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Article ; Online: Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats.

Wang, Zhengchao / Zhu, Qing / Wang, Weili / Yi, Fan / Li, Pin-Lan / Boini, Krishna M / Li, Ningjun

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology

2017 Volume 42, Issue 3, Page(s) 1264–1273

Abstract: ... salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known ... to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats.: Methods ... Uninephrectomized Dahl S rats were infused with vehicle or VA (50mg/kg/d) into the renal medulla and fed with a low ...

Abstract	Background: Our previous study has detected a stem cell deficiency in the renal medulla in Dahl salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats. Methods: Uninephrectomized Dahl S rats were infused with vehicle or VA (50mg/kg/d) into the renal medulla and fed with a low (LS) or high salt diet (HS). Stem cell marker and number were analyzed by immunohistochemistry, Real-time RT-PCR and Western blot. Sodium excretion and blood pressure were measured. Results: VA significantly increased the mRNA and protein levels of FGF2, a stem cell niche factor, and CD133, a stem cell marker. The number of CD133+ cells was significantly increased in the renal medulla in VA-treated rats. Meanwhile, high salt-induced increases in the mRNA level of proinflammatory factors interleukin-1β and interleukin-6 were blocked in VA-treated rats. Functionally, sodium excretion in response to the blood pressure increase and acute sodium loading was significantly enhanced, sodium retention attenuated, high salt-induced increase of blood pressure reduced in VA-treated rats. Conclusion: Activation of stem cell function by VA inhibits the activation of proinflammatory factors and attenuates salt-sensitive hypertension in Dahl S rats.
MeSH term(s)	AC133 Antigen/analysis ; AC133 Antigen/metabolism ; Animals ; Antihypertensive Agents/pharmacology ; Enzyme Inhibitors/pharmacology ; Fibroblast Growth Factor 2/analysis ; Fibroblast Growth Factor 2/metabolism ; Hypertension/drug therapy ; Hypertension/metabolism ; Kidney Medulla/cytology ; Kidney Medulla/drug effects ; Male ; Rats, Inbred Dahl ; Sodium Chloride, Dietary/metabolism ; Stem Cells/cytology ; Stem Cells/drug effects ; Valproic Acid/administration & dosage ; Valproic Acid/pharmacology
Chemical Substances	AC133 Antigen ; Antihypertensive Agents ; Enzyme Inhibitors ; Sodium Chloride, Dietary ; Fibroblast Growth Factor 2 (103107-01-3) ; Valproic Acid (614OI1Z5WI)
Language	English
Publishing date	2017-07-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000478955
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Article: Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats

Wang, Zhengchao / Zhu, Qing / Wang, Weili / Yi, Fan / Li, Pin-Lan / Boini, Krishna M. / Li, Ningjun

Cellular Physiology and Biochemistry

2017 Volume 42, Issue 3, Page(s) 1264–1273

Abstract: ... salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known ... to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats. Methods ... Uninephrectomized Dahl S rats were infused with vehicle or VA (50mg/kg/d) into the renal medulla and fed with a low ...

