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  1. Article ; Online: Jean Rodier: History of Manganism in Morocco.

    Hicham, C / Reis, J / Rodier, M / Belahsen, F / Spencer, P S

    Neurotoxicology

    2020  Volume 81, Page(s) 66–69

    Abstract: Jean Rodier (1920-2003), distinguished researcher and scientist, directed the Toxicology Department ...

    Abstract Jean Rodier (1920-2003), distinguished researcher and scientist, directed the Toxicology Department of Hygiene Institute of Rabat under the French Protectorate. From 1946, he developed numerous lines of research in occupational health, in particular on Manganism, a neurological disorder that impacted miners in his home country of Morocco. His many papers on Manganism, only one of which was published in English, describe field and laboratory research studies that focused its prevention and management.
    MeSH term(s) Biomedical Research/history ; History, 20th Century ; History, 21st Century ; Humans ; Manganese Poisoning/diagnosis ; Manganese Poisoning/epidemiology ; Manganese Poisoning/history ; Manganese Poisoning/prevention & control ; Miners/history ; Mining/history ; Morocco/epidemiology ; Occupational Diseases/diagnosis ; Occupational Diseases/epidemiology ; Occupational Diseases/history ; Occupational Diseases/prevention & control ; Occupational Health/history ; Risk Assessment ; Risk Factors ; Toxicology/history
    Language English
    Publishing date 2020-09-02
    Publishing country Netherlands
    Document type Biography ; Historical Article ; Journal Article ; Portrait
    ZDB-ID 800820-6
    ISSN 1872-9711 ; 0161-813X
    ISSN (online) 1872-9711
    ISSN 0161-813X
    DOI 10.1016/j.neuro.2020.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Senolytic Targeting of Bcl-2 Anti-Apoptotic Family Increases Cell Death in Irradiated Sarcoma Cells.

    Lafontaine, Julie / Cardin, Guillaume B / Malaquin, Nicolas / Boisvert, Jean-Sébastien / Rodier, Francis / Wong, Philip

    Cancers

    2021  Volume 13, Issue 3

    Abstract: Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local ... ...

    Abstract Radiotherapy (RT) is a key component of cancer treatment. Most of the time, radiation is given after surgery but for soft-tissue sarcomas (STS), pre-surgical radiation is commonly utilized. However, despite improvements in RT accuracy, the rate of local recurrence remains high and is the major cause of death for patients with STS. A better understanding of cell fates in response to RT could provide new therapeutic options to enhance tumour cell killing by RT and facilitate surgical resection. Here, we showed that irradiated STS cell cultures do not die but instead undergo therapy-induced senescence (TIS), which is characterized by proliferation arrest, senescence-associated β-galactosidase activity, secretion of inflammatory cytokines and persistent DNA damage. STS-TIS was also associated with increased levels of the anti-apoptotic Bcl-2 family of proteins which rendered cells targetable using senolytic Bcl-2 inhibitors. As oppose to radiation alone, the addition of senolytic agents Venetoclax (ABT-199) or Navitoclax (ABT-263) after irradiation induced a rapid apoptotic cell death in STS monolayer cultures and in a more complex three-dimensional culture model. Together, these data suggest a new promising therapeutic approach for sarcoma patients who receive neoadjuvant RT. The addition of senolytic agents to radiation treatments may significantly reduce tumour volume prior to surgery and thereby improve the clinical outcome of patients.
    Language English
    Publishing date 2021-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13030386
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  3. Article: Méthodologie pour développer une formation aux bonnes pratiques de préparation des anticancéreux en réalité virtuelle à 360°.

    Descotes, G / Moine, M / Beau, F / Noyer, V / Nicoulaud, J-C / Divanon, F / Jourdan, N / Bobay-Madic, A / Rodier, S

    Annales pharmaceutiques francaises

    2020  Volume 78, Issue 4, Page(s) 324–334

    Abstract: Objective: Describe the process for designing and creating SimUPAC 360°, a virtual reality training in anti-cancer drug production units.: Methods: A multi-centre (a University Hospital, a General Hospital and a Cancer Control Centre), inter- ... ...

