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  1. Article ; Online: Training medical students on electronic patient communication.

    Cheloff, Abraham Z / Wrenn, Katherine C / Johnson, Garret M / Joseph, Nicholos P / Fernández, Leonor / Cluett, Jennifer L / Kriegel, Gila R / Weinstein, Amy R

    Medical education

    2023  Volume 57, Issue 5, Page(s) 458–459

    MeSH term(s) Humans ; Students, Medical ; Education, Medical ; Curriculum ; Communication ; Electronics
    Language English
    Publishing date 2023-02-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 195274-2
    ISSN 1365-2923 ; 0308-0110
    ISSN (online) 1365-2923
    ISSN 0308-0110
    DOI 10.1111/medu.15040
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  2. Article ; Online: Racial and Ethnic Disparities in Disease Severity on Admission Chest Radiographs among Patients Admitted with Confirmed Coronavirus Disease 2019: A Retrospective Cohort Study.

    Joseph, Nicholos P / Reid, Nicholas J / Som, Avik / Li, Matthew D / Hyle, Emily P / Dugdale, Caitlin M / Lang, Min / Betancourt, Joseph R / Deng, Francis / Mendoza, Dexter P / Little, Brent P / Narayan, Anand K / Flores, Efrén J

    Radiology

    2020  Volume 297, Issue 3, Page(s) E303–E312

    Abstract: Background Disease severity on chest radiographs has been associated with higher risk of disease progression and adverse outcomes from coronavirus disease 2019 (COVID-19). Few studies have evaluated COVID-19-related racial and/or ethnic disparities in ... ...

    Abstract Background Disease severity on chest radiographs has been associated with higher risk of disease progression and adverse outcomes from coronavirus disease 2019 (COVID-19). Few studies have evaluated COVID-19-related racial and/or ethnic disparities in radiology. Purpose To evaluate whether non-White minority patients hospitalized with confirmed COVID-19 infection presented with increased severity on admission chest radiographs compared with White or non-Hispanic patients. Materials and Methods This single-institution retrospective cohort study was approved by the institutional review board. Patients hospitalized with confirmed COVID-19 infection between March 17, 2020, and April 10, 2020, were identified by using the electronic medical record (
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Betacoronavirus ; COVID-19 ; Cohort Studies ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/epidemiology ; Ethnicity/statistics & numerical data ; Female ; Humans ; Lung/diagnostic imaging ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Racial Groups/statistics & numerical data ; Radiography ; Radiography, Thoracic/methods ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-07-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80324-8
    ISSN 1527-1315 ; 0033-8419
    ISSN (online) 1527-1315
    ISSN 0033-8419
    DOI 10.1148/radiol.2020202602
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  3. Article ; Online: Medical Student Mobilization During a Crisis: Lessons From a COVID-19 Medical Student Response Team.

    Soled, Derek / Goel, Shivangi / Barry, Danika / Erfani, Parsa / Joseph, Nicholos / Kochis, Michael / Uppal, Nishant / Velasquez, David / Vora, Kruti / Scott, Kirstin Woody

    Academic medicine : journal of the Association of American Medical Colleges

    2020  Volume 95, Issue 9, Page(s) 1384–1387

    Abstract: Problem: On March 17, 2020, the Association of American Medical Colleges recommended the suspension of all direct patient contact responsibilities for medical students because of the COVID-19 pandemic. Given this change, medical students nationwide had ... ...

    Abstract Problem: On March 17, 2020, the Association of American Medical Colleges recommended the suspension of all direct patient contact responsibilities for medical students because of the COVID-19 pandemic. Given this change, medical students nationwide had to grapple with how and where they could fill the evolving needs of their schools' affiliated clinical sites, physicians, patients, and the community.
    Approach: At Harvard Medical School (HMS), student leaders created a COVID-19 Medical Student Response Team to: (1) develop a student-led organizational structure that would optimize students' ability to efficiently mobilize interested peers in the COVID-19 response, both clinically and in the community, in a strategic, safe, smart, and resource-conscious way; and (2) serve as a liaison with the administration and hospital leaders to identify evolving needs and rapidly engage students in those efforts.
    Outcomes: Within a week of its inception, the COVID-19 Medical Student Response Team had more than 500 medical student volunteers from HMS and had shared the organizational framework of the response team with multiple medical schools across the country. The HMS student volunteers joined any of the 4 virtual committees to complete this work: Education for the Medical Community, Education for the Broader Community, Activism for Clinical Support, and Community Activism.
    Next steps: The COVID-19 Medical Student Response Team helped to quickly mobilize hundreds of students and has been integrated into HMS's daily workflow. It may serve as a useful model for other schools and hospitals seeking medical student assistance during the COVID-19 pandemic. Next steps include expanding the initiative further, working with the leaders of response teams at other medical schools to coordinate efforts, and identifying new areas of need at local hospitals and within nearby communities that might benefit from medical student involvement as the pandemic evolves.
    MeSH term(s) Betacoronavirus ; Boston ; COVID-19 ; Coronavirus Infections/epidemiology ; Education, Medical/organization & administration ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Students, Medical ; Universities ; Volunteers
    Keywords covid19
    Language English
    Publishing date 2020-06-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/ACM.0000000000003401
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 112: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article: Medical Student Mobilization During A Crisis: Lessons From A COVID-19 Medical Student Response Team

