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  1. Book ; Thesis: Regulierte Sekretion in Endothelzellen

    Biesemann, Anja

    die Rolle von Rabs und RabGAPs in der Exozytose von Weibel-Palade-bodies

    2013  

    Author's details vorgelegt von Anja Biesemann
    Keywords Weibel-Palade-Körperchen ; Rab-Proteine ; Willebrand-Faktor
    Subject Faktor VIII A ; Anti-bleeding factor ; Faktor-VIII-assoziiertes Antigen ; Ristocetin-Cofaktor ; Blutgerinnungsfaktor VIII A ; Weibel-Palade-Granula ; WPK ; Weibel-Palade bodies ; WPBs ; WPB
    Language German
    Size VI, 150 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 2013
    HBZ-ID HT018572024
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2013 MB 1162 order for loan Magazin

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  2. Book ; Thesis: Regulierte Sekretion in Endothelzellen

    Biesemann, Anja

    die Rolle von Rabs und RabGAPs in der Exozytose von Weibel-Palade-bodies

    2013  

    Author's details vorgelegt von Anja Biesemann
    Language German
    Size 2 Mikrofiches, Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis @[Münster (Westfalen), Univ., Diss.], 2013
    Database Special collection on veterinary medicine and general parasitology

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    Inter-library loan at ZB MED

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  3. Book ; Thesis: Regulierte Sekretion in Endothelzellen

    Biesemann, Anja

    die Rolle von Rabs und RabGAPs in der Exozytose von Weibel-Palade-bodies

    2013  

    Author's details vorgelegt von Anja Biesemann
    Language German
    Size 2 Mikrofiches
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Univ., Diss.--Münster (Westfalen), 2013
    Database Former special subject collection: coastal and deep sea fishing

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    Inter-library loan at ZB MED

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  4. Article ; Online: Tip-end fusion of a rod-shaped secretory organelle.

    Naß, Johannes / Koerdt, Sophia N / Biesemann, Anja / Chehab, Tarek / Yasuda, Takao / Fukuda, Mitsunori / Martín-Belmonte, Fernando / Gerke, Volker

    Cellular and molecular life sciences : CMLS

    2022  Volume 79, Issue 6, Page(s) 344

    Abstract: Weibel-Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with ... ...

    Abstract Weibel-Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with Ca
    MeSH term(s) Cells, Cultured ; Exocytosis/physiology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Weibel-Palade Bodies/metabolism ; von Willebrand Factor/genetics ; von Willebrand Factor/metabolism
    Chemical Substances von Willebrand Factor
    Language English
    Publishing date 2022-06-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04367-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Rab35 protein regulates evoked exocytosis of endothelial Weibel-Palade bodies.

    Biesemann, Anja / Gorontzi, Alexandra / Barr, Francis / Gerke, Volker

    The Journal of biological chemistry

    2017  Volume 292, Issue 28, Page(s) 11631–11640

    Abstract: Weibel-Palade bodies (WPB) are secretory organelles of endothelial cells that undergo evoked exocytosis following intracellular ... ...

    Abstract Weibel-Palade bodies (WPB) are secretory organelles of endothelial cells that undergo evoked exocytosis following intracellular Ca
    MeSH term(s) ADP-Ribosylation Factors/antagonists & inhibitors ; ADP-Ribosylation Factors/genetics ; ADP-Ribosylation Factors/metabolism ; Amino Acid Substitution ; Calcium Signaling ; Cells, Cultured ; Down-Regulation ; Endothelium, Vascular/cytology ; Endothelium, Vascular/metabolism ; Exocytosis ; GTPase-Activating Proteins/genetics ; GTPase-Activating Proteins/metabolism ; Green Fluorescent Proteins/genetics ; Green Fluorescent Proteins/metabolism ; Histamine/metabolism ; Human Umbilical Vein Endothelial Cells/cytology ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Immunoprecipitation ; Membrane Proteins/antagonists & inhibitors ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Mutagenesis, Site-Directed ; Point Mutation ; RNA Interference ; Recombinant Fusion Proteins/metabolism ; Weibel-Palade Bodies/metabolism ; rab GTP-Binding Proteins/antagonists & inhibitors ; rab GTP-Binding Proteins/genetics ; rab GTP-Binding Proteins/metabolism
    Chemical Substances ACAP2 protein, human ; GTPase-Activating Proteins ; Membrane Proteins ; Recombinant Fusion Proteins ; TBC1D10A protein, human ; Green Fluorescent Proteins (147336-22-9) ; Histamine (820484N8I3) ; RAB35 protein, human (EC 3.6.1.-) ; ADP-Ribosylation Factors (EC 3.6.5.2) ; ADP-ribosylation factor 6 (EC 3.6.5.2) ; rab GTP-Binding Proteins (EC 3.6.5.2)
    Language English
    Publishing date 2017-05-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1074/jbc.M116.773333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.108: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Tip-end fusion of a rod-shaped secretory organelle

    Naß, Johannes / Koerdt, Sophia N. / Biesemann, Anja / Chehab, Tarek / Yasuda, Takao / Fukuda, Mitsunori / Martín-Belmonte, Fernando / Gerke, Volker

    Cellular and molecular life sciences. 2022 June, v. 79, no. 6

    2022  

    Abstract: Weibel–Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with Ca²⁺- or cAMP-raising agonists. We show ... ...

    Abstract Weibel–Palade bodies (WPB) are elongated, rod-like secretory organelles unique to endothelial cells that store the pro-coagulant von-Willebrand factor (VWF) and undergo regulated exocytosis upon stimulation with Ca²⁺- or cAMP-raising agonists. We show here that WPB preferentially initiate fusion with the plasma membrane at their tips and identify synaptotagmin-like protein 2-a (Slp2-a) as a positive regulator of VWF secretion most likely mediating this topological selectivity. Following secretagogue stimulation, Slp2-a accumulates at one WPB tip before fusion occurs at this site. Depletion of Slp2-a reduces Ca²⁺-dependent secretion of highly multimeric VWF and interferes with the formation of actin rings at WPB–plasma membrane fusion sites that support the expulsion of the VWF multimers and most likely require a tip-end fusion topology. Phosphatidylinositol (4,5)-bisphosphate [PI(4,5)P₂] binding via the C2A domain of Slp2-a is required for accumulation of Slp2-a at the tip ends of fusing WPB, suggesting that Slp2-a mediates polar exocytosis by initiating contacts between WPB tips and plasma membrane PI(4,5)P₂.
    Keywords actin ; exocytosis ; membrane fusion ; organelles ; plasma membrane ; secretion ; topology
    Language English
    Dates of publication 2022-06
    Size p. 344.
    Publishing place Springer International Publishing
    Document type Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-022-04367-2
    Database NAL-Catalogue (AGRICOLA)

    Full text online

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    In stock of ZB MED Bonn / Germany

    Z 4' 47/14: Show issues

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  7. Article ; Online: Direct observation of microtubule pushing by cortical dynein in living cells.

    Mazel, Tomáš / Biesemann, Anja / Krejczy, Magda / Nowald, Janos / Müller, Olga / Dehmelt, Leif

    Molecular biology of the cell

    2013  Volume 25, Issue 1, Page(s) 95–106

    Abstract: Microtubules are under the influence of forces mediated by cytoplasmic dynein motors associated with the cell cortex. If such microtubules are free to move, they are rapidly transported inside cells. Here we directly observe fluorescent protein-labeled ... ...

    Abstract Microtubules are under the influence of forces mediated by cytoplasmic dynein motors associated with the cell cortex. If such microtubules are free to move, they are rapidly transported inside cells. Here we directly observe fluorescent protein-labeled cortical dynein speckles and motile microtubules. We find that several dynein complex subunits, including the heavy chain, the intermediate chain, and the associated dynactin subunit Dctn1 (also known as p150glued) form spatially resolved, dynamic speckles at the cell cortex, which are preferentially associated with microtubules. Measurements of bleaching and dissociation kinetics at the cell cortex reveal that these speckles often contain multiple labeled dynein heavy-chain molecules and turn over rapidly within seconds. The dynamic behavior of microtubules, such as directional movement, bending, or rotation, is influenced by association with dynein speckles, suggesting a direct physical and functional interaction. Our results support a model in which rapid turnover of cell cortex-associated dynein complexes facilitates their search to efficiently capture and push microtubules directionally with leading plus ends.
    MeSH term(s) Animals ; COS Cells ; Chlorocebus aethiops ; Dyneins/metabolism ; Mice ; Microscopy, Fluorescence ; Microtubule-Associated Proteins/metabolism ; Microtubules/metabolism ; Microtubules/ultrastructure ; Single-Cell Analysis ; Stochastic Processes ; Time-Lapse Imaging
    Chemical Substances Microtubule-Associated Proteins ; Mtap2 protein, mouse ; Dyneins (EC 3.6.4.2)
    Language English
    Publishing date 2013-10-30
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1098979-1
    ISSN 1939-4586 ; 1059-1524
    ISSN (online) 1939-4586
    ISSN 1059-1524
    DOI 10.1091/mbc.E13-07-0376
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2853: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 410: Show issues

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