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Article ; Online: Close-Up Look at Electronic Spectroscopic Signatures of Common Pharmaceuticals in Solution.

Gómez, Sara / Ambrosetti, Matteo / Giovannini, Tommaso / Cappelli, Chiara

The journal of physical chemistry. B

2024 Volume 128, Issue 10, Page(s) 2432–2446

Abstract: Simulating electronic properties and spectral signals requires robust computational approaches that need tuning with the system's peculiarities. In this paper, we test implicit and fully atomistic solvation models for the calculation of UV-vis and ... ...

Abstract	Simulating electronic properties and spectral signals requires robust computational approaches that need tuning with the system's peculiarities. In this paper, we test implicit and fully atomistic solvation models for the calculation of UV-vis and electronic circular dichroism (ECD) spectra of two pharmaceutically relevant molecules, namely, (2
MeSH term(s)	Solvents/chemistry ; Water/chemistry ; Solutions ; Molecular Dynamics Simulation ; Circular Dichroism
Chemical Substances	Solvents ; Water (059QF0KO0R) ; Solutions
Language	English
Publishing date	2024-02-28
Publishing country	United States
Document type	Journal Article
ISSN	1520-5207
ISSN (online)	1520-5207
DOI	10.1021/acs.jpcb.3c07795
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Article ; Online: Le nuove normative avvicinano o allontanano ancora di più la riabilitazione cardiovascolare dal mondo cardiologico?

Ambrosetti, Marco / Morici, Nuccia / Riccio, Carmine / Oliva, Fabrizio

Giornale italiano di cardiologia (2006)

2024 Volume 25, Issue 3, Page(s) 146–147

Title translation	New policies and laws for cardiac rehabilitation in Italy: time to reaffirm the unity of cardiology?
MeSH term(s)	Humans ; Cardiac Rehabilitation ; Cardiology ; Italy ; Cardiovascular System ; Policy
Language	Italian
Publishing date	2024-02-23
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2272414-X
ISSN	1972-6481 ; 1827-6806
ISSN (online)	1972-6481
ISSN	1827-6806
DOI	10.1714/4209.41998
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Article ; Online: Onychocytic Matricoma: A Clinical, Dermoscopic, and Pathological Analysis of 14 Cases.

Perrin, Christophe / Coutts, Michael / Boukari, Feriel / Ambrosetti, Damien

The American Journal of dermatopathology

2024 Volume 46, Issue 5, Page(s) 259–270

Abstract: Abstract: Onychocytic matricoma (OCM) is a benign neoplasm of the nail matrix. Only 18 cases of this tumor have been reported in the literature to date. We retrospectively analyzed the clinical features of 14 patients with OCM. The most common clinical ... ...

Abstract	Abstract: Onychocytic matricoma (OCM) is a benign neoplasm of the nail matrix. Only 18 cases of this tumor have been reported in the literature to date. We retrospectively analyzed the clinical features of 14 patients with OCM. The most common clinical feature was longitudinal xanthopachyonychia (n = 9), followed by longitudinal leukopachyonychia (=3) and longitudinal pachymelanonychia (n = 2). The most common clinical findings identified following dermoscopy and analysis at high magnification of classical photographs were free-edge thickening of the nail plate without pitting (n = 14), longitudinal ridging (n = 7), round white clods (n = 7), white dots (n = 7), and filiform hemorrhages (n = 7), followed by oval and linear white clods (n = 5), fuzzy lateral border (n = 5), and red-purple blood clods (n = 3). Nail clipping histopathology showed a thickened nail plate with multiple, small, round-to-oval spaces. The tumor expressed immunopositivity for LEF-1. Dermoscopy of the nail plate and nail clipping histology provides useful information with regards to the differential diagnosis with subungual squamous cell carcinoma and nail melanoma. Ex vivo-in vivo correlation facilitates a better dermoscopic assessment of this unique underrecognized disease. However, the differential diagnosis between OCM and onychocytic carcinoma requires biopsy of the tumor. LEF-1 as an onychogenic marker can be used to resolve the differential diagnosis between OCM and subungual longitudinal acanthoma/seborrheic keratosis.
MeSH term(s)	Humans ; Skin Neoplasms/pathology ; Retrospective Studies ; Nail Diseases/diagnosis ; Nail Diseases/pathology ; Acanthoma/pathology ; Nails, Malformed/pathology ; Carcinoma, Squamous Cell/diagnosis ; Diagnosis, Differential ; Dermoscopy
Language	English
Publishing date	2024-03-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	448469-1
ISSN	1533-0311 ; 0193-1091
ISSN (online)	1533-0311
ISSN	0193-1091
DOI	10.1097/DAD.0000000000002674
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Zs.A 1518: Show issues

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Article ; Online: Tinea corporis with misleading clinical and histologic features of lymphomatoid papulosis.

