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  1. Article: Strengthening Muscle Health of Community-Dwelling Older Adults in Singapore: Evidence Towards Clinical Implementation.

    Maier, A B / Chew, S T H / Goh, J / Koh, F H X / Tan, N C

    The Journal of frailty & aging

    2023  Volume 12, Issue 4, Page(s) 258–266

    Abstract: The prevalence of sarcopenia will inevitably increase as the population ages in Singapore, rendering it a growing public health concern with a significant impact on healthcare resources. This article firstly summarizes the current understanding of the ... ...

    Abstract The prevalence of sarcopenia will inevitably increase as the population ages in Singapore, rendering it a growing public health concern with a significant impact on healthcare resources. This article firstly summarizes the current understanding of the epidemiology, diagnosis and management of sarcopenia, focusing on community-dwelling older individuals. Early identification is key to preventing and minimizing muscle loss. Appropriate interventions, including resistance exercise training, nutritional interventions and prehabilitation program, should be tailored to each patient. We suggest several key actions to ultimately improve awareness and overcome challenges in identifying and managing sarcopenia to improve patient outcomes. A paradigm shift where muscle health is seen as an integral component to maintaining good health with longer lifespan is needed. Education - of healthcare professionals and the public - serves as the foundation to improving awareness of muscle health and sarcopenia, and to promoting physical exercise across the age spectrum for sarcopenia prevention. The use of cost-effective evidence-based modalities (e.g., calf circumference measurement, 5-times chair stand test or bioelectric impedance assessment) enable early identification of muscle loss in routine practice. Providing subsidies for nutritional interventions (e.g., oral nutritional supplements) and exercise (e.g., ActiveSG gym membership) would encourage uptake of and adherence to interventions. Further high-quality research on interventions and their outcomes is important to determine the optimal strategy in different patient populations and to demonstrate clinical significance and value of addressing sarcopenia. Having local champions within healthcare institution would facilitate the much-needed change in healthcare culture where muscle health is a part of routine clinical practice.
    MeSH term(s) Humans ; Aged ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology ; Sarcopenia/prevention & control ; Independent Living ; Singapore/epidemiology ; Muscle, Skeletal ; Exercise ; Muscle Strength
    Language English
    Publishing date 2023-11-27
    Publishing country France
    Document type Journal Article
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2023.31
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Prevention of postoperative pulmonary complications in the hypoxaemic patient - gathering the evidence for noninvasive respiratory support.

    Abbott, Tom E F / Pearse, Rupert M / Chew, Michelle S

    European journal of anaesthesiology

    2020  Volume 37, Issue 4, Page(s) 263–264

    MeSH term(s) Humans ; Hypoxia ; Noninvasive Ventilation ; Postoperative Period
    Language English
    Publishing date 2020-03-04
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 605770-6
    ISSN 1365-2346 ; 0265-0215
    ISSN (online) 1365-2346
    ISSN 0265-0215
    DOI 10.1097/EJA.0000000000001188
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Online: Hardness of Random Reordered Encodings of Parity for Resolution and CDCL

    Chew, Leroy / de Colnet, Alexis / Slivovsky, Friedrich / Szeider, Stefan

    2024  

    Abstract: ... variable orders (Chew and Heule 2020). We provide an analytical explanation for their hardness by showing ...

    Abstract Parity reasoning is challenging for Conflict-Driven Clause Learning (CDCL) SAT solvers. This has been observed even for simple formulas encoding two contradictory parity constraints with different variable orders (Chew and Heule 2020). We provide an analytical explanation for their hardness by showing that they require exponential resolution refutations with high probability when the variable order is chosen at random. We obtain this result by proving that these formulas, which are known to be Tseitin formulas, have Tseitin graphs of linear treewidth with high probability. Since such Tseitin formulas require exponential resolution proofs, our result follows. We generalize this argument to a new class of formulas that capture a basic form of parity reasoning involving a sum of two random parity constraints with random orders. Even when the variable order for the sum is chosen favorably, these formulas remain hard for resolution. In contrast, we prove that they have short DRAT refutations. We show experimentally that the running time of CDCL SAT solvers on both classes of formulas grows exponentially with their treewidth.
    Keywords Computer Science - Computational Complexity
    Subject code 004
    Publishing date 2024-02-01
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: COF-300 synthesis and colloidal stabilization with substituted benzoic acids.

    Ji, Woojung / Kim, Dean M / Posson, Brendan M / Carlson, Kyla J / Chew, Alison C / Chew, Alyssa J / Hossain, Meherin / Mojica, Alexis F / Ottoes, Sachi M / Tran, Donna V / Greenberg, Matthew W / Hamachi, Leslie S

    RSC advances

    2023  Volume 13, Issue 21, Page(s) 14484–14493

    Abstract: Colloidal covalent organic framework (COF) synthesis enables morphological control of crystallite size and shape. Despite numerous examples of 2D COF colloids with various linkage chemistries, 3D imine-linked COF colloids are more challenging synthetic ... ...

    Abstract Colloidal covalent organic framework (COF) synthesis enables morphological control of crystallite size and shape. Despite numerous examples of 2D COF colloids with various linkage chemistries, 3D imine-linked COF colloids are more challenging synthetic targets. Here we report a rapid (15 min-5 day) synthesis of hydrated COF-300 colloids ranging in length (251 nm-4.6 μm) with high crystallinity and moderate surface areas (150 m
    Language English
    Publishing date 2023-05-12
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra02202a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Blends of palm kernel oil, soybean oil and palm stearin as an alternative to milk fat for frozen dessert application.

    Hasan, T / Thoo, Y Y / Chew, C L / Kong, P S / Siow, L F

    Journal of food science and technology

    2022  Volume 59, Issue 8, Page(s) 3010–3019

    Abstract: In this study, the ternary blends of palm kernel oil (PKO), soybean oil (SBO) and two types of palm stearin (PS) (PS33 and PS38) were systematically prepared and evaluated for their application as an alternative to milk fat in frozen dessert. The ... ...

    Abstract In this study, the ternary blends of palm kernel oil (PKO), soybean oil (SBO) and two types of palm stearin (PS) (PS33 and PS38) were systematically prepared and evaluated for their application as an alternative to milk fat in frozen dessert. The physicochemical characteristics namely fatty acids constituent, triacylglycerols (TAGs) composition, melting behavior, solid fat content (SFC) and microstructure were studied. All ternary blends of PKO/SBO/PS33 and PKO/SBO/PS38 had comparable microstructure to that of milk fat. However, 80/15/5 (PKO/SBO/PS33) and 80/15/5 to 80/5/15 (PKO/SBO/PS38) mixtures were found to have similar SFC as milk fat at temperature above 20 °C, allowing these ternary blends to be completely melted at body temperature. With this, 80/15/5 (PKO/SBO/PS33) and 80/15/5 to 80/5/15 (PKO/SBO/PS38) mixtures were able to provide similar meltdown and mouth feel as milk fat at room temperature. Nonetheless, fatty acids constituent, TAGs composition and melting behavior of the blends were different from milk fat. This study showed that ternary blends of PKO, SBO and PS at ratios 80/15/5 (PKO/SBO/PS33) and 80/15/5 to 80/5/15 (PKO/SBO/PS38) can be potentially used as a milk fat alternative for frozen dessert application based on its similar microstructure and SFC profile as the milk fat.
    Supplementary information: The online version contains supplementary material available at 10.1007/s13197-022-05507-z.
    Language English
    Publishing date 2022-06-23
    Publishing country India
    Document type Journal Article
    ZDB-ID 242498-8
    ISSN 0975-8402 ; 0022-1155
    ISSN (online) 0975-8402
    ISSN 0022-1155
    DOI 10.1007/s13197-022-05507-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Exploring the treatment burden of disease-modifying anti-rheumatic drug monitoring in people with rheumatoid arthritis.

    Ryan, Sarah / Bullock, Laurna / Manning, Fay / A Chew-Graham, Carolyn / Paskins, Zoe

    Rheumatology advances in practice

    2023  Volume 7, Issue 2, Page(s) rkad054

    Abstract: Objectives: People with RA taking DMARDs require safety monitoring to identify potential side effects. The aim of this study was to explore the perspectives of patients and family members on DMARD monitoring and how the associated treatment burden could ...

