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  1. Article ; Online: Ethically problematic tactic: advertising CyberKnife as a therapeutic modality to patients (and underinformed clinicians) is inaccurate.

    Stieber, Volker W

    International journal of radiation oncology, biology, physics

    2009  Volume 73, Issue 2, Page(s) 638

    MeSH term(s) Advertising as Topic/ethics ; Radiosurgery/instrumentation ; Radiosurgery/standards ; Radiotherapy Dosage
    Language English
    Publishing date 2009-02-01
    Publishing country United States
    Document type Letter
    ZDB-ID 197614-x
    ISSN 1879-355X ; 0360-3016
    ISSN (online) 1879-355X
    ISSN 0360-3016
    DOI 10.1016/j.ijrobp.2008.09.059
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  2. Article ; Online: Tumor treating fields and maintenance temozolomide for newly-diagnosed glioblastoma: a cost-effectiveness study.

    Guzauskas, Gregory F / Pollom, Erqi L / Stieber, Volker W / Wang, Bruce C M / Garrison, Louis P

    Journal of medical economics

    2019  Volume 22, Issue 10, Page(s) 1006–1013

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Antineoplastic Agents, Alkylating/administration & dosage ; Antineoplastic Agents, Alkylating/economics ; Combined Modality Therapy/economics ; Cost-Benefit Analysis ; Disease-Free Survival ; Glioblastoma/diagnosis ; Glioblastoma/drug therapy ; Humans ; Temozolomide/administration & dosage ; Temozolomide/economics
    Chemical Substances Antineoplastic Agents, Alkylating ; Temozolomide (YF1K15M17Y)
    Language English
    Publishing date 2019-05-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2270945-9
    ISSN 1941-837X ; 1369-6998
    ISSN (online) 1941-837X
    ISSN 1369-6998
    DOI 10.1080/13696998.2019.1614933
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  3. Article ; Online: Radiation therapy for visual pathway tumors.

    Stieber, Volker W

    Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

    2008  Volume 28, Issue 3, Page(s) 222–230

    Abstract: The multimodality management of visual pathway tumors frequently involves radiation. Most commonly, photons are delivered via multiple focused beams aimed at the tumor while sparing adjacent tissues. The dose can be delivered in multiple treatments ( ... ...

    Abstract The multimodality management of visual pathway tumors frequently involves radiation. Most commonly, photons are delivered via multiple focused beams aimed at the tumor while sparing adjacent tissues. The dose can be delivered in multiple treatments (radiation therapy) or in a single treatment (radiosurgery). Children with visual pathway gliomas should be treated with chemotherapy alone, delaying the use of radiation therapy until progression. Definitive radiation therapy of optic nerve sheath meningiomas results in stable vision in most patients. Radiation therapy or radiosurgery for pituitary tumors can result in control of both tumor growth and hormone hypersecretion. Postoperative radiation therapy or radiosurgery of craniopharyngiomas significantly improves local control rates compared with surgery alone. Radiation therapy is highly effective for eradicating orbital pseudolymphoma and lymphoma. The risk of complications from radiation treatment is dependent on the organ at risk, the cumulative dose it receives, and the dose delivered per fraction.
    MeSH term(s) Craniopharyngioma/complications ; Craniopharyngioma/pathology ; Craniopharyngioma/radiotherapy ; Humans ; Lymphoma/complications ; Lymphoma/pathology ; Lymphoma/radiotherapy ; Meningioma/complications ; Meningioma/pathology ; Meningioma/radiotherapy ; Optic Nerve/anatomy & histology ; Optic Nerve/pathology ; Optic Nerve/radiation effects ; Optic Nerve Diseases/etiology ; Optic Nerve Diseases/pathology ; Optic Nerve Diseases/radiotherapy ; Optic Nerve Glioma/pathology ; Optic Nerve Glioma/radiotherapy ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/pathology ; Pituitary Neoplasms/radiotherapy ; Pseudolymphoma/complications ; Pseudolymphoma/pathology ; Pseudolymphoma/radiotherapy ; Radiation Dosage ; Radiotherapy/adverse effects ; Radiotherapy/methods
    Language English
    Publishing date 2008-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1189901-3
    ISSN 1536-5166 ; 1070-8022
    ISSN (online) 1536-5166
    ISSN 1070-8022
    DOI 10.1097/WNO.0b013e318177ee9d
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  4. Article ; Online: NRG/RTOG 0837: Randomized, phase II, double-blind, placebo-controlled trial of chemoradiation with or without cediranib in newly diagnosed glioblastoma.

    Batchelor, Tracy T / Won, Minhee / Chakravarti, Arnab / Hadjipanayis, Costas G / Shi, Wenyin / Ashby, Lynn S / Stieber, Volker W / Robins, H Ian / Gray, Heidi J / Voloschin, Alfredo / Fiveash, John B / Robinson, Clifford G / Chamarthy, UshaSree / Kwok, Young / Cescon, Terrence P / Sharma, Anand K / Chaudhary, Rekha / Polley, Mei-Yin / Mehta, Minesh P

    Neuro-oncology advances

    2023  Volume 5, Issue 1, Page(s) vdad116

    Abstract: Background: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in ... ...

    Abstract Background: A randomized, phase II, placebo-controlled, and blinded clinical trial (NCT01062425) was conducted to determine the efficacy of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, versus placebo in combination with radiation and temozolomide in newly diagnosed glioblastoma.
    Methods: Patients with newly diagnosed glioblastoma were randomly assigned 2:1 to receive (1) cediranib (20 mg) in combination with radiation and temozolomide; (2) placebo in combination with radiation and temozolomide. The primary endpoint was 6-month progression-free survival (PFS) based on blinded, independent radiographic assessment of postcontrast T1-weighted and noncontrast T2-weighted MRI brain scans and was tested using a 1-sided
    Results: One hundred and fifty-eight patients were randomized, out of which 9 were ineligible and 12 were not evaluable for the primary endpoint, leaving 137 eligible and evaluable. 6-month PFS was 46.6% in the cediranib arm versus 24.5% in the placebo arm (
    Conclusions: This study met its primary endpoint of prolongation of 6-month PFS with cediranib in combination with radiation and temozolomide versus placebo in combination with radiation and temozolomide. There was no difference in overall survival between the 2 arms.
    Language English
    Publishing date 2023-10-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdad116
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  5. Article ; Online: Germline polymorphisms in

    Scheurer, Michael E / Zhou, Renke / Gilbert, Mark R / Bondy, Melissa L / Sulman, Erik P / Yuan, Ying / Liu, Yanhong / Vera, Elizabeth / Wendland, Merideth M / Youssef, Emad F / Stieber, Volker W / Komaki, Ritsuko R / Flickinger, John C / Kenyon, Lawrence C / Robins, H Ian / Hunter, Grant K / Crocker, Ian R / Chao, Samuel T / Pugh, Stephanie L /
    Armstrong, Terri S

    Neuro-oncology advances

    2022  Volume 4, Issue 1, Page(s) vdac152

    Abstract: Background: We sought to identify clinical and genetic predictors of temozolomide-related myelotoxicity among patients receiving therapy for glioblastoma.: Methods: Patients (: Results: 23% of patients developed myelotoxicity (: Conclusions: ... ...

    Abstract Background: We sought to identify clinical and genetic predictors of temozolomide-related myelotoxicity among patients receiving therapy for glioblastoma.
    Methods: Patients (
    Results: 23% of patients developed myelotoxicity (
    Conclusions: Myelotoxicity during concurrent chemoradiation with temozolomide is an uncommon but serious event, often leading to treatment cessation. Successful prediction of toxicity may lead to more cost-effective individualized monitoring of at-risk subjects. The addition of genetic factors greatly enhanced our ability to predict toxicity among a group of similarly treated glioblastoma patients.
    Language English
    Publishing date 2022-10-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 3009682-0
    ISSN 2632-2498 ; 2632-2498
    ISSN (online) 2632-2498
    ISSN 2632-2498
    DOI 10.1093/noajnl/vdac152
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  6. Article: Advances in radiation therapy for brain tumors.

    Stieber, Volker W / Mehta, Minesh P

    Neurologic clinics

    2007  Volume 25, Issue 4, Page(s) 1005–33, ix

    Abstract: Radiation therapy is used postoperatively as adjunctive therapy to decrease local failure; to delay tumor progression and prolong survival; as a curative treatment; as a therapy that halts further tumor growth; to alter function; and for palliation. ... ...

    Abstract Radiation therapy is used postoperatively as adjunctive therapy to decrease local failure; to delay tumor progression and prolong survival; as a curative treatment; as a therapy that halts further tumor growth; to alter function; and for palliation. Registration of MRI scan data sets with the treatment-planning CT scan is essential for accurate definition of the tumor and surrounding organs at risk. Integrating additional imaging studies that reflect the biologic characteristics of central nervous system tumors is an area of active research. Conformal treatment delivery is used to spare adjacent normal tissue from receiving unnecessary dose. In the dose range used when treating these tumors, the probability of causing serious late toxicity is relatively low and secondary malignancies are rare.
    MeSH term(s) Brain Neoplasms/radiotherapy ; Emergency Medical Services ; Glioblastoma/radiotherapy ; Glioma/radiotherapy ; Humans ; Meningeal Neoplasms/radiotherapy ; Meningioma/radiotherapy ; Palliative Care ; Pituitary Neoplasms/radiotherapy ; Quality of Life/psychology ; Radiotherapy/adverse effects ; Radiotherapy/trends
    Language English
    Publishing date 2007-11
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1013148-6
    ISSN 1557-9875 ; 0733-8619
    ISSN (online) 1557-9875
    ISSN 0733-8619
    DOI 10.1016/j.ncl.2007.07.005
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  7. Article: The role of radiosurgery in the management of malignant brain tumors.

    Stieber, Volker W / Ellis, Thomas L

    Current treatment options in oncology

    2005  Volume 6, Issue 6, Page(s) 501–508

    Abstract: Stereotactic radiosurgery (SRS) provides the means for creating lesions in deep-seated areas of the brain inaccessible to invasive surgery, using single high doses of focused ionizing radiation, administered using stereotactic guidance. It is a surgical ... ...