Perrin, Christophe / Toni, Giorgio / Coutts, Michael / Ambrosetti, Damien

Histopathology

2022 Volume 81, Issue 5, Page(s) 680–682

MeSH term(s)	Hodgkin Disease/pathology ; Humans ; Lymphomatoid Papulosis/diagnosis ; Lymphomatoid Papulosis/pathology ; Mycosis Fungoides/pathology ; Skin Neoplasms/diagnosis ; Skin Neoplasms/pathology ; Tinea/diagnosis
Language	English
Publishing date	2022-07-18
Publishing country	England
Document type	Letter
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14723
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Zs.A 1328: Show issues

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Article: Skewed Sex Ratios at Birth in Italian Migrant Populations: Evidence from a Longitudinal Register 1999-2017.

Ambrosetti, Elena / Ortensi, Livia Elisa / Castagnaro, Cinzia / Attili, Marina

European journal of population = Revue europeenne de demographie

2022 Volume 38, Issue 2, Page(s) 301–315

Abstract: Many studies in different settings have suggested that migrants from countries with skewed sex ratios at birth tend to adjust the sex of their offspring to ensure the birth of at least one male child. Enlarging the scope of existing research, the present ...

Abstract	Many studies in different settings have suggested that migrants from countries with skewed sex ratios at birth tend to adjust the sex of their offspring to ensure the birth of at least one male child. Enlarging the scope of existing research, the present study explores the phenomenon by studying the sex ratio at birth and sex selection at birth among migrants in Italy, focussing on birth order and the sex of the previous child. We perform a descriptive analysis of SRB by birth order (first, second and third), sex of the previous children, inter-birth interval and citizenship of the child. We analyse data from the Longitudinal register on reproductive histories from 1999 to 2017 (ISTAT). Results show significantly higher values of SRB for third births among Indian and Chinese communities when the first and second births are girls. A skewed SRB is also present among Indian babies born after a female firstborn. A more detailed analysis of SRBs for immigrants from China and India, by the sex of the previous children and inter-birth interval between second and third birth, did not indicate significant changes in SRB when the inter-birth interval is longer. Our study provides evidence for policymaking. However, further research is needed to address the causes of sex selection among immigrant communities. Efforts to alter gender norms and reduce son preference within communities are required to tackle gender discrimination against second-generation girls.
Language	English
Publishing date	2022-03-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2015429-X
ISSN	1572-9885 ; 0168-6577
ISSN (online)	1572-9885
ISSN	0168-6577
DOI	10.1007/s10680-022-09612-9
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Article ; Online: Quantum Mechanics/Fluctuating Charge Protocol to Compute Solvatochromic Shifts.

Ambrosetti, Matteo / Skoko, Sulejman / Giovannini, Tommaso / Cappelli, Chiara

Journal of chemical theory and computation

2021 Volume 17, Issue 11, Page(s) 7146–7156

Abstract: Despite the potentialities of the quantum mechanics (QM)/fluctuating charge (FQ) approach to model the spectral properties of solvated systems, its extensive use has been hampered by the lack of reliable parametrizations of solvents other than water. In ... ...

Abstract	Despite the potentialities of the quantum mechanics (QM)/fluctuating charge (FQ) approach to model the spectral properties of solvated systems, its extensive use has been hampered by the lack of reliable parametrizations of solvents other than water. In this paper, we substantially extend the applicability of QM/FQ to solvating environments of different polarities and hydrogen-bonding capabilities. The reliability and robustness of the approach are demonstrated by challenging the model to simulate solvatochromic shifts of four organic chromophores, which display large shifts when dissolved in apolar, aprotic or polar, protic solvents.
Language	English
Publishing date	2021-10-07
Publishing country	United States
Document type	Journal Article
ISSN	1549-9626
ISSN (online)	1549-9626
DOI	10.1021/acs.jctc.1c00763
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Article ; Online: Onychomatricoma: a clinicopathological, immunohistochemical, and molecular study of 10 cases highlighting recurrent RB1 deletion and the potential diagnostic value of LEF-1.

