LIVIVO - Search results -

Search results

Result 1 - 10 of total 169

Article ; Online: In situ

Ihara, Shiro / Yoshinaga, Mizumo / Miyazaki, Hiroya / Wada, Kota / Hata, Satoshi / Saito, Hikaru / Murayama, Mitsuhiro

2023 Volume 15, Issue 23, Page(s) 10133–10140

Abstract: The nanoscale characterization of thermally activated solid reactions plays a pivotal role in products manufactured by nanotechnology. Recently, ...

Abstract	The nanoscale characterization of thermally activated solid reactions plays a pivotal role in products manufactured by nanotechnology. Recently,
MeSH term(s)	Electron Microscope Tomography ; Anaerobiosis ; Microscopy, Electron, Transmission ; Microscopy, Electron ; Nanoparticles
Language	English
Publishing date	2023-06-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2515664-0
ISSN	2040-3372 ; 2040-3364
ISSN (online)	2040-3372
ISSN	2040-3364
DOI	10.1039/d3nr00992k
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist.

Kadokawa, Hiroya / Yoshino, Ryunosuke / Saito, Risa / Hirokawa, Takatsugu

Animal reproduction science

2022 Volume 241, Page(s) 106992

Abstract: Brain ethanolamine plasmalogens (EPls) are unique alkenylacyl-glycerophospholipids and the only recognized ligands of G-protein-coupled receptor 61 (GPR61), a newly identified receptor that colocalizes with GnRH receptors on gonadotrophs. As the chemical ...

Abstract	Brain ethanolamine plasmalogens (EPls) are unique alkenylacyl-glycerophospholipids and the only recognized ligands of G-protein-coupled receptor 61 (GPR61), a newly identified receptor that colocalizes with GnRH receptors on gonadotrophs. As the chemical synthesis of EPl is challenging, only one chemosynthetic EPl, 1-(1Z-octadecenyl)- 2-oleoyl-sn-glycero-3-phosphoethanolamine (PLAPE; C18:0-C18:1), is commercially available. Therefore, we tested the hypothesis that PLAPE stimulates gonadotropin secretion from bovine gonadotrophs. We prepared anterior pituitary cells from healthy, post-pubertal heifers, cultured for 3.5 d, and then treated them with increasing concentrations (0, 0.5, 5, 50, or 500 pg/mL) of PLAPE for 5 mi, before either no treatment or GnRH stimulation. After 2 h, medium samples were harvested for FSH and LH assays. PLAPE (5-500 pg/mL) stimulated (P < 0.01) basal FSH and LH secretion, and such stimulation effects were inhibited by a SMAD pathway inhibitor. In the presence of GnRH, PLAPE at 0.5 and 5 pg/mL stimulated FSH and LH secretion (P < 0.01). However, a higher dose of PLAPE (500 pg/mL) suppressed GnRH-induced FSH and LH, and such suppressive effects were inhibited by an ERK pathway inhibitor. PLAPE stimulated gonadotropin secretion in the presence of EPls extracted from the brains of young heifers, but not old cows. Additionally, we performed in silico molecular-docking simulations using the deep-learning algorithm, AlphaFold2. The simulations revealed the presence of three binding sites for PLAPE in the three-dimensional structural model of GPR61. In conclusion, PLAPE stimulated gonadotropin secretion from bovine gonadotrophs and might act as a chemosynthetic agonist of GPR61.
MeSH term(s)	Animals ; Cattle ; Female ; Follicle Stimulating Hormone/metabolism ; Follicle Stimulating Hormone/pharmacology ; Gonadotrophs/metabolism ; Gonadotropin-Releasing Hormone/metabolism ; Gonadotropin-Releasing Hormone/pharmacology ; Plasmalogens/metabolism ; Plasmalogens/pharmacology
Chemical Substances	Plasmalogens ; phosphatidal ethanolamines ; Gonadotropin-Releasing Hormone (33515-09-2) ; Follicle Stimulating Hormone (9002-68-0)
Language	English
Publishing date	2022-05-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2022.106992
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 3232: Show issues
Z 80/707: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Correction to: A phase I study of inotuzumab ozogamicin as a single agent in pediatric patients in Japan with relapsed/refractory CD22-positive acute lymphoblastic leukemia (INO-Ped-ALL-1).