Institution	Laboratory for Developmental Biology and Neurosciences, College of Life Sciences, Fujian Normal University, Fuzhou, China Department of Pharmacology & Toxicology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia, USA Institute of Hypertension, Sun Yat-sen University School of Medicine, Guangzhou, China Department of Pharmacology, Shandong University School of Medicine, Jinan, China
Abstract	Background: Our previous study has detected a stem cell deficiency in the renal medulla in Dahl salt-sensitive (S) rats. This study determined whether infusion of valproic acid (VA), an agent known to stimulate the stem cell function, attenuated salt-sensitive hypertension in Dahl S rats. Methods: Uninephrectomized Dahl S rats were infused with vehicle or VA (50mg/kg/d) into the renal medulla and fed with a low (LS) or high salt diet (HS). Stem cell marker and number were analyzed by immunohistochemistry, Real-time RT-PCR and Western blot. Sodium excretion and blood pressure were measured. Results: VA significantly increased the mRNA and protein levels of FGF2, a stem cell niche factor, and CD133, a stem cell marker. The number of CD133+ cells was significantly increased in the renal medulla in VA-treated rats. Meanwhile, high salt-induced increases in the mRNA level of proinflammatory factors interleukin-1β and interleukin-6 were blocked in VA-treated rats. Functionally, sodium excretion in response to the blood pressure increase and acute sodium loading was significantly enhanced, sodium retention attenuated, high salt-induced increase of blood pressure reduced in VA-treated rats. Conclusion: Activation of stem cell function by VA inhibits the activation of proinflammatory factors and attenuates salt-sensitive hypertension in Dahl S rats.
Keywords	CD133 ; Inflammation ; Interleukin-1β ; Fibroblast growth factor-2 ; Sodium excretion
Language	English
Publishing date	2017-07-11
Publisher	S. Karger AG
Publishing place	Basel, Switzerland
Document type	Article
Note	Original Paper ; This article is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (CC BY-NC-ND).
ZDB-ID	1067572-3
ISSN	1421-9778 ; 1015-8987
ISSN (online)	1421-9778
ISSN	1015-8987
DOI	10.1159/000478955
Database	Karger publisher's database

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Article ; Online: Contribution of membrane raft redox signalling to visfatin-induced inflammasome activation and podocyte injury.

Koka, Saisudha / Surineni, Sreenidhi / Singh, Gurinder Bir / Boini, Krishna M

Aging

2023 Volume 15, Issue 22, Page(s) 12738–12748

Abstract: Recently we have shown that adipokine visfatin-induced NLRP3 inflammasome activation contributes to podocyte injury. However, the molecular mechanisms of how visfatin-induces the Nlrp3 inflammasome activation and podocyte damage is still unknown. The ... ...

Abstract	Recently we have shown that adipokine visfatin-induced NLRP3 inflammasome activation contributes to podocyte injury. However, the molecular mechanisms of how visfatin-induces the Nlrp3 inflammasome activation and podocyte damage is still unknown. The present study tested whether membrane raft (MR) redox signalling pathway plays a central role in visfatin-induced NLRP3 inflammasomes formation and activation in podocytes. Upon visfatin stimulation an aggregation of NADPH oxidase subunits, gp91phox and p47phox was observed in the membrane raft (MR) clusters, forming a MR redox signalling platform in podocytes. The formation of this signalling platform was blocked by prior treatment with MR disruptor MCD or NADPH oxidase inhibitor DPI. In addition, visfatin stimulation significantly increased the colocalization of Nlrp3 with Asc or Nlrp3 with caspase-1, IL-β production, cell permeability in podocytes compared to control cells. Pretreatment with MCD, DPI, WEHD significantly abolished the visfatin-induced colocalization of NLRP3 with Asc or NLRP3 with caspase-1, IL-1β production and cell permeability in podocytes. Furthermore, Immunofluorescence analysis demonstrated that visfatin treatment significantly decreased the podocin and nephrin expression (podocyte damage) and prior treatments with DPI, WEHD, MCD attenuated this visfatin-induced podocin and nephrin reduction. In conclusion, our results suggest that visfatin stimulates membrane raft clustering in the membrane of podocytes to form redox signaling platforms by aggregation and activation of NADPH oxidase subunits enhancing O
MeSH term(s)	Inflammasomes/metabolism ; Podocytes/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Nicotinamide Phosphoribosyltransferase/metabolism ; NADPH Oxidases/metabolism ; Caspase 1/metabolism ; Oxidation-Reduction
Chemical Substances	Inflammasomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Nicotinamide Phosphoribosyltransferase (EC 2.4.2.12) ; NADPH Oxidases (EC 1.6.3.-) ; Caspase 1 (EC 3.4.22.36)
Language	English
Publishing date	2023-11-17
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	1945-4589
ISSN (online)	1945-4589
DOI	10.18632/aging.205243
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Article ; Online: What do we know about the effect of night-shift work on cardiovascular risk factors? An umbrella review.