Perrin, Christophe / Pedeutour, Florence / Coutts, Michael / Ambrosetti, Damien / Dadone-Montaudié, Bérengère

Histopathology

2023 Volume 82, Issue 5, Page(s) 767–778

Abstract: Aims: Onychomatricoma (OM), an uncommon benign fibroepithelial neoplasm of the nail unit, is sometimes diagnostically challenging for clinicians and pathologists. OM consistently expresses CD34, but no specific immunohistohemical markers or recurrent ... ...

Abstract	Aims: Onychomatricoma (OM), an uncommon benign fibroepithelial neoplasm of the nail unit, is sometimes diagnostically challenging for clinicians and pathologists. OM consistently expresses CD34, but no specific immunohistohemical markers or recurrent genetic alterations have been identified to date. Recent studies have suggested that Wnt signalling is a key molecular characteristic of OM. Methods and results: Ten cases were analysed: four classical OM including two with pleomorphic cells; two superficial acral fibromyxoma-like variants of OM; three micropapilliferum variants of OM including one with pleomorphic cells; and one proliferating variant of OM. Immunohistochemically, the spindle cells were positive with CD34 (n = 10) and CD99 (n = 1), with focal reactivity for CD10 (n = 5). The epithelial component of the tumours expressed immunopositivity for LEF-1. Using array comparative genomic hybridization (aCGH), we demonstrated that all OM, including its variants that were tested (n = 8), harboured a few copy number alterations with losses of whole or part of chromosome 13 including the RB1 gene (n = 8) and chromosome 16 (n = 6). Conclusion: We report a recurrent loss of RB1 (13q) as a possible driver molecular event in OM indicating a relationship between OM and other lesions of the spectrum of the so-called '13q/RB1' family of tumours. We did not identify a role for the Wnt/beta-catenin signalling pathway, as has been proposed in a recent study. LEF-1 could be a potential sensitive and specific marker of OM and should be used in the differential diagnosis between OM, superficial acral fibromyxoma, and the CD34-positive fibrosing family of tumours.
MeSH term(s)	Humans ; Antigens, CD34/metabolism ; Biomarkers, Tumor/metabolism ; Cell Adhesion Molecules/metabolism ; Comparative Genomic Hybridization ; Fibroma/pathology ; Nail Diseases/pathology ; Retinoblastoma Binding Proteins/metabolism ; Skin Neoplasms/pathology ; Ubiquitin-Protein Ligases/metabolism
Chemical Substances	Antigens, CD34 ; Biomarkers, Tumor ; Cell Adhesion Molecules ; RB1 protein, human ; Retinoblastoma Binding Proteins ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; LEF1 protein, human
Language	English
Publishing date	2023-01-24
Publishing country	England
Document type	Journal Article
ZDB-ID	131914-0
ISSN	1365-2559 ; 0309-0167
ISSN (online)	1365-2559
ISSN	0309-0167
DOI	10.1111/his.14864
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Zs.A 1328: Show issues

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Article ; Online: Simulating Absorption Spectra of Flavonoids in Aqueous Solution: A Polarizable QM/MM Study.

Skoko, Sulejman / Ambrosetti, Matteo / Giovannini, Tommaso / Cappelli, Chiara

Molecules (Basel, Switzerland)

2020 Volume 25, Issue 24

Abstract: We present a detailed computational study of the UV/Vis spectra of four relevant flavonoids in aqueous solution, namely luteolin, kaempferol, quercetin, and myricetin. The absorption spectra are simulated by exploiting a fully polarizable quantum ... ...

Abstract	We present a detailed computational study of the UV/Vis spectra of four relevant flavonoids in aqueous solution, namely luteolin, kaempferol, quercetin, and myricetin. The absorption spectra are simulated by exploiting a fully polarizable quantum mechanical (QM)/molecular mechanics (MM) model, based on the fluctuating charge (FQ) force field. Such a model is coupled with configurational sampling obtained by performing classical molecular dynamics (MD) simulations. The calculated QM/FQ spectra are compared with the experiments. We show that an accurate reproduction of the UV/Vis spectra of the selected flavonoids can be obtained by appropriately taking into account the role of configurational sampling, polarization, and hydrogen bonding interactions.
MeSH term(s)	Computer Simulation ; Flavonoids/chemistry ; Hydrogen Bonding ; Molecular Conformation ; Molecular Dynamics Simulation ; Normal Distribution ; Physical Phenomena ; Quantum Theory ; Spectrophotometry, Ultraviolet ; Static Electricity ; Ultraviolet Rays ; Water/chemistry
Chemical Substances	Flavonoids ; Water (059QF0KO0R) ; myricetin (76XC01FTOJ)
Language	English
Publishing date	2020-12-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules25245853
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Article ; Online: Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss.

