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Book ; Online: D-Nikud

Rosenthal, Adi / Shaked, Nadav

Enhancing Hebrew Diacritization with LSTM and Pretrained Models

2024

Abstract: D-Nikud, a novel approach to Hebrew diacritization that integrates the strengths of LSTM networks ...

Abstract	D-Nikud, a novel approach to Hebrew diacritization that integrates the strengths of LSTM networks and BERT-based (transformer) pre-trained model. Inspired by the methodologies employed in Nakdimon, we integrate it with the TavBERT pre-trained model, our system incorporates advanced architectural choices and diverse training data. Our experiments showcase state-of-the-art results on several benchmark datasets, with a particular emphasis on modern texts and more specified diacritization like gender.
Keywords	Computer Science - Computation and Language
Publishing date	2024-01-30
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-term outcomes of modern multidisciplinary management of sinonasal cancers: The M. D. Anderson experience.

Bahig, Houda / Ehab, Hanna Y / Garden, Adam S / Ng, Sweet Ping / Frank, Steven J / Nguyen, Theresa / Gunn, Gary B / Rosenthal, David I / Fuller, Clifton D / Ferrarotto, Renata / Bell, Diana / Su, Shirley / Phan, Jack

Head & neck

2023 Volume 45, Issue 7, Page(s) 1692–1703

Abstract: Purpose: To report long-term outcomes of modern radiotherapy for sinonasal cancers.: Methods and materials: A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate ... ...

Abstract	Purpose: To report long-term outcomes of modern radiotherapy for sinonasal cancers. Methods and materials: A retrospective analysis of patients with sinonasal tumors treated with intensity-modulated radiotherapy or proton therapy. Multivariate analysis was used to determine predictive variables of progression free survival (PFS) and overall survival (OS). Results: Three hundred and eleven patients were included, with median follow-up of 75 months. The most common histologies were squamous cell (42%), adenoid cystic (15%), and sinonasal undifferentiated carcinoma (15%). Induction chemotherapy was administered to 47% of patients; 68% had adjuvant radiotherapy. Ten-year local control, regional control, distant metastasis free survival, PFS, and overall survival rates were 73%, 88%, 47%, 32%, and 51%, respectively. Age, non-nasal cavity tumor site, T3-4 stage, neck dissection, and radiation dose were predictive of PFS, while age, non-nasal cavity tumor site, T3-4 stage, positive margins, neck dissection, and use of neoadjuvant chemotherapy were predictive of OS. There was a 13% rate of late grade ≥3 toxicities. Conclusion: This cohort of patients with sinonasal cancer treated with modern radiotherapy demonstrates favorable disease control rate and acceptable toxicity profile.
MeSH term(s)	Humans ; Retrospective Studies ; Disease-Free Survival ; Paranasal Sinus Neoplasms/pathology ; Nose Neoplasms/pathology ; Maxillary Sinus Neoplasms/pathology ; Radiotherapy, Intensity-Modulated/methods
Language	English
Publishing date	2023-05-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	645165-2
ISSN	1097-0347 ; 0148-6403 ; 1043-3074
ISSN (online)	1097-0347
ISSN	0148-6403 ; 1043-3074
DOI	10.1002/hed.27381
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Article ; Online: Translation and validation of the multiple sclerosis walking scale 12 for the German population - the MSWS-12/D.

Chorschew, Anna / Kesgin, Firat / Bellmann-Strobl, Judith / Flachenecker, Peter / Schiffmann, Insa / Rosenthal, Friederike / Althoff, Patrick / Drebinger, Daniel / Arsenova, Radina / Rasche, Ludwig / Dorsch, Eva-Maria / Heesen, Christoph / Paul, Friedemann / Stellmann, Jan-Patrick / Schmitz-Hübsch, Tanja

Health and quality of life outcomes

2023 Volume 21, Issue 1, Page(s) 110

Abstract: ... into German language (MSWS-12/D) and to evaluate its psychometric properties.: Methods: The MSWS-12 was ... scored EDSS of 0. In this sample, MSWS-12/D showed floor effects (36% with score 0) and for internal ... consistency, a Cronbach's alpha of 0.98 was calculated. MSWS-12/D score showed a relevant correlation to EDSS ...

