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  1. Article ; Online: Intermolecular radical cation Diels-Alder (RCDA) reaction of bicyclooctadienes: biomimetic formal total synthesis of kingianin A and total syntheses of kingianins D, F, H, and J.

    Lim, Hee Nam / Parker, Kathlyn A

    The Journal of organic chemistry

    2014  Volume 79, Issue 3, Page(s) 919–926

    Abstract: Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were ... without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates ... prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand's one ...

    Abstract Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were obtained by the intermolecular radical cation Diels-Alder (RCDA) reaction. Each isomer was cleanly isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates from commercially available materials in 10, 13, 9, and 17 steps, respectively. Kingianin A has already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand's one-step, three-carbon homologation.
    MeSH term(s) Bridged Bicyclo Compounds/chemistry ; Cations/chemistry ; Chromatography, High Pressure Liquid ; Cycloaddition Reaction ; Molecular Structure ; Polycyclic Aromatic Hydrocarbons/chemical synthesis ; Polycyclic Aromatic Hydrocarbons/chemistry ; Stereoisomerism
    Chemical Substances Bridged Bicyclo Compounds ; Cations ; Polycyclic Aromatic Hydrocarbons ; kingianin A
    Language English
    Publishing date 2014-01-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021/jo402082y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4473: Show issues Location:
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  2. Article: Intermolecular Radical Cation Diels–Alder (RCDA) Reaction of Bicyclooctadienes: Biomimetic Formal Total Synthesis of Kingianin A and Total Syntheses of Kingianins D, F, H, and J

    Lim, Hee Nam / Parker Kathlyn A

    Journal of organic chemistry. 2014 Feb. 07, v. 79, no. 3

    2014  

    Abstract: Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were ... isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way ... already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied ...

    Abstract Three endo bicyclooctadienol dimers corresponding to kingianins A and H, D, and F and J were obtained by the intermolecular radical cation Diels–Alder (RCDA) reaction. Each isomer was cleanly isolated without the aid of preparative HPLC. Kingianins D, F, H, and J were prepared by way of these intermediates from commercially available materials in 10, 13, 9, and 17 steps, respectively. Kingianin A has already been prepared from one of these compounds. Completion of the synthesis of kingianin H relied on Manchand’s one-step, three-carbon homologation.
    Keywords biomimetics ; cations ; cycloaddition reactions ; high performance liquid chromatography ; isomers ; organic chemistry ; organic compounds
    Language English
    Dates of publication 2014-0207
    Size p. 919-926.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 123490-0
    ISSN 1520-6904 ; 0022-3263
    ISSN (online) 1520-6904
    ISSN 0022-3263
    DOI 10.1021%2Fjo402082y
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 4' 49/42: Show issues
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  3. Article ; Online: Consumer Experience of Mistreatment and Fraud in Financial Services: Implications from an Integrative Consumer Vulnerability Framework.

    Lim, H / Letkiewicz, J C

    Journal of consumer policy

    2023  Volume 46, Issue 2, Page(s) 109–135

    Abstract: This study utilizes the National Financial Well-Being Survey (NFWS) from the Consumer Financial Protection Bureau (CFPB) to investigate the profiles of American consumers who experience mistreatment or a type of fraud in financial services (compromised ... ...

    Abstract This study utilizes the National Financial Well-Being Survey (NFWS) from the Consumer Financial Protection Bureau (CFPB) to investigate the profiles of American consumers who experience mistreatment or a type of fraud in financial services (compromised accounts). An integrative consumer vulnerability framework was used as the theoretical framework to examine how disadvantaged consumer characteristics and vulnerable consumer characteristics are associated with mistreatment and compromised accounts. Consumers in vulnerable states, due to low financial capability, cognitive decline, material hardships, financial shocks, and more exposure to various financial services, were more likely to report experiencing mistreatment and having their financial accounts compromised. Consumers from higher socio-economic status were more likely to have been victims of mistreatment and compromised accounts in financial services. These findings offer implications for consumer financial education and protection.
    Language English
    Publishing date 2023-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1477235-8
    ISSN 1573-0700 ; 0342-5843 ; 0168-7034
    ISSN (online) 1573-0700
    ISSN 0342-5843 ; 0168-7034
    DOI 10.1007/s10603-023-09535-w
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  4. Article ; Online: Antimicrobial peptide thanatin fused endolysin PA90 (Tha-PA90) for the control of Acinetobacter baumannii infection in mouse model.

    Lim, Jeonghyun / Myung, Heejoon / Lim, Daejin / Song, Miryoung

    Journal of biomedical science

    2024  Volume 31, Issue 1, Page(s) 36

    Abstract: Background: This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these ...

