LIVIVO - Search results -

Search results

Result 1 - 10 of total 21

Search options

Article ; Online: Immunohistochemistry utilization in the diagnosis of melanoma.

Dinehart, Matthew S / Dinehart, Scott M / Sukpraprut-Braaten, Suporn / High, Whitney A

2020 Volume 47, Issue 5, Page(s) 446–450

Abstract: Background: The use of immunohistochemical (IHC) stains in dermatopathology is commonplace; however, little is known regarding utilization trends in melanoma diagnosis. Current Medicare local coverage determinations (LCDs) state that most pigmented ... ...

Abstract	Background: The use of immunohistochemical (IHC) stains in dermatopathology is commonplace; however, little is known regarding utilization trends in melanoma diagnosis. Current Medicare local coverage determinations (LCDs) state that most pigmented lesions, including melanoma, can be diagnosed using H&E alone. Methods: Histopathology reports for all biopsy-proven melanomas excised between January 1, 2017 and June 30, 2018, at a single dermatology clinic, were identified with the following parameters abstracted: laboratory/dermatopathologist rendering the diagnosis, whether IHC was performed, type/number of stains utilized, presence/depth of invasion, and melanoma subtype. The association of characteristics with IHC utilization was evaluated using χ Results: Three hundred and fifty six eligible melanomas were identified. IHC was employed in 228 (64%) of the diagnoses. Invasive melanoma was diagnosed in 199 cases (55.9%) while 157 (44.1%) were identified as melanoma in situ (MIS). Of the 228 that utilized IHC, 117 were performed on invasive melanoma (58.8%) and 111 were performed on MIS (70.7%). Conclusion: Our findings suggest a higher IHC usage for the diagnosis of melanoma than previously reported. Existing LCDs regarding IHC utilization in melanoma do not reflect the current state of practice. Further investigation regarding IHC utilization and the development of appropriate-use criteria for melanoma IHC is necessary.
MeSH term(s)	Biopsy ; Female ; Humans ; Immunohistochemistry/methods ; Immunohistochemistry/statistics & numerical data ; MART-1 Antigen/metabolism ; Male ; Medicare/standards ; Medicare/statistics & numerical data ; Melanoma/diagnosis ; Melanoma/metabolism ; Melanoma/pathology ; Neoplasm Invasiveness/pathology ; Nevus, Pigmented/pathology ; Retrospective Studies ; SOXE Transcription Factors/metabolism ; Skin Neoplasms/pathology ; United States/epidemiology
Chemical Substances	MART-1 Antigen ; SOX10 protein, human ; SOXE Transcription Factors
Language	English
Publishing date	2020-01-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	187078-6
ISSN	1600-0560 ; 0303-6987
ISSN (online)	1600-0560
ISSN	0303-6987
DOI	10.1111/cup.13648
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 1043: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Level of Evidence Review for a Gene Expression Profile Test for Cutaneous Melanoma.

Dubin, Danielle P / Dinehart, Scott M / Farberg, Aaron S

American journal of clinical dermatology

2019 Volume 20, Issue 6, Page(s) 763–770

Abstract: Background: The advent of molecular medicine may allow for individualized cancer prognostication, which should enable better clinical management and, hopefully, improve patient outcomes. A 31-gene expression profile (31-GEP) test is currently available ... ...