Nakayama, Hideki / Ogawa, Chitose / Sekimizu, Masahiro / Fujisaki, Hiroyuki / Kosaka, Yoshiyuki / Hashimoto, Hiroya / Saito, Akiko M / Horibe, Keizo

International journal of hematology

2023 Volume 117, Issue 5, Page(s) 786

Language	English
Publishing date	2023-03-21
Publishing country	Japan
Document type	Published Erratum
ZDB-ID	1076875-0
ISSN	1865-3774 ; 0917-1258 ; 0925-5710
ISSN (online)	1865-3774
ISSN	0917-1258 ; 0925-5710
DOI	10.1007/s12185-023-03584-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 269: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article: Chemosynthetic ethanolamine plasmalogen stimulates gonadotropin secretion from bovine gonadotrophs by acting as a potential GPR61 agonist

Kadokawa, Hiroya / Yoshino, Ryunosuke / Saito, Risa / Hirokawa, Takatsugu

Animal reproduction science. 2022 June, v. 241

2022

Abstract	Brain ethanolamine plasmalogens (EPls) are unique alkenylacyl-glycerophospholipids and the only recognized ligands of G-protein-coupled receptor 61 (GPR61), a newly identified receptor that colocalizes with GnRH receptors on gonadotrophs. As the chemical synthesis of EPl is challenging, only one chemosynthetic EPl, 1-(1Z-octadecenyl)− 2-oleoyl-sn-glycero-3-phosphoethanolamine (PLAPE; C18:0-C18:1), is commercially available. Therefore, we tested the hypothesis that PLAPE stimulates gonadotropin secretion from bovine gonadotrophs. We prepared anterior pituitary cells from healthy, post-pubertal heifers, cultured for 3.5 d, and then treated them with increasing concentrations (0, 0.5, 5, 50, or 500 pg/mL) of PLAPE for 5 mi, before either no treatment or GnRH stimulation. After 2 h, medium samples were harvested for FSH and LH assays. PLAPE (5–500 pg/mL) stimulated (P < 0.01) basal FSH and LH secretion, and such stimulation effects were inhibited by a SMAD pathway inhibitor. In the presence of GnRH, PLAPE at 0.5 and 5 pg/mL stimulated FSH and LH secretion (P < 0.01). However, a higher dose of PLAPE (500 pg/mL) suppressed GnRH-induced FSH and LH, and such suppressive effects were inhibited by an ERK pathway inhibitor. PLAPE stimulated gonadotropin secretion in the presence of EPls extracted from the brains of young heifers, but not old cows. Additionally, we performed in silico molecular-docking simulations using the deep-learning algorithm, AlphaFold2. The simulations revealed the presence of three binding sites for PLAPE in the three-dimensional structural model of GPR61. In conclusion, PLAPE stimulated gonadotropin secretion from bovine gonadotrophs and might act as a chemosynthetic agonist of GPR61.
Keywords	G-protein coupled receptors ; agonists ; algorithms ; animal reproduction ; anterior pituitary ; brain ; computer simulation ; ethanolamine ; ligands ; models ; secretion ; synthesis
Language	English
Dates of publication	2022-06
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	429674-6
ISSN	1873-2232 ; 0378-4320
ISSN (online)	1873-2232
ISSN	0378-4320
DOI	10.1016/j.anireprosci.2022.106992
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 3232: Show issues
Z 80/707: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Correction to

Hiroya Nitta / Takeshi Saito / Yorinao Shitaoka

Earth, Planets and Space, Vol 72, Iss 1, Pp 1-

Recent eruption history inferred from eruption ages of the two latest lava fows using multi-dating at Yokodake Volcano, Japan

2020 Volume 4

Abstract: An amendment to this paper has been published and can be accessed via the original article. ...

