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  1. Article ; Online: Double Intramolecular 1,2 C-H Addition of

    Culver, Damien B / Boncella, James M

    Inorganic chemistry

    2023  Volume 62, Issue 48, Page(s) 19383–19388

    Abstract: Ruthenium pincer complexes have a rich history of coordination and reaction chemistries. In this work, we report our discoveries of previously unreported Ru pincer coordination geometries. We found that mono tuck-in ... ...

    Abstract Ruthenium pincer complexes have a rich history of coordination and reaction chemistries. In this work, we report our discoveries of previously unreported Ru pincer coordination geometries. We found that mono tuck-in κ
    Language English
    Publishing date 2023-11-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.3c02499
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A new approach to a powered knee prosthesis: Layering powered assistance onto strictly passive prosthesis behavior.

    Culver, Steve C / Vailati, Léo G / Morgenroth, David C / Goldfarb, Michael

    Wearable technologies

    2023  Volume 4, Page(s) e21

    Abstract: This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control ... ...

    Abstract This article describes a novel approach to the control of a powered knee prosthesis where the control system provides passive behavior for most activities and then provides powered assistance only for those activities that require them. The control approach presented here is based on the categorization of knee joint function during activities into four behaviors: resistive stance behavior, active stance behavior, ballistic swing, and non-ballistic swing. The approach is further premised on the assumption that healthy non-perturbed swing-phase is characterized by a ballistic swing motion, and therefore, a replacement of that function should be similarly ballistic. The control system utilizes a six-state finite-state machine, where each state provides different constitutive behaviors (concomitant with the four aforementioned knee behaviors) which are appropriate for a range of activities. Transitions between states and torque control within states is controlled by user motion, such that the control system provides, to the extent possible, knee torque behavior as a reaction to user motion, including for powered behaviors. The control system is demonstrated on a novel device that provides a sufficiently low impedance to enable a strictly passive ballistic swing-phase, while also providing sufficiently high torque to offer powered stance-phase knee-extension during activities such as step-over stair ascent. Experiments employing the knee and control system on an individual with transfemoral amputation are presented that compare the functionality of the power-supplemented nominally passive system with that of a conventional passive microprocessor-controlled knee prosthesis.
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Journal Article
    ISSN 2631-7176
    ISSN (online) 2631-7176
    DOI 10.1017/wtc.2023.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: A Primarily-Passive Knee Prosthesis with Powered Stance and Swing Assistance.

    Culver, Steve C / Vailati, Leo G / Goldfarb, Michael

    IEEE ... International Conference on Rehabilitation Robotics : [proceedings

    2022  Volume 2022, Page(s) 1–6

    Abstract: This paper describes a knee prosthesis that provides primarily-passive behavior akin to a state-of-the-art modulated passive microprocessor-controlled knee prosthesis (MPK), but also offers powered stance and swing assistance, which are layered on top of ...

    Abstract This paper describes a knee prosthesis that provides primarily-passive behavior akin to a state-of-the-art modulated passive microprocessor-controlled knee prosthesis (MPK), but also offers powered stance and swing assistance, which are layered on top of the passive functionality. The combination of both passive and powered behaviors is enabled by a unique electronically-selectable two-speed transmission, which enables the combination of very low output impedance and high resistive torques necessary for passive functionality, while also enabling the generative torque-speed characteristics suitable for stance and swing phase assistance. A control system is described that consolidates behaviors appropriate for a wide range of activities of daily living (ADLs) into six states, with each state providing adaptive torque behaviors appropriate for different phases of gait, whether powered or passive. Experimental results on an individual with transfemoral amputation suggest that the prosthesis and controller provide similar or improved passive behaviors relative to a commercially-available MPK, in addition to providing powered functionality commensurate with a powered prosthesis.
    MeSH term(s) Activities of Daily Living ; Amputees ; Artificial Limbs ; Biomechanical Phenomena ; Gait ; Humans ; Knee Prosthesis ; Prosthesis Design ; Walking
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Journal Article
    ISSN 1945-7901
    ISSN (online) 1945-7901
    DOI 10.1109/ICORR55369.2022.9896545
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: The desirability of a Periscopic quality in correcting lenses.

    Culver, C M

    Transactions of the American Ophthalmological Society

    2014  Volume 8, Page(s) 119–120

    Language English
    Publishing date 2014-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 391375-2
    ISSN 1545-6110 ; 0065-9533
    ISSN (online) 1545-6110
    ISSN 0065-9533
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    In stock of ZB MED Cologne/Königswinter

    Ul I Zs.22: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Surgically induced aortic coarctation in a neonatal porcine model allows for longitudinal assessment of cardiovascular changes.

    Stellon, Michael / Gober, Leah / Culver, Matthew Allen / Hermsen, Joshua / Irrer, Dana / Witzenburg, Colleen / Roldán-Alzate, Alejandro / Lamers, Luke

    American journal of physiology. Heart and circulatory physiology

    2024  Volume 326, Issue 5, Page(s) H1117–H1123

    Abstract: Noncritical aortic coarctation (COA) typically presents beyond early childhood with hypertension. Correction of COA does not ensure a return to normal cardiovascular health, but the mechanisms are poorly understood. Therefore, we developed a porcine COA ... ...