Abstract	Background: Gait impairment is a relevant problem in persons with multiple sclerosis (pwMS). The Multiple Sclerosis Walking Scale 12 (MSWS-12) is a valid Patient Reported Outcome Measure (PROM) to evaluate walking ability in pwMS. The aim of this study was to provide a linguistically valid translation of MSWS-12 into German language (MSWS-12/D) and to evaluate its psychometric properties. Methods: The MSWS-12 was translated in a process modified from guidelines for the cross-cultural adaption of PROMs, and a pre-test was applied in a small sample of 20 pwMS to evaluate comprehensibility and acceptance. Psychometric properties (floor and ceiling effects, internal consistency, construct validity) were then assessed in 124 pwMS seen at academic MS centers. Construct validity was evaluated against Expanded Disability Status Scale (EDSS) and maximum gait speed in the Timed 25-Foot Walk (T25FW). Results: Although the sample covered a wide spectrum of symptom severity, the majority had rather low levels of disability (EDSS median 2.0) and 6.5% scored EDSS of 0. In this sample, MSWS-12/D showed floor effects (36% with score 0) and for internal consistency, a Cronbach's alpha of 0.98 was calculated. MSWS-12/D score showed a relevant correlation to EDSS (ρ = 0.73) and T25FW speed (r=-0.72). Conclusion: We provide MSWS-12/D as a linguistically valid German version of MSWS-12. Psychometric properties (acceptance, floor and ceiling effects, internal consistency and construct validity) in pwMS were similar to those described for the original version. This indicates that MSWS-12/D can be applied as equivalent to the original version in German speaking pwMS. Results support the relevance of PROMs to capture patient perception of walking ability in addition to performance-based assessments such as maximum walking speed or maximum walking distance.
MeSH term(s)	Humans ; Multiple Sclerosis ; Disability Evaluation ; Quality of Life ; Walking ; Language ; Reproducibility of Results
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Journal Article
ZDB-ID	2098765-1
ISSN	1477-7525 ; 1477-7525
ISSN (online)	1477-7525
ISSN	1477-7525
DOI	10.1186/s12955-023-02190-2
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Article ; Online: Investigation of Vitamin D

Schmitz, Lisa Marie / Kinner, Alina / Althoff, Kirsten / Rosenthal, Katrin / Lütz, Stephan

Chembiochem : a European journal of chemical biology

2021 Volume 22, Issue 13, Page(s) 2266–2274

Abstract: The active vitamin D metabolites 25-OH-D and 1α,25-(OH) ...

Abstract	The active vitamin D metabolites 25-OH-D and 1α,25-(OH)
MeSH term(s)	Actinobacteria/metabolism ; Cholecalciferol/chemistry ; Cholecalciferol/metabolism ; Ergocalciferols/chemistry ; Ergocalciferols/metabolism ; Hydroxylation ; Molecular Structure
Chemical Substances	Ergocalciferols ; Cholecalciferol (1C6V77QF41)
Language	English
Publishing date	2021-05-04
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2020469-3
ISSN	1439-7633 ; 1439-4227
ISSN (online)	1439-7633
ISSN	1439-4227
DOI	10.1002/cbic.202100027
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Article ; Online: Absolute calibration of the Lyman-α measurement apparatus at DIII-D.

Laggner, F M / Bortolon, A / Rosenthal, A M / Wilks, T M / Hughes, J W / Freeman, C / Golfinopoulos, T / Nagy, A / Mauzey, D / Shafer, M W

The Review of scientific instruments

2021 Volume 92, Issue 3, Page(s) 33522

Abstract: The LLAMA (Lyman-Alpha Measurement Apparatus) diagnostic was recently installed on the DIII-D ... within their uncertainties. A first conversion of the measured signal obtained from DIII-D indicates that the Ly-α brightness ... tokamak [Rosenthal et al., Rev. Sci. Instrum. (submitted) (2020)]. LLAMA is a pinhole camera system ...

Abstract	The LLAMA (Lyman-Alpha Measurement Apparatus) diagnostic was recently installed on the DIII-D tokamak [Rosenthal et al., Rev. Sci. Instrum. (submitted) (2020)]. LLAMA is a pinhole camera system with a narrow band Bragg mirror, a bandpass interference filter, and an absolute extreme ultraviolet photodiode detector array, which measures the Ly-α brightness in the toroidal direction on the inboard, high field side (HFS) and outboard, low field side (LFS). This contribution presents a setup and a procedure for an absolute calibration near the Ly-α line at 121.6 nm. The LLAMA in-vacuum components are designed as a compact, transferable setup that can be mounted in an ex situ vacuum enclosure that is equipped with an absolutely calibrated Ly-α source. The spectral purity and stability of the Ly-α source are characterized using a vacuum ultraviolet spectrometer, while the Ly-α source brightness is measured by a NIST-calibrated photodiode. The non-uniform nature of the Ly-α source emission was overcome by performing a calibration procedure that scans the Ly-α source position and employs a numerical optimization to determine the emission pattern. Nominal and measured calibration factors are determined and compared, showing agreement within their uncertainties. A first conversion of the measured signal obtained from DIII-D indicates that the Ly-α brightness on the HFS and LFS is on the order of 10
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0038134
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Article ; Online: Bertram E. Bromberg, D.D.S., M.D. 1918 to 2014.