Boini, Stephanie / Bourgkard, Eve / Ferrières, Jean / Esquirol, Yolande

Frontiers in public health

2022 Volume 10, Page(s) 1034195

Abstract: Objective: To evaluate the existing evidence on the effect of night-shift work and its subtypes (permanent and rotating) on cardiovascular risk factors: diabetes, lipid disorders, being overweight, hypertension, smoking habits, sedentariness, and ... ...

Abstract	Objective: To evaluate the existing evidence on the effect of night-shift work and its subtypes (permanent and rotating) on cardiovascular risk factors: diabetes, lipid disorders, being overweight, hypertension, smoking habits, sedentariness, and occupational psychosocial stressors. Method: A Web of Sciences and Cochrane review library search was conducted to identify systematic reviews with or without meta-analysis dealing with the quantification of the link between night-shift work and the studied cardiovascular risk factors in working populations. We used the AMSTAR 2 to evaluate the quality of each review. The main results of the included systematic reviews were compiled in a summary structured around the different cardiovascular risk factors. Results: After selection, 33 systematic reviews were included: nine for diabetes, four for lipid disorders, nine for being overweight, four for hypertension, two for smoking habits, three for occupational psychosocial stressors and two for sedentariness. The results confirmed an excess risk of diabetes of about 10% regardless of the type of night work. A stated excess risk of being overweight at around 25% was also highlighted for shift workers overall, which could reach 38% among night-shift workers. An increased risk of obesity, estimated at 5% for night-shift workers and at 18% for rotating shift workers, was observed. An excess risk of hypertension was estimated at around 30% when considering the broad definition of shift work and when night periods were included in rotating shifts. The literature provided inconsistent results for the link between lipid disorders and night-shift work. Shift workers appeared to be more likely to smoke. The link between shift work and occupational psychosocial stressors was scarcely explored in the available studies. Sedentariness was scarcely considered in systematic reviews, which prevents any firm conclusions. Conclusion: The consequences of night work in terms of diabetes, being overweight/obesity and hypertension are established. Monitoring of these cardiovascular risk factors for these night-shift workers could be implemented by practitioners. In contrast, the links with lipid disorders, sedentariness, smoking habits, and occupational psychosocial stressors warrant further investigation. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021275212, PROSPERO (ID CRD42021275212).
MeSH term(s)	Humans ; Shift Work Schedule/adverse effects ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Risk Factors ; Systematic Reviews as Topic ; Heart Disease Risk Factors ; Overweight/epidemiology ; Hypertension/epidemiology ; Obesity/epidemiology ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2022-11-23
Publishing country	Switzerland
Document type	Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1034195
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Article ; Online: Co-exposures to physical and psychosocial work factors increase the occurrence of workplace injuries among French care workers.

Colin, Régis / Wild, Pascal / Paris, Christophe / Boini, Stéphanie

Frontiers in public health

2022 Volume 10, Page(s) 1055846

Abstract: Objective: The aim of this study was to analyze the effect of co-exposures to physical and psychosocial factors (PSF) regarding the incidence of workplace injuries (WI) among care workers. Additional objective was to identify the work factors associated ...

Abstract	Objective: The aim of this study was to analyze the effect of co-exposures to physical and psychosocial factors (PSF) regarding the incidence of workplace injuries (WI) among care workers. Additional objective was to identify the work factors associated with the co-exposure combinations leading to the highest rates of WI. Methods: The study sample consisted of 4,418 care workers participating to the French Working Conditions Survey both in 2013 and 2016. WI were assessed during the 4-year follow-up by matching the databases of the National Health Insurance Funds' compensation system. We assessed exposure for physical factors and PSF using factorial analyses and hierarchical clustering. We implemented a Poisson regression model with the WI incidence as the outcome and the clusters as independent variables of interest. Logistic regression model allowed identifying the work factors that predicted co-exposure combinations with a WI rate > 40%. Results: WI were highly related to both physical and psychosocial exposures. With low exposure to one or the other, there was no increased risk of WI. Physical factors and PSF potentiated each other and their co-exposure significantly increased the risk of WI, with model predicted rates per 1,000 persons-year for those most exposed to physical risk of 14.6 [4.5-24.8] with low PSF and 38.0 [29.8-46.3] with high PSF. Work factors that predicted co-exposure combinations with a rate > 40 WI% were: working as nursing assistant or hospital services officer, lack of predictability and flexibility of schedules, overtime, controlled schedules, work-family imbalance and insufficient preventive measures. Conclusions: Our findings highlight the need to take into account psychosocial factors in addition of only considering physical factors when analyzing WI occurrence, as usually done. Prevention actions must be taken to reduce both physical and psychosocial exposure. These results provide keys points for the prevention of WI among care workers.
MeSH term(s)	Humans ; Workplace ; Health Personnel ; Surveys and Questionnaires ; Logistic Models ; Incidence
Language	English
Publishing date	2022-12-13
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2022.1055846
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Article ; Online: Relationship between night work and health-related quality of life: an analysis based on profiles and cumulative duration of exposure to night work among French workers in the CONSTANCES cohort.