    Abstract Noncritical aortic coarctation (COA) typically presents beyond early childhood with hypertension. Correction of COA does not ensure a return to normal cardiovascular health, but the mechanisms are poorly understood. Therefore, we developed a porcine COA model to study the secondary cardiovascular changes. Eight male neonatal piglets (4 sham, 4 COA) underwent left posterolateral thoracotomy with descending aorta (DAO) mobilization. COA was created via a 1-cm longitudinal DAO incision with suture closure, plication, and placement and an 8-mm external band. All animals had cardiac catheterization at 6 (11-13 kg), 12 (26-31 kg), and 20 (67-70 kg) wk of age. Aortic luminal diameters were similar along the thoracic aorta, except for the COA region [6.4 mm COA vs. 17.3 mm sham at 20 wk (
    MeSH term(s) Humans ; Child, Preschool ; Infant, Newborn ; Male ; Animals ; Swine ; Aortic Coarctation/surgery ; Constriction, Pathologic/complications ; Aorta, Thoracic/surgery ; Aorta ; Hypertension
    Language English
    Publishing date 2024-03-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 603838-4
    ISSN 1522-1539 ; 0363-6135
    ISSN (online) 1522-1539
    ISSN 0363-6135
    DOI 10.1152/ajpheart.00087.2024
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.89: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Evaluation of Tofacitinib in Primary Sclerosing Cholangitis and Associated Colitis: A Multicenter, Retrospective Study.

    Schregel, Ida / Ramos, Guilherme P / Ioannou, Stephanie / Culver, Emma / Färkkilä, Martti / Schramm, Christoph

    Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

    2023  Volume 21, Issue 13, Page(s) 3448–3450.e3

    MeSH term(s) Humans ; Retrospective Studies ; Cholangitis, Sclerosing/complications ; Cholangitis, Sclerosing/drug therapy ; Colitis ; Colitis, Ulcerative
    Chemical Substances tofacitinib (87LA6FU830)
    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2119789-1
    ISSN 1542-7714 ; 1542-3565
    ISSN (online) 1542-7714
    ISSN 1542-3565
    DOI 10.1016/j.cgh.2023.01.014
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5836: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Myeloid cell activation during Zika virus encephalitis predicts recovery of functional cortical connectivity.

    Agner, Shannon C / Brier, Lindsey M / Hill, Jeremy / Liu, Ethan / Bice, Annie / Rahn, Rachel M / Culver, Joseph P / Klein, Robyn S

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Neurologic complications of Zika virus (ZIKV) infection across the lifespan have been described during outbreaks in Southeast Asia, South America, and Central America since 2016. In the adult CNS ZIKV tropism for neurons is tightly linked to its effects, ...

    Abstract Neurologic complications of Zika virus (ZIKV) infection across the lifespan have been described during outbreaks in Southeast Asia, South America, and Central America since 2016. In the adult CNS ZIKV tropism for neurons is tightly linked to its effects, with neuronal loss within the hippocampus during acute infection and protracted synapse loss during recovery, which is associated with cognitive deficits. The effects of ZIKV on cortical networks have not been evaluated. Although animal behavior assays have been used previously to model cognitive impairment, in vivo brain imaging can provide orthogonal information regarding the health of brain networks in real time, providing a tool to translate findings in animal models to humans. In this study, we use widefield optical imaging to measure cortical functional connectivity (FC) in mice during acute infection with, and recovery from, intracranial infection with a mouse-adapted strain of ZIKV. Acute ZIKV infection leads to high levels of myeloid cell activation, with loss of neurons and presynaptic termini in the cerebral cortex and associated loss of FC primarily within the somatosensory cortex. During recovery, neuron numbers, synapses and FC recover to levels near those of healthy mice. However, hippocampal injury and impaired spatial cognition persist. The magnitude of activated myeloid cells during acute infection predicted both recovery of synapses and the degree of FC recovery after recovery from ZIKV infection. These findings suggest that a robust inflammatory response may contribute to the health of functional brain networks after recovery from infection.
    Language English
    Publishing date 2023-07-06
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.07.06.547991
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  8. Article ; Online: Novel regulation of renal gluconeogenesis by Atp6ap2 in response to high fat diet via PGC1-α/AKT-1 pathway.

    Akhtar, Safia / Culver, Silas A / Siragy, Helmy M

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 11367

    Abstract: Recent studies suggested that renal gluconeogenesis is substantially stimulated in the kidney in presence of obesity. However, the mechanisms responsible for such stimulation are not well understood. Recently, our laboratory demonstrated that mice fed ... ...