Abstract	An amendment to this paper has been published and can be accessed via the original article.
Keywords	Geography. Anthropology. Recreation ; G ; Geodesy ; QB275-343 ; Geology ; QE1-996.5
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Dynamic changes and importance of plasma concentrations of ether phospholipids, of which the majority are plasmalogens, in postpartum Holstein dairy cows

Saito, Risa / Kubo, Tomoaki / Wakatsuki, Takuji / Asato, Yuuki / Tanigawa, Tamako / Kotaniguchi, Miyako / Hashimoto, Maki / Kitamura, Shinichi / Kadokawa, Hiroya

Reproduction, Fertility and Development. 2023, v. 35, no. 12 p.622-639

2023

Abstract: Context: Ethanolamine plasmalogens (EPls) and choline plasmalogens (CPls) are classes of ethanolamine ether phospholipids (ePE) and choline ether phospholipids (ePC), respectively. EPls play crucial roles in maternal and breastfed infant bodies and ... ...

Abstract	Context: Ethanolamine plasmalogens (EPls) and choline plasmalogens (CPls) are classes of ethanolamine ether phospholipids (ePE) and choline ether phospholipids (ePC), respectively. EPls play crucial roles in maternal and breastfed infant bodies and stimulate gonadotropin secretion by gonadotrophs. Aims: To estimate changes in and importance of plasma concentrations of EPls and CPls, utilising newly developed enzymatic fluorometric assays for ePE and ePC in postpartum Holstein cows. Methods: Plasma samples were collected from 3weeks before expected parturition until approximately 8weeks after parturition (16 primiparous and 38 multiparous cows) for analysis. Key results: Plasma concentrations of ePE and ePC, most of which are plasmalogens, declined before and increased after parturition and stabilised near the day of the first postpartum ovulation (1stOV). From weeks 2 to 3 after parturition, third-parity cows exhibited ePE concentrations that were higher than those of other parity cows. The days from parturition to 1stOV correlated with days from parturition to conception. On the day of 1stOV, milk yield correlated with plasma concentration of both ePE and ePC, while ePC concentration correlated negatively with milk fat percentage. At the early luteal phase after 1stOV, plasma ePE concentration correlated with plasma anti-Müllerian hormone concentration (r =0.39, P <0.01), and plasma ePC concentration correlated with plasma follicle-stimulating hormone concentration (r =0.43, P <0.01). Conclusion: The concentrations of ePE and ePC changed dramatically around parturition and 1stOV, and the concentrations correlated with important parameters for milk production and reproduction. Implications: The blood plasmalogen may play important roles in postpartum dairy cows.
Keywords	Holstein ; blood ; breast feeding ; choline ; conception ; ethanolamine ; fluorometry ; follicle-stimulating hormone ; menstrual cycle ; milk fat percentage ; milk yield ; ovulation ; parity (reproduction) ; parturition ; phospholipids ; secretion ; aging ; anti-Müllerian hormone ; choline plasmalogen ; ethanolamine plasmalogens ; first postpartum ovulation ; FSH ; functional lipids ; G protein-coupled receptor 61 ; GPR61 ; LH ; parity ; phospholipase A1 ; postpartum Holstein dairy cows ; ruminant
Language	English
Size	p. 622-639.
Publishing place	CSIRO Publishing
Document type	Article ; Online
ZDB-ID	1019913-5
ISSN	1448-5990 ; 1031-3613
ISSN (online)	1448-5990
ISSN	1031-3613
DOI	10.1071/RD23057
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 5258: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Left Main Trunk Occlusion Due to Impella-Related Thrombus in a Patient With Extracorporeal Cardiopulmonary Resuscitation.

