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Article ; Online: Understanding YTHDF2-mediated mRNA Degradation By m

Zhang, Ting-He / Jo, Sumin / Zhang, Michelle / Wang, Kai / Gao, Shou-Jiang / Huang, Yufei

ArXiv

2024

Abstract: N6-methyladenosine (m ...

Abstract	N6-methyladenosine (m
Language	English
Publishing date	2024-01-15
Publishing country	United States
Document type	Preprint
ISSN	2331-8422
ISSN (online)	2331-8422
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Asian Americans and Racial Justice in Medicine.

Ko, Michelle / Ngo, Victoria / Zhang, Angela Y / Mabeza, Russyan M / Hahn, Monica

The New England journal of medicine

2024 Volume 390, Issue 4, Page(s) 372–378

MeSH term(s)	Humans ; Asian ; Medicine ; Racial Groups ; Social Justice ; Antiracism
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMms2307748
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Ua VI Zs.34: Show issues

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Article ; Online: A multifaceted signal recorder of cellular experiences using Cas12a base-editing.

Zhang, Pengfei / Chan, Michelle M

Trends in biotechnology

2022 Volume 40, Issue 11, Page(s) 1279–1281

Abstract: Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating ... ...

Abstract	Technological advances have led to the emergence of lineage tracers, but signal recorders for mammalian systems have remained elusive. Kempton et al. have developed a Cas12a base-editing signal recorder capable of capturing diverse signals and operating in various experimental designs. The recorder enables new opportunities to chronicle cellular history.
MeSH term(s)	Animals ; CRISPR-Cas Systems ; Gene Editing ; Mammals
Language	English
Publishing date	2022-08-03
Publishing country	England
Document type	Journal Article
ZDB-ID	47474-5
ISSN	1879-3096 ; 0167-7799
ISSN (online)	1879-3096
ISSN	0167-7799
DOI	10.1016/j.tibtech.2022.07.009
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Zs.A 2750: Show issues

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Article ; Online: Virtual Crossmatch: By Any Other Name.

Locke, Arlene F / Hickey, Michelle / Valenzuela, Nicole M / Butler, Carrie / Sosa, Rebecca / Zheng, Ying / Gjertson, David / Reed, Elaine F / Zhang, Qiuheng

Transplantation

2023 Volume 107, Issue 10, Page(s) e274

Language	English
Publishing date	2023-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	208424-7
ISSN	1534-6080 ; 0041-1337
ISSN (online)	1534-6080
ISSN	0041-1337
DOI	10.1097/TP.0000000000004724
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Zs.A 488: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 509: Show issues

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Article: Designing user-centered decision support systems for climate disasters: What information do communities and rescue responders need during floods?

Hillin, Julia / Alizadeh, Bahareh / Li, Diya / Thompson, Courtney M / Meyer, Michelle A / Zhang, Zhe / Behzadan, Amir H

Journal of emergency management (Weston, Mass.)

2024 Volume 22, Issue 7, Page(s) 71–85

Abstract: Flooding events are the most common natural hazard globally, resulting in vast destruction and loss of life. An effective flood emergency response is necessary to lessen the negative impacts of flood disasters. However, disaster management and response ... ...