    Abstract Recent studies suggested that renal gluconeogenesis is substantially stimulated in the kidney in presence of obesity. However, the mechanisms responsible for such stimulation are not well understood. Recently, our laboratory demonstrated that mice fed high fat diet (HFD) exhibited increase in renal Atp6ap2 [also known as (Pro)renin receptor] expression. We hypothesized that HFD upregulates renal gluconeogenesis via Atp6ap2-PGC-1α and AKT pathway. Using real-time polymerase chain reaction, western blot analysis and immunostaining, we evaluated renal expression of the Atp6ap2 and renal gluconeogenic enzymes, PEPCK and G6Pase, in wild type and inducible nephron specific Atp6ap2 knockout mice fed normal diet (ND, 12 kcal% fat) or a high-fat diet (HFD, 45 kcal% fat) for 8 weeks. Compared with ND, HFD mice had significantly higher body weight (23%) (P < 0.05), renal mRNA and protein expression of Atp6ap2 (39 and 35%), PEPCK (44 and 125%) and G6Pase (39 and 44%) respectively. In addition, compared to ND, HFD mice had increased renal protein expression of PGC-1α by 32% (P < 0.05) and downregulated AKT by 33% (P < 0.05) respectively in renal cortex. Atp6ap2-KO abrogated these changes in the mice fed HFD. In conclusion, we identified novel regulation of renal gluconeogenesis by Atp6ap2 in response to high fat diet via PGC1-α/AKT-1 pathway.
    MeSH term(s) Animals ; Blood Glucose/analysis ; Body Weight ; Diet, High-Fat ; Fructose-Bisphosphatase/metabolism ; Gluconeogenesis/physiology ; Glucose-6-Phosphatase/metabolism ; Kidney/enzymology ; Kidney/metabolism ; Mice ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha/metabolism ; Phosphoenolpyruvate Carboxykinase (ATP)/metabolism ; Proto-Oncogene Proteins c-akt/metabolism ; Proton-Translocating ATPases/genetics ; Proton-Translocating ATPases/physiology ; Pyruvate Kinase/metabolism ; RNA, Messenger/genetics ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/physiology
    Chemical Substances ATP6AP2 protein, mouse ; Blood Glucose ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha ; Ppargc1a protein, mouse ; RNA, Messenger ; Receptors, Cell Surface ; Pyruvate Kinase (EC 2.7.1.40) ; Akt1 protein, mouse (EC 2.7.11.1) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Fructose-Bisphosphatase (EC 3.1.3.11) ; Glucose-6-Phosphatase (EC 3.1.3.9) ; Proton-Translocating ATPases (EC 3.6.3.14) ; Phosphoenolpyruvate Carboxykinase (ATP) (EC 4.1.1.49)
    Language English
    Publishing date 2021-05-31
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-90952-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Attention-Based CNN-BiLSTM for Sleep State Classification of Spatiotemporal Wide-Field Calcium Imaging Data.

    Zhang, Xiaohui / Landsness, Eric C / Miao, Hanyang / Chen, Wei / Tang, Michelle / Brier, Lindsey M / Culver, Joseph P / Lee, Jin-Moo / Anastasio, Mark A

    ArXiv

    2024  

    Abstract: Background: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of ... ...

    Abstract Background: Wide-field calcium imaging (WFCI) with genetically encoded calcium indicators allows for spatiotemporal recordings of neuronal activity in mice. When applied to the study of sleep, WFCI data are manually scored into the sleep states of wakefulness, non-REM (NREM) and REM by use of adjunct EEG and EMG recordings. However, this process is time-consuming, invasive and often suffers from low inter- and intra-rater reliability. Therefore, an automated sleep state classification method that operates on spatiotemporal WFCI data is desired.
    New method: A hybrid network architecture consisting of a convolutional neural network (CNN) to extract spatial features of image frames and a bidirectional long short-term memory network (BiLSTM) with attention mechanism to identify temporal dependencies among different time points was proposed to classify WFCI data into states of wakefulness, NREM and REM sleep.
    Results: Sleep states were classified with an accuracy of 84% and Cohen's kappa of 0.64. Gradient-weighted class activation maps revealed that the frontal region of the cortex carries more importance when classifying WFCI data into NREM sleep while posterior area contributes most to the identification of wakefulness. The attention scores indicated that the proposed network focuses on short- and long-range temporal dependency in a state-specific manner.
    Comparison with existing method: On a 3-hour WFCI recording, the CNN-BiLSTM achieved a kappa of 0.67, comparable to a kappa of 0.65 corresponding to the human EEG/EMG-based scoring.
    Conclusions: The CNN-BiLSTM effectively classifies sleep states from spatiotemporal WFCI data and will enable broader application of WFCI in sleep.
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Preprint
    ISSN 2331-8422
    ISSN (online) 2331-8422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: The Role of Ryanodine Receptor 2 in Drug-Associated Learning.

    Barber, Kara R / Vizcarra, Velia S / Zilch, Ashlyn / Majuta, Lisa / Diezel, Cody C / Culver, Oliver P / Hughes, Brandon W / Taniguchi, Makoto / Streicher, John M / Vanderah, Todd W / Riegel, Arthur C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Type-2 ryanodine receptor (RyR2) ion channels facilitate the release of ... ...

    Abstract Type-2 ryanodine receptor (RyR2) ion channels facilitate the release of Ca
    Language English
    Publishing date 2023-10-05
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.03.560743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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