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  1. Article ; Online: Acute high-intensity interval exercise is less pro-oxidative/thrombotic compared to isovolumic moderate-intensity steady-state exercise.

    Fall, Lewis / Stacey, Benjamin S / Calverley, Thomas / Owens, Thomas / Thyer, Kaitlin / Griffiths, Rhodri / Phillips, Rhodri / Bailey, Damian M

    Journal of physiology and biochemistry

    2022  Volume 79, Issue 1, Page(s) 35–46

    Abstract: While high-intensity interval training (HIIT) has emerged as a more time-efficient alternative to moderate-intensity steady-state exercise (MISS), the impact on systemic free radical formation and link to activated coagulation remains unknown. We ... ...

    Abstract While high-intensity interval training (HIIT) has emerged as a more time-efficient alternative to moderate-intensity steady-state exercise (MISS), the impact on systemic free radical formation and link to activated coagulation remains unknown. We recruited sixteen healthy males aged 21 ± 3 y who performed incremental cycle ergometry to determine peak oxygen uptake ([Formula: see text]
    MeSH term(s) Male ; Humans ; Single-Blind Method ; Exercise ; Oxidative Stress ; Oxygen Consumption ; Exercise Test
    Language English
    Publishing date 2022-08-30
    Publishing country Spain
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 1325104-1
    ISSN 1877-8755 ; 0034-9402 ; 1138-7548
    ISSN (online) 1877-8755
    ISSN 0034-9402 ; 1138-7548
    DOI 10.1007/s13105-022-00918-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 198: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Radiation-induced small bowel disease: latest developments and clinical guidance.

    Stacey, Rhodri / Green, John T

    Therapeutic advances in chronic disease

    2013  Volume 5, Issue 1, Page(s) 15–29

    Abstract: Ionizing radiation is commonly used to treat a number of malignancies. Although highly effective and now more targeted, many patients suffer side effects. The number of cancer survivors has increased and so there are more patients presenting with ... ...

    Abstract Ionizing radiation is commonly used to treat a number of malignancies. Although highly effective and now more targeted, many patients suffer side effects. The number of cancer survivors has increased and so there are more patients presenting with symptoms that have arisen as a result of radiotherapy. Radiation damage to small bowel tissue can cause acute or chronic radiation enteritis producing symptoms such as pain, bloating, nausea, faecal urgency, diarrhoea and rectal bleeding which can have a significant impact on patient's quality of life. This review outlines the pathogenesis of radiation injury to the small bowel along with the prevention of radiation damage via radiotherapy techniques plus medications such as angiotensin-converting enzyme inhibitors, statins and probiotics. It also covers the treatment of both acute and chronic radiation enteritis via a variety of medical (including hyperbaric oxygen), dietetic, endoscopic and surgical therapies.
    Language English
    Publishing date 2013-12-05
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2554816-5
    ISSN 2040-6231 ; 2040-6223
    ISSN (online) 2040-6231
    ISSN 2040-6223
    DOI 10.1177/2040622313510730
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Nonendoscopic therapies for the management of radiation-induced rectal bleeding.

    Stacey, Rhodri / Green, John T

    Current opinion in supportive and palliative care

    2013  Volume 7, Issue 2, Page(s) 175–182

    Abstract: Purpose of review: Rectal bleeding is one of several gastrointestinal side effects that occur after radiotherapy for pelvic malignancy. It can develop during treatment as a result of inflammation, or may be delayed for up to several years, where it is ... ...