Abstract	Background: The advent of molecular medicine may allow for individualized cancer prognostication, which should enable better clinical management and, hopefully, improve patient outcomes. A 31-gene expression profile (31-GEP) test is currently available for patients diagnosed with cutaneous melanoma; this test helps inform patients' individual treatment plans, especially when combined with traditional biomarkers. Objective: The objective of this study was to review the current literature and establish the level of evidence for a cutaneous melanoma 31-GEP test. Methods: A review of seven development and validation studies for the 31-GEP test was conducted. The respective strengths and weaknesses of each study were applied to the level of evidence criteria from major organizations that publish guidelines for melanoma management: American Joint Committee on Cancer, National Comprehensive Cancer Network, and American Academy of Dermatology. Results: Evaluating each study led to classifying the 31-GEP test as level I/II, I-IIIB, and IIA according to American Joint Committee on Cancer, National Comprehensive Cancer Network, and American Academy of Dermatology criteria, respectively. This stands in contrast to the official unrated status conferred by the American Joint Committee on Cancer and National Comprehensive Cancer Network and the II/IIIC rating designated by the American Academy of Dermatology. Conclusions: Differences between the authors' findings and official published ratings may be attributed to chronological issues, as many of the studies were not yet published when the aforementioned organizations conducted their reviews. There was also difficulty in applying the National Comprehensive Cancer Network criteria to this prognostic test, as their guidelines were intended for evaluation of predictive markers. Nevertheless, based upon the most current data available, integration of the 31-GEP test into clinical practice may be warranted in certain clinical situations.
MeSH term(s)	Biomarkers, Tumor/genetics ; Clinical Decision-Making/methods ; Dermatology/methods ; Disease-Free Survival ; Evidence-Based Medicine/methods ; Gene Expression Profiling/methods ; Humans ; Kaplan-Meier Estimate ; Medical Oncology/methods ; Melanoma/genetics ; Melanoma/mortality ; Melanoma/pathology ; Melanoma/therapy ; Molecular Diagnostic Techniques/methods ; Neoplasm Staging ; Patient Selection ; Prognosis ; Skin Neoplasms/genetics ; Skin Neoplasms/mortality ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
Chemical Substances	Biomarkers, Tumor
Language	English
Publishing date	2019-07-29
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	1502476-3
ISSN	1179-1888 ; 1175-0561
ISSN (online)	1179-1888
ISSN	1175-0561
DOI	10.1007/s40257-019-00464-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 5639: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Intermittent Vismodegib Therapy in Basal Cell Nevus Syndrome.

Yang, Xinyi / Dinehart, Scott M

JAMA dermatology

2016 Volume 152, Issue 2, Page(s) 223–224

MeSH term(s)	Adult ; Anilides/administration & dosage ; Anilides/adverse effects ; Anilides/agonists ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Basal Cell Nevus Syndrome/drug therapy ; Basal Cell Nevus Syndrome/pathology ; Drug Administration Schedule ; Female ; Humans ; Male ; Middle Aged ; Pyridines/administration & dosage ; Pyridines/adverse effects ; Pyridines/agonists ; Skin Neoplasms/drug therapy ; Skin Neoplasms/pathology ; Treatment Outcome
Chemical Substances	Anilides ; Antineoplastic Agents ; HhAntag691 ; Pyridines
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	2701761-8
ISSN	2168-6084 ; 2168-6068
ISSN (online)	2168-6084
ISSN	2168-6068
DOI	10.1001/jamadermatol.2015.3210
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui VI Zs.32: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Reply to: "Comment on 'Occurrence of vismodegib-induced cramps (muscular spasms) in the treatment of basal cell carcinoma: A prospective study in 30 patients'".

Dinehart, Matthew S / McMurray, Stacy / Dinehart, Scott / Lebwohl, Mark

Journal of the American Academy of Dermatology

2018 Volume 88, Issue 1, Page(s) e19

MeSH term(s)	Humans ; Prospective Studies ; Muscle Cramp/chemically induced ; Muscle Cramp/drug therapy ; Carcinoma, Basal Cell/drug therapy ; Anilides/adverse effects ; Skin Neoplasms/drug therapy ; Spasm/chemically induced ; Spasm/drug therapy ; Antineoplastic Agents/therapeutic use
Chemical Substances	HhAntag691 ; Anilides ; Antineoplastic Agents
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2018.07.069
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1540: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Integrating gene expression profiling into NCCN high-risk cutaneous squamous cell carcinoma management recommendations: impact on patient management.

Farberg, Aaron S / Hall, Mary A / Douglas, Leah / Covington, Kyle R / Kurley, Sarah J / Cook, Robert W / Dinehart, Scott M

Current medical research and opinion

2020 Volume 36, Issue 8, Page(s) 1301–1307

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Squamous Cell/genetics ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Cohort Studies ; Female ; Gene Expression Profiling ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Practice Guidelines as Topic ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Skin Neoplasms/therapy
Language	English
Publishing date	2020-05-18
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80296-7
ISSN	1473-4877 ; 0300-7995
ISSN (online)	1473-4877
ISSN	0300-7995
DOI	10.1080/03007995.2020.1763284
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 955: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾

Article ; Online: Evidence-Based Consensus Recommendations for the Evolving Treatment of Patients with High-Risk and Advanced Cutaneous Squamous Cell Carcinoma.