Gédor, Maud / Bourgkard, Ève / Dziurla, Mathieu / Ribet, Céline / Goldberg, Marcel / Grzebyk, Michel / Hédelin, Guy / Boini, Stéphanie

International archives of occupational and environmental health

2024 Volume 97, Issue 4, Page(s) 377–386

Abstract: Objective: The aim of this study is to estimate the association between night work and health-related quality of life (HRQoL) among French workers. The association between cumulative duration of night work and HRQoL was also investigated.: Methods: ... ...

Abstract	Objective: The aim of this study is to estimate the association between night work and health-related quality of life (HRQoL) among French workers. The association between cumulative duration of night work and HRQoL was also investigated. Methods: Three career-long night work exposure groups were defined at inclusion in the CONSTANCES cohort: permanent night workers, rotating night workers and former night workers. Day workers with no experience of night work were the reference group. HRQoL was assessed using the Short Form Health Survey (SF-12), in particular the physical component summary (PCS) and mental component summary (MCS) scores, with a higher score indicating better HRQoL. Several linear regression models were built to test the association between night work exposure and HRQoL. The relationship between cumulative duration of night work and HRQoL scores was analyzed using generalised additive models. Results: The sample consisted of 10,372 participants. Former night workers had a significantly lower PCS score than day workers (β [95% CI]: - 1.09 [- 1.73; - 0.45], p = 0.001), whereas permanent night workers had a significantly higher MCS score (β [95% CI]: 1.19 [0.009; 2.36], p = 0.048). A significant decrease in PCS score from 5 to 20 years of cumulative night work was observed among former night workers. Conclusions: Former night workers had poorer physical HRQoL in contrast to permanent and rotating night workers who had similar or even better HRQoL than day workers, suggesting the well-known healthy worker survivor effect. Consequently, both current and former night workers require regular and specific follow-up focused on the physical components of their health.
MeSH term(s)	Humans ; Quality of Life ; Health Surveys ; Physical Examination ; Multivariate Analysis ; Survivors ; Surveys and Questionnaires
Language	English
Publishing date	2024-03-11
Publishing country	Germany
Document type	Journal Article
ZDB-ID	129038-1
ISSN	1432-1246 ; 0340-0131 ; 0367-9977
ISSN (online)	1432-1246
ISSN	0340-0131 ; 0367-9977
DOI	10.1007/s00420-024-02053-3
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Article ; Online: Effect of Joint Exposure to Psychosocial and Physical Work Factors on the Incidence of Workplace Injuries: Results From a Longitudinal Survey.

Colin, Régis / Wild, Pascal / Paris, Christophe / Boini, Stéphanie

Journal of occupational and environmental medicine

2021 Volume 63, Issue 11, Page(s) 921–930

Abstract: Objective: To analyze the interaction between physical and psychosocial work factors regarding the workplace injuries incidence among 6900 workers out of a longitudinal survey.: Methods: Based on responses to questionnaires, we obtained exposure ... ...