Abstract	Flooding events are the most common natural hazard globally, resulting in vast destruction and loss of life. An effective flood emergency response is necessary to lessen the negative impacts of flood disasters. However, disaster management and response efforts face a complex scenario. Simultaneously, regular citizens attempt to navigate the various sources of information being distributed and determine their best course of action. One thing is evident across all disaster scenarios: having accurate information and clear communication between citizens and rescue personnel is critical. This research aims to identify the diverse needs of two groups, rescue operators and citizens, during flood disaster events by investigating the sources and types of information they rely on and information that would improve their responses in the future. This information can improve the design and implementation of existing and future spatial decision support systems (SDSSs) during flooding events. This research identifies information characteristics crucial for rescue operators and everyday citizens' response and possible evacuation to flooding events by qualitatively coding survey responses from rescue responders and the public. The results show that including local input in SDSS development is crucial for improving higher-resolution flood risk quantification models. Doing so democratizes data collection and analysis, creates transparency and trust between people and governments, and leads to transformative solutions for the broader scientific community.
MeSH term(s)	Humans ; Floods ; Disasters ; Disaster Planning ; Communication ; Data Collection
Language	English
Publishing date	2024-04-04
Publishing country	United States
Document type	Journal Article
ZDB-ID	2799989-0
ISSN	1543-5865
ISSN	1543-5865
DOI	10.5055/jem.0741
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Article ; Online: Racial discrimination during middle age predicts higher serum phosphorylated tau and neurofilament light chain levels a decade later: A study of aging black Americans.

Simons, Ronald L / Ong, Mei Ling / Lei, Man-Kit / Beach, Steven R H / Zhang, Yue / Philibert, Robert / Mielke, Michelle M

Alzheimer's & dementia : the journal of the Alzheimer's Association

2024

Abstract: Introduction: Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans.: Methods: The present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to ... ...

Abstract	Introduction: Recent evidence suggests that exposure to the stress of racism may increase the risk of dementia for Black Americans. Methods: The present study used 17 years of data from a sample of 255 Black Americans to investigate the extent to which exposure to racial discrimination predicts subsequent changes in serum Alzheimer's Disease Research Center (ADRC) biomarkers: serum phosphorylated tau181(p-tau181), neurofilament light (NfL), and glial fibrillary acidic protein (GFAP). We hypothesized that racial discrimination assessed during middle age would predict increases in these serum biomarkers as the participants aged into their 60s. Results: Our findings indicate that exposure to various forms of racial discrimination during a person's 40s and early 50s predicts an 11-year increase in both serum p-tau181 and NfL. Racial discrimination was not associated with subsequent levels of GFAP. Discussion: These findings suggest that racial discrimination in midlife may contribute to increased AD pathology and neurodegeneration later in life. Highlights: A 17-year longitudinal study of Black Americans. Assessments of change in serum p-tau181, neurofilament light, and glial fibrillary acidic protein. Exposure to racial discrimination during middle age predicted increases in p-tau181 and neurofilament light. Education was positively related to both p-tau181 and exposure to racial discrimination.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2211627-8
ISSN	1552-5279 ; 1552-5260
ISSN (online)	1552-5279
ISSN	1552-5260
DOI	10.1002/alz.13751
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Zs.A 6316: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 540: Show issues

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Article ; Online: TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma.

Niese, Michelle L / Pajulas, Abigail L / Rostron, Cameron R / Cheung, Cherry C L / Krishnan, Maya S / Zhang, Jilu / Cannon, Anthony M / Kaplan, Mark H

Mucosal immunology

2024

Abstract: Multi-cytokine-producing Th9 cells secrete IL-9 and type 2 cytokines and mediate mouse and human allergic inflammation. However, the cytokines that promote a multi-cytokine secreting phenotype have not been defined. Tumor necrosis factor superfamily ... ...

Abstract	Multi-cytokine-producing Th9 cells secrete IL-9 and type 2 cytokines and mediate mouse and human allergic inflammation. However, the cytokines that promote a multi-cytokine secreting phenotype have not been defined. Tumor necrosis factor superfamily member TL1A signals through its receptor DR3 to increase IL-9. Here we demonstrate that TL1A increases expression of IL-9 and IL-13 co-expressing cells in murine Th9 cell cultures, inducing a multi-cytokine phenotype. Mechanistically, this is linked to histone modifications allowing for increased accessibility at the Il9 and Il13 loci. We further show that TL1A alters the transcription factor network underlying expression of IL-9 and IL-13 in Th9 cells and increases binding of transcription factors to Il9 and Il13 loci. TL1A-priming enhances the pathogenicity of Th9 cells in murine models of allergic airway disease through the increased expression of IL-9 and IL-13. Lastly, in both chronic and memory-recall models of allergic airway disease, blockade of TL1A signaling decreases the multi-cytokine Th9 cell population and attenuates the allergic phenotype. Taken together, these data demonstrate that TL1A promotes the development of multi-cytokine Th9 cells that drive allergic airway diseases and that targeting pathogenic T helper cell-promoting cytokines could be an effective approach for modifying disease.
Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2411370-0
ISSN	1935-3456 ; 1933-0219
ISSN (online)	1935-3456
ISSN	1933-0219
DOI	10.1016/j.mucimm.2024.03.006
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Zs.A 6796: Show issues