    Abstract Purpose of review: Rectal bleeding is one of several gastrointestinal side effects that occur after radiotherapy for pelvic malignancy. It can develop during treatment as a result of inflammation, or may be delayed for up to several years, where it is characteristically due to vascular neogenesis within ischaemic tissue. More patients with radiation-induced rectal bleeding are presenting to medical professionals as the number of cancer survivors continues to increase. This review outlines the nonendoscopic treatments that presently exist.
    Recent findings: Guidance was published on the management of gastrointestinal side effects of radiotherapy in 2012. Recent publications have assessed many agents for the treatment of rectal bleeding including antibiotics, colonic irrigation, formalin and ozone therapy. The 'HOT-II' randomized controlled trial of hyperbaric oxygen (HBO) therapy is keenly awaited.
    Summary: There is no consensus on the optimal management of radiation-induced rectal bleeding. Therapies with evidence of benefit from randomized trials (of variable quality) are sucralfate enemas, antibiotics, vitamin A and HBO therapy. Other nonendoscopic therapies exist; however, there is a paucity of evidence to recommend these at present. Well constructed, randomized controlled trials are required to compare and evaluate therapeutic options.
    MeSH term(s) Gastrointestinal Hemorrhage/etiology ; Gastrointestinal Hemorrhage/therapy ; Humans ; Pelvic Neoplasms/radiotherapy ; Proctitis/etiology ; Proctitis/therapy ; Radiation Injuries/therapy
    Language English
    Publishing date 2013-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2633726-5
    ISSN 1751-4266 ; 1751-4258
    ISSN (online) 1751-4266
    ISSN 1751-4258
    DOI 10.1097/SPC.0b013e32835f3e00
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6946: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Sequence-Dependent Self-Assembly and Structural Diversity of Islet Amyloid Polypeptide-Derived β-Sheet Fibrils.

    Wang, Shih-Ting / Lin, Yiyang / Spencer, Ryan K / Thomas, Michael R / Nguyen, Andy I / Amdursky, Nadav / Pashuck, E Thomas / Skaalure, Stacey C / Song, Cheng Yu / Parmar, Paresh A / Morgan, Rhodri M / Ercius, Peter / Aloni, Shaul / Zuckermann, Ronald N / Stevens, Molly M

    ACS nano

    2017  Volume 11, Issue 9, Page(s) 8579–8589

    Abstract: Determining the structural origins of amyloid fibrillation is essential for understanding both the pathology of amyloidosis and the rational design of inhibitors to prevent or reverse amyloid formation. In this work, the decisive roles of peptide ... ...

    Abstract Determining the structural origins of amyloid fibrillation is essential for understanding both the pathology of amyloidosis and the rational design of inhibitors to prevent or reverse amyloid formation. In this work, the decisive roles of peptide structures on amyloid self-assembly and morphological diversity were investigated by the design of eight amyloidogenic peptides derived from islet amyloid polypeptide. Among the segments, two distinct morphologies were highlighted in the form of twisted and planar (untwisted) ribbons with varied diameters, thicknesses, and lengths. In particular, transformation of amyloid fibrils from twisted ribbons into untwisted structures was triggered by substitution of the C-terminal serine with threonine, where the side chain methyl group was responsible for the distinct morphological change. This effect was confirmed following serine substitution with alanine and valine and was ascribed to the restriction of intersheet torsional strain through the increased hydrophobic interactions and hydrogen bonding. We also studied the variation of fibril morphology (i.e., association and helicity) and peptide aggregation propensity by increasing the hydrophobicity of the peptide side group, capping the N-terminus, and extending sequence length. We anticipate that our insights into sequence-dependent fibrillation and morphological diversity will shed light on the structural interpretation of amyloidogenesis and development of structure-specific imaging agents and aggregation inhibitors.
    MeSH term(s) Amino Acid Sequence ; Amyloid/chemistry ; Amyloid/ultrastructure ; Humans ; Hydrogen Bonding ; Hydrophobic and Hydrophilic Interactions ; Islet Amyloid Polypeptide/chemistry ; Islet Amyloid Polypeptide/ultrastructure ; Microscopy, Atomic Force ; Protein Conformation, beta-Strand ; X-Ray Diffraction
    Chemical Substances Amyloid ; Islet Amyloid Polypeptide
    Language English
    Publishing date 2017-08-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.7b02325
    Database MEDical Literature Analysis and Retrieval System OnLINE

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