Saito, Takayuki / Yamamoto, Hiroyuki / Oishi, Shogo / Uchino, Gaku / Murakami, Hirohisa / Kawai, Hiroya / Takaya, Tomofumi

JACC. Cardiovascular interventions

2021 Volume 14, Issue 22, Page(s) e313–e316

MeSH term(s)	Cardiopulmonary Resuscitation/adverse effects ; Humans ; Shock, Cardiogenic/diagnosis ; Shock, Cardiogenic/etiology ; Shock, Cardiogenic/therapy ; Thrombosis/diagnostic imaging ; Thrombosis/etiology ; Treatment Outcome
Language	English
Publishing date	2021-10-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2021.08.043
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6669: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Ethanolamine plasmalogens derived from whale brain stimulate both follicle-stimulating hormone and luteinizing hormone secretion by bovine gonadotrophs.

Saito, Risa / Bando, Takeharu / Kotaniguchi, Miyako / Tamura, Tsutomu / Kuno, Tomoe / Watanabe, Kenji / Mizukami, Yoichi / Kitamura, Shinichi / Kadokawa, Hiroya

Animal science journal = Nihon chikusan Gakkaiho

2023 Volume 94, Issue 1, Page(s) e13839

Abstract: Ethanolamine plasmalogens (EPls) are the only known ligands of a novel receptor, G protein-coupled receptor 61, and bovine brain EPls stimulate follicle-stimulating hormone (FSH) but not luteinizing hormone (LH), secreted by bovine gonadotrophs. We ... ...

Abstract	Ethanolamine plasmalogens (EPls) are the only known ligands of a novel receptor, G protein-coupled receptor 61, and bovine brain EPls stimulate follicle-stimulating hormone (FSH) but not luteinizing hormone (LH), secreted by bovine gonadotrophs. We hypothesized that the brain EPls of whales (Balaenoptera edeni), another Cetartiodactyla with at least twice the lifespan of bovines, could stimulate FSH secretion by gonadotrophs. To test this hypothesis, bovine gonadotrophs (from approximately 2-year-old Japanese Black heifers) were cultured for 3.5 days and treated with increasing concentrations of brain EP1s from whales (approximately 22 years old). FSH and LH secretion was stimulated by all tested concentrations of whale EPls (p < 0.05). To clarify the important differences between bovine and whale EPls, we utilized two-dimensional liquid chromatography-mass spectrometry, which revealed 35 peaks. Among them, we observed significant differences between 12 EPl molecular species. Additionally, we identified differentially expressed genes for enzymes involved in EPl synthesis or degradation in the hypothalamus of young heifers and old cows (approximately 10 years old) as compared to whales (approximately 28 years old) via deep sequencing of the transcriptome. We conclude that whale brains contain unique EPls that stimulate both FSH and LH secretion by bovine gonadotrophs.
MeSH term(s)	Cattle ; Animals ; Female ; Follicle Stimulating Hormone/metabolism ; Gonadotrophs/metabolism ; Whales/metabolism ; Gonadotropin-Releasing Hormone ; Brain/metabolism ; Pituitary Gland, Anterior/metabolism
Chemical Substances	Follicle Stimulating Hormone (9002-68-0) ; phosphatidal ethanolamines ; Gonadotropin-Releasing Hormone (33515-09-2)
Language	English
Publishing date	2023-05-29
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2095161-9
ISSN	1740-0929 ; 1344-3941
ISSN (online)	1740-0929
ISSN	1344-3941
DOI	10.1111/asj.13839
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Ethanolamine plasmalogens derived from scallops stimulate both follicle-stimulating hormone and luteinizing hormone secretion by bovine gonadotrophs.

Kadokawa, Hiroya / Kotaniguchi, Miyako / Mawatari, Shiro / Saito, Risa / Fujino, Takehiko / Kitamura, Shinichi

Scientific reports

2022 Volume 12, Issue 1, Page(s) 16789

Abstract: Brain ethanolamine plasmalogens (EPls) are the only known ligands of G-protein-coupled receptor 61, a novel receptor that stimulates follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), secretion by bovine gonadotrophs. We hypothesized ... ...