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Article ; Online: Association between positive blood culture and clinical outcomes among children treated for sepsis in the emergency department.

Clemens, Nancy / Wilson, Paria M / Lipshaw, Matthew J / Depinet, Holly / Zhang, Yin / Eckerle, Michelle

The American journal of emergency medicine

2023 Volume 76, Page(s) 13–17

Abstract: Objective: Among children treated for sepsis in a pediatric emergency department (ED), compare clinical features and outcomes between those with blood cultures positive versus negative for a bacterial pathogen.: Design: Single-center retrospective ... ...

Abstract	Objective: Among children treated for sepsis in a pediatric emergency department (ED), compare clinical features and outcomes between those with blood cultures positive versus negative for a bacterial pathogen. Design: Single-center retrospective cohort study. Setting: Pediatric emergency department (ED) at a quaternary pediatric care center. Patients: Children aged 0-18 years treated for sepsis defined by the Children's Hospital Association's Improving Pediatric Sepsis Outcomes (IPSO) definition. Interventions: None. Measurements and main results: We analyzed 1307 patients treated for sepsis during the study period, of which 117 (9.0%) had blood cultures positive for a bacterial pathogen. Of children with blood culture positive sepsis, 62 (53.0%) had organ dysfunction compared to 514 (43.2%) with culture negative sepsis (adjusted odds ratio 1.56, 95% confidence interval (CI) 1.04-2.34, adjusting for age, high risk medical conditions, and time to antibiotics). Children with blood culture positive sepsis had a larger base deficit, -4 vs -1 (p < 0.01), and higher procalcitonin, 3.84 vs 0.56 ng/mL (p < 0.01). Conclusions: Children meeting the IPSO Sepsis definition with blood culture positive for a bacterial pathogen have higher rates of organ dysfunction than those who are culture negative, although our 9% rate of blood culture positivity is lower than previously cited literature from the pediatric intensive care unit.
MeSH term(s)	Humans ; Child ; Blood Culture ; Multiple Organ Failure ; Retrospective Studies ; Sepsis/diagnosis ; Sepsis/therapy ; Emergency Service, Hospital
Language	English
Publishing date	2023-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	605890-5
ISSN	1532-8171 ; 0735-6757
ISSN (online)	1532-8171
ISSN	0735-6757
DOI	10.1016/j.ajem.2023.10.045
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Zs.A 2005: Show issues

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Article: Tracking Changes in Students' Online Self-Regulated Learning Behaviors and Achievement Goals Using Trace Clustering and Process Mining.

Taub, Michelle / Banzon, Allison M / Zhang, Tom / Chen, Zhongzhou

Frontiers in psychology

2022 Volume 13, Page(s) 813514

Abstract: Success in online and blended courses requires engaging in self-regulated learning (SRL), especially for challenging STEM disciplines, such as physics. This involves students planning how they will navigate course assignments and activities, setting ... ...

Abstract	Success in online and blended courses requires engaging in self-regulated learning (SRL), especially for challenging STEM disciplines, such as physics. This involves students planning how they will navigate course assignments and activities, setting goals for completion, monitoring their progress and content understanding, and reflecting on how they completed each assignment. Based on Winne & Hadwin's COPES model, SRL is a series of events that temporally unfold during learning, impacted by changing internal and external factors, such as goal orientation and content difficulty. Thus, as goal orientation and content difficulty change throughout a course, so might students' use of SRL processes. This paper studies how students' SRL behavior and achievement goal orientation change over time in a large (
Language	English
Publishing date	2022-03-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2022.813514
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Article ; Online: The Association of Class I and II Human Leukocyte Antigen Serotypes With End-Stage Kidney Disease Due to Membranoproliferative Glomerulonephritis and Dense Deposit Disease.