    Abstract Objectives: People with RA taking DMARDs require safety monitoring to identify potential side effects. The aim of this study was to explore the perspectives of patients and family members on DMARD monitoring and how the associated treatment burden could be minimized to optimize concordance and safety.
    Methods: Thirteen adults with RA on DMARDs and three family members participated in semi-structured telephone interviews between July 2021 and January 2022. Data were analysed using a framework method. Findings were discussed with a group of stakeholders to develop implications for practice.
    Results: Two main themes were identified: (i) making sense of drug monitoring; and (ii) work involved in drug monitoring. Participants perceived DMARDs as necessary to reduce symptoms, with drug monitoring providing an opportunity for a holistic assessment of wellbeing. Participants expressed a preference for face-to-face consultations, which allowed them to share their concerns, rather than remote, often transactional, care. The limited availability of convenient appointment times, travel requirements and parking increased the work involved for patients and family members.
    Conclusion: Drug monitoring was accepted as a necessity of DMARD treatment, but increased the work for people with RA related to organizing and attending appointments. The potential for treatment burden needs to be assessed proactively by clinicians when a DMARD is commenced. Where identified, strategies for minimizing the treatment burden can form part of a shared management plan, including the offer of regular contact with health professionals, with an emphasis on person-centred care.
    Language English
    Publishing date 2023-06-16
    Publishing country England
    Document type Journal Article
    ISSN 2514-1775
    ISSN (online) 2514-1775
    DOI 10.1093/rap/rkad054
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Challenge of "Monomorphic" Mucoepidermoid Carcinoma-Report of a Rare Case with Pure Spindle-Clear Cell Morphology.

    Qu, Xinyi / Chew, Edwin Jun Chen / Selvarajan, Sathiyamoorthy / Wu, Bingcheng / Agaimy, Abbas / Petersson, Fredrik

    Head and neck pathology

    2023  Volume 17, Issue 3, Page(s) 864–870

    Abstract: Background: Mucoepidermoid carcinoma is a malignant salivary gland tumor which, in most cases, is composed of variable proportions of mucous, epidermoid, and intermediate cells.: Methods: We report a case of parapharyngeal mucoepidermoid carcinoma ... ...

    Abstract Background: Mucoepidermoid carcinoma is a malignant salivary gland tumor which, in most cases, is composed of variable proportions of mucous, epidermoid, and intermediate cells.
    Methods: We report a case of parapharyngeal mucoepidermoid carcinoma with highly unusual ("monomorphic") light microscopic features as well as atypical immunohistochemical properties. Molecular analysis was performed using the TruSight RNA fusion panel.
    Results: The tumor featured heretofore undescribed histopathological features: sheets and nests composed of monomorphic neoplastic (plump spindle to epithelioid) cells with no mucous, intermediate, glandular/columnar, or any other cell type identified. The neoplastic cells displayed variable clear cell change and only expressed cytokeratin 7. Despite this non-classical morphology, the presence of the classical CRTC1::MAML2 fusion was demonstrated.
    Conclusions: Mucoepidermoid carcinoma featuring a uniform ("monomorphic") population of neoplastic cells is a novel observation. A confident diagnosis of mucoepidermoid carcinoma can be made upon detection of the CRTC1/3::MAML2 fusion. Our case increases the spectrum of histopathological appearances that mucoepidermoid carcinoma may display.
    MeSH term(s) Humans ; DNA-Binding Proteins/genetics ; Trans-Activators ; Carcinoma, Mucoepidermoid/pathology ; Transcription Factors/genetics ; Salivary Gland Neoplasms/genetics ; Salivary Gland Neoplasms/pathology
    Chemical Substances DNA-Binding Proteins ; Trans-Activators ; Transcription Factors
    Language English
    Publishing date 2023-04-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2407834-7
    ISSN 1936-0568 ; 1936-055X
    ISSN (online) 1936-0568
    ISSN 1936-055X
    DOI 10.1007/s12105-023-01547-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Factors related to COVID-19 mortality among three Swedish intensive care units-A retrospective study.

    Taxbro, Knut / Hammarskjöld, Fredrik / Nilsson, Mats / Persson, Magnus / Chew, Michelle S / Sunnergren, Ola

    Acta anaesthesiologica Scandinavica

    2023  Volume 67, Issue 6, Page(s) 788–796

    Abstract: Background: Mortality due to acute hypoxemic respiratory failure (AHRF) in patients with coronavirus disease-19 (COVID-19) differs across units, regions, and countries. These variations may be attributed to several factors, including comorbidities, ... ...

    Abstract Background: Mortality due to acute hypoxemic respiratory failure (AHRF) in patients with coronavirus disease-19 (COVID-19) differs across units, regions, and countries. These variations may be attributed to several factors, including comorbidities, acute physiological derangement, disease severity, treatment, ethnicity, healthcare system strain, and socioeconomic status. This study aimed to explore the features of patient characteristics, clinical management, and staffing that may be related to mortality among three intensive care units (ICUs) within the same hospital system in South Sweden.
    Methods: We retrospectively analyzed ICU patients with COVID-19 and AHRF in Region Jönköping County, Sweden. The primary outcome was the 90-day mortality rate. We used univariate and multivariable logistic regression analyses to investigate the relationship of predictors with outcomes.
    Results: Between March 15, 2020, and May 31, 2021, 331 patients with AHRF and COVID-19 were admitted to the three ICUs. There were differences in disease severity, treatments, process-related factors, and socioeconomic factors between the units. These factors were related to 90-day mortality. After multivariable adjustment, age, severity of acute respiratory distress syndrome, and the number of nurses per ICU-bed independently predicted 90-day mortality.
    Conclusion: Age, disease severity, and nurse staffing, but not treatment or socioeconomic status, were independently associated with 90-day mortality among critically ill patients with AHRF due to COVID-19. We also identified variations in care related processes, which may be a modifiable risk factor and warrants future investigation.
    MeSH term(s) Humans ; COVID-19 ; Retrospective Studies ; Sweden/epidemiology ; Intensive Care Units ; Respiratory Insufficiency/therapy
    Language English
    Publishing date 2023-03-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 80002-8
    ISSN 1399-6576 ; 0001-5172
    ISSN (online) 1399-6576
    ISSN 0001-5172
    DOI 10.1111/aas.14232
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Virtual Follow-Up in Patients Initiating Antineoplastic Treatment in the Ambulatory Setting.

    Chew, Lauren J / Urman, Danielle S / Maxwell, Kevin / Ajmera, Archana / Millard, Frederick / McKay, Rana R

    JCO oncology practice

    2024  , Page(s) OP2300777

    Abstract: Purpose: Initiating antineoplastic therapy can be distressful and affect patient retention of treatment-related side effects and safety protocols. Return visits can range from 8 to 28 days after treatment, during which patients may develop treatment- ... ...

    Abstract Purpose: Initiating antineoplastic therapy can be distressful and affect patient retention of treatment-related side effects and safety protocols. Return visits can range from 8 to 28 days after treatment, during which patients may develop treatment-related questions and toxicities. This study's objective is to evaluate how implementing a follow-up phone call 24-48 hours after initial antineoplastic infusion, compared with standard pretreatment education, affects patient satisfaction and education retention.
    Methods: We conducted a single-center pilot study where patients who were literate, English-speaking, with genitourinary malignancies, initiating intravenous chemotherapy or immunotherapy were eligible. The primary end point was patient knowledge retention. Secondary end points included patient satisfaction. The Leuven's Questionnaire Patient Knowledge Tool, a validated, standardized tool, was used to evaluate patient knowledge retention, with a higher score indicating more retention. Telephone follow-up was initiated 24-48 hours after initial infusion, where Leuven's Questionnaire was used to assess patient knowledge. A nurse then reinforced treatment-related education, reviewed notification parameters, and coordinated appropriate follow-up. One week later, participants were sent a follow-up Leuven's Questionnaire and standardized patient satisfaction assessment.
    Results: Thirty-one patients with renal cell carcinoma, prostate, bladder, germ cell/testicular, or adrenal cancers were included in the study. Mean preintervention Leuven's Questionnaire score was 5.3 and mean postintervention score was 8.1 on a 1-10 scale (
    Conclusion: Proactive telephonic follow-up for oncology patients improves education retention, patient satisfaction, and has potential to improve patient safety and quality of care.
    Language English
    Publishing date 2024-03-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3028198-2
    ISSN 2688-1535 ; 2688-1527
    ISSN (online) 2688-1535
    ISSN 2688-1527
    DOI 10.1200/OP.23.00777
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Narrow Complex Tachycardia With an Unusual Block.

    Chew, Derek S / Quinn, F Russell / Wilton, Stephen B

    Circulation

    2019  Volume 140, Issue 24, Page(s) 2040–2043

    MeSH term(s) Adult ; Arrhythmias, Cardiac/diagnosis ; Arrhythmias, Cardiac/physiopathology ; Diagnosis, Differential ; Electrocardiography/methods ; Heart Conduction System/physiopathology ; Humans ; Male ; Tachycardia/diagnosis ; Tachycardia/physiopathology
    Language English
    Publishing date 2019-12-09
    Publishing country United States
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.119.043297
    Database MEDical Literature Analysis and Retrieval System OnLINE

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