    Title translation Methodology to develop a virtual reality training for good practices in the preparation of anti-cancer drugs.
    Abstract Objective: Describe the process for designing and creating SimUPAC 360°, a virtual reality training in anti-cancer drug production units.
    Methods: A multi-centre (a University Hospital, a General Hospital and a Cancer Control Centre), inter-professional (pharmacists, hospital pharmacy technicians and health executives) working group has been set up. It was based on videoconferencing and online document sharing. The work was divided into six phases: choice of target audience and training objectives, definition of the business model, development of the scenario, shooting and editing, creation of the training tool and finally tests, adjustments and validation of the tool.
    Results: After brainstorming, 77 errors were proposed. Three areas have been defined: covering area, storage and production area, and isolator. They contained 15 errors among the 77 proposed and 20 points of interest. The shooting was carried out over 2 days, in 2 hospitals. Assembly was carried out by a service provider specialist in real virtuality. Before to go online, the tool was tested and validated by experts.
    Discussion: The establishment of a multi-centric and interdisciplinary working group, the choice of target audience, pedagogical objectives and business model ensure the economic viability and scientific and technical robustness of the tool. The scenario development requires to define: activity areas and then, number, difficulty and typology of errors.
    Conclusion: Creation of a virtual reality training requires a consistent and structured methodology. This methodology will make it possible to develop other training scenarios.
    MeSH term(s) Antineoplastic Agents/adverse effects ; Antineoplastic Agents/chemistry ; Drug Compounding/methods ; Education, Pharmacy/organization & administration ; Hospitals, University ; Humans ; Medication Errors/prevention & control ; Models, Organizational ; Pharmacists ; Pharmacy Service, Hospital ; Pharmacy Technicians ; Teaching ; Virtual Reality
    Chemical Substances Antineoplastic Agents
    Language French
    Publishing date 2020-01-23
    Publishing country France
    Document type Journal Article
    ZDB-ID 307-4
    ISSN 0003-4509
    ISSN 0003-4509
    DOI 10.1016/j.pharma.2019.12.006
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  4. Article ; Online: Covering of wound infection in hip arthroplasty with local cutaneous flaps.

    Ruffenach, L / Dibiase, L / Jenny, J Y / Boeri, C / Ronde Oustau, C / Klein, S / Bruant-Rodier, C / Bodin, F / Dissaux, C

    Annales de chirurgie plastique et esthetique

    2022  Volume 68, Issue 4, Page(s) 333–338

    Abstract: Total hip arthroplasty is a very common procedure to treat osteoarthritis. One of the complication is the infection which occurs in about 1% of the cases. The manifestation of infection can be poor wound healing with dehiscence and exposition of bone or ... ...

    Abstract Total hip arthroplasty is a very common procedure to treat osteoarthritis. One of the complication is the infection which occurs in about 1% of the cases. The manifestation of infection can be poor wound healing with dehiscence and exposition of bone or prosthetic components. Hip arthroplasty infections are difficult to treat. It required an associated multidisciplinary approach with infectiology, orthopedic and plastic surgeries. The study included five patients with hip wound dehiscence after total hip arthroplasty. Coverage after orthopedic surgery was provided by local cutaneous flap. These cutaneous flaps were either a deep inferior epigastric perforator flap (DIEP) or a transposition flap. The orthopedic and the plastic treatment were done at the same time. Two deep inferior epigastric flaps were performed for patients with a deep defect with bone or prosthesis exposure. Four transposition flaps were done in three patients with wound dehiscence but without direct contact with the prosthesis. Three transposition flaps were done from the abdominal wall and one from the posterior thigh. The mean follow up was 18 months, ranging from 10 to 24months. After healing, there was no recurrence of the infection. In all cases, the coverage was obtained. The prosthesis was salvage and the gait was possible. Cutaneous flaps are easy and safe to cover the hip. They are reliable flaps even in patients with multiple co-morbidities. They do not cause sequelae on the recipient site. This study is the first about cutaneous flap for covering hip defects in hip arthroplasty infections.
    MeSH term(s) Humans ; Arthroplasty, Replacement, Hip/adverse effects ; Surgical Flaps ; Skin ; Wound Infection ; Postoperative Complications ; Mammaplasty/methods
    Language English
    Publishing date 2022-07-17
    Publishing country France
    Document type Journal Article
    ZDB-ID 605676-3
    ISSN 1768-319X ; 0294-1260
    ISSN (online) 1768-319X
    ISSN 0294-1260
    DOI 10.1016/j.anplas.2022.06.004
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  5. Article ; Online: Myofibril and mitochondria morphogenesis are coordinated by a mechanical feedback mechanism in muscle.