Abstract	Brain ethanolamine plasmalogens (EPls) are the only known ligands of G-protein-coupled receptor 61, a novel receptor that stimulates follicle-stimulating hormone (FSH), but not luteinizing hormone (LH), secretion by bovine gonadotrophs. We hypothesized that the recently developed neuroprotective EPls extracted from scallop (Pecten yessoensis) (scallop EPls) could stimulate FSH secretion by gonadotrophs. To test this hypothesis, bovine gonadotrophs were cultured for 3.5 days and treated with increasing concentrations of scallop EPls. FSH secretion was stimulated by all tested concentrations of scallop EPls (P < 0.05). Surprisingly, LH secretion was stimulated by both 0.5 (P < 0.05) and 5 (P < 0.01) ng/mL of scallop EPls. To clarify the important differences between bovine brain and scallop EPls, we utilized two-dimensional liquid chromatography-mass spectrometry, which revealed 44 peaks, including 10 large peaks. Among them, eight were scallop-specific EPl molecular species, occupying approximately 58% of the total area percentage of scallop EPls. Almost all large peaks contained 4, 5, or 6 unsaturated double bonds in the carbon chain at the sn-2 position of the glycerol backbone. Our results showed that EPls from scallops, lacking pituitary glands, stimulated both FSH and LH secretion by bovine gonadotrophs.
MeSH term(s)	Animals ; Carbon ; Cattle ; Follicle Stimulating Hormone ; Glycerol ; Gonadotrophs/metabolism ; Gonadotropin-Releasing Hormone/metabolism ; Pectinidae/metabolism ; Pituitary Gland/metabolism ; Pituitary Gland, Anterior/metabolism ; Plasmalogens ; Receptors, G-Protein-Coupled
Chemical Substances	Plasmalogens ; Receptors, G-Protein-Coupled ; phosphatidal ethanolamines ; Gonadotropin-Releasing Hormone (33515-09-2) ; Carbon (7440-44-0) ; Follicle Stimulating Hormone (9002-68-0) ; Glycerol (PDC6A3C0OX)
Language	English
Publishing date	2022-10-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-20794-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Recent eruption history inferred from eruption ages of the two latest lava flows using multi-dating at Yokodake Volcano, Japan

Hiroya Nitta / Takeshi Saito / Yorinao Shitaoka

Earth, Planets and Space, Vol 72, Iss 1, Pp 1-

2020 Volume 15

Abstract: Abstract Reconstruction of the eruption history of an active volcano is necessary to elucidate its volcanic activity and to assess the probability of its volcanic eruption. Yokodake volcano in central Japan is the only active volcano among the ... ...

Abstract	Abstract Reconstruction of the eruption history of an active volcano is necessary to elucidate its volcanic activity and to assess the probability of its volcanic eruption. Yokodake volcano in central Japan is the only active volcano among the Yatsugatake volcano group. It has effused nine lava flows, most of which have not been dated. For this study, we ascertained the eruption ages of the latest lava (Y9) and second most recent lava (Y8) using radiocarbon (14C), thermoluminescence (TL), and paleomagnetic dating methods. Results revealed the eruption ages of the two lava flows and the recent eruption history of Yokodake volcano. Yokodake volcano effused its Y8 lava flow at ca. 3.4 ka, ejected NYk-2 tephra with explosive eruption at ca. 2.4–2.2 ka, and effused the Y9 lava flow associated with Y9-T tephra at ca. 0.6 ka. Magma eruption rates of Yokodake at 34 ky and 3.4 ky were estimated as about 9 × 10−3 km3/ky and 1 × 10−2 km3/ky, indicating a stable eruption rate maintained during the past 34 ky. This result suggests that Yokodake volcano retains some potential for eruption, although the volcanic activity of the Yatsugatake volcanoes (10−1–10−2 km3/ky) has weakened over time.
Keywords	Eruption rate ; Holocene lava ; Paleomagnetic dating ; Radiocarbon (14C) dating ; Thermoluminescence (TL) dating ; Yatsugatake volcanoes ; Geography. Anthropology. Recreation ; G ; Geodesy ; QB275-343 ; Geology ; QE1-996.5
Language	English
Publishing date	2020-07-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

To top

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED