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Article ; Online: The O((1)D) + H2 (X (1)Σ+, v, j) → OH(X (2)Π, v', j') + H((2)S) reaction at low collision energy: when a simple statistical description of the dynamics works.

Rivero-Santamaría, A / González-Martínez, M L / González-Lezana, T / Rubayo-Soneira, J / Bonnet, L / Larrégaray, P

Physical chemistry chemical physics : PCCP

2011 Volume 13, Issue 18, Page(s) 8136–8139

Abstract: ... precise quantum wave packet calculations [J. Phys. Chem. A, 2009, 113, 5285]. ...

Abstract	In this communication, we highlight that statistical approaches for chemical reactions describe reasonably well the low energy dynamics of the title process. Consequently, such methods prove to be valuable to compute rate constants from low to room temperatures. Results are compared with experiment and recent precise quantum wave packet calculations [J. Phys. Chem. A, 2009, 113, 5285].
Language	English
Publishing date	2011-05-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/c0cp02662j
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Article ; Online: Sellami H, Gdoura R, Mabrouk I, Frikha-Gargouri O, Keskes L, Mallek Z, Aouni M, Hammami A. A proposed mouse model to study male infertility provoked by genital serovar E, Chlamydia trachomatis. J Androl. 2011;32:86-94.

Motrich, Ruben D / Rivero, Virginia E

Journal of andrology

2011 Volume 32, Issue 5, Page(s) 471–472

MeSH term(s)	Animals ; Chlamydia Infections/complications ; Female ; Infertility, Male/etiology ; Male ; Spermatozoa/physiology
Language	English
Publishing date	2011-09
Publishing country	United States
Document type	Comment ; Editorial
ZDB-ID	604624-1
ISSN	1939-4640 ; 0196-3635
ISSN (online)	1939-4640
ISSN	0196-3635
DOI	10.2164/jandrol.110.012096
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Zs.A 1585: Show issues

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Article ; Online: Early use of high-efficacy therapies in multiple sclerosis in the United States: benefits, barriers, and strategies for encouraging adoption.

Singer, Barry A / Feng, Jenny / Chiong-Rivero, Horacio

Journal of neurology

2024

Abstract: Multiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy ... ...

Abstract	Multiple sclerosis (MS) is characterized by progressive neuroinflammation and neurodegeneration from disease onset that, if left untreated, can result in the accumulation of irreversible neurological disability. Early intervention with high-efficacy therapies (HETs) is increasingly recognized as the best strategy to delay or mitigate disease progression from the earliest stages of the disease and to prevent long-term neurodegeneration. Although there is growing clinical and real-world evidence supporting early HET intervention, foregoing this strategy in favor of a traditional escalation approach prioritizing lower-efficacy disease-modifying therapies remains a common approach in clinical practice. This review explores potential health care professional- and patient-related barriers to the early use of HETs in patients with MS in the United States. Barriers can include regulatory and reimbursement restrictions; knowledge gaps and long-term safety concerns among health care professionals; and various individual, cultural, and societal factors affecting patients. Potential strategies for overcoming these barriers and encouraging early HET use are proposed.
Language	English
Publishing date	2024-04-14
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	187050-6
ISSN	1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
ISSN (online)	1432-1459
ISSN	0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
DOI	10.1007/s00415-024-12305-4
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Ui II Zs.40: Show issues

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Article ; Online: Negative pressure device used in pediatric patients with Hostile abdomen. Case series.

Serrano Concha, K / Morales Mayorga, H / Acosta Farina, D / Mendoza Saldarreaga, L / Pólit Guerrero, V / Oliveros Rivero, J / Acosta Bowen, D

Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica

2024 Volume 37, Issue 1, Page(s) 37–41

Abstract: Introduction: Hostile abdomen is a surgical condition characterized by loss of space between organs and structures in the abdomen. Negative pressure therapy use has been widely described in adults; the case is not the same for pediatric patients. The ... ...