    Abstract Stereotactic radiosurgery (SRS) provides the means for creating lesions in deep-seated areas of the brain inaccessible to invasive surgery, using single high doses of focused ionizing radiation, administered using stereotactic guidance. It is a surgical technique designed to produce a specific radiobiological effect within a sharply defined target region in a single treatment session. Its technical application requires a stereotactic coordinate system, highly accurate patient repositioning (usually fixed), and multiple convergent beams of photon radiation. SRS appears to provide no benefit in the upfront treatment of newly diagnosed malignant gliomas but may be used to effectively palliate small well-demarcated volumes of recurrent disease. For selected patients with brain metastases treated with whole-brain radiation therapy (WBRT), the addition of SRS improves median survival. In selected patients with brain metastases, it is also rational to withhold WBRT in favor of radiosurgery alone, with WBRT reserved for salvage without a decrease in median survival time.
    MeSH term(s) Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Combined Modality Therapy ; Cranial Irradiation ; Glioma/radiotherapy ; Glioma/secondary ; Glioma/surgery ; Humans ; Radiosurgery ; Salvage Therapy
    Language English
    Publishing date 2005-09-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2057351-0
    ISSN 1534-6277 ; 1527-2729
    ISSN (online) 1534-6277
    ISSN 1527-2729
    DOI 10.1007/s11864-005-0028-8
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  8. Article ; Online: Glossopharyngeal neuralgia treated with gamma knife surgery: treatment outcome and failure analysis.

    Stieber, Volker W / Bourland, J Daniel / Ellis, Thomas L

    Journal of neurosurgery

    2005  Volume 102, Issue s_supplement, Page(s) 155–157

    Abstract: Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal neuralgia (TN), treatment with microvascular decompression (MVD) has been successful in both. Because gamma knife ... ...

    Abstract ✓ Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal neuralgia (TN), treatment with microvascular decompression (MVD) has been successful in both. Because gamma knife surgery (GKS) has also been shown to be effective in treating TN, it seemed reasonable to apply it to GPN. The authors present the first report of GKS-treated GPN in a patient who presented with severe, poorly controlled GPN and who refused MVD.
    Language English
    Publishing date 2005-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.2005.102.s_supplement.0155
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  9. Article: Glossopharyngeal neuralgia treated with gamma knife surgery: treatment outcome and failure analysis. Case report.

    Stieber, Volker W / Bourland, J Daniel / Ellis, Thomas L

    Journal of neurosurgery

    2005  Volume 102 Suppl, Page(s) 155–157

    Abstract: Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal neuralgia (TN), treatment with microvascular decompression (MVD) has been successful in both. Because gamma knife ... ...

    Abstract Glossopharyngeal neuralgia (GPN) is a rare condition in which patients present with intractable deep throat pain. Similar to trigeminal neuralgia (TN), treatment with microvascular decompression (MVD) has been successful in both. Because gamma knife surgery (GKS) has also been shown to be effective in treating TN, it seemed reasonable to apply it to GPN. The authors present the first report of GKS-treated GPN in a patient who presented with severe, poorly controlled GPN and who refused MVD.
    MeSH term(s) Female ; Glossopharyngeal Nerve/physiopathology ; Glossopharyngeal Nerve/surgery ; Humans ; Pain/diagnosis ; Pain Measurement ; Radiation Dosage ; Radiosurgery/instrumentation ; Treatment Failure ; Trigeminal Neuralgia/physiopathology ; Trigeminal Neuralgia/surgery
    Language English
    Publishing date 2005-01-15
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/jns.2005.102.s_supplement.0155
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  10. Article: Lessons learned from randomised clinical trials in adult low grade glioma.

    Papagikos, Michael A / Shaw, Edward G / Stieber, Volker W

    The Lancet. Oncology

    2005  Volume 6, Issue 4, Page(s) 240–244

    Abstract: Lesson" is a Middle English word that has been defined as "a passage from sacred writings read in a service of worship" as well as "something learned by study or experience". The term is quite appropriate in assessment of what has been learned from ... ...

    Abstract "Lesson" is a Middle English word that has been defined as "a passage from sacred writings read in a service of worship" as well as "something learned by study or experience". The term is quite appropriate in assessment of what has been learned from randomised trials in adult low-grade gliomas, since the treatment of these tumours has traditionally been guided as much by belief as by fact. Therefore, when assessing these trials we can apply the principles of hermeneutics. Thus, the first meaning of "lesson" given here can be described as literal, whereas the second may be seen as figurative. Since hermeneutics may also refer to an in-depth analysis of a particular text, the investigators will present their interpretation of data from randomised trials. The goal is to show that the lessons learned are not necessarily literal or dogmatic but can be much more allegorical in nature.
    MeSH term(s) Adult ; Brain Neoplasms/radiotherapy ; Chemotherapy, Adjuvant ; Glioma/radiotherapy ; Humans ; Prognosis ; Quality of Life ; Radiotherapy Dosage ; Randomized Controlled Trials as Topic ; Treatment Outcome
    Language English
    Publishing date 2005-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(05)70095-4
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