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  1. Article ; Online: Multiparametric Magnetic Resonance Imaging of the Prostate.

    Scappatura, Giuseppe

    Radiologic technology

    2021  Volume 93, Issue 2, Page(s) 221–227

    MeSH term(s) Humans ; Image-Guided Biopsy ; Magnetic Resonance Imaging ; Male ; Multiparametric Magnetic Resonance Imaging ; Prostatic Neoplasms/diagnostic imaging ; Retrospective Studies
    Language English
    Publishing date 2021-10-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 414079-5
    ISSN 1943-5657 ; 0033-8397
    ISSN (online) 1943-5657
    ISSN 0033-8397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Radiological Examinations in Patients With COVID-19.

    Scappatura, Giuseppe

    Radiologic technology

    2020  Volume 92, Issue 1, Page(s) 82–86

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections/diagnostic imaging ; Cross Infection/prevention & control ; Humans ; Infection Control/methods ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Pandemics ; Personal Protective Equipment ; Pneumonia, Viral/diagnostic imaging ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-09-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 414079-5
    ISSN 1943-5657 ; 0033-8397
    ISSN (online) 1943-5657
    ISSN 0033-8397
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Congenital Ventricular Diverticulum.

    Rao, Carmelo Massimiliano / Lucà, Fabiana / Franzutti, Claudio / Scappatura, Giuseppe / Arcadi, Nicola / Fratto, Pasquale / Benedetto, Francesco Antonio / Gelsomino, Sandro

    Journal of clinical medicine

    2023  Volume 12, Issue 9

    Abstract: Herein, we describe a 54-year-old patient with a congenital ventricular diverticulum (CVD), referred to our emergency department for presyncope episodes and multiple re-entrant ventricular tachycardias (VT). Significantly, echocardiographic findings were ...

    Abstract Herein, we describe a 54-year-old patient with a congenital ventricular diverticulum (CVD), referred to our emergency department for presyncope episodes and multiple re-entrant ventricular tachycardias (VT). Significantly, echocardiographic findings were not clear, and the diagnosis was made by cardiac magnetic resonance imaging (CMRI), which showed the presence of an apical accessory cavity connected to the ventricle and contracting synchronously. CMRI allowed the differential diagnosis with other outpouching cardiac defects. The patient underwent a subcutaneous implantable cardioverter defibrillator (S-ICD) implant and was referred for heart transplantation (HT). The diagnosis, treatment, and main findings of the CVD are discussed in this case report.
    Language English
    Publishing date 2023-04-27
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12093153
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Extended-spectrum β-lactamase & carbapenemase-producing fermentative Gram-negative bacilli in clinical isolates from a University Hospital in Southern Italy.

    Mancuso, Giuseppe / Midiri, Angelina / Zummo, Sebastiana / Gerace, Elisabetta / Scappatura, Giuseppina / Biondo, Carmelo

    The new microbiologica

    2021  Volume 44, Issue 4, Page(s) 227–233

    Abstract: The aim of this study was to determine the prevalence of extended-spectrum β-lactamases (ESBLs)- and carbapenemase-producing fermentative Gram-negative bacteria (FGNB) in a University Hospital in Southern Italy. These bacteria have the potential to ... ...

    Abstract The aim of this study was to determine the prevalence of extended-spectrum β-lactamases (ESBLs)- and carbapenemase-producing fermentative Gram-negative bacteria (FGNB) in a University Hospital in Southern Italy. These bacteria have the potential to disseminate bacterial resistance in healthcare settings and cause untreatable and prolonged infections associated with high rates of mortality. A retrospective observational study was carried out in a University Hospital in Sicily from January to December 2019. A total of 1046 FGNB were recovered from different clinical samples among which 40%, 15% and 37% were, respectively, MDR, carbapenemase and ESBL producers. Antibiotic resistance profile of FGNB against the first-line drugs was remarkably high. K. pneumoniae (57%) followed by E. coli (27%) were found here as the major sources of ESBL producers. The highest proportion of ESBL producers was from ICU ward (72%), and were isolated from urine samples (63.6%) followed by blood samples (54%). Carbapenemase production among the FGNB in our study was about 0.9%, which is more than twice than the prevalence rate reported by the European Antimicrobial Resistance Surveillance Network (ECDC) (0.4%). To our knowledge, this is the first report on the prevalence of ESBL and carbapenemase-producing FGNB in this region. Our data clearly indicate the importance of implementing antibiotic stewardship strategies in our region to reduce the unnecessary use of antibiotics.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacterial Proteins ; Drug Resistance, Multiple, Bacterial ; Escherichia coli ; Gram-Negative Bacteria ; Hospitals ; Humans ; Microbial Sensitivity Tests ; Sicily ; beta-Lactamases
    Chemical Substances Anti-Bacterial Agents ; Bacterial Proteins ; beta-Lactamases (EC 3.5.2.6) ; carbapenemase (EC 3.5.2.6)
    Language English
    Publishing date 2021-12-19
    Publishing country Italy
    Document type Journal Article ; Observational Study
    ZDB-ID 756168-4
    ISSN 1121-7138 ; 0391-5352
    ISSN 1121-7138 ; 0391-5352
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Congenital Ventricular Diverticulum

    Carmelo Massimiliano Rao / Fabiana Lucà / Claudio Franzutti / Giuseppe Scappatura / Nicola Arcadi / Pasquale Fratto / Francesco Antonio Benedetto / Sandro Gelsomino

    Journal of Clinical Medicine, Vol 12, Iss 3153, p

    2023  Volume 3153

    Abstract: Herein, we describe a 54-year-old patient with a congenital ventricular diverticulum (CVD), referred to our emergency department for presyncope episodes and multiple re-entrant ventricular tachycardias (VT). Significantly, echocardiographic findings were ...

    Abstract Herein, we describe a 54-year-old patient with a congenital ventricular diverticulum (CVD), referred to our emergency department for presyncope episodes and multiple re-entrant ventricular tachycardias (VT). Significantly, echocardiographic findings were not clear, and the diagnosis was made by cardiac magnetic resonance imaging (CMRI), which showed the presence of an apical accessory cavity connected to the ventricle and contracting synchronously. CMRI allowed the differential diagnosis with other outpouching cardiac defects. The patient underwent a subcutaneous implantable cardioverter defibrillator (S-ICD) implant and was referred for heart transplantation (HT). The diagnosis, treatment, and main findings of the CVD are discussed in this case report.
    Keywords congenital ventricular diverticulum (CVD) ; congenital cardiac disorder ; re-entrant ventricular tachycardias (VT) ; cardiac magnetic resonance imaging (MRI) ; Medicine ; R
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Late-onset Fabry disease due to a new (p.Pro380Leu) pathogenic variant of GLA Gene.

    Cianci, Vittoria / Pascarella, Angelo / Gasparini, Sara / Donadio, Vincenzo / Liguori, Rocco / Incensi, Alex / Rao, Carmelo Massimiliano / Franzutti, Claudio / Scappatura, Giuseppe / Aguglia, Umberto / Ferlazzo, Edoardo

    Metabolic brain disease

    2022  Volume 37, Issue 8, Page(s) 3023–3026

    Abstract: Fabry disease is a rare X-linked lysosomal storage disorder due to pathogenic variants of the galactosidase alpha (GLA) gene, leading to a deficiency of alpha-galactosidase A. The inadequate enzymatic activity leads to progressive glycosphingolipids ... ...

    Abstract Fabry disease is a rare X-linked lysosomal storage disorder due to pathogenic variants of the galactosidase alpha (GLA) gene, leading to a deficiency of alpha-galactosidase A. The inadequate enzymatic activity leads to progressive glycosphingolipids accumulation within tissues and subsequent multi-systemic dysfunction, with predominant involvement of heart, kidney, and nervous system. Two subtypes are recognized: the classic type and the late-onset type. We here describe the clinical characteristics of a patient with late-onset Fabry disease carrying a not previously identified GLA gene variant. This 50-year-old man came to hospital because of an acute ischemic stroke. He also complained of acroparesthesia and had angiokeratomas in the nape and the back. Blood alpha-galactosidase A activity was low, plasmatic lyso-Gb3 level was borderline, cardiac MRI showed cardiac fibrosis, brain MRI documented cerebrovascular disease, and skin biopsy revealed small fiber neuropathy without globotriaosylceramide-3 skin deposits. Genetic study by means of targeted next-generation sequencing analysis disclosed a missense substitution c.1139C>T (p.Pro380Leu) in the GLA gene. We suggest that this novel variant should be considered as pathogenic and associated with a late-onset variant of Fabry disease with a predominant neurological phenotype.
    MeSH term(s) Male ; Humans ; alpha-Galactosidase/genetics ; Fabry Disease/genetics ; Galactosidases/genetics ; Ischemic Stroke ; Phenotype ; Mutation
    Chemical Substances alpha-Galactosidase (EC 3.2.1.22) ; Galactosidases (EC 3.2.1.-)
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 632824-6
    ISSN 1573-7365 ; 0885-7490
    ISSN (online) 1573-7365
    ISSN 0885-7490
    DOI 10.1007/s11011-022-01079-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Identifying and managing CAR T-cell-mediated toxicities: on behalf of an Italian CAR-T multidisciplinary team.

    Martino, Massimo / Macheda, Sebastiano / Aguglia, Umberto / Arcudi, Luciano / Pucci, Giulia / Martino, Bruno / Altomonte, Maria / Rossetti, Antonio Maria / Cusumano, Giuseppa / Russo, Letteria / Imbalzano, Lucrezia / Stelitano, Caterina / Alati, Caterina / Germano', Jessyca / Labate, Demetrio / Amalfi, Vincenzo / Florenzano, Maria Teresa / Morabito, Antonella / Borzumati, Vittoria /
    Dattola, Vincenzo / Gattuso, Caterina / Moschella, Antonio / Quattrone, Domenico / Curmaci, Francesco / Franzutti, Claudio / Scappatura, Giuseppe / Rao, Carmelo Massimiliano / Loddo, Viviana / Pontari, Antonella / Pellicano', Maria / Surace, Rosangela / Sanguedolce, Cristina / Naso, Virginia / Ferreri, Anna / Irrera, Giuseppe / Console, Giuseppe / Moscato, Tiziana / Loteta, Barbara / Canale, Filippo Antonio / Trimarchi, Alfonso / Monteleone, Renza / Al Sayyad, Said / Cirrone, Frank / Bruno, Benedetto

    Expert opinion on biological therapy

    2021  Volume 22, Issue 3, Page(s) 407–421

    Abstract: Introduction: Chimeric antigen receptor (CAR)-T-cell therapy is a new treatment for patients with hematologic malignancies in which other therapies have failed.: Areas covered: The review provides an overview for recognizing and managing the most ... ...

    Abstract Introduction: Chimeric antigen receptor (CAR)-T-cell therapy is a new treatment for patients with hematologic malignancies in which other therapies have failed.
    Areas covered: The review provides an overview for recognizing and managing the most acute toxicities related to CAR-T cells.
    Expert opinion: The development of immune-mediated toxicities is a common challenge of CAR-T therapy. The mechanism that determines this toxicity is still unclear, although an unfavorable tumor microenvironment and a pro-inflammatory state put patients at risk. The monitoring, diagnosis, and treatment of post-CAR-T toxicities must be determined and based on international guidelines and internal clinical practice. It is urgent to identify biomarkers that can identify patients at greater risk of developing complications. The adoption of consistent grading criteria is necessary to improve toxicity management strategies continually. The first-line therapy consists of supportive care and treatment with tocilizumab or corticosteroids. An early start of cytokine blockade therapies could mitigate toxicity. The plan will include cytokine release prophylaxis, a risk-adapted treatment, prevention of on-target/off-tumor effect, and a switch on/off CAR-T approach.
    MeSH term(s) Hematologic Neoplasms/therapy ; Humans ; Immunotherapy, Adoptive/adverse effects ; Patient Care Team ; Receptors, Chimeric Antigen ; T-Lymphocytes ; Tumor Microenvironment
    Chemical Substances Receptors, Chimeric Antigen
    Language English
    Publishing date 2021-09-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2021.1974394
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  9. Article: DIDECMO: a new polymethylpentene oxygenator for pediatric extracorporeal membrane oxygenation.

    Agati, Salvatore / Ciccarello, Giuseppe / Fachile, Nicola / Scappatura, Rosa Maria / Grasso, Daniela / Salvo, Dario / Undar, Akif / Mignosa, Carmelo

    ASAIO journal (American Society for Artificial Internal Organs : 1992)

    2006  Volume 52, Issue 5, Page(s) 509–512

    Abstract: We reviewed the performance of a new polymethylpentene oxygenator (DIDECMO, Dideco, Mirandola, Italy) in terms of clinical safety and efficiency in priming, oxygenation, and oxygenator resistance in neonatal and pediatric extracorporeal membrane ... ...

    Abstract We reviewed the performance of a new polymethylpentene oxygenator (DIDECMO, Dideco, Mirandola, Italy) in terms of clinical safety and efficiency in priming, oxygenation, and oxygenator resistance in neonatal and pediatric extracorporeal membrane oxygenation (ECMO) patients. Between March 2005 and January 2006, 14 patients required ECMO in the San Vincenzo Hospital. Of these, 8 (median age, 9 days; range, 3 days to 15 months) received normothermic ECMO for postcardiotomy heart failure after surgery for congenital heart disease. The DIDECMO oxygenator was used in all patients (median weight, 2.4 kg; range, 2 to 7 kg). According to our previous experience, all patients received the same anticoagulation management. DIDECMO is a new phosphorylcholine-coated, polymethylpentene hollow-fiber oxygenator recommended for a maximum blood flow of 2300 ml/min with a membrane surface area of 0.67 m2 and validated to be used up to 5 days. Static priming was 100 ml and mean support time 05 hours (range, 36 to 198 hours). No oxygenators were changed during support. Median pressure drop during overall assistance was 24 mm Hg. Carbon dioxide elimination was obtained with a 1:1 blood flow/air flow ratio. Neither oxygenator-related major nor minor adverse events occurred during support. In our initial experience, the new polymethylpentene DIDECMO oxygenator provided adequate gas exchange and offered technical advantages in terms of low priming volume and acceptable hemodynamic resistance despite pulsatile flow regimen. Also, we used this device for more than 8 days without any technical problems.
    MeSH term(s) Cardiac Output, Low/therapy ; Cardiac Surgical Procedures/adverse effects ; Extracorporeal Membrane Oxygenation/instrumentation ; Heart Defects, Congenital/surgery ; Humans ; Infant ; Infant, Newborn ; Oxygenators, Membrane ; Polyenes ; Pulsatile Flow
    Chemical Substances Polyenes ; poly(methylpentene) (9016-80-2)
    Language English
    Publishing date 2006-09
    Publishing country United States
    Document type Evaluation Studies ; Journal Article
    ZDB-ID 759982-1
    ISSN 1538-943X ; 1058-2916 ; 0162-1432
    ISSN (online) 1538-943X
    ISSN 1058-2916 ; 0162-1432
    DOI 10.1097/01.mat.0000237693.09432.13
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