    Soled, Derek / Goel, Shivangi / Barry, Danika / Erfani, Parsa / Joseph, Nicholos / Kochis, Michael / Uppal, Nishant / Velasquez, David / Vora, Kruti / Scott, Kirstin Woody

    Acad. med

    Abstract: PROBLEM: On March 17, 2020, the Association of American Medical Colleges recommended the suspension of all direct patient contact responsibilities for medical students because of the COVID-19 pandemic. Given this change, medical students nationwide had ... ...

    Abstract PROBLEM: On March 17, 2020, the Association of American Medical Colleges recommended the suspension of all direct patient contact responsibilities for medical students because of the COVID-19 pandemic. Given this change, medical students nationwide had to grapple with how and where they could fill the evolving needs of their schools' affiliated clinical sites, physicians, and patients and the community. APPROACH: At Harvard Medical School (HMS), student leaders created a COVID-19 Medical Student Response Team to: (1) develop a student-led organizational structure that would optimize students' ability to efficiently mobilize interested peers in the COVID-19 response, both clinically and in the community, in a strategic, safe, smart, and resource-conscious way; and (2) serve as a liaison with the administration and hospital leaders to identify evolving needs and rapidly engage students in those efforts. OUTCOMES: Within a week of its inception, the COVID-19 Medical Student Response Team had more than 500 medical student volunteers from HMS and had shared the organizational framework of the response team with multiple medical schools across the country. The HMS student volunteers joined any of the 4 virtual committees to complete this work: Education for the Medical Community, Education for the Broader Community, Activism for Clinical Support, and Community Activism. NEXT STEPS: The COVID-19 Medical Student Response Team helped to quickly mobilize hundreds of students and has been integrated into HMS's daily workflow. It may serve as a useful model for other schools and hospitals seeking medical student assistance during the COVID-19 pandemic. Next steps include expanding the initiative further, working with the leaders of response teams at other medical schools to coordinate efforts, and identifying new areas of need at local hospitals and within nearby communities that might benefit from medical student involvement as the pandemic evolves.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32282373
    Database COVID19

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  5. Article ; Online: Medical Student Mobilization During a Crisis

    Soled, Derek / Goel, Shivangi / Barry, Danika / Erfani, Parsa / Joseph, Nicholos / Kochis, Michael / Uppal, Nishant / Velasquez, David / Vora, Kruti / Scott, Kirstin Woody

    Academic Medicine

    Lessons From a COVID-19 Medical Student Response Team

    2020  Volume 95, Issue 9, Page(s) 1384–1387

    Keywords Education ; General Medicine ; covid19
    Language English
    Publisher Ovid Technologies (Wolters Kluwer Health)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 96192-9
    ISSN 1938-808X ; 1040-2446
    ISSN (online) 1938-808X
    ISSN 1040-2446
    DOI 10.1097/acm.0000000000003401
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Zs.A 112: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  6. Article ; Online: CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia.

    Bonifant, Challice L / Szoor, Arpad / Torres, David / Joseph, Nicholos / Velasquez, Mireya Paulina / Iwahori, Kota / Gaikwad, Amos / Nguyen, Phuong / Arber, Caroline / Song, Xiao-Tong / Redell, Michele / Gottschalk, Stephen

    Molecular therapy : the journal of the American Society of Gene Therapy

    2016  Volume 24, Issue 9, Page(s) 1615–1626

    Abstract: Immunotherapy with CD123-specific T-cell engager proteins or with T cells expressing CD123-specific chimeric antigen receptors is actively being pursued for acute myeloid leukemia. T cells secreting bispecific engager molecules (ENG-T cells) may present ... ...