Title translation	Dispositivo de presión negativa empleado en pacientes pediátricos con abdomen hostil: serie de casos.
Abstract	Introduction: Hostile abdomen is a surgical condition characterized by loss of space between organs and structures in the abdomen. Negative pressure therapy use has been widely described in adults; the case is not the same for pediatric patients. The goal of this study is to present short-term results of negative pressure therapy use in pediatric patients with hostile abdomen due to different etiologies. Material and methods: Pediatric hostile abdomen patients (< 18 years) who were treated Negative pressure therapy using ABTHERA were identified and retrospectively reviewed. Results: 7 patients were included in this study. Median age was 16 (range: 9-17 yo). 5 (71.4%) were male and 2 (28.6%) females. 3 (43%) had significant past medical/surgical history (Systemic Lupus Erythematosus, complicated appendectomy and ventriculoperitoneal-shunt). The device was set at a continuous pressure ranging from -50 to -125 mmHg. Pre and post-surgical findings were reported using Bjork's classification. Devices were replaced every 4-7 days (median 5 days). Total amount of replacements was 1-4 (median 3). 5 (71.4%) patients required invasive mechanical ventilation during use of Negative pressure therapy based on clinical status. 4 (57%) patients received enteral nutrition. 1 (14%) patient required re-intervention posterior to definitive closure due to retroperitoneal abscess development. Outcome, evaluated by (oral tolerance, bowel movement and absence of pain), was favorable in all patients. Conclusion: Negative pressure therapy devices generate favorable results in hostile abdomen in pediatric population but further information is needed to assess pressure settings and device replacement frequency.
MeSH term(s)	Adult ; Female ; Humans ; Child ; Male ; Adolescent ; Retrospective Studies ; Abdomen ; Abdominal Abscess ; Appendectomy ; Defecation
Language	Spanish
Publishing date	2024-01-01
Publishing country	Spain
Document type	Case Reports
ZDB-ID	1214833-7
ISSN	2445-2807 ; 0214-1221
ISSN (online)	2445-2807
ISSN	0214-1221
DOI	10.54847/cp.2024.01.16
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Zs.A 4152: Show issues

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Article ; Online: Rational use of eculizumab in secondary atypical hemolytic uremic syndrome.

Cordero, Lucía / Cavero, Teresa / Gutiérrez, Eduardo / Trujillo, Hernando / Sandino, Justo / Auñón, Pilar / Rivero, Marta / Morales, Enrique

Frontiers in immunology

2024 Volume 14, Page(s) 1310469

Abstract: Background: Secondary atypical hemolytic uremic syndrome (secondary aHUS) is a heterogeneous group of thrombotic microangiopathies (TMA) associated with various underlying conditions. Unlike primary aHUS, there is still no hard evidence on the efficacy ... ...

Abstract	Background: Secondary atypical hemolytic uremic syndrome (secondary aHUS) is a heterogeneous group of thrombotic microangiopathies (TMA) associated with various underlying conditions. Unlike primary aHUS, there is still no hard evidence on the efficacy of complement blockade in secondary aHUS, since the two main series that investigated this subject showed discrepant results. Our work aims to reassess the efficacy of eculizumab in treating secondary aHUS. Methods: Observational, retrospective, single-center study, in which we analyzed the hematological and renal evolution of 23 patients diagnosed with secondary aHUS who received treatment with eculizumab and compared them with a control cohort of 14 patients. Complete renal response was defined as the recovery of renal function before the event, partial renal response as a recovery of 50% of lost glomerular filtration rate, and hematological response as normalization of hemoglobin and platelets. Results: We found no statistically significant differences in baseline characteristics or disease severity between both groups. After a median of 5 doses of eculizumab, the group of patients who received complement blockade presented a significant difference in renal response (complete in 52.3% of patients and partial in 23.8%) compared to the control cohort (complete response 14.3% and partial of 14.3%). Rates of hematological remission were similar in both groups (90.9% in the eculizumab cohort and 85.7% in the control cohort). Conclusion: Early and short-term use of eculizumab in patients with secondary aHUS could be an effective and safe therapeutic option, assuring better renal recovery compared to patients who do not receive complement blockade.
MeSH term(s)	Humans ; Atypical Hemolytic Uremic Syndrome/drug therapy ; Retrospective Studies ; Kidney ; Antibodies, Monoclonal, Humanized/therapeutic use ; Complement System Proteins/therapeutic use
Chemical Substances	eculizumab (A3ULP0F556) ; Antibodies, Monoclonal, Humanized ; Complement System Proteins (9007-36-7)
Language	English
Publishing date	2024-01-11
Publishing country	Switzerland
Document type	Observational Study ; Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2023.1310469
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Article ; Online: Techno-economic evaluation of UV light technologies in water remediation.

Pelayo, Deva / Rivero, María J / Santos, Germán / Gómez, Pedro / Ortiz, Inmaculada

The Science of the total environment

2023 Volume 868, Page(s) 161376

Abstract: ... photocatalysis, UV-C/H ...

