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  1. Article: 'Muscle superman' Cristobal Guillermo dos Remedios: five decades of endless energy.

    Braet, Filip

    Biophysical reviews

    2020  Volume 12, Issue 4, Page(s) 755–756

    Language English
    Publishing date 2020-07-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2486483-3
    ISSN 1867-2469 ; 1867-2450
    ISSN (online) 1867-2469
    ISSN 1867-2450
    DOI 10.1007/s12551-020-00718-0
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  2. Article ; Online: Let's have a chat about chatbot(s) in (biological) microscopy.

    Braet, Filip / Poger, David

    Journal of microscopy

    2023  Volume 292, Issue 2, Page(s) 59–63

    MeSH term(s) Microscopy ; Software
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Letter
    ZDB-ID 219263-9
    ISSN 1365-2818 ; 0022-2720
    ISSN (online) 1365-2818
    ISSN 0022-2720
    DOI 10.1111/jmi.13230
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 838: Show issues Location:
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  3. Article ; Online: Big data in contemporary electron microscopy: challenges and opportunities in data transfer, compute and management.

    Poger, David / Yen, Lisa / Braet, Filip

    Histochemistry and cell biology

    2023  Volume 160, Issue 3, Page(s) 169–192

    Abstract: The second decade of the twenty-first century witnessed a new challenge in the handling of microscopy data. Big data, data deluge, large data, data compliance, data analytics, data integrity, data interoperability, data retention and data lifecycle are ... ...

    Abstract The second decade of the twenty-first century witnessed a new challenge in the handling of microscopy data. Big data, data deluge, large data, data compliance, data analytics, data integrity, data interoperability, data retention and data lifecycle are terms that have introduced themselves to the electron microscopy sciences. This is largely attributed to the booming development of new microscopy hardware tools. As a result, large digital image files with an average size of one terabyte within one single acquisition session is not uncommon nowadays, especially in the field of cryogenic electron microscopy. This brings along numerous challenges in data transfer, compute and management. In this review, we will discuss in detail the current state of international knowledge on big data in contemporary electron microscopy and how big data can be transferred, computed and managed efficiently and sustainably. Workflows, solutions, approaches and suggestions will be provided, with the example of the latest experiences in Australia. Finally, important principles such as data integrity, data lifetime and the FAIR and CARE principles will be considered.
    MeSH term(s) Big Data ; Microscopy, Electron
    Language English
    Publishing date 2023-04-13
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1222930-1
    ISSN 1432-119X ; 0301-5564 ; 0948-6143
    ISSN (online) 1432-119X
    ISSN 0301-5564 ; 0948-6143
    DOI 10.1007/s00418-023-02191-8
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  4. Article ; Online: Zebrafish: An emerging and expedient model for liver studies?

    Shami, Gerald J / Cheng, Delfine / Morsch, Marco / Braet, Filip

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 8, Page(s) 1839–1840

    MeSH term(s) Animals ; Zebrafish ; Liver ; Disease Models, Animal
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15625
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  5. Article ; Online: Giant mitochondria in cardiomyocytes: cellular architecture in health and disease.

    Li, Amy / Shami, Gerald J / Griffiths, Lisa / Lal, Sean / Irving, Helen / Braet, Filip

    Basic research in cardiology

    2023  Volume 118, Issue 1, Page(s) 39

    Abstract: Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and ... ...

    Abstract Giant mitochondria are frequently observed in different disease models within the brain, kidney, and liver. In cardiac muscle, these enlarged organelles are present across diverse physiological and pathophysiological conditions including in ageing and exercise, and clinically in alcohol-induced heart disease and various cardiomyopathies. This mitochondrial aberration is widely considered an early structural hallmark of disease leading to adverse organ function. In this thematic paper, we discuss the current state-of-knowledge on the presence, structure and functional implications of giant mitochondria in heart muscle. Despite its demonstrated reoccurrence in different heart diseases, the literature on this pathophysiological phenomenon remains relatively sparse since its initial observations in the early 60s. We review historical and contemporary investigations from cultured cardiomyocytes to human tissue samples to address the role of giant mitochondria in cardiac health and disease. Finally, we discuss their significance for the future development of novel mitochondria-targeted therapies to improve cardiac metabolism and functionality.
    MeSH term(s) Humans ; Myocytes, Cardiac/metabolism ; Mitochondrial Swelling ; Mitochondria/metabolism ; Cardiomyopathies ; Myocardium/metabolism ; Mitochondria, Heart/metabolism
    Language English
    Publishing date 2023-09-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-023-01011-3
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  6. Article ; Online: Foreword to the special issue on zebrafish imaging: Emerging techniques and methodologies.

    Morsch, Marco / Braet, Filip / Cheng, Delfine

    Micron (Oxford, England : 1993)

    2020  Volume 136, Page(s) 102877

    Language English
    Publishing date 2020-05-14
    Publishing country England
    Document type Editorial
    ZDB-ID 207808-9
    ISSN 1878-4291 ; 0047-7206 ; 0968-4328
    ISSN (online) 1878-4291
    ISSN 0047-7206 ; 0968-4328
    DOI 10.1016/j.micron.2020.102877
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    Zs.A 1927: Show issues Location:
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  7. Article ; Online: Gentle palpating liver sinusoidal endothelial cells reveals the dynamic behavior and formation of fenestrae: A new window for biomedical research.

    Braet, Filip / Wisse, Eddie

    Hepatology (Baltimore, Md.)

    2018  Volume 67, Issue 6, Page(s) 2460–2461

    MeSH term(s) Biomedical Research ; Endothelial Cells ; Endothelium ; Hepatocytes ; Liver
    Language English
    Publishing date 2018-04-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 604603-4
    ISSN 1527-3350 ; 0270-9139
    ISSN (online) 1527-3350
    ISSN 0270-9139
    DOI 10.1002/hep.29706
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    Zs.A 1660: Show issues Location:
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  8. Article: From Microenvironment Remediation to Novel Anti-Cancer Strategy: The Emergence of Zero Valent Iron Nanoparticles.

    Wu, Ya-Na / Yang, Li-Xing / Wang, Pei-Wen / Braet, Filip / Shieh, Dar-Bin

    Pharmaceutics

    2022  Volume 14, Issue 1

    Abstract: Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti- ... ...

    Abstract Accumulated studies indicate that zero-valent iron (ZVI) nanoparticles demonstrate endogenous cancer-selective cytotoxicity, without any external electric field, lights, or energy, while sparing healthy non-cancerous cells in vitro and in vivo. The anti-cancer activity of ZVI-based nanoparticles was anti-proportional to the oxidative status of the materials, which indicates that the elemental iron is crucial for the observed cancer selectivity. In this thematic article, distinctive endogenous anti-cancer mechanisms of ZVI-related nanomaterials at the cellular and molecular levels are reviewed, including the related gene modulating profile in vitro and in vivo. From a material science perspective, the underlying mechanisms are also analyzed. In summary, ZVI-based nanomaterials demonstrated prominent potential in precision medicine to modulate both programmed cell death of cancer cells, as well as the tumor microenvironment. We believe that this will inspire advanced anti-cancer therapy in the future.
    Language English
    Publishing date 2022-01-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics14010099
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  9. Article ; Online: Foreword to the special issue on applications of atomic force microscopy in cell biology.

    Braet, Filip / Taatjes, Douglas J

    Seminars in cell & developmental biology

    2017  Volume 73, Page(s) 1–3

    MeSH term(s) Animals ; Cell Biology/history ; History, 20th Century ; History, 21st Century ; Humans ; Microscopy, Atomic Force/history ; Microscopy, Scanning Tunneling/history
    Language English
    Publishing date 2017-06-30
    Publishing country England
    Document type Historical Article ; Introductory Journal Article
    ZDB-ID 1312473-0
    ISSN 1096-3634 ; 1084-9521
    ISSN (online) 1096-3634
    ISSN 1084-9521
    DOI 10.1016/j.semcdb.2017.06.025
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    Zs.A 2918: Show issues Location:
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  10. Article ; Online: Giant mitochondria in human liver disease.

    Shami, Gerald J / Samarska, Iryna V / Koek, Ger H / Li, Amy / Palma, Elena / Chokshi, Shilpa / Wisse, Eddie / Braet, Filip

    Liver international : official journal of the International Association for the Study of the Liver

    2023  Volume 43, Issue 11, Page(s) 2365–2378

    Abstract: This thematic review aims to provide an overview of the current state of knowledge about the occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their presence and accumulation are considered to be a major pathological ... ...

    Abstract This thematic review aims to provide an overview of the current state of knowledge about the occurrence of giant mitochondria or megamitochondria in liver parenchymal cells. Their presence and accumulation are considered to be a major pathological hallmark of the health and fate of liver parenchymal cells that leads to overall tissue deterioration and eventually results in organ failure. The first description on giant mitochondria dates back to the 1960s, coinciding with the availability of the first generation of electron microscopes in clinical diagnostic laboratories. Detailed accounts on their ultrastructure have mostly been described in patients suffering from alcoholic liver disease, chronic hepatitis, hepatocellular carcinoma and non-alcoholic fatty liver disease. Interestingly, from this extensive literature survey, it became apparent that giant mitochondria or megamitochondria present themselves with or without highly organised crystal-like intramitochondrial inclusions. The origin, formation and potential role of giant mitochondria remain to-date largely unanswered. Likewise, the biochemical composition of the well-organised crystal-like inclusions and their possible impact on mitochondrial function is unclear. Herein, concepts about the possible mechanism of their formation and three-dimensional architecture will be approached. We will furthermore discuss their importance in diagnostics, including future research outlooks and potential therapeutic interventions to cure liver disease where giant mitochondria are implemented.
    MeSH term(s) Humans ; Mitochondrial Swelling ; Mitochondria, Liver/pathology ; Liver Diseases, Alcoholic/pathology ; Non-alcoholic Fatty Liver Disease/pathology ; Hepatitis, Chronic/pathology ; Liver/pathology
    Language English
    Publishing date 2023-08-24
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2102783-3
    ISSN 1478-3231 ; 1478-3223
    ISSN (online) 1478-3231
    ISSN 1478-3223
    DOI 10.1111/liv.15711
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