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Article ; Online: Recuperative herbal formula Jing Si maintains vasculature permeability balance, regulates inflammation and assuages concomitants of "Long-Covid".

Chiang, Chien-Yi / Lin, Yu-Jung / Weng, Wen-Tsan / Lin, Heng-Dao / Lu, Cheng-You / Chen, Wan-Jing / Shih, Cheng Yen / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Shibu, Marthandam Asokan / Huang, Chih-Yang

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 163, Page(s) 114752

Abstract: ... the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects ...

Abstract	Coronavirus disease 2019 (COVID-19) is a worldwide health threat that has long-term effects on the patients and there is currently no efficient cure prescribed for the treatment and the prolonging effects. Traditional Chinese medicines (TCMs) have been reported to exert therapeutic effect against COVID-19. In this study, the therapeutic effects of Jing Si herbal tea (JSHT) against COVID-19 infection and associated long-term effects were evaluated in different in vitro and in vivo models. The anti-inflammatory effects of JSHT were studied in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in Omicron pseudotyped virus-induced acute lung injury model. The effect of JSHT on cellular stress was determined in HK-2 proximal tubular cells and H9c2 cardiomyoblasts. The therapeutic benefits of JSHT on anhedonia and depression symptoms associated with long COVID were evaluated in mice models for unpredictable chronic mild stress (UCMS). JSHT inhibited the NF-ƙB activities, and significantly reduced LPS-induced expression of TNFα, COX-2, NLRP3 inflammasome, and HMGB1. JSHT was also found to significantly suppress the production of NO by reducing iNOS expression in LPS-stimulated RAW 264.7 cells. Further, the protective effects of JSHT on lung tissue were confirmed based on mitigation of lung injury, repression in TMRRSS2 and HMGB-1 expression and reduction of cytokine storm in the Omicron pseudotyped virus-induced acute lung injury model. JSHT treatment in UCMS models also relieved chronic stress and combated depression symptoms. The results therefore show that JSHT attenuates the cytokine storm by repressing NF-κB cascades and provides the protective functions against symptoms associated with long COVID-19 infection.
MeSH term(s)	Mice ; Humans ; Animals ; Post-Acute COVID-19 Syndrome ; Lipopolysaccharides/adverse effects ; Cytokine Release Syndrome ; Cytokines/metabolism ; COVID-19 ; Inflammation/drug therapy ; Inflammation/metabolism ; Acute Lung Injury/metabolism ; NF-kappa B/metabolism
Chemical Substances	Lipopolysaccharides ; Cytokines ; NF-kappa B
Language	English
Publishing date	2023-04-26
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.114752
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Article ; Online: The future of carbon neutrality from a scientific research perspective: an interview with Jing-Hai Li.

Chen, Li-Hua

National science review

2023 Volume 10, Issue 9, Page(s) nwad007

Abstract: Since China announced that it will strive to achieve carbon peak by 2030 and carbon neutrality by 2060, it has become the focus of the whole society. The implementation of carbon peaking and carbon neutrality goals requires a range of revolutionary ... ...

Abstract	Since China announced that it will strive to achieve carbon peak by 2030 and carbon neutrality by 2060, it has become the focus of the whole society. The implementation of carbon peaking and carbon neutrality goals requires a range of revolutionary technologies and involves an array of key scientific questions. A great deal of research has focused on the development of new concepts and innovative technologies on carbon science and sustainable development
Language	English
Publishing date	2023-01-09
Publishing country	China
Document type	Journal Article
ZDB-ID	2745465-4
ISSN	2053-714X ; 2053-714X
ISSN (online)	2053-714X
ISSN	2053-714X
DOI	10.1093/nsr/nwad007
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Article ; Online: Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast

Wang, Chien-Hao / Yang, Jai-Sing / Chen, Chao-Jung / Su, San-Hua / Yu, Hsin-Yuan / Juan, Yu-Ning / Chiu, Yu-Jen / Ho, Tsung-Jung

Tzu chi medical journal

2024 Volume 36, Issue 2, Page(s) 152–165

Abstract: Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were ...

Abstract	Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis. Materials and methods: The Results: In Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.
Language	English
Publishing date	2024-03-26
Publishing country	India
Document type	Journal Article
ZDB-ID	2452925-4
ISSN	2223-8956 ; 2223-8956
ISSN (online)	2223-8956
ISSN	2223-8956
DOI	10.4103/tcmj.tcmj_267_23
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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses.

Shao, Hao-Tian / Gao, Liang / Li, Hao-Tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze-En / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry science

2023 Volume 102, Issue 8, Page(s) 102761

Abstract: ... enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ...