    Abstract Immunotherapy with CD123-specific T-cell engager proteins or with T cells expressing CD123-specific chimeric antigen receptors is actively being pursued for acute myeloid leukemia. T cells secreting bispecific engager molecules (ENG-T cells) may present a promising alternative to these approaches. To evaluate therapeutic potential, we generated T cells to secrete CD123/CD3-bispecific engager molecules. CD123-ENG T cells recognized primary acute myeloid leukemia (AML) cells and cell lines in an antigen-dependent manner as judged by cytokine production and/or tumor killing, and redirected bystander T cells to AML cells. Infusion of CD123-ENG T cells resulted in regression of AML in xenograft models conferring a significant survival advantage of treated mice in comparison to mice that received control T cells. At high effector to target ratios, CD123-ENG T cells recognized normal hematopoietic stem and progenitor cells (HSPCs) with preferential recognition of HSPCs from cord blood compared to bone marrow. We therefore introduced the CD20 suicide gene that can be targeted in vivo with rituximab into CD123-ENG T cells. The expression of CD20 did not diminish the anti-AML activity of CD123-ENG T cells, but allowed for rituximab-mediated ENG-T cell elimination. Thus, ENG-T cells coexpressing CD20 suicide and CD123 engager molecules may present a promising immunotherapeutic approach for AML.
    MeSH term(s) Animals ; Antigens, CD20/genetics ; Antigens, CD20/metabolism ; CD3 Complex/genetics ; CD3 Complex/metabolism ; Cell Line, Tumor ; Cell Survival/drug effects ; Cell Survival/genetics ; Complement System Proteins/immunology ; Complement System Proteins/metabolism ; Cytokines/secretion ; Cytotoxicity, Immunologic ; Disease Models, Animal ; Genes, Transgenic, Suicide/genetics ; Genetic Vectors/genetics ; Hematopoietic Stem Cells/immunology ; Hematopoietic Stem Cells/metabolism ; Humans ; Immunotherapy/methods ; Interleukin-3 Receptor alpha Subunit/genetics ; Interleukin-3 Receptor alpha Subunit/metabolism ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/immunology ; Leukemia, Myeloid, Acute/therapy ; Mice ; Retroviridae/genetics ; Rituximab/pharmacology ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transduction, Genetic ; Xenograft Model Antitumor Assays
    Chemical Substances Antigens, CD20 ; CD3 Complex ; Cytokines ; Interleukin-3 Receptor alpha Subunit ; Rituximab (4F4X42SYQ6) ; Complement System Proteins (9007-36-7)
    Language English
    Publishing date 2016-09-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1038/mt.2016.116
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  7. Book ; Online: Institutionalizing farmer field schools

    Neza, Brian Nicholas / Higiro, Joseph / Mwangi, Lucy Wangari / Ochatum, Nathan

    Twigire Muhinzi National Extension System in Rwanda

    (Country investment highlights ; number 8)

    2021  

    Institution FAO
    International Food Policy Research Institute
    Author's details Brian Nicholas Neza, Joseph Higiro, Lucy Wangari Mwangi, Nathan Ochatum ; Food and Agriculture Organization of the United Nations; IFPRI, International Food Policy Research Institute
    Series title Country investment highlights ; number 8
    FAO Investment Centre country investment highlights
    Collection FAO Investment Centre country investment highlights
    Language English
    Size 1 Online-Ressource (VIII, 42 Seiten), 1Illustrationen
    Publisher Food and Agriculture Organization of the United Nations ; International Food Policy Research Institute
    Publishing place Rome
    Publishing country Italy
    Document type Book ; Online
    Note Open Access
    HBZ-ID HT021432599
    ISBN 978-92-5-135094-2 ; 92-5-135094-9
    DOI 10.4060/cb7131en
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article ; Online: Evaluation of paravertebral blocks in improving post-procedural pain and decreasing hospital admission after microwave ablation of liver tumors.

    Joseph, Nicholos / Sun, Virginia H / Som, Avik / Di Capua, John / Elsamaloty, Lina / Huang, Junjian / Vazquez, Rafael

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13854

    Abstract: ... 14% vs. 0%, p = 0.01) and a lower rate of post-procedure admissions (OR 0.23, p = 0.003 ...