    Avellaneda, Jerome / Rodier, Clement / Daian, Fabrice / Brouilly, Nicolas / Rival, Thomas / Luis, Nuno Miguel / Schnorrer, Frank

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2091

    Abstract: Complex animals build specialised muscles to match specific biomechanical and energetic needs. Hence, composition and architecture of sarcomeres and mitochondria are muscle type specific. However, mechanisms coordinating mitochondria with sarcomere ... ...

    Abstract Complex animals build specialised muscles to match specific biomechanical and energetic needs. Hence, composition and architecture of sarcomeres and mitochondria are muscle type specific. However, mechanisms coordinating mitochondria with sarcomere morphogenesis are elusive. Here we use Drosophila muscles to demonstrate that myofibril and mitochondria morphogenesis are intimately linked. In flight muscles, the muscle selector spalt instructs mitochondria to intercalate between myofibrils, which in turn mechanically constrain mitochondria into elongated shapes. Conversely in cross-striated leg muscles, mitochondria networks surround myofibril bundles, contacting myofibrils only with thin extensions. To investigate the mechanism causing these differences, we manipulated mitochondrial dynamics and found that increased mitochondrial fusion during myofibril assembly prevents mitochondrial intercalation in flight muscles. Strikingly, this causes the expression of cross-striated muscle specific sarcomeric proteins. Consequently, flight muscle myofibrils convert towards a partially cross-striated architecture. Together, these data suggest a biomechanical feedback mechanism downstream of spalt synchronizing mitochondria with myofibril morphogenesis.
    MeSH term(s) Animals ; Biomechanical Phenomena ; Drosophila ; Drosophila Proteins ; Drosophila melanogaster ; Feedback ; Flight, Animal/physiology ; Male ; Mechanical Phenomena ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Morphogenesis/physiology ; Muscle Development ; Muscle, Skeletal/cytology ; Muscle, Skeletal/metabolism ; Myofibrils/metabolism ; Myofibrils/ultrastructure ; Myogenic Regulatory Factors ; Sarcomeres/metabolism ; Transcription Factors
    Chemical Substances Drosophila Proteins ; GAL4 protein, Drosophila ; Mef2 protein, Drosophila ; Myogenic Regulatory Factors ; Transcription Factors
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22058-7
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  6. Article: Accumulation of sucrose in vacuoles isolated from red beet tissue.

    Doll, S / Rodier, F / Willenbrink, J

    Planta

    2014  Volume 144, Issue 5, Page(s) 407–411

    Abstract: Vacuoles were isolated from red beets (Beta vulgaris L.) by slicing the tissue and separated using a discontinuous dextran gradient centrifugation. The uptake of sucrose against a concentration gradient into the dextran-impermeable [(3)H]-H2O space of ... ...

    Abstract Vacuoles were isolated from red beets (Beta vulgaris L.) by slicing the tissue and separated using a discontinuous dextran gradient centrifugation. The uptake of sucrose against a concentration gradient into the dextran-impermeable [(3)H]-H2O space of these organelles was studied using silicone layer filtering centrifugation on both fluorometric and (14)C-measurement of sucrose. The rate is 24 nmol sucrose (unit betacyanin)(-1) h(-1) and appears to be stimulated by ATP to an uptake rate of 34 nmol. Control experiments with slices cut from red beet tissue and incubated with [(14)C]sucrose gave comparable results. An ATPase activity dependent on both Mg(2+) and K(+) seems to be localized at the inner surface of the tonoplast. This activity is strongly inhibited by EDAC and tartrate and there is no effect of oligomycin, whereas a slight stimulation was caused by DCCD.
    Language English
    Publishing date 2014-01-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 208909-9
    ISSN 1432-2048 ; 0032-0935 ; 1866-2749
    ISSN (online) 1432-2048
    ISSN 0032-0935 ; 1866-2749
    DOI 10.1007/BF00380115
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  7. Article ; Online: Colchicine to prevent sympathetic denervation after acute myocardial infarction: the COLD-MI trial.

    Huet, Fabien / Mariano-Goulart, Denis / Aguilhon, Sylvain / Delbaere, Quentin / Lacampagne, Alain / Fauconnier, Jérémy / Leclercq, Florence / Macia, Jean-Christophe / Akodad, Mariama / Jammoul, Nidal / Prunier, Fabrice / Mewton, Nathan / Angoulvant, Denis / Lozza, Catherine / Soltani, Sonia / Rodier, Annabelle / Grandemange, Sylvie / Dupuy, Anne-Marie / Cristol, Jean-Paul /
    Amico, Mailis / Nagot, Nicolas / Roubille, François

    European heart journal

    2024  Volume 45, Issue 9, Page(s) 725–727

    MeSH term(s) Humans ; Colchicine/therapeutic use ; Myocardial Infarction/complications ; Sympathectomy
    Chemical Substances Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae042
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  8. Article: Intra- and inter-rater consistency of dual assessment by radiologist and neurologist for evaluating DWI-ASPECTS in ischemic stroke.

    Bing, F / Berger, I / Fabry, A / Moroni, A-L / Casile, C / Morel, N / M'Biene, S / Guellerin, J / Pignal-Jacquard, C / Vadot, W / Rodier, G / Delory, T / Jund, J

    Revue neurologique

    2021  Volume 178, Issue 3, Page(s) 219–225

    Abstract: Objectives: To estimate the intra -and inter-rater consistency of radiologist and neurologist working in pairs attributing DWI-ASPECTS (Diffusion Alberta Stroke Program Early CT Score) in patients with acute middle cerebral artery ischemic stroke ... ...

    Abstract Objectives: To estimate the intra -and inter-rater consistency of radiologist and neurologist working in pairs attributing DWI-ASPECTS (Diffusion Alberta Stroke Program Early CT Score) in patients with acute middle cerebral artery ischemic stroke referred for mechanical thrombectomy, intravenous thrombolysis or bridging therapy.
    Methods: Five neurologists and 5 radiologists working in pairs and in hour period scored independently and in two reading sessions anonymized DWI-ASPECTS of 80 patients presenting with acute anterior ischaemic stroke in our center. We measured agreement between pairs using intraclass correlation coefficients (ICCs). A Fleiss kappa was used for dichotomized (0-6;7-10) and trichotomized (0-3;4-6;7-10) ASPECTS. The interrater distribution of the score in the trichotomized (0-3;4-6;7-10) ASPECTS was calculated. We determined the interrater (Cohen kappa) and intrarater (Fleiss kappa) agreement on the ASPECTS regions.
    Results: The average DWI-ASPECTS was 6.35 (SD±2.44) for the first reading, and 6.47 (SD±2.44) for the second one. The ICC was 0.853 (95%CI, 0.798-0.896) for the interrater, and 0.862 (95%CI, 0.834-0.885) for the intrarater evaluation. Kappa coefficients were high for dichotomized (k=0.75) and trichotomized (k=0.64) ASPECTS. Evaluators agreement on the ASPECTS category (0-3), (4-6) and (7-10) was 88, 76 and 93% respectively. The anatomic region infarcted was well identified (k=0.70-0.77), except for the internal capsula (k=0.57). Interrater agreement was fair for M5 (k=0.37), moderate for internal capsula (0.52) and substantial for the other regions (0.60-0.79).
    Conclusions: Reliability of DWI-ASPECTS is good when determined by radiologist and neurologist working in pairs, which corresponds to our current clinical practice. However, discrepancies are possible for cut-off determination, which may impact the indication of thrombectomy, and for the determination of the exact infarcted region. Agreement to propose category (4-6) is lower than for (0-3) and (8-10) ASPECTS categories.
    MeSH term(s) Brain Ischemia/diagnostic imaging ; Brain Ischemia/therapy ; Humans ; Ischemic Stroke ; Neurologists ; Radiologists ; Reproducibility of Results ; Stroke/diagnostic imaging ; Stroke/therapy
    Language English
    Publishing date 2021-11-14
    Publishing country France
    Document type Journal Article
    ZDB-ID 4593-7
    ISSN 2213-0004 ; 0035-3787
    ISSN (online) 2213-0004
    ISSN 0035-3787
    DOI 10.1016/j.neurol.2021.08.007
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  9. Article ; Online: Quantitative monitoring of galactolipid hydrolysis by pancreatic lipase-related protein 2 using thin layer chromatography and thymol-sulfuric acid derivatization.

    Sahaka, Moulay / Amara, Sawsan / Lecomte, Jérôme / Rodier, Jean-David / Lafont, Dominique / Villeneuve, Pierre / Gontero, Brigitte / Carrière, Frédéric

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2021  Volume 1173, Page(s) 122674

    Abstract: Galactolipids are the most abundant lipids on earth where they are mainly found in photosynthetic membranes of plant, algae, and cyanobacteria. Pancreatic lipase-related protein 2 (PLRP2) is an enzyme with galactolipase activity allowing mammals, ... ...

    Abstract Galactolipids are the most abundant lipids on earth where they are mainly found in photosynthetic membranes of plant, algae, and cyanobacteria. Pancreatic lipase-related protein 2 (PLRP2) is an enzyme with galactolipase activity allowing mammals, especially herbivores, to digest this important source of fatty acids. We present a method for the quantitative analysis of galactolipids and galactosylated products resulting from their digestion by guinea pig PLRP2 (GPLRP2), using thin-layer-chromatography (TLC), thymol-sulfuric acid as derivatization reagent and scanning densitometry for detection. Thymol-sulfuric acid reagent has been used for the colorimetric detection of carbohydrates. It is shown here that the derivatization of galactosyl group from galactolipids by this reagent is not affected by the bound acyl glycerol, acyl chains length and number of galactose residues in the polar head. This allowed quantifying simultaneously the initial substrate and all galactosylated products generated upon the hydrolysis of monogalactosyl di-octanoylglycerol (C8-MGDG) by GPLRP2 using a single calibration with C8-MGDG as reference standard. The reaction products, monogalactosyl monooctanoyl glycerol (C8-MGMG) and monogalactosyl glycerol (MGG), were identified and quantified, MGG being recovered from the aqueous phase and analyzed by a separate TLC analysis. This method is therefore suitable to quantify the products resulting from the release of both fatty acids present in MGDG and thereby shows that PLRP2 can contribute to the complete digestion of galactolipids and further intestinal absorption of their fatty acids.
    Language English
    Publishing date 2021-03-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2021.122674
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  10. Article: Le ganglion sentinelle dans les cancers invasifs du sein. Questions actuelles et essais cliniques nationaux et internationaux.

    Rodier, J F

    Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

    2004  Volume 8, Issue 1, Page(s) 29–32

    Abstract: Sentinel lymph node biopsy is a major diagnostic procedure in breast cancer surgery. Although adopted worldwide, its routine practice has not been validated yet. This article proposes a review of national and international controlled clinical trials ... ...

    Title translation The sentinel node in invasive breast cancer. Unsolved questions and review of the national and international clinical trials.
    Abstract Sentinel lymph node biopsy is a major diagnostic procedure in breast cancer surgery. Although adopted worldwide, its routine practice has not been validated yet. This article proposes a review of national and international controlled clinical trials whose aims are definitely to answer remaining unsolved questions.
    MeSH term(s) Age Factors ; Axilla ; Breast Neoplasms/diagnosis ; Breast Neoplasms/pathology ; Clinical Trials as Topic ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes/pathology ; Lymphatic Metastasis/pathology ; Lymphatic Metastasis/radiotherapy ; Randomized Controlled Trials as Topic ; Sentinel Lymph Node Biopsy/methods
    Language French
    Publishing date 2004-02
    Publishing country France
    Document type Comparative Study ; English Abstract ; Journal Article ; Review
    ZDB-ID 1397169-4
    ISSN 1278-3218
    ISSN 1278-3218
    DOI 10.1016/j.canrad.2003.09.004
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