Abstract	Disinfection commonly follows conventional treatments in wastewater treatment and remediation plants aiming at reducing the presence of pathogens. However, the presence of the so called "micropollutants" has emerged as a serious concern, therefore developing tertiary treatments that are not only able to remove pathogens but also to degrade micropollutants is worth investigating. Nowadays, UV-C photo-degradation processes are widely used for disinfection due to their simplicity and easy operation; additionally, they have shown potential for the removal of contaminants of emerging concern. Conventional mercury lamps are being replaced by light-emitting diodes (LEDs) that avoid the use of toxic mercury and can be switched on and off with no effect on the lamp lifetime. This work aims to comparatively evaluate the performance of several photo-degradation technologies for the removal of two targeted micropollutants, the pharmaceutical dexamethasone (DXMT) and the herbicide S-metolachlor (MTLC), using UV irradiation doses typical of disinfection processes. To this end, the technical performance of UV-A/UV-C photolysis, UV-A/UV-C photocatalysis, UV-C/H
Language	English
Publishing date	2023-01-06
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2022.161376
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Zs.A 949: Show issues

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Article ; Online: Vidas vulneráveis ser migrante em tempos de conservadorismo e crise pandêmica na América Latina

Gustavo Dias / Fulvio Rivero Sierra

Cadernos de Campo, Iss 30, Pp 11-

2021 Volume 27

Keywords	Anthropology ; GN1-890 ; Political science ; J ; Social Sciences ; H
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Long-term healthcare utilization and costs of babies born after assisted reproductive technologies (ART): a record linkage study with 10-years' follow-up in England.

Hua, Xinyang / Rivero-Arias, Oliver / Quigley, Maria A / Kurinczuk, Jennifer J / Carson, Claire

Human reproduction (Oxford, England)

2023 Volume 38, Issue 12, Page(s) 2507–2515

Abstract: ... Support Award [MR/W029286/1]. X.H. is an Australia National Health and Medical Research Council (NHMRC ...

Abstract	Study question: Is the long-term health care utilization of children born after ART more costly to the healthcare system in England than children born to mothers with no fertility problems? Summary answer: Children born after ART had significantly more general practitioner (GP) consultations and higher primary care costs up to 10 years after birth, and significantly higher hospital admission costs in the first year after birth, compared to children born to mothers with no fertility problems. What is known already: There is evidence that children born after ART are at an increased risk of adverse birth outcomes and a small increased risk of rare adverse outcomes in childhood. Study design, size, duration: We conducted a longitudinal study of 368 088 mother and baby pairs in England using a bespoke linked dataset. Singleton babies born 1997-2018, and their mothers, who were registered at GP practices in England contributing data to the Clinical Practice Research Datalink (CPRD), were identified through the CPRD GOLD mother-baby dataset; this data was augmented with further linkage to the mothers' Human Fertilisation and Embryology Authority (HFEA) Register data. Four groups of babies were identified through the mothers' records: a 'fertile' comparison group, an 'untreated sub-fertile' group, an 'ovulation induction' group, and an ART group. Babies were followed-up from birth to 28 February 2021, unless censored due to loss to follow-up (e.g. leaving GP practice, emigration) or death. Participants/materials, setting, methods: The CPRD collects anonymized coded patient electronic health records from a network of GPs in the UK. We estimated primary care costs and hospital admission costs for babies in the four fertility groups using the CPRD GOLD data and the linked Hospital Episode Statistics (HES) Admitted Patient Care (APC) data. Linear regression was used to compare the care costs in the different groups. Inverse probability weights were generated and applied to adjust for potential bias caused by attrition due to loss to follow-up. Main results and the role of chance: Children born to mothers with no fertility problems had significantly fewer consultations and lower primary care costs compared to the other groups throughout the 10-years' follow up. Regarding hospital costs, children born after ART had significantly higher hospital admission costs in the first year after birth compared to those born to mothers with no fertility problems (difference = £307 (95% CI: 153, 477)). The same pattern was observed in children born after untreated subfertility and ovulation induction. Limitations, reasons for caution: HFEA linkage uses non-donor data cycles only, and the introduction of consent for data use reduced the availability of HFEA records after 2009. The fertility groups were derived by augmenting HFEA data with evidence from primary care records; however, there remains some potential misclassification of exposure groups. The cost of neonatal critical care is not captured in the HES APC data, which may cause underestimation of the cost differences between the comparison group and the infertility groups. Wider implications of the findings: The findings can help anticipate the financial impact on the healthcare system associated with subfertility and ART, particularly as the demand for these treatments grows. Study funding/competing interest(s): C.C. and this work were funded by a UK Medical Research Council Career Development Award [MR/L019671/1] and a UK MRC Transition Support Award [MR/W029286/1]. X.H. is an Australia National Health and Medical Research Council (NHMRC) Emerging Leadership Fellow [grant number 2009253]. The authors declare no competing interest. Trial registration number: N/A.
MeSH term(s)	Infant ; Infant, Newborn ; Child ; Female ; Humans ; Longitudinal Studies ; Follow-Up Studies ; Reproductive Techniques, Assisted/adverse effects ; England/epidemiology ; Patient Acceptance of Health Care ; Infertility/etiology ; Fertilization in Vitro/methods
Language	English
Publishing date	2023-10-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632776-x
ISSN	1460-2350 ; 0268-1161 ; 1477-741X
ISSN (online)	1460-2350
ISSN	0268-1161 ; 1477-741X
DOI	10.1093/humrep/dead198
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Article ; Online: Detection of hepatitis E virus genotype 3 in an Algerian mouse (Mus spretus) in Portugal.