Rabinowits, Guilherme / Migden, Michael R / Schlesinger, Todd E / Ferris, Robert L / Freeman, Morganna / Guild, Valerie / Koyfman, Shlomo / Pavlick, Anna C / Swanson, Neil / Wolf, Gregory T / Dinehart, Scott M

JID innovations

2021 Volume 1, Issue 4, Page(s) 100045

Abstract: Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disease ... ...

Abstract	Cutaneous squamous cell carcinoma is the second most common skin cancer in the United States. Currently, there is no standardized management approach for patients with cutaneous squamous cell carcinoma who develop metastatic or locally advanced disease and are not candidates for curative surgery or curative radiation. To address this issue, the Expert Cutaneous Squamous Cell Carcinoma Leadership program convened an expert steering committee to develop evidence-based consensus recommendations on the basis of a large, structured literature review. Consensus was achieved through modified Delphi methodology. The steering committee included five dermatologists, three medical oncologists, two head and neck surgeons, one radiation oncologist, and a patient advocacy group representative. The steering committee aligned on the following clinical topics: diagnosis and identification of patients considered not candidates for surgery; staging systems and risk stratification in cutaneous squamous cell carcinoma; the role of radiation therapy, surgery, and systemic therapy in the management of advanced disease, with a focus on immunotherapy; referral patterns; survivorship care; and inclusion of the patient's perspective. Consensus was achieved on 34 recommendations addressing 12 key clinical questions. The Expert Cutaneous Squamous Cell Carcinoma Leadership steering committee's evidence-based consensus recommendations may provide healthcare professionals with practically oriented guidance to help optimize outcomes for patients with advanced cutaneous squamous cell carcinoma.
Language	English
Publishing date	2021-08-25
Publishing country	United States
Document type	Journal Article
ISSN	2667-0267
ISSN (online)	2667-0267
DOI	10.1016/j.xjidi.2021.100045
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Radiation therapy for widespread actinic keratoses.

Dinehart, Scott M / Graham, Matt / Maners, Ann

The Journal of clinical and aesthetic dermatology

2011 Volume 4, Issue 7, Page(s) 47–50

Abstract: Objective: To profile 16 patients with widespread and resistant actinic keratoses (AKs) treated with radiation therapy.: Design: Chart review and phone interviews of 16 patients who were treated with radiation therapy between 2003 and 2010.: ... ...

Abstract	Objective: To profile 16 patients with widespread and resistant actinic keratoses (AKs) treated with radiation therapy. Design: Chart review and phone interviews of 16 patients who were treated with radiation therapy between 2003 and 2010. Setting: A specialized dermatological practice primarily treating patients with skin cancer. Participants: The study population at the time of treatment was aged 70 to 87 with a mean age of 79.6 years and included 14 men and two women. Measurements: Patients were followed at two weeks and six months after treatment to assess clinical outcome. All adverse effects were recorded. Patients were contacted for phone interview to assess patient satisfaction after treatment. Results: Patients all had significant reduction of AKs in the radiation field with a majority (90%) reporting they were "very satisfied" with their treatment outcome. Of 16 patients at two weeks post-treatment, 13 had complete clinical resolution of their AK after radiation therapy. Three of 16 patients had significant reduction (50-99%) in AK in the treatment field. Patients reported improved quality of life, a reduced need for frequent clinic visits, and long-term remission from the development of new AKs within the treatment field. Conclusion: Patients meeting suggested specific criteria developed by the authors may be treated successfully with radiation therapy with good outcomes at six-month follow up and high levels of patient satisfaction.
Language	English
Publishing date	2011-07-14
Publishing country	United States
Document type	Case Reports
ISSN	2689-9175
ISSN (online)	2689-9175
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Evaluation of the American Joint Committee on Cancer staging system for cutaneous squamous cell carcinoma and proposal of a new staging system.

Dinehart, Scott M / Peterson, Steven

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2006 Volume 31, Issue 11 Pt 1, Page(s) 1379–1384

Abstract: Purpose: To identify and propose corrections for deficiencies in the American Joint Committee on Cancer (AJCC) system for staging cutaneous squamous cell carcinoma (CSCC).: Materials and methods: Prognostic factors for CSCC were identified by ... ...