Abstract	Meloxicam is a nonsteroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under 2 different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under 2 dosing schedules: 10 doses at 24-h intervals and 15 doses at 12-h intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at 2 time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 d for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
MeSH term(s)	Animals ; Female ; Meloxicam/analysis ; Egg Yolk/chemistry ; Chickens ; Drug Residues/analysis ; Ovum/chemistry ; Administration, Oral ; Eggs/analysis
Chemical Substances	Meloxicam (VG2QF83CGL)
Language	English
Publishing date	2023-04-27
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
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Article ; Online: A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur.

Zhou, Jing / Liu, Feng-Jie / Li, Xin-Xin / Li, Ping / Yang, Hua / Liu, Yuan-Cai / Chen, Yan-He / Wei, Chao-Dan / Li, Hui-Jun

Chinese herbal medicines

2021 Volume 13, Issue 3, Page(s) 430–438

Abstract: ... to rapidly screen the traceable markers for herbal product authentication.: Methods: Commercial Jing ... materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS ... of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur ...

Abstract	Objective: The quality evaluation of herbal products remains a big challenge. Traceable markers are the core concept of the authentication of herbal products. However, the discovery of traceable markers is labor-intensive and time-consuming. The aim of this study is to develop a convenient approach to rapidly screen the traceable markers for herbal product authentication. Methods: Commercial Jing Liqueur and its 22 species of herbal ingredients were analyzed using HPLC-QTOF-MS and GC-MS to characterize nonvolatile and volatile chemicals. The acquired data were imported into MZmine 2 software for mass detection, chromatogram building, deconvolution and alignment. The aligned data were exported into a csv file and then traceable markers were selected using the built-in filter function in Excel. Finally, the traceable markers were identified by searching against online databases or publications, some of which were confirmed by reference standards. Results: A total of 288 chemical features transferred from herbal materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS were annotated, while nine volatile markers detected by GC-MS were annotated. Moreover, 30 of these markers were confirmed by comparing with reference standards. A chemical fingerprint consisting of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur. Conclusion: A strategy for rapid discovery of traceable markers in herbal products using MZmine 2 software was developed.
Language	English
Publishing date	2021-05-28
Publishing country	Singapore
Document type	Journal Article
ISSN	2589-3610
ISSN (online)	2589-3610
DOI	10.1016/j.chmed.2021.05.004
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Article: Interactive network pharmacology and electrochemical analysis reveals electron transport-mediating characteristics of Chinese medicine formula Jing Guan Fang.

Tsai, Po-Wei / Mailem, Ryan Christian / Tayo, Lemmuel L / Hsueh, Chung-Chuan / Tseng, Chi-Chun / Chen, Bor-Yann

Journal of the Taiwan Institute of Chemical Engineers

2023 Volume 147, Page(s) 104898

Abstract: Background: Jing Guan Fang (JGF) is an anti-COVID-19 Chinese Medicine decoction comprised of five ...

Abstract	Background: Jing Guan Fang (JGF) is an anti-COVID-19 Chinese Medicine decoction comprised of five medicinal herbs to possess anti-inflammatory and antiviral properties for treatment. This study aims to electrochemically decipher the anti-coronavirus activity of JGF and show that microbial fuel cells may serve as a platform for screening efficacious herbal medicines and providing scientific bases for the mechanism of action (MOA) of TCMs. Methods: Electrochemical techniques (e.g., cyclic voltammetry) and MFCs were adopted as the bioenergy-based platforms to assess the bioenergy-stimulating characteristics of JGF. Phytochemical analysis correlated polyphenolic and flavonoid content with antioxidant activity and bioenergy-stimulating properties. Network pharmacology on the active compounds was employed to identify anti-inflammatory and anti-COVID-19 protein targets, and molecular docking validated Significant findings: This first-attempt results show that JGF possesses significant reversible bioenergy-stimulation (amplification 2.02 ± 0.04) properties suggesting that its antiviral efficacy is both bioenergy-steered and electron mediated. Major flavonoids and flavone glycosides identified by HPLC (e.g., baicalein and baicalin, respectively) possess electron-shuttling (ES) characteristics that allow herbal medicines to treat COVID-19 via (1) reversible scavenging of ROS to lessen inflammation; (2) inhibition of viral proteins; and (3) targeting of immunomodulatory pathways to stimulate the immune response according to network pharmacology.
Language	English
Publishing date	2023-05-08
Publishing country	Netherlands
Document type	Journal Article
ISSN	1876-1070
ISSN	1876-1070
DOI	10.1016/j.jtice.2023.104898
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Article ; Online: Exploring the Mechanism of Yi-Jing Decoction in Treating Polycystic Ovary Syndrome by Using Network Pharmacology.

Lin, Yue / Xiang, Liu / Li, Xianhai / Tang, Qiang / Meng, Fanbo / Chen, Wei

Current medicinal chemistry

2022 Volume 30, Issue 21, Page(s) 2463–2474

Abstract: Background: Yi-Jing decoction (YJD), a traditional Chinese medicine prescription, has been ...

Abstract	Background: Yi-Jing decoction (YJD), a traditional Chinese medicine prescription, has been reported to be effective in the treatment of polycystic ovary syndrome (PCOS). However, the underlying mechanisms of YJD in treating PCOS are still unclear. Objective: In the present work, the effective ingredients of YJD and their treatment mechanisms on PCOS were systematically analyzed. Methods: The effective ingredients of YJD and targets of PCOS were selected from public databases. The network pharmacology method was used to analyze the ingredients, potential targets, and pathways of YJD for the treatment of PCOS. Results: One hundred and three active ingredients were identified from YJD, of which 82 were hit by 65 targets associated with PCOS. By constructing the disease-common targetcompound network, five ingredients (quercetin, arachidonate, beta-sitosterol, betacarotene, and cholesterol) were selected out as the key ingredients of YJD, which can interact with the 10 hub genes (VEGFA, AKT1, TP53, ALB, TNF, PIK3CA, IGF1, INS, IL1B, PTEN) against PCOS. These genes are mainly involved in prostate cancer, steroid hormone biosynthesis, and EGFR tyrosine kinase inhibitor resistance pathways. In addition, the results of molecular docking showed that the ingredients of YJD have a good binding affinity with the hub genes. Conclusion: These results demonstrate that the treatment of PCOS by YJD is through regulating the levels of androgen and insulin and improving the inflammatory microenvironment.
MeSH term(s)	Female ; Male ; Humans ; Molecular Docking Simulation ; Network Pharmacology ; Polycystic Ovary Syndrome/drug therapy ; Arachidonic Acids ; Databases, Factual ; Medicine, Chinese Traditional ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Tumor Microenvironment
Chemical Substances	Arachidonic Acids ; Drugs, Chinese Herbal
Language	English
Publishing date	2022-05-06
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	1319315-6
ISSN	1875-533X ; 0929-8673
ISSN (online)	1875-533X
ISSN	0929-8673
DOI	10.2174/0929867329666220508180611
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Article ; Online: The genetic assimilation in language borrowing inferred from Jing People.

Huang, Xiufeng / Zhou, Qinghui / Bin, Xiaoyun / Lai, Shu / Lin, Chaowen / Hu, Rong / Xiao, Jiashun / Luo, Dajun / Li, Yingxiang / Wei, Lan-Hai / Yeh, Hui-Yuan / Chen, Gang / Wang, Chuan-Chao

American journal of physical anthropology

2018 Volume 166, Issue 3, Page(s) 638–648

Abstract: Objectives: The Jing people are a recognized ethnic group in Guangxi, southwest China, who are ... populations into Jing people during their language change due to the very limited genetic information ... of this population.: Materials and methods: We collected blood samples from 37 Jing and 3 Han Chinese individuals ...

Abstract	Objectives: The Jing people are a recognized ethnic group in Guangxi, southwest China, who are the immigrants from Vietnam during the 16th century. They speak Vietnamese but with lots of language borrowings from Cantonese, Zhuang, and Mandarin. However, it's unclear if there is large-scale gene flow from surrounding populations into Jing people during their language change due to the very limited genetic information of this population. Materials and methods: We collected blood samples from 37 Jing and 3 Han Chinese individuals from Wanwei, Shanxin, and Wutou islands in Guangxi and genotyped about 600,000 genome-wide single nucleotide polymorphisms (SNPs). We used Principal Component Analysis (PCA), ADMIXTURE analysis, f statistics, qpWave and qpAdm to infer the population genetic structure and admixture. Results: Our data revealed that the Jing people are genetically similar to the populations in southwest China and mainland Southeast Asia. But compared with Vietnamese, they show significant evidence of gene flow from surrounding East Asians. The admixture proportion is estimated to be around 35-42% in different Jing groups using southern Han Chinese as a proxy. The majority of the paternal lineages of Jing people are most likely from surrounding East Asians. Discussion: We conclude that the formation and language change of present-day Jing people have involved genetic assimilation of surrounding East Asian populations. The language borrowing, in this case, is not only a cultural phenomenon but has involved demic diffusion.
MeSH term(s)	Anthropology, Physical ; Asian Continental Ancestry Group/genetics ; China/ethnology ; Female ; Gene Flow/genetics ; Genetics, Population ; Humans ; Language ; Male ; Principal Component Analysis ; Vietnam/ethnology
Language	English
Publishing date	2018-02-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	219376-0
ISSN	1096-8644 ; 0002-9483
ISSN (online)	1096-8644
ISSN	0002-9483
DOI	10.1002/ajpa.23449
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Article ; Online: Reconstructed Jing River streamflow from western China: A 399-year perspective for hydrological changes in the Loess Plateau

Zhao, Xiaoen / Fang, Keyan / Chen, Feng / Martín, Hadad / Roig, Fidel A.