    Abstract Background: This study addresses the urgent need for infection control agents driven by the rise of drug-resistant pathogens such as Acinetobacter baumannii. Our primary aim was to develop and assess a novel endolysin, Tha-PA90, designed to combat these challenges.
    Methods: Tha-PA90 incorporates an antimicrobial peptide (AMP) called thanatin at its N-terminus, enhancing bacterial outer membrane permeability and reducing host immune responses. PA90 was selected as the endolysin component. The antibacterial activity of the purified Tha-PA90 was evaluated using an in vitro colony-forming unit (CFU) reduction assay and a membrane permeability test. A549 cells were utilized to measure the penetration into the cytosol and the cytotoxicity of Tha-PA90. Finally, infection control was monitored in A. baumannii infected mice following the intraperitoneal administration of Tha-PA90.
    Results: Tha-PA90 demonstrated remarkable in vitro efficacy, completely eradicating A. baumannii strains, even drug-resistant variants, at a low concentration of 0.5 μM. Notably, it outperformed thanatin, achieving only a < 3-log reduction at 4 μM. Tha-PA90 exhibited 2-3 times higher membrane permeability than a PA90 and thanatin mixture or PA90 alone. Tha-PA90 was found within A549 cells' cytosol with no discernible cytotoxic effects. Furthermore, Tha-PA90 administration extended the lifespan of A. baumannii-infected mice, reducing bacterial loads in major organs by up to 3 logs. Additionally, it decreased proinflammatory cytokine levels (TNF-α and IL-6), reducing the risk of sepsis from rapid bacterial lysis. Our findings indicate that Tha-PA90 is a promising solution for combating drug-resistant A. baumannii. Its enhanced efficacy, low cytotoxicity, and reduction of proinflammatory responses render it a potential candidate for infection control.
    Conclusions: This study underscores the significance of engineered endolysins in addressing the pressing challenge of drug-resistant pathogens and offers insights into improved infection management strategies.
    MeSH term(s) Animals ; Mice ; Acinetobacter baumannii ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides ; Anti-Bacterial Agents/pharmacology ; Acinetobacter Infections/drug therapy ; Microbial Sensitivity Tests ; Endopeptidases
    Chemical Substances thanatin ; endolysin (EC 3.4.99.-) ; Antimicrobial Peptides ; Antimicrobial Cationic Peptides ; Anti-Bacterial Agents ; Endopeptidases (EC 3.4.-)
    Language English
    Publishing date 2024-04-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1193378-1
    ISSN 1423-0127 ; 1021-7770
    ISSN (online) 1423-0127
    ISSN 1021-7770
    DOI 10.1186/s12929-024-01027-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4037: Show issues Location:
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  5. Article ; Online: A Bilayer Method for Measuring Toughness and Strength of Dental Ceramics.

    Chai, H / Russ, J / Vardhaman, S / Lim, C H / Zhang, Y

    Journal of dental research

    2024  Volume 103, Issue 4, Page(s) 419–426

    Abstract: The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength ... ...

    Abstract The ever-increasing usage of ceramic materials in restorative dentistry necessitates a simple and effective method to evaluate flexural strength σ
    MeSH term(s) Materials Testing ; Ceramics/chemistry ; Tooth ; Dentistry ; Dental Porcelain ; Surface Properties
    Chemical Substances Dental Porcelain (12001-21-7)
    Language English
    Publishing date 2024-02-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80207-4
    ISSN 1544-0591 ; 0022-0345
    ISSN (online) 1544-0591
    ISSN 0022-0345
    DOI 10.1177/00220345231225445
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    Ul III Zs.75: Show issues Location:
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    Zs.MO 262: Show issues

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  6. Article ; Conference proceedings: Safety and efficacy of biliary endoscopic balloon-based laser treatment vs. endobiliary radiofrequency ablation in swine models

    Jeong, S. / Lim, J. H. / Lee, J. / Lee, D. H.

    Endoscopy

    2024  Volume 56, Issue S 02

    Event/congress ESGE Days 2024, Berlin, Germany, 2024-04-25
    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80120-3
    ISSN 1438-8812 ; 0013-726X
    ISSN (online) 1438-8812
    ISSN 0013-726X
    DOI 10.1055/s-0044-1783253
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 669: Show issues Location:
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    Zs.MO 162: Show issues

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  7. Article ; Online: Loneliness as a risk factor for dementia and other adverse health outcomes.

    Na, Peter J / Lim, Yen Ying / Pietrzak, Robert H

    International psychogeriatrics

    2023  Volume 35, Issue 6, Page(s) 271–274

    MeSH term(s) Humans ; Loneliness ; Risk Factors ; Dementia ; Outcome Assessment, Health Care
    Language English
    Publishing date 2023-02-03
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1038825-4
    ISSN 1741-203X ; 1041-6102
    ISSN (online) 1741-203X
    ISSN 1041-6102
    DOI 10.1017/S104161022300011X
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2621: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 513: Show issues

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  8. Article ; Online: Psychological well-being of healthcare workers during COVID-19 in a mental health institution.

    Leung, HoiTing / Lim, Madeline / Lim, Wee Onn / Lee, Sara-Ann / Lee, Jimmy

    PloS one

    2024  Volume 19, Issue 3, Page(s) e0300329

    Abstract: Introduction: This study examined the psychological wellbeing of Healthcare Workers (HCWs) during COVID-19 in a mental health setting, associations of psychosocial wellbeing with coping style, and ways that organisations can mitigate the psychosocial ... ...

    Abstract Introduction: This study examined the psychological wellbeing of Healthcare Workers (HCWs) during COVID-19 in a mental health setting, associations of psychosocial wellbeing with coping style, and ways that organisations can mitigate the psychosocial burden on HCWs.
    Methods: Thirty-seven Mental HCWs (MHCWs) from infected and non-infected wards (control group), were recruited and assessed at three timepoints. Psychological wellbeing, perceived cohesion, and coping style (Brief-COPE) were assessed. Reports on individual coping and feedback on the organisation were collected through in-depth interview. Comparison between infected and non-infected wards, as well as comparison of psychosocial measures and perceived cohesion, across the three timepoints were made. As there were no significant changes in coping styles across the timepoints, Timepoint 1 (T1) coping style was used to correlate with the psychosocial measures across all timepoints. Thematic analysis was used for qualitative data.
    Results: MHCWs from infected wards reported significantly higher levels of stress, χ2(1) = 6.74, p = 0.009, effect size: medium (ε2 = 0.198), and more severe sleep disturbance (PSQI), χ2(1) = 6.20, p = 0.013, effect size: medium (ε2 = 0.182), as compared to the control group at T2. They also engaged in more problem-focused coping (T2 and T3) and emotion-focused coping (T2). As expected, negative coping style was correlated with negative outcomes except problem-focused coping that was correlated with both negative (sleep disturbance and anxiety symptoms) and positive outcomes (wellbeing). Emotion-focused coping was moderately correlated (Tb = 0.348, p<0.017) with higher levels of wellbeing at T2. Thematic analyses revealed MHCWs felt supported by the responsiveness of the institution, emotional and informational support, and the availability from direct leaders, presence of team and hospital leaders on the ground, helped build trust and confidence in the leadership.
    Conclusions: MHCWs experienced significantly higher levels of stress and sleep disturbance during COVID-19. The ways that organizations can offset the psychological burden of pandemics on MHCWs are discussed.
    MeSH term(s) Humans ; COVID-19/epidemiology ; Mental Health ; Adaptation, Psychological ; Psychological Well-Being ; Stress, Psychological/psychology ; Health Personnel/psychology
    Language English
    Publishing date 2024-03-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0300329
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  9. Article: Letter to the Editor: Obesity Definition for Muscle Outcomes in Sarcopenic Obesity: Utility of Waist Circumference Revisited.

    Lim, J P / Chew, J / Ismail, N H / Lim, W S

    The Journal of frailty & aging

    2021  Volume 10, Issue 4, Page(s) 334–336

    MeSH term(s) Body Mass Index ; Humans ; Muscles ; Obesity ; Sarcopenia/diagnosis ; Waist Circumference
    Language English
    Publishing date 2021-09-13
    Publishing country France
    Document type Letter
    ZDB-ID 2856228-8
    ISSN 2273-4309 ; 2260-1341
    ISSN (online) 2273-4309
    ISSN 2260-1341
    DOI 10.14283/jfa.2021.28
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Is there a temporal relationship between atrial fibrillation and stroke? A review.

    Dlima, Jessica / Kitisarn, Rooj / Lim, Han / Thijs, Vincent

    BMJ neurology open

    2024  Volume 6, Issue 1, Page(s) e000512

    Abstract: Importance: Atrial fibrillation (AF) is an established risk factor for ischaemic stroke. The introduction of continuous cardiac rhythm monitoring devices has enabled detection of brief and asymptomatic episodes of AF.: Observations: The search ... ...

    Abstract Importance: Atrial fibrillation (AF) is an established risk factor for ischaemic stroke. The introduction of continuous cardiac rhythm monitoring devices has enabled detection of brief and asymptomatic episodes of AF.
    Observations: The search yielded 727 studies, 11 of which met the inclusion criteria. Four studies suggested a strong temporal association between episodes of AF and stroke, while seven indicated a weak relationship. The conflicting nature of the studies may be attributed to inconsistencies in ischaemic stroke verification (n=5/11), event rate and power (n=6/11) and lack of controlling for anticoagulation (n=10/11), mitigating the relationship between AF episodes and stroke.
    Conclusions and relevance: The temporal relationship between AF and stroke still remains unclear due to varying study methodology, lack of control for anticoagulation and inconsistent stroke subtyping. Our review identifies limitations to the current literature and makes recommendations for future studies assessing the temporal relationship between AF episodes and cardioembolic stroke.
    Language English
    Publishing date 2024-01-24
    Publishing country England
    Document type Journal Article
    ISSN 2632-6140
    ISSN (online) 2632-6140
    DOI 10.1136/bmjno-2023-000512
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