Abstract	Purpose: To identify and propose corrections for deficiencies in the American Joint Committee on Cancer (AJCC) system for staging cutaneous squamous cell carcinoma (CSCC). Materials and methods: Prognostic factors for CSCC were identified by retrospective analysis of the published literature. Limitations and deficiencies in the current AJCC staging system for CSCC were then determined using these prognostic factors. Results: Size, histologic differentiation, location, previous treatment, depth of invasion, tumor thickness, histologic subtype, perineural spread, and scar etiology are the most powerful tumor prognostic indicators in patients with localized disease. The most important prognostic factors for patients with nodal metastases are the location, number, and size of the positive lymph nodes. Proposed changes for the T classification include increased stratification of tumor size, identification of patients with perineural invasion, and the addition of tumor thickness or depth of invasion. The N classification has been expanded to include the number and size of nodal metastases. Conclusion: The current AJCC staging system for carcinoma of the skin has deficiencies that limit its use for CSCC. The proposed TMN staging system for CSCC more accurately reflects the prognosis and natural history of CSCC.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/secondary ; Humans ; Lymphatic Metastasis ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local ; Neoplasm Staging/methods ; Neoplasm Staging/standards ; Prognosis ; Skin Neoplasms/pathology ; Skin Neoplasms/secondary
Language	English
Publishing date	2006-01-04
Publishing country	United States
Document type	Evaluation Studies ; Journal Article
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.2310/6350.2005.31201
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1212: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Dietary supplements: altered coagulation and effects on bruising.

Dinehart, Scott M / Henry, Lance

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.

2005 Volume 31, Issue 7 Pt 2, Page(s) 819–26; discussion 826

Abstract: Background: Patient use of dietary supplements that alter coagulation or have an effect on bruising is becoming increasingly common.: Objective: To identify and describe dietary supplements that alter coagulation or are reported to alter bruising ... ...

Abstract	Background: Patient use of dietary supplements that alter coagulation or have an effect on bruising is becoming increasingly common. Objective: To identify and describe dietary supplements that alter coagulation or are reported to alter bruising during and after surgical procedures. Methods: The MEDLINE, Cochrane Collaboration, and International Bibliographic Information on Dietary Supplements databases were searched for articles using the search words "bruising," "bleeding," "coagulation," "hemostasis," "herbal medicine," "alternative medicine," and "dietary supplement." Additional sources were obtained from manual searches of recent journal articles. Results: In vivo and in vitro evidence supports the notion that many dietary supplements alter coagulation. Limited evidence is available to support anecdotal claims of diminished postoperative bruising after the use of dietary supplements. Conclusion: Surgeons should be aware that many of their patients are taking dietary supplements that may alter coagulation. Because most patients will not readily volunteer this information, specific steps should be taken to obtain it prior to more extensive surgical procedures.
MeSH term(s)	Blood Coagulation/drug effects ; Contusions/drug therapy ; Dietary Supplements ; Humans ; Phytotherapy
Language	English
Publishing date	2005-05-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1227586-4
ISSN	1524-4725 ; 1076-0512
ISSN (online)	1524-4725
ISSN	1076-0512
DOI	10.1111/j.1524-4725.2005.31726
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1212: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Sentinel lymph node biopsy and completion lymph node dissection for malignant melanoma are not standard of care.

Coldiron, Brett M / Dinehart, Scott / Rogers, Howard W

Clinics in dermatology

2009 Volume 27, Issue 4, Page(s) 350–354

Abstract: Malignant melanoma is a cutaneous malignancy characterized by high metastatic potential and an unpredictable course. Enormous amounts of research have been done into surgical and adjunctive therapies for melanoma. Given the regularity with which sentinel ...

Abstract	Malignant melanoma is a cutaneous malignancy characterized by high metastatic potential and an unpredictable course. Enormous amounts of research have been done into surgical and adjunctive therapies for melanoma. Given the regularity with which sentinel lymph node biopsy and completion lymph node dissection are performed at private and academic hospitals, it would seem that evidence supporting these procedures is not controversial. A growing body of studies, however, points to sentinel lymph node biopsy and completion lymph node dissection as ineffective treatment for malignant melanoma and necessitates a discussion of what constitutes standard of care.
MeSH term(s)	Humans ; Lymph Node Excision/standards ; Melanoma/pathology ; Melanoma/surgery ; Sentinel Lymph Node Biopsy/standards ; Skin Neoplasms/pathology ; Skin Neoplasms/surgery
Language	English
Publishing date	2009-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1064149-x
ISSN	1879-1131 ; 0738-081X
ISSN (online)	1879-1131
ISSN	0738-081X
DOI	10.1016/j.clindermatol.2009.02.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 972: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito