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  1. Article ; Online: Comments regarding: Cooper LF, Stanford C, Feine J, McGuire M. Prospective assessment of CAD-CAM zirconia abutment and lithium disilicate crown restorations: 2.4 year results. J Prosthet Dent 2016;116:33-9.

    Afrashtehfar, Kelvin I / de Souza, Raphael Freitas

    The Journal of prosthetic dentistry

    2017  Volume 119, Issue 3, Page(s) 313

    MeSH term(s) Computer-Aided Design ; Crowns ; Dental Porcelain ; Prospective Studies ; Zirconium
    Chemical Substances lithia disilicate ; Dental Porcelain (12001-21-7) ; Zirconium (C6V6S92N3C) ; zirconium oxide (S38N85C5G0)
    Language English
    Publishing date 2017-06-20
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 218157-5
    ISSN 1097-6841 ; 0022-3913
    ISSN (online) 1097-6841
    ISSN 0022-3913
    DOI 10.1016/j.prosdent.2017.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ul III Zs.145: Show issues Location:
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  2. Book ; Thesis: Die Rückfußarthrodese bei postinfektiöser Sprunggelenkdestruktion mit einem retrograden Arthrodesennagel

    Staubach, Raphael

    2019  

    Institution Goethe-Universität Frankfurt am Main
    Author's details vorgelegt von Raphael Staubach
    Language German
    Size vii, 113 Seiten, Illustrationen, Diagramme, 30 cm
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2019
    Note Zusammenfassung auf Deutsch und Englisch
    HBZ-ID HT020457605
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2020 E 680 order for loan Magazin

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  3. Article ; Online: Continuous reproduction of planktonic foraminifera in laboratory culture.

    Meilland, Julie / Siccha, Michael / Morard, Raphaël / Kucera, Michal

    The Journal of eukaryotic microbiology

    2024  , Page(s) e13022

    Abstract: Planktonic foraminifera were long considered obligate sexual outbreeders but recent observations have shown that nonspinose species can reproduce by multiple fission. The frequency of multiple fission appears low but the survival rate of the offspring is ...

    Abstract Planktonic foraminifera were long considered obligate sexual outbreeders but recent observations have shown that nonspinose species can reproduce by multiple fission. The frequency of multiple fission appears low but the survival rate of the offspring is high and specimens approaching fission can be distinguished. We made use of this observation and established a culturing protocol aimed at enhancing the detection and frequency of fission. Using this protocol, we selectively cultured specimens of Neogloboquadrina pachyderma and raised the frequency of reproduction by fission in culture from 3% in randomly selected specimens to almost 60%. By feeding the resulting offspring different strains of live diatoms, we obtained a thriving offspring population and during the subsequent 6 months of culturing, we observed two more successive generations produced by fission. This provides evidence that in nonspinose species of planktonic foraminifera, reproduction by multiple fission is likely clonal and corresponds to the schizont phase known from benthic foraminifera. We subsequently tested if a similar culturing strategy could be applied to Globigerinita glutinata, representing a different clade of planktonic foraminifera, and we were indeed able to obtain offspring via multiple fission in this species. This work opens new avenues for laboratory-based experimental work with planktonic foraminifera.
    Language English
    Publishing date 2024-02-25
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1147218-2
    ISSN 1550-7408 ; 1066-5234
    ISSN (online) 1550-7408
    ISSN 1066-5234
    DOI 10.1111/jeu.13022
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  4. Article ; Online: Management of Patients with Kidney Failure and Pericarditis.

    Rosen, Raphael J / Valeri, Anthony M

    Clinical journal of the American Society of Nephrology : CJASN

    2022  Volume 18, Issue 2, Page(s) 270–272

    MeSH term(s) Humans ; Pericarditis/drug therapy ; Kidney Failure, Chronic
    Language English
    Publishing date 2022-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2226665-3
    ISSN 1555-905X ; 1555-9041
    ISSN (online) 1555-905X
    ISSN 1555-9041
    DOI 10.2215/CJN.07470622
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  5. Article ; Online: Hs27 fibroblast response to contact guidance cues.

    Kim, C / Robitaille, M / Christodoulides, J / Ng, Y / Raphael, M / Kang, W

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 21691

    Abstract: Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge ... ...

    Abstract Contact guidance is the phenomena of how cells respond to the topography of their external environment. The morphological and dynamic cell responses are strongly influenced by topographic features such as lateral and vertical dimensions, namely, ridge and groove widths and groove depth ([Formula: see text], respectively). However, experimental studies that independently quantify the effect of the individual dimensions as well as their coupling on cellular function are still limited. In this work, we perform extensive parametric studies in the dimensional space-well beyond the previously studied range in the literature-to explore topographical effects on morphology and migration of Hs27 fibroblasts via static and dynamic analyses of live cell images. Our static analysis reveals that the [Formula: see text] is most significant, followed by the [Formula: see text]. The fibroblasts appear to be more elongated and aligned in the groove direction as the [Formula: see text] increases, but their trend changes after 725 nm. Interestingly, the cell shape and alignment show a very strong correlation regardless of [Formula: see text]. Our dynamic analysis confirms that directional cell migration is also strongly influenced by the [Formula: see text], while the effect of the [Formula: see text] and [Formula: see text] is statistically insignificant. Directional cell migration, as observed in the static cell behavior, shows the statistically significant transition when the [Formula: see text] is 725 nm, showing the intimate links between cell morphology and migration. We propose possible scenarios to offer mechanistic explanations of the observed cell behavior.
    MeSH term(s) Cues ; Fibroblasts ; Cell Membrane
    Language English
    Publishing date 2023-12-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-48913-9
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  6. Article ; Online: In Situ

    Magnussen, Olaf M / Drnec, Jakub / Qiu, Canrong / Martens, Isaac / Huang, Jason J / Chattot, Raphaël / Singer, Andrej

    Chemical reviews

    2024  Volume 124, Issue 3, Page(s) 629–721

    Abstract: Electrochemical and electrocatalytic processes are of key importance for the transition to a sustainable energy supply as well as for a wide variety of other technologically relevant fields. Further development of these processes requires in-depth ... ...

    Abstract Electrochemical and electrocatalytic processes are of key importance for the transition to a sustainable energy supply as well as for a wide variety of other technologically relevant fields. Further development of these processes requires in-depth understanding of the atomic, nano, and micro scale structure of the materials and interfaces in electrochemical devices under reaction conditions. We here provide a comprehensive review of
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207949-5
    ISSN 1520-6890 ; 0009-2665
    ISSN (online) 1520-6890
    ISSN 0009-2665
    DOI 10.1021/acs.chemrev.3c00331
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    In stock of ZB MED Bonn / Germany

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  7. Book ; Online: Preservation of Affordable Rental Housing

    Schwartz, Heather L / Bostic, Raphael W / Green, Richard K / Reina, Vincent J / Davis, Lois M

    Evaluation of the MacArthur Foundation's Window of Opportunity Initiative

    2016  

    Keywords History of the Americas ; Society & culture: general ; Poverty & unemployment ; Sociology ; History
    Language English
    Size 1 Online-Ressource
    Publisher RAND Corporation
    Document type Book ; Online
    Note English
    HBZ-ID HT030610038
    ISBN 9780833094919 ; 0833094912
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  8. Article: HATCHet2: clone- and haplotype-specific copy number inference from bulk tumor sequencing data.

    Myers, Matthew A / Arnold, Brian J / Bansal, Vineet / Mullen, Katelyn M / Zaccaria, Simone / Raphael, Benjamin J

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Multi-region DNA sequencing of primary tumors and metastases from individual patients helps identify somatic aberrations driving cancer development. However, most methods to infer copy-number aberrations (CNAs) analyze individual samples. We introduce ... ...

    Abstract Multi-region DNA sequencing of primary tumors and metastases from individual patients helps identify somatic aberrations driving cancer development. However, most methods to infer copy-number aberrations (CNAs) analyze individual samples. We introduce HATCHet2 to identify haplotype- and clone-specific CNAs simultaneously from multiple bulk samples. HATCHet2 introduces a novel statistic, the mirrored haplotype B-allele frequency (mhBAF), to identify mirrored-subclonal CNAs having different numbers of copies of parental haplotypes in different tumor clones. HATCHet2 also has high accuracy in identifying focal CNAs and extends the earlier HATCHet method in several directions. We demonstrate HATCHet2's improved accuracy using simulations and a single-cell sequencing dataset. HATCHet2 analysis of 50 prostate cancer samples from 10 patients reveals previously-unreported mirrored-subclonal CNAs affecting cancer genes.
    Language English
    Publishing date 2023-07-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.13.548855
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Topographical depth reveals contact guidance mechanism distinct from focal adhesion confinement.

    Robitaille, Michael C / Kim, Chunghwan / Christodoulides, Joseph A / Calhoun, Patrick J / Kang, Wonmo / Liu, Jinny / Byers, Jeff M / Raphael, Marc P

    Cytoskeleton (Hoboken, N.J.)

    2024  Volume 81, Issue 4-5, Page(s) 238–248

    Abstract: Cellular response to the topography of their environment, known as contact guidance, is a crucial aspect to many biological processes yet remains poorly understood. A prevailing model to describe cellular contact guidance involves the lateral confinement ...

    Abstract Cellular response to the topography of their environment, known as contact guidance, is a crucial aspect to many biological processes yet remains poorly understood. A prevailing model to describe cellular contact guidance involves the lateral confinement of focal adhesions (FA) by topography as an underlying mechanism governing how cells can respond to topographical cues. However, it is not clear how this model is consistent with the well-documented depth-dependent contact guidance responses in the literature. To investigate this model, we fabricated a set of contact guidance chips with lateral dimensions capable of confining focal adhesions and relaxing that confinement at various depths. We find at the shallowest depth of 330 nm, the model of focal adhesion confinement is consistent with our observations. However, the cellular response at depths of 725 and 1000 nm is inadequately explained by this model. Instead, we observe a distinct reorganization of F-actin at greater depths in which topographically induced cell membrane deformation alters the structure of the cytoskeleton. These results are consistent with an alternative curvature-hypothesis to explain cellular response to topographical cues. Together, these results indicate a confluence of two molecular mechanisms operating at increased induced membrane curvature that govern how cells sense and respond to topography.
    MeSH term(s) Focal Adhesions/metabolism ; Actins/metabolism ; Humans ; Animals ; Cytoskeleton/metabolism
    Chemical Substances Actins
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, Non-U.S. Gov't
    ZDB-ID 2534372-5
    ISSN 1949-3592 ; 1949-3584
    ISSN (online) 1949-3592
    ISSN 1949-3584
    DOI 10.1002/cm.21810
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    Zs.A 1840: Show issues Location:
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  10. Article ; Online: Immunotherapy and Radiation Therapy Sequencing in Breast Cancer: A Systematic Review.

    Verma, Saurav / Young, Sympascho / Boldt, Gabriel / Blanchette, Phillip / Lock, Michael / Helou, Joelle / Raphael, Jacques

    International journal of radiation oncology, biology, physics

    2024  Volume 118, Issue 5, Page(s) 1422–1434

    Abstract: Purpose: In the past decade, immune checkpoint inhibitors (ICIs) have emerged as a treatment option for metastatic breast cancer (BC). More recently, ICIs have been approved in the perioperative setting. This has led to clinical scenarios where ... ...

    Abstract Purpose: In the past decade, immune checkpoint inhibitors (ICIs) have emerged as a treatment option for metastatic breast cancer (BC). More recently, ICIs have been approved in the perioperative setting. This has led to clinical scenarios where radiation therapy (RT) is given concurrently with ICIs. On the other hand, moderate and ultrahypofractionated schedules of RT are being widely adopted in the adjuvant setting, in addition to an increased use of metastasis-directed therapy. Furthermore, RT can modulate the tumor microenvironment and induce a systemic response at nonirradiated sites, an "abscopal effect." The amplification of antitumor immune response is used as the rationale behind the concomitant use of ICIs and RT. To date, there is a lack of literature on the optimal sequence, timing, dose/fractionation schema, and treated RT volumes with ICIs in patients with BC, especially in the era of ultrahypofractionation.
    Methods and materials: We conducted a systematic review to delineate the reported treatment details, safety, and efficacy of combining ICI and RT in patients with BC. PubMed, Embase, and Cochrane CENTRAL were searched between 2014 and 2023. Data were extracted to assess the details of ICIs/RT delivery, safety, and efficacy.
    Results: Of the 12 eligible studies, 9 involved patients with metastatic BC. Most studies were phase 1/2, had a small sample size (range, 8-28), and were heterogenous in patient population and reported outcomes. The combination was reported to be safe. We identified 1 study in the perioperative setting, which did a posthoc analysis of safety/efficacy of ICIs in the adjuvant setting with receipt and pattern of RT.
    Conclusions: In conclusion, there are limited data on the dose, timing, fractionation, and volumes of RT in both the adjuvant and metastatic setting in BC. Ongoing/future trials should collect and report such data on RT details, whenever RT is used in combination with ICIs.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/radiotherapy ; Immunotherapy/methods ; Dose Fractionation, Radiation ; Tumor Microenvironment
    Language English
    Publishing date 2024-01-07
    Publishing country United States
    Document type Systematic Review ; Journal Article ; Review
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2024.01.001
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