Afolabi, Halimat / Zhang, Bing M / O'Shaughnessy, Michelle / Chertow, Glenn M / Lafayette, Richard / Charu, Vivek

American journal of kidney diseases : the official journal of the National Kidney Foundation

2023 Volume 83, Issue 1, Page(s) 79–89

Abstract: Rationale & objective: Membranoproliferative glomerulonephritis (MPGN), encompassing several distinct diseases, is a rare but significant cause of kidney failure in the United States. The potential etiologies of MPGN are unclear, but prior studies have ... ...

Abstract	Rationale & objective: Membranoproliferative glomerulonephritis (MPGN), encompassing several distinct diseases, is a rare but significant cause of kidney failure in the United States. The potential etiologies of MPGN are unclear, but prior studies have suggested dysregulation of the alternative complement pathway and, recently, autoimmunity as potential mechanisms driving MPGN pathogenesis. In this study, we examined HLA associations with end-stage kidney disease (ESKD) due to MPGN and dense deposit disease (DDD) in a large racially and ethnically diverse US-based cohort. Study design: Case-control study. Setting & participants: Using US Renal Data System (USRDS) and United Network for Organ Sharing (UNOS) data, we identified 3,424 patients with kidney failure due to MPGN and 263 due to DDD. We matched patients to kidney donor controls on designated race and ethnicity in a 1:15 ratio. Exposure: 58 class I and II HLA serotypes. Outcome: Case-control status. Analytical approach: For each disease cohort, univariable and multivariable logistic regression analyses were used to investigate associations between the disease and 58 HLA serotypes. In subgroup analyses, we investigated HLA associations in White and Black patients. We also studied antiglomerular basement membrane (anti-GBM) nephritis as a positive-control outcome. We applied a Bonferroni correction to account for multiple comparisons. Results: Eighteen serotypes were significantly associated with the odds of having MPGN in univariable analyses, with DR17 having the strongest association (odds ratio [OR], 1.55 [95% CI, 1.44-1.68], P=4.33e Limitations: Reliance on HLA serotypes (rather than genotype), lack of biopsy-confirmed diagnoses. Conclusions: HLA-DR17 is associated with ESKD due to MPGN in a racially and ethnically diverse cohort. The strength of association was similar in White and Black patients, suggesting a role in the pathogenesis of MPGN. No HLA associations were observed in patients with DDD. Plain-language summary: Prior studies have suggested dysregulation of the alternative complement pathway as a potential etiology of membranoproliferative glomerulonephritis (MPGN), but recent evidence from a British White population has implicated an autoimmune mechanism in MPGN pathogenesis. We investigated HLA associations between MPGN and dense deposit disease (DDD) in a large racially and ethnically diverse cohort of patients. We found that HLA-DR17 is associated with end-stage kidney disease (ESKD) due to MPGN in both White and Black patients. By contrast, no significant HLA associations with ESKD due to DDD were identified. These results suggest a role for autoimmunity in some cases of MPGN and highlight differences in the disease etiology of MPGN compared with DDD.
MeSH term(s)	Humans ; Glomerulonephritis, Membranoproliferative ; Serogroup ; Case-Control Studies ; Kidney Failure, Chronic/etiology ; HLA Antigens
Chemical Substances	HLA Antigens
Language	English
Publishing date	2023-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	604539-x
ISSN	1523-6838 ; 0272-6386
ISSN (online)	1523-6838
ISSN	0272-6386
DOI	10.1053/j.ajkd.2023.06.005
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Zs.MO 468: Show issues

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