W2) ; Transcription Factor CHOP (147336-12-7)
Language	English
Publishing date	2023-04-01
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1150271-x
ISSN	1347-5215 ; 0918-6158
ISSN (online)	1347-5215
ISSN	0918-6158
DOI	10.1248/bpb.b22-00913
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Article ; Online: Dysregulation of stress granule dynamics by DCTN1 deficiency exacerbates TDP-43 pathology in Drosophila models of ALS/FTD.

Ueda, Tetsuhiro / Takeuchi, Toshihide / Fujikake, Nobuhiro / Suzuki, Mari / Minakawa, Eiko N / Ueyama, Morio / Fujino, Yuzo / Kimura, Nobuyuki / Nagano, Seiichi / Yokoseki, Akio / Onodera, Osamu / Mochizuki, Hideki / Mizuno, Toshiki / Wada, Keiji / Nagai, Yoshitaka

Acta neuropathologica communications

2024 Volume 12, Issue 1, Page(s) 20

Abstract: The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is aberrantly accumulated in the neurons of most ...

Abstract	The abnormal aggregation of TDP-43 into cytoplasmic inclusions in affected neurons is a major pathological hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Although TDP-43 is aberrantly accumulated in the neurons of most patients with sporadic ALS/FTD and other TDP-43 proteinopathies, how TDP-43 forms cytoplasmic aggregates remains unknown. In this study, we show that a deficiency in DCTN1, a subunit of the microtubule-associated motor protein complex dynactin, perturbs the dynamics of stress granules and drives the formation of TDP-43 cytoplasmic aggregation in cultured cells, leading to the exacerbation of TDP-43 pathology and neurodegeneration in vivo. We demonstrated using a Drosophila model of ALS/FTD that genetic knockdown of DCTN1 accelerates the formation of ubiquitin-positive cytoplasmic inclusions of TDP-43. Knockdown of components of other microtubule-associated motor protein complexes, including dynein and kinesin, also increased the formation of TDP-43 inclusions, indicating that intracellular transport along microtubules plays a key role in TDP-43 pathology. Notably, DCTN1 knockdown delayed the disassembly of stress granules in stressed cells, leading to an increase in the formation of pathological cytoplasmic inclusions of TDP-43. Our results indicate that a deficiency in DCTN1, as well as disruption of intracellular transport along microtubules, is a modifier that drives the formation of TDP-43 pathology through the dysregulation of stress granule dynamics.
MeSH term(s)	Animals ; Humans ; Amyotrophic Lateral Sclerosis/pathology ; DNA-Binding Proteins/genetics ; DNA-Binding Proteins/metabolism ; Drosophila/metabolism ; Dynactin Complex/genetics ; Frontotemporal Dementia/pathology ; Stress Granules ; Drosophila Proteins/genetics
Chemical Substances	DNA-Binding Proteins ; Dynactin Complex ; TBPH protein, Drosophila ; Drosophila Proteins
Language	English
Publishing date	2024-02-04
Publishing country	England
Document type	Journal Article
ZDB-ID	2715589-4
ISSN	2051-5960 ; 2051-5960
ISSN (online)	2051-5960
ISSN	2051-5960
DOI	10.1186/s40478-024-01729-8
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Article ; Online: GDP-bound Rab27a regulates clathrin disassembly through HSPA8 after insulin secretion.

Kodera, Soshiro / Kimura, Toshihide / Nishioka, Tomoki / Kaneko, Yukiko K / Yamaguchi, Momoka / Kaibuchi, Kozo / Ishikawa, Tomohisa

Archives of biochemistry and biophysics

2023 Volume 749, Page(s) 109789

Abstract: Clathrin-dependent endocytosis is a key process for secretory cells, in which molecules on the plasma membrane are both degraded and recycled in a stimulus-dependent manner. There are many reports showing that disruption of endocytosis is involved in the ...