Rosenthal, Samuel G / Brewer, Bruce W

Plastic and reconstructive surgery

2014 Volume 135, Issue 3, Page(s) 935–936

MeSH term(s)	History, 20th Century ; History, 21st Century ; Humans ; Leadership ; Reconstructive Surgical Procedures/history ; Societies, Medical/history ; Surgery, Plastic/history ; United States
Language	English
Publishing date	2014-11-21
Publishing country	United States
Document type	Biography ; Historical Article ; Portrait
ZDB-ID	208012-6
ISSN	1529-4242 ; 0032-1052 ; 0096-8501
ISSN (online)	1529-4242
ISSN	0032-1052 ; 0096-8501
DOI	10.1097/prs.0000000000001066
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Uk I Zs.142: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 293: Show issues

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Article ; Online: Completely epicardial implantable cardioverter/defibrillator (ICD) and CRT-D systems: A case series and systematic literature review.

Tonko, Johanna B / Blauth, Christopher / Rosenthal, Eric / Rinaldi, Christopher A

Pacing and clinical electrophysiology : PACE

2021 Volume 44, Issue 9, Page(s) 1616–1630

Abstract: ... defibrillation coils for ICD/CRT-D is a feasible treatment option for patients with either failed or ...

Abstract	Background: Epicardial ICD systems and CRT-Ds using high voltage coils represent an alternative to transvenous systems in patients without central venous access and prior device complications including infection. Objective: We present a case series in the adult population of epicardial ICD/CRTD systems using high voltage epicardial coils. We summarize the existing data regarding techniques, efficacy, and safety. Methods: A retrospective board approved medical record review was conducted for all patients undergoing epicardial ICD/CRTD placement at our institution between January 2010 and May 2020. The literature was reviewed for prior published trials, case reports, and case series of epicardial high voltage coil insertions. Results: Eleven patients (six female, mean age 48 years) underwent epicardial ICD/CRTD implant including 5/11 completely epicardial CRTD systems. The procedure was performed via median sternotomy in eight patients, left anterior thoracotomy in two patients, and sub-xiphoid approach in one patient. After a mean follow up of 35 months, appropriate successful shocks were delivered in two (18%) patients and no patients received an inappropriate shock. Three of five (60%) patients had volumetric remodeling with CRT with significant improvement of LV EF. Device-related complications requiring a surgical/percutaneous revision or another DFT test occurred in six patients (54%). One patient died during follow up due to refractory heart failure. No cases of epicardial device infection, coronary artery compression, constrictive pericarditis, or erosion of defibrillator coils into intrathoracic organs were reported. No randomized studies comparing safety and efficacy of traditional transvenous or subcutaneous ICD systems and epicardial ICD systems using contemporary high voltage coils were found nor any studies directly comparing epicardial defibrillator patches versus epicardial coils. Thirteen case series and 24 single case reports published between 2004 and 2020 were identified describing in total a heterogenous group of 188 patients with ICD systems incorporating one or more epi- or pericardially positioned shock coils. Conclusion: The use of epicardial defibrillation coils for ICD/CRT-D is a feasible treatment option for patients with either failed or contraindicated transvenous ICD systems. Dedicated epicardial high voltage leads with integrated pace-sense electrodes and specialized delivery tools for minimal invasive implantations may improve longer term outcomes.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cardiac Resynchronization Therapy Devices ; Defibrillators, Implantable ; Female ; Humans ; Male ; Middle Aged ; Pericardium ; Postoperative Complications ; Retrospective Studies
Language	English
Publishing date	2021-08-02
Publishing country	United States
Document type	Case Reports ; Journal Article ; Systematic Review
ZDB-ID	424437-0
ISSN	1540-8159 ; 0147-8389
ISSN (online)	1540-8159
ISSN	0147-8389
DOI	10.1111/pace.14318
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Zs.A 1466: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Effect of High-Dose vs Standard-Dose Vitamin D

Brown, Justin C / Rosenthal, Michael H / Ma, Chao / Zhang, Sui / Nimeiri, Halla S / McCleary, Nadine J / Abrams, Thomas A / Yurgelun, Matthew B / Cleary, James M / Rubinson, Douglas A / Schrag, Deborah / Bullock, Andrea J / Allen, Jill / Zuckerman, Dan / Chan, Emily / Chan, Jennifer A / Wolpin, Brian / Constantine, Michael / Weckstein, Douglas J /

Faggen, Meredith A / Thomas, Christian A / Kournioti, Chryssanthi / Yuan, Chen / Zheng, Hui / Hollis, Bruce W / Fuchs, Charles S / Ng, Kimmie / Meyerhardt, Jeffrey A

Cancers

2020 Volume 12, Issue 11

Abstract: Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism ... through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis ... colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D ...