Journal of Hydrology. 2023 June, v. 621 p.129573-

2023

Abstract: The Jing River is a secondary tributary of the Yellow River, which flows through the middle ... machine learning models and simple linear regression to reconstruct the January-June streamflow of the Jing River ... information than with a single model. Over the past nearly four centuries, the Jing River has experienced ...

Abstract	The Jing River is a secondary tributary of the Yellow River, which flows through the middle of the Loess Plateau in China. Severe water scarcity and soil erosion in the basin have threatened sustainable social and economic development. To assess and solve the region’s water resource problems, it is important to understand its historical hydrological climate change. Accordingly, we used five machine learning models and simple linear regression to reconstruct the January-June streamflow of the Jing River based on the tree ring width of Pinus tabulaeformis and Pinus armandii. By combining six models into an ensemble streamflow reconstruction, we obtained a more accurate reconstruction and streamflow variability information than with a single model. Over the past nearly four centuries, the Jing River has experienced seven high streamflow periods and ten low streamflow periods. The main atmospheric forcing factors driving the streamflow variability are the Pacific Decadal Oscillation and the El Niño-Southern Oscillation, which regulate the climate and hydrology of the region by affecting water vapor fluxes and the Asian monsoon. The different climate scenarios revealed the continued reduction in the future Jing River streamflow and a worsening water resource situation. This new streamflow reconstruction can serve as a valuable reference for analyzing regional hydrology and informing water resource management and policy formulations.
Keywords	Pinus armandii ; Pinus tabuliformis ; basins ; climate ; climate change ; economic development ; growth rings ; issues and policy ; models ; monsoon season ; regression analysis ; rivers ; soil erosion ; stream flow ; water management ; water shortages ; water vapor ; China ; Yellow River ; Tree rings ; Machine learning ; Streamflow reconstruction ; Jing River
Language	English
Dates of publication	2023-06
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	1473173-3
ISSN	1879-2707 ; 0022-1694
ISSN (online)	1879-2707
ISSN	0022-1694
DOI	10.1016/j.jhydrol.2023.129573
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Egg residue and depletion of meloxicam in Jing Hong laying hens following multiple oral doses

Shao, Hao-Tian / Gao, Liang / Li, Hao-tian / Zhang, Mei / Chen, Jun-Cheng / Duan, Ming-Hui / Li, Ze'en / Dai, Yan / Li, Xing-Ping / Yang, Fan

Poultry Science. 2023 Apr. 27, p.102761-

2023 , Page(s) 102761–

Abstract: ... results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs ...

Abstract	Meloxicam is a non-steroidal anti-inflammatory drug (NSAID) commonly used in an extra-label manner in commercial laying hens for the treatment of foot lesions, which are a common issue in this species. The present study aimed to determine the depletion profiles of meloxicam in eggs with multiple oral administration under two different dosing regimens and to further recommend reasonable withdrawal intervals (WDIs). Meloxicam (1 mg/kg) was administered orally to laying hens under two dosing schedules: 10 doses at 24-hour intervals and 15 doses at 12-hour intervals. Eggs were collected daily after the first dosing, and meloxicam concentrations in both yolk and white were determined by a high-performance liquid chromatography (HPLC) method. The weight ratio of white to yolk in the whole egg was 1.54 (the mean of 20 eggs with repeated tests), and this value combined with the meloxicam concentrations in white and yolk were used to calculate the drug concentrations in whole eggs. Meloxicam was quickly eliminated from egg white, and its concentrations could only be quantified at two time points during the elimination phase. The elimination half-lives in yolk and whole egg were 3.07 ± 1.00 and 2.98 ± 0.88 d, respectively, after 10 repeated doses. And the corresponding elimination half-lives were 2.30 ± 0.83 and 2.18 ± 0.67 d, respectively, after repeated 15 doses. Considering the time when meloxicam was not detectable in eggs with the time of ovum development and maturation, a withdrawal interval (WDI) was suggested as 17 days for both dosing schedules. The current results enriched the study on the residue of meloxicam in domestic Jing Hong laying hens and provided WDIs to help ensure animal-derived food safety.
Keywords	animal-based foods ; egg albumen ; eggs ; food safety ; half life ; high performance liquid chromatography ; meloxicam ; nonsteroidal anti-inflammatory agents ; oral administration ; ova ; poultry science ; withdrawal interval ; Jing Hong laying hens ; HPLC ; the weight ratio of white to yolk
Language	English
Dates of publication	2023-0427
Size	p. 102761
Publishing place	Elsevier Inc.
Document type	Article ; Online
Note	Pre-press version ; Use and reproduction
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102761
Database	NAL-Catalogue (AGRICOLA)

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