Abstract	Objective: To analyze the interaction between physical and psychosocial work factors regarding the workplace injuries incidence among 6900 workers out of a longitudinal survey. Methods: Based on responses to questionnaires, we obtained exposure groups respectively for physical factors and for psychosocial factors using hierarchical clustering. We performed multiple Poisson regression model with the workplace injuries incidence during 4 years of follow-up as the outcome and the clusters as the independent variables of interest. Results: High psychosocial exposure had a deleterious effect on workplace injuries incidence, which was no longer significant when adjusting for physical factors. The difference in model-based workplace injuries rates between high and low psychosocial exposures seemed to increase (non-significantly) with increasing physical exposure. Conclusions: The risk of workplace injuries was highest among workers with high physical exposures regardless of the psychosocial exposures.
MeSH term(s)	Humans ; Incidence ; Longitudinal Studies ; Occupational Exposure/adverse effects ; Risk Factors ; Surveys and Questionnaires ; Workplace/psychology
Language	English
Publishing date	2021-06-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1223932-x
ISSN	1536-5948 ; 1076-2752
ISSN (online)	1536-5948
ISSN	1076-2752
DOI	10.1097/JOM.0000000000002313
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Article ; Online: Do the work unit characteristics directly or indirectly affect psychological distress in female call-handlers?

Boini, Stéphanie / Chouaniere, Dominique / Wild, Pascal

International archives of occupational and environmental health

2021 Volume 94, Issue 4, Page(s) 707–721

Abstract: Purpose: This study aimed to test if work unit characteristics (WUCs) reported by call-center managers were directly related to the psychological distress reported by call-handlers or if these associations were mediated by the psychosocial working ... ...

Abstract	Purpose: This study aimed to test if work unit characteristics (WUCs) reported by call-center managers were directly related to the psychological distress reported by call-handlers or if these associations were mediated by the psychosocial working conditions (PWC). Methods: Managers of 105 call-centers were interviewed about their call-center's WUCs by occupational physicians. 2719 female call-handlers from these call-centers completed self-reported questionnaires to evaluate PWC (Karasek, Siegrist, and other specific workplace stressors) and psychological distress (GHQ12 score). A two-level analysis tested the relationships between the 14 WUCs and GHQ12 score, with and without adding PWC as confounders. Unchanged coefficients between WUCs and GHQ12 score were assumed to flag a direct association between WUCs and psychological distress. In the case of changed coefficients, the mediated proportion was estimated using multiple mixed models. Results: Five out of fourteen WUCs were related to GHQ12 score: outbound-call type, call-center size, number of activity parameters displayed on the screen, the existence of a fixed break, and the assigned role of the supervisor being the monitoring/supervision of call-handler activities. After adding PWC, the association remained statistically significant only for outbound calls. For the other WUCs, the proportion of mediation by stressor ranged from 56 to 66%. Mediation was mostly through job demand, lack of reward and ethical conflict dimensions. Conclusion: The main results were that (1) associations exist between the WUCs reported by managers and the psychological distress reported by call-handlers, and (2) that most of these associations are mediated by psychosocial working conditions.
MeSH term(s)	Adult ; Female ; France ; Humans ; Interviews as Topic ; Middle Aged ; Occupational Stress/psychology ; Organizational Culture ; Psychological Distress ; Risk Factors ; Workload/psychology ; Workplace/psychology ; Young Adult
Language	English
Publishing date	2021-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	129038-1
ISSN	1432-1246 ; 0340-0131 ; 0367-9977
ISSN (online)	1432-1246
ISSN	0340-0131 ; 0367-9977
DOI	10.1007/s00420-020-01614-6
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Article ; Online: Low Back Pain and Upper-Extremity Musculoskeletal Disorders in French Postal Workers Driving Light-Duty Vehicles for Mail and Parcel Delivery.

Radauceanu, Anca / Grzebyk, Michel / Boini, Stéphanie / Dziurla, Mathieu / Atain-Kouadio, Jean-Jacques / Aublet-Cuvelier, Agnès

International journal of environmental research and public health

2023 Volume 20, Issue 3

Abstract: Occupational driving of light-duty vehicles (LDVs) became increasingly important in parcel delivery faced with the explosive growth of e-commerce. Since musculoskeletal disorders (MSDs) represent the most reported driving-related health problem, we aimed ...