Santos-Silva, Sérgio / Moraes, Danny Franciele da Silva Dias / López-López, Pedro / Paupério, Joana / Queirós, João / Rivero-Juarez, António / Lux, Laura / Ulrich, Rainer G / Gonçalves, Helena M R / Van der Poel, Wim H M / Nascimento, Maria S J / Mesquita, João R

Veterinary research communications

2024

Abstract: Virus monitoring in small mammals is central to the design of epidemiological control strategies for rodent-borne zoonotic viruses. Synanthropic small mammals are versatile and may be potential carriers of several microbial agents. In the present work, a ...

Abstract	Virus monitoring in small mammals is central to the design of epidemiological control strategies for rodent-borne zoonotic viruses. Synanthropic small mammals are versatile and may be potential carriers of several microbial agents. In the present work, a total of 330 fecal samples of small mammals were collected at two sites in the North of Portugal and screened for zoonotic hepatitis E virus (HEV, species Paslahepevirus balayani). Synanthropic small mammal samples (n = 40) were collected in a city park of Porto and belonged to the species Algerian mouse (Mus spretus) (n = 26) and to the greater white-toothed shrew (Crocidura russula) (n = 14). Furthermore, additional samples were collected in the Northeast region of Portugal and included Algerian mouse (n = 48), greater white-toothed shrew (n = 47), wood mouse (Apodemus sylvaticus) (n = 43), southwestern water vole (Arvicola sapidus) (n = 52), Cabrera's vole (Microtus cabrerae) (n = 49) and Lusitanian pine vole (Microtus lusitanicus) (n = 51). A nested RT-PCR targeting a part of open reading frame (ORF) 2 region of the HEV genome was used followed by sequencing and phylogenetic analysis. HEV RNA was detected in one fecal sample (0.3%; 95% confidence interval, CI: 0.01-1.68) from a synanthropic Algerian mouse that was genotyped as HEV-3, subgenotype 3e. This is the first study reporting the detection of HEV-3 in a synanthropic rodent, the Algerian mouse. The identified HEV isolate is probably the outcome of either a spill-over infection from domestic pigs or wild boars, or the result of passive viral transit through the intestinal tract. This finding reinforces the importance in the surveillance of novel potential hosts for HEV with a particular emphasis on synanthropic animals.
Language	English
Publishing date	2024-01-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	406735-6
ISSN	1573-7446 ; 0165-7380
ISSN (online)	1573-7446
ISSN	0165-7380
DOI	10.1007/s11259-024-10293-4
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Zs.A 3453: Show issues

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Article: Preclinical Models of Adrenocortical Cancer.

Sedlack, Andrew J H / Hatfield, Samual J / Kumar, Suresh / Arakawa, Yasuhiro / Roper, Nitin / Sun, Nai-Yun / Nilubol, Naris / Kiseljak-Vassiliades, Katja / Hoang, Chuong D / Bergsland, Emily K / Hernandez, Jonathan M / Pommier, Yves / Del Rivero, Jaydira

Cancers

2023 Volume 15, Issue 11

Abstract: Adrenocortical cancer is an aggressive endocrine malignancy with an incidence of 0.72 to 1.02 per million people/year, and a very poor prognosis with a five-year survival rate of 22%. As an orphan disease, clinical data are scarce, meaning that drug ... ...

Abstract	Adrenocortical cancer is an aggressive endocrine malignancy with an incidence of 0.72 to 1.02 per million people/year, and a very poor prognosis with a five-year survival rate of 22%. As an orphan disease, clinical data are scarce, meaning that drug development and mechanistic research depend especially on preclinical models. While a single human ACC cell line was available for the last three decades, over the last five years, many new in vitro and in vivo preclinical models have been generated. Herein, we review both in vitro (cell lines, spheroids, and organoids) and in vivo (xenograft and genetically engineered mouse) models. Striking leaps have been made in terms of the preclinical models of ACC, and there are now several modern models available publicly and in repositories for research in this area.