Abstract	Clathrin-dependent endocytosis is a key process for secretory cells, in which molecules on the plasma membrane are both degraded and recycled in a stimulus-dependent manner. There are many reports showing that disruption of endocytosis is involved in the onset of various diseases. Recently, it has been reported that such disruption in pancreatic β-cells causes impaired insulin secretion and might be associated with the pathology of diabetes mellitus. Compared with exocytosis, there are few reports on the molecular mechanism of endocytosis in pancreatic β-cells. We previously reported that GDP-bound Rab27a regulates endocytosis through its GDP-dependent effectors after insulin secretion. In this study, we identified heat shock protein family A member 8 (HSPA8) as a novel interacting protein for GDP-bound Rab27a. HSPA8 directly bound GDP-bound Rab27a via the β2 region of its substrate binding domain (SBD). The β2 fragment was capable of inhibiting the interaction between HSPA8 and GDP-bound Rab27a, and suppressed glucose-induced clathrin-dependent endocytosis in pancreatic β-cells. The region also affected clathrin dynamics on purified clathrin-coated vesicles (CCVs). These results suggest that the interaction between GDP-bound Rab27a and HSPA8 regulates clathrin disassembly from CCVs and subsequent vesicle transport. The regulatory stages in endocytosis by HSPA8 differ from those for other GDP-bound Rab27a effectors. This study shows that GDP-bound Rab27a dominantly regulates each stage in glucose-induced endocytosis through its specific effectors in pancreatic β-cells.
MeSH term(s)	Insulin Secretion ; rab GTP-Binding Proteins/metabolism ; rab27 GTP-Binding Proteins/metabolism ; Clathrin/metabolism ; Endocytosis/physiology ; Glucose/metabolism ; Insulin/metabolism
Chemical Substances	rab GTP-Binding Proteins (EC 3.6.5.2) ; rab27 GTP-Binding Proteins ; Clathrin ; Glucose (IY9XDZ35W2) ; Insulin
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109789
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Article ; Online: Accurate deep learning model using semi-supervised learning and Noisy Student for cervical cancer screening in low magnification images.

Yuki Kurita / Shiori Meguro / Naoko Tsuyama / Isao Kosugi / Yasunori Enomoto / Hideya Kawasaki / Takashi Uemura / Michio Kimura / Toshihide Iwashita

PLoS ONE, Vol 18, Iss 5, p e

2023 Volume 0285996

Abstract: Deep learning technology has been used in the medical field to produce devices for clinical practice. Deep learning methods in cytology offer the potential to enhance cancer screening while also providing quantitative, objective, and highly reproducible ... ...

Abstract	Deep learning technology has been used in the medical field to produce devices for clinical practice. Deep learning methods in cytology offer the potential to enhance cancer screening while also providing quantitative, objective, and highly reproducible testing. However, constructing high-accuracy deep learning models necessitates a significant amount of manually labeled data, which takes time. To address this issue, we used the Noisy Student Training technique to create a binary classification deep learning model for cervical cytology screening, which reduces the quantity of labeled data necessary. We used 140 whole-slide images from liquid-based cytology specimens, 50 of which were low-grade squamous intraepithelial lesions, 50 were high-grade squamous intraepithelial lesions, and 40 were negative samples. We extracted 56,996 images from the slides and then used them to train and test the model. We trained the EfficientNet using 2,600 manually labeled images to generate additional pseudo labels for the unlabeled data and then self-trained it within a student-teacher framework. Based on the presence or absence of abnormal cells, the created model was used to classify the images as normal or abnormal. The Grad-CAM approach was used to visualize the image components that contributed to the classification. The model achieved an area under the curve of 0.908, accuracy of 0.873, and F1-score of 0.833 with our test data. We also explored the optimal confidence threshold score and optimal augmentation approaches for low-magnification images. Our model efficiently classified normal and abnormal images at low magnification with high reliability, making it a promising screening tool for cervical cytology.
Keywords	Medicine ; R ; Science ; Q
Subject code	006
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
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Article ; Online: Accurate deep learning model using semi-supervised learning and Noisy Student for cervical cancer screening in low magnification images.

Kurita, Yuki / Meguro, Shiori / Tsuyama, Naoko / Kosugi, Isao / Enomoto, Yasunori / Kawasaki, Hideya / Uemura, Takashi / Kimura, Michio / Iwashita, Toshihide

PloS one

2023 Volume 18, Issue 5, Page(s) e0285996

Abstract	Deep learning technology has been used in the medical field to produce devices for clinical practice. Deep learning methods in cytology offer the potential to enhance cancer screening while also providing quantitative, objective, and highly reproducible testing. However, constructing high-accuracy deep learning models necessitates a significant amount of manually labeled data, which takes time. To address this issue, we used the Noisy Student Training technique to create a binary classification deep learning model for cervical cytology screening, which reduces the quantity of labeled data necessary. We used 140 whole-slide images from liquid-based cytology specimens, 50 of which were low-grade squamous intraepithelial lesions, 50 were high-grade squamous intraepithelial lesions, and 40 were negative samples. We extracted 56,996 images from the slides and then used them to train and test the model. We trained the EfficientNet using 2,600 manually labeled images to generate additional pseudo labels for the unlabeled data and then self-trained it within a student-teacher framework. Based on the presence or absence of abnormal cells, the created model was used to classify the images as normal or abnormal. The Grad-CAM approach was used to visualize the image components that contributed to the classification. The model achieved an area under the curve of 0.908, accuracy of 0.873, and F1-score of 0.833 with our test data. We also explored the optimal confidence threshold score and optimal augmentation approaches for low-magnification images. Our model efficiently classified normal and abnormal images at low magnification with high reliability, making it a promising screening tool for cervical cytology.
MeSH term(s)	Female ; Humans ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/pathology ; Early Detection of Cancer ; Deep Learning ; Reproducibility of Results ; Supervised Machine Learning ; Squamous Intraepithelial Lesions ; Students
Language	English
Publishing date	2023-05-18
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0285996
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Article ; Online: Dietary Problems Are Associated with Frailty Status in Older People with Fewer Teeth in Japan.

Miyano, Takashi / Kaneko, Ryosuke / Kimura, Toshihide / Maruoka, Misa / Kishimura, Akihiro / Kato, Koichiro / Furuta, Michiko / Yamashita, Yoshihisa

International journal of environmental research and public health

2022 Volume 19, Issue 23

Abstract: This study aimed to investigate the association between dietary problems and frailty according to tooth loss in older Japanese people. This cross-sectional study included 160 older people (mean age 82.6 years) from Japan. Frailty status was assessed ... ...

Abstract	This study aimed to investigate the association between dietary problems and frailty according to tooth loss in older Japanese people. This cross-sectional study included 160 older people (mean age 82.6 years) from Japan. Frailty status was assessed using the Study of Osteoporotic Fractures (SOF) criteria, which consists of (i) weight loss > 5% in the past year, (ii) inability to perform five chair stands, and (iii) self-perceived reduced energy level. Frailty was defined as the presence of ≥2 items of SOF criteria. Multivariate logistic regression analyses were performed with frailty as the dependent variable and dietary problems as the independent variable, stratified according to having <20 teeth. Low appetite and no enjoyment of eating were associated with frailty after adjusting for covariates in participants with <20 teeth. Dietary problems, including low appetite, eating alone, and negative attitudes toward enjoyment of eating were associated with a self-perceived reduced energy level in participants with <20 teeth. However, this association was not observed in participants with ≥20 teeth. In older people with fewer teeth, dietary problems have been suggested to be associated with frailty. Therefore, it may be necessary to pay attention to dietary problems, especially in older people with tooth loss.
MeSH term(s)	Humans ; Aged ; Aged, 80 and over ; Frail Elderly ; Cross-Sectional Studies ; Geriatric Assessment ; Tooth Loss/epidemiology ; Frailty/epidemiology ; Osteoporotic Fractures ; Japan/epidemiology ; Independent Living
Language	English
Publishing date	2022-12-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph192316260
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Article ; Online: Dietary Problems Are Associated with Frailty Status in Older People with Fewer Teeth in Japan

Takashi Miyano / Ryosuke Kaneko / Toshihide Kimura / Misa Maruoka / Akihiro Kishimura / Koichiro Kato / Michiko Furuta / Yoshihisa Yamashita

International Journal of Environmental Research and Public Health, Vol 19, Iss 16260, p

2022 Volume 16260

Abstract	This study aimed to investigate the association between dietary problems and frailty according to tooth loss in older Japanese people. This cross-sectional study included 160 older people (mean age 82.6 years) from Japan. Frailty status was assessed using the Study of Osteoporotic Fractures (SOF) criteria, which consists of (i) weight loss > 5% in the past year, (ii) inability to perform five chair stands, and (iii) self-perceived reduced energy level. Frailty was defined as the presence of ≥2 items of SOF criteria. Multivariate logistic regression analyses were performed with frailty as the dependent variable and dietary problems as the independent variable, stratified according to having <20 teeth. Low appetite and no enjoyment of eating were associated with frailty after adjusting for covariates in participants with <20 teeth. Dietary problems, including low appetite, eating alone, and negative attitudes toward enjoyment of eating were associated with a self-perceived reduced energy level in participants with <20 teeth. However, this association was not observed in participants with ≥20 teeth. In older people with fewer teeth, dietary problems have been suggested to be associated with frailty. Therefore, it may be necessary to pay attention to dietary problems, especially in older people with tooth loss.
Keywords	frailty ; tooth loss ; dietary problems ; community-dwelling older people ; Medicine ; R
Subject code	150
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: An adrenal incidentaloma that had appeared to produce dehydroepiandrosterone-sulfate in excess before immunohistochemical study of the tumor.

Yamamoto, Toshihide / Kimura, Takuma / Kubo, Yuki / Nakatsuka, Shin-Ichi / Harada, Hiromasa / Suzuki, Takashi / Sasano, Hironobu

Endocrine journal

2022 Volume 70, Issue 1, Page(s) 43–46

Abstract: Adrenal incidentaloma is a clinically unapparent adrenal mass more than one cm in diameter detected during imaging performed not for adrenal disease. A 34-year-old man was evaluated for AI with a diameter of 3.5 cm in the left adrenal. He was obese with ... ...

Abstract	Adrenal incidentaloma is a clinically unapparent adrenal mass more than one cm in diameter detected during imaging performed not for adrenal disease. A 34-year-old man was evaluated for AI with a diameter of 3.5 cm in the left adrenal. He was obese with body mass index of 33,9. Blood pressure was 110-120/90 mmHg. The general laboratory tests were unremarkable. An adrenal hormone screening set revealed that ACTH was 6.9 pg/mL, cortisol 14.9 μg/dL, renin activity 0.9 ng/mL/h, aldosterone 79.4 pg/mL, dehydroepiandrosterone-sulfate (DHEA-S) measured on two occasions 5,217 ng/mL and 6,477 ng/mL (gender- and age-adjusted reference values, 1,060-4,640 ng/mL). The levels of metanephrine and normetanephrine were normal. The tumor was thought to produce solely DHEA-S. The excised left adrenal tissue contained a tumor with a diameter of 26 mm and neighboring adrenal tissue. The tumor consisted mostly of acidophil cells without necrosis, capsular or vascular invasion, and mitosis. Immunohistochemical study revealed followings: the cells of the tumors were stained positive for 3β-hydroxysteroid dehydrogenase, and 17α-hydroxylase, and 11β-hydroxylase, weakly positive for DHEA sulphotransferase, and negative for aldosterone synthetase. The atrophy of neighboring tissue was presumably caused by excess cortisol production. Four months after surgery, the cortisol level was 11.2 μg/dL and DHEA-S level 1,462 ng/mL. The tumor is considered to be a cortisol-producing adenoma with modestly excessive DHEA-S production rather than isolated DHEA-S-producing adenoma. Immunohistochemical study of steroidogenic enzymes is a valuable addition to blood hormone measurement to clarify steroid production profile.
MeSH term(s)	Male ; Humans ; Adult ; Dehydroepiandrosterone Sulfate ; Hydrocortisone ; Aldosterone ; Adrenal Gland Neoplasms/diagnosis ; Adenoma/pathology ; Mixed Function Oxygenases ; Sulfates ; Dehydroepiandrosterone
Chemical Substances	Dehydroepiandrosterone Sulfate (57B09Q7FJR) ; Hydrocortisone (WI4X0X7BPJ) ; Aldosterone (4964P6T9RB) ; Mixed Function Oxygenases (EC 1.-) ; Sulfates ; Dehydroepiandrosterone (459AG36T1B)
Language	English
Publishing date	2022-09-29
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	1151918-6
ISSN	1348-4540 ; 0918-8959
ISSN (online)	1348-4540
ISSN	0918-8959
DOI	10.1507/endocrj.EJ22-0116
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Article ; Online: Harmine suppresses collagen production in hepatic stellate cells by inhibiting DYRK1B.