Abstract	Occupational driving of light-duty vehicles (LDVs) became increasingly important in parcel delivery faced with the explosive growth of e-commerce. Since musculoskeletal disorders (MSDs) represent the most reported driving-related health problem, we aimed to analyze the risk of low back pain (LBP) and upper-extremity musculoskeletal disorders (UEMSDs) associated with driving LDVs for parcel delivery. In 306 postal workers exposed to driving and 100 unexposed workers, information on occupational driving, physical/psychosocial constraints, and work organization were collected via a questionnaire. MSDs were assessed using the Nordic Questionnaire, 14 additional questions regarding LBP, and a standardized clinical examination for UEMSDs. Statistical modeling consisted of multivariable logistic regression for UEMSDs and the item response theory approach for LBP. UEMSDs were associated with the distance of rural rounds and inversely associated with urban/mixed delivery rounds. Handling heavy loads was associated with LBP, and high physical demands during delivery rounds were related to MSDs. Karasek dimensions and mobbing actions were associated with MSDs. Work recognition, driving training, using an automatic gearbox, and the utilization of additional staff during peak periods were inversely associated with MSDs. Our results suggest that the distance driven in rural settings and high physical demands were associated with MSDs, while some organizational factors could protect from MSDs.
MeSH term(s)	Humans ; Low Back Pain/epidemiology ; Low Back Pain/etiology ; Postal Service ; Occupational Diseases/epidemiology ; Occupational Diseases/psychology ; Risk Factors ; Musculoskeletal Diseases/epidemiology ; Musculoskeletal Diseases/psychology ; Surveys and Questionnaires ; Upper Extremity ; Prevalence
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2175195-X
ISSN	1660-4601 ; 1661-7827
ISSN (online)	1660-4601
ISSN	1661-7827
DOI	10.3390/ijerph20032509
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Article: Regulation of Antioxidant Enzyme Levels in Rat Brain.

Guggilla, Sandhyarani / Karthik, Middela / Shylendra, Boini

Advances in experimental medicine and biology

2022 Volume 1339, Page(s) 21–26

Abstract: The whole plant of Nasturtium microphyllum is used as traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants were subjected to acute toxicity and then screened for antiepileptic activity on maximal ...

Abstract	The whole plant of Nasturtium microphyllum is used as traditional Indian medicine to treat epilepsy. Previous studies have demonstrated that extracts of these plants were subjected to acute toxicity and then screened for antiepileptic activity on maximal electroshock (MES)- and pentylenetetrazole (PTZ)-induced seizure models in albino Wistar rats. The purpose of the present study is to investigate the effect of ethanolic (95%) extract of N. microphyllum (EENM) on antioxidant enzymes in rat brain after induction of seizures by MES and PTZ. Our aim of study was relationship between seizure activities and altered levels of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GP), glutathione reductase (GR), catalase, and lipid peroxidation on rat brain. Superoxide dismutase, glutathione peroxidase, glutathione reductase, and catalase were decreased in rat brain due to seizure, and it was restored significantly by administration of ethanol extract of N. microphyllum on treated rats. Similar dose-dependent results were obtained in PTZ model also, whereas EERS significantly decreased lipid peroxidation in both models. The anticonvulsant activity of EERS might have antioxidant properties and it delays the generation of free radical in MES- and PTZ-induced epilepsy.
MeSH term(s)	Animals ; Antioxidants/metabolism ; Brain/metabolism ; Catalase/metabolism ; Glutathione/metabolism ; Glutathione Peroxidase/metabolism ; Lipid Peroxidation ; Oxidative Stress ; Pentylenetetrazole ; Rats ; Rats, Wistar ; Superoxide Dismutase/metabolism
Chemical Substances	Antioxidants ; Catalase (EC 1.11.1.6) ; Glutathione Peroxidase (EC 1.11.1.9) ; Superoxide Dismutase (EC 1.15.1.1) ; Glutathione (GAN16C9B8O) ; Pentylenetetrazole (WM5Z385K7T)
Language	English
Publishing date	2022-01-13
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-78787-5_3
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