Abstract	Skeletal muscle and adipose tissue express the vitamin D receptor and may be a mechanism through which vitamin D supplementation slows cancer progression and reduces cancer death. In this exploratory analysis of a double-blind, multicenter, randomized phase II clinical trial, 105 patients with advanced or metastatic colorectal cancer who were receiving chemotherapy were randomized to either high-dose vitamin D
Language	English
Publishing date	2020-11-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers12113451
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Article ; Online: Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents.

Pal, Kavita / Raza, Md Kausar / Legac, Jenny / Rahman, Abdur / Manzoor, Shoaib / Bhattacharjee, Souvik / Rosenthal, Philip J / Hoda, Nasimul

European journal of medicinal chemistry

2022 Volume 248, Page(s) 115055

Abstract: ... of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide hybrids by using multicomponent Petasis reaction as the key step and ...

Abstract	Malaria is the most lethal parasitic infections in the world. To address the emergence of drug resistance to current antimalarials, here we report the design and synthesis of new series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide hybrids by using multicomponent Petasis reaction as the key step and evaluated in vitro for their antimalarial effectiveness. The structure of all the compounds were confirmed by NMR Spectroscopy and mass spectrometry. Most of the compounds showed potent antimalarial activity against both CQ-sensitive (3D7) and CQ-resistant (W2) strains. A8, A5, and A4 are the most potent compounds that showed excellent anti-plasmodial activity against CQ-resistant strain in the nanomolar range with IC
MeSH term(s)	Humans ; Antimalarials/chemistry ; Molecular Docking Simulation ; Plasmodium falciparum/metabolism ; Plasmodium ; Pyrimidines/chemistry
Chemical Substances	Antimalarials ; Pyrimidines
Language	English
Publishing date	2022-12-29
Publishing country	France
Document type	Journal Article
ZDB-ID	188597-2
ISSN	1768-3254 ; 0009-4374 ; 0223-5234
ISSN (online)	1768-3254
ISSN	0009-4374 ; 0223-5234
DOI	10.1016/j.ejmech.2022.115055
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Article ; Online: A 1D Lyman-alpha profile camera for plasma edge neutral studies on the DIII-D tokamak.

Rosenthal, A M / Hughes, J W / Bortolon, A / Laggner, F M / Wilks, T M / Vieira, R / Leccacorvi, R / Marmar, E / Nagy, A / Freeman, C / Mauzey, D

The Review of scientific instruments

2021 Volume 92, Issue 3, Page(s) 33523

Abstract: A one dimensional, absolutely calibrated pinhole camera system was installed on the DIII-D tokamak ... of 20 lines of sight, viewing the plasma edge on the inboard and outboard side of DIII-D. The cameras' ...

Abstract	A one dimensional, absolutely calibrated pinhole camera system was installed on the DIII-D tokamak to measure edge Lyman-alpha (Ly-α) emission from hydrogen isotopes, which can be used to infer neutral density and ionization rate profiles. The system is composed of two cameras, each providing a toroidal fan of 20 lines of sight, viewing the plasma edge on the inboard and outboard side of DIII-D. The cameras' views lie in a horizontal plane 77 cm below the midplane. At its tangency radius, each channel provides a radial resolution of ∼2 cm full width at half maximum (FWHM) with a total coverage of 22 cm. Each camera consists of a rectangular pinhole, Ly-α reflective mirror, narrow-band Ly-α transmission filter, and a 20 channel AXUV photodetector. The combined mirror and transmission filter have a FWHM of 5 nm, centered near the Ly-α wavelength of 121.6 nm and is capable of rejecting significant, parasitic carbon-III (C-III) emission from intrinsic plasma impurities. To provide a high spatial resolution measurement in a compact footprint, the camera utilizes advanced engineering and manufacturing techniques including 3D printing, high stability mirror mounts, and a novel alignment procedure. Absolutely calibrated, spatially resolved Ly-α brightness measurements utilize a bright, isolated line with low parasitic surface reflections and enable quantitative comparison to modeling to study divertor neutral leakage, main chamber fueling, and radial particle transport.
Language	English
Publishing date	2021-04-06
Publishing country	United States
Document type	Journal Article
ZDB-ID	209865-9
ISSN	1089-7623 ; 0034-6748
ISSN (online)	1089-7623
ISSN	0034-6748
DOI	10.1063/5.0024115
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