Yamaguchi, Momoka / Ohbayashi, Saya / Ooka, Akira / Yamashita, Hinako / Motohashi, Nanami / Kaneko, Yukiko K / Kimura, Toshihide / Saito, Shin-Ya / Ishikawa, Tomohisa

Biochemical and biophysical research communications

2022 Volume 600, Page(s) 136–141

Abstract: Liver fibrosis is a major consequence of chronic liver disease, where excess extracellular matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The suppression of collagen production in HSCs is therefore regarded as a ... ...

Abstract	Liver fibrosis is a major consequence of chronic liver disease, where excess extracellular matrix is deposited, due caused by the activation of hepatic stellate cells (HSCs). The suppression of collagen production in HSCs is therefore regarded as a therapeutic target of liver fibrosis. The present study investigated effects of harmine, which is a β-carboline alkaloid and known as an inhibitor of dual-specificity tyrosine-regulated kinases (DYRKs), on the production of collagen in HSCs. LX-2 cells, a human HSC cell line, were treated with harmine (0-10 μM) for 48 h in the presence or absence of TGF-β1 (5 ng/ml). The expression of collagen type I α1 (COL1A1) and DYRK isoforms was investigated by Western blotting, quantitative RT-PCR, or immunofluorescence. The influence of knockdown of each DYRK isoform on the COL1A1 expression was further investigated. The expression of COL1A1 was markedly increased by treating with TGF-β1 for 48 h in LX-2 cells. Harmine (10 μM) significantly inhibited the increased expression of COL1A1. LX-2 cells expressed mRNAs of DYRK1A, DYRK1B, DYRK2, and DYRK4, although the expression of DYRK4 was much lower than the others. Knockdown of DYRK1B, but not DYRK1A or DYRK2, with siRNA significantly suppressed TGF-β1-induced increase in COL1A1 expression. These results suggest that harmine suppresses COL1A1 expression via inhibiting DYRK1B in HSCs and therefore might be effective for the treatment of liver fibrosis.
MeSH term(s)	Collagen Type I, alpha 1 Chain/antagonists & inhibitors ; Collagen Type I, alpha 1 Chain/biosynthesis ; Harmine/pharmacology ; Hepatic Stellate Cells/drug effects ; Hepatic Stellate Cells/metabolism ; Humans ; Liver Cirrhosis/metabolism ; Protein Serine-Threonine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/antagonists & inhibitors ; Protein-Tyrosine Kinases/metabolism ; Transforming Growth Factor beta1/metabolism ; Dyrk Kinases
Chemical Substances	COL1A1 protein, human ; Collagen Type I, alpha 1 Chain ; Transforming Growth Factor beta1 ; Harmine (4FHH5G48T7) ; Protein-Tyrosine Kinases (EC 2.7.10.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1)
Language	English
Publishing date	2022-02-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205723-2
ISSN	1090-2104 ; 0006-291X ; 0006-291X
ISSN (online)	1090-2104 ; 0006-291X
ISSN	0006-291X
DOI	10.1016/j.bbrc.2022.02.054
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