Chiereghin, Chiara / Robusto, Michela / Massa, Valentina / Castorina, Pierangela / Ambrosetti, Umberto / Asselta, Rosanna / Soldà, Giulia

Cells

2022 Volume 11, Issue 11

Abstract: Hearing relies on the proper functioning of auditory hair cells and on actin-based cytoskeletal structures. Diaphanous-related formins (DRFs) are evolutionarily conserved cytoskeletal proteins that regulate the nucleation of linear unbranched actin ... ...

Abstract	Hearing relies on the proper functioning of auditory hair cells and on actin-based cytoskeletal structures. Diaphanous-related formins (DRFs) are evolutionarily conserved cytoskeletal proteins that regulate the nucleation of linear unbranched actin filaments. They play key roles during metazoan development, and they seem particularly pivotal for the correct physiology of the reproductive and auditory systems. Indeed, in
MeSH term(s)	Adaptor Proteins, Signal Transducing/metabolism ; Animals ; Deafness/genetics ; Drosophila Proteins/metabolism ; Drosophila melanogaster/metabolism ; Formins ; Hearing Loss/genetics
Chemical Substances	Adaptor Proteins, Signal Transducing ; Drosophila Proteins ; Formins ; diaphanous protein, Drosophila
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	2661518-6
ISSN	2073-4409 ; 2073-4409
ISSN (online)	2073-4409
ISSN	2073-4409
DOI	10.3390/cells11111726
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Article ; Online: Gas Humidification During Helmet Continuous Positive Airway Pressure: A Crossover Randomized Physiologic Study in Healthy Subjects.

Ambrosetti, Lorenzo / Giani, Marco / Rezoagli, Emanuele / Fiorillo, Chiara / Vitale, Daniela / Giacchè, Damiano / Ravasio, Giambattista / Fumagalli, Roberto / Foti, Giuseppe / Lucchini, Alberto

Dimensions of critical care nursing : DCCN

2023 Volume 43, Issue 1, Page(s) 21–27

Abstract: Background: In the last decades, the use of the helmet interface to deliver noninvasive respiratory support has steadily increased. When delivering oxygen therapy, conditioning of inspired gas is mandatory, as the water content of medical gas is ... ...

Abstract	Background: In the last decades, the use of the helmet interface to deliver noninvasive respiratory support has steadily increased. When delivering oxygen therapy, conditioning of inspired gas is mandatory, as the water content of medical gas is neglectable. To minimize the risk of airway damage, it is recommended to achieve an absolute humidity greater than 10 mg H2O/L. The primary aim of the study was to assess the performance of 3 different heated humidifiers to condition gas during helmet continuous positive airway pressure and to compare them with a setting without active humidification. Methods: We performed a crossover randomized physiological study in healthy volunteers. Absolute humidity, relative humidity, and temperature were measured during 4 steps (no humidification and the 3 heated humidifiers, performed in a randomized order) and at 3 time points (after 1, 5, and 10 minutes). Results: Eight subjects participated to the study. Without active humidification, absolute humidity was constantly below the recommended level. All humidifiers conditioned the inspired gases to an average absolute humidity greater than 10 mg H2O/L. Overall, the best performance, in terms of absolute humidity, was obtained with H900 (19.74 ± 0.50 mg H2O/L), followed by TurbH2O (-6.82 mg H2O/L vs H900; 95% confidence interval, -8.49 to -5.14; P < .05) and F&P 810 (-9.03 mg H2O/L vs H900; 95% confidence interval, -10.70 to -7.35; P < .05). Conclusions: Active humidification is required to achieve adequate conditioning of inspired gas during helmet continuous positive airway pressure. The choice between different humidifiers available on the market should be made according to the local needs and expertise.
MeSH term(s)	Humans ; Continuous Positive Airway Pressure ; Healthy Volunteers ; Humidity ; Hot Temperature ; Oxygen Inhalation Therapy
Language	English
Publishing date	2023-12-07
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	632780-1
ISSN	1538-8646 ; 0730-4625
ISSN (online)	1538-8646
ISSN	0730-4625
DOI	10.1097/DCC.0000000000000616
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