    Abstract Although ablations are performed with conscious sedation or general anesthesia, microwave ablations can be painful post procedure. Newer analgesic modalities, including regional blocks, have promoted the proliferation of less invasive anesthesia care for ablative procedures. This study evaluates whether bilateral paravertebral blocks reduce the need for additional analgesics in comparison to unilateral blocks in microwave ablations. In this retrospective study, individuals undergoing microwave ablation who underwent unilateral versus bilateral nerve blocks at a single institution from 2017 to 2019 were compared. Categorical variables were analyzed using Pearson's chi-squared tests. Comparisons of means were completed using multiple T-tests corrected using the Holm-Sidak method with α = 0.05. Regression modeling was used to identify factors related to increased MME (milligram morphine equivalent) usage and post-procedure admission rates. A total of 106 patients undergoing 112 liver MWA procedures were included in this analysis, with patients receiving either a bilateral or unilateral block. Pre-procedural characteristics demonstrated no significant differences in age or gender. Bilateral blocks were associated with decreased usage of gabapentin (14% vs. 0%, p = 0.01) and a lower rate of post-procedure admissions (OR 0.23, p = 0.003). Therefore, when using paravertebral blocks, bilateral blocks are superior to unilateral blocks, as demonstrated by decreased rates of hospital admission and reduced use of systemic neuropathic pain medication. Additionally, reducing post-procedural MME may reduce the rate of admission to the hospital.
    MeSH term(s) Humans ; Pain, Procedural ; Microwaves/adverse effects ; Retrospective Studies ; Nerve Block ; Hospitals ; Liver Neoplasms/surgery
    Chemical Substances MME (78185-58-7)
    Language English
    Publishing date 2023-08-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-36607-1
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  9. Article: On the use of the reproduction number for SARS-CoV-2: Estimation, misinterpretations and relationships with other ecological measures.

    Jewell, Nicholas P / Lewnard, Joseph A

    Journal of the Royal Statistical Society. Series A, (Statistics in Society)

    2022  

    Abstract: The basic reproduction number, ...

    Abstract The basic reproduction number,
    Language English
    Publishing date 2022-06-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1490715-X
    ISSN 1467-985X ; 0964-1998 ; 0035-9238
    ISSN (online) 1467-985X
    ISSN 0964-1998 ; 0035-9238
    DOI 10.1111/rssa.12860
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  10. Article ; Online: Small-Group Teaching: Should It Be Recorded?

    Crook, Peter / Javadzadeh, Shagayegh / Shone, Rebecca / Joseph, Vikram / Banerjee, Debasish / Annear, Nicholas M P

    Medical science educator

    2023  Volume 33, Issue 5, Page(s) 1073–1079

    Abstract: Background: Recording large-group lectures is commonplace in higher education, allowing students to access content asynchronously and remotely. With the move towards online learning during the COVID-19 pandemic, recording of small-group teaching ... ...

    Abstract Background: Recording large-group lectures is commonplace in higher education, allowing students to access content asynchronously and remotely. With the move towards online learning during the COVID-19 pandemic, recording of small-group teaching sessions has also become increasingly common; however, the educational value of this practice is unknown.
    Methods: All medical students rotating through the Acute Medicine Department of a large teaching hospital were invited to enrol in the study. Consenting students were recorded for the second half of an online case-based learning (CBL) session. The recording was available for 6 months; viewing patterns were analysed. Students were sent a questionnaire after the session, asking them to reflect on the recorded and unrecorded halves of the session.
    Findings: Thirty-three students underwent recording in 12 separate groups; 31 students (94%) completed the questionnaire. All 31 respondents (100%) described the session as "useful" or "very useful". Twenty-four respondents (77%) recommended continuing to record small-group sessions and 17 (55%) reported being "likely" or "very likely" to watch the recording. Six respondents (19%) reported a negative impact of being recorded. During 6 months of follow-up, no students returned to view the recording for more than 1 minute.
    Conclusion: Despite positive feedback for the session and high student demand for ongoing recording, no students viewed the recording for any significant duration. One-fifth of students reported a negative impact of being recorded. The findings from this study do not support routine recording of small-group CBL sessions, even where demand for this may exist.
    Supplementary information: The online version contains supplementary material available at 10.1007/s40670-023-01837-5.
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article
    ISSN 2156-8650
    ISSN (online) 2156-8650
    DOI 10.1007/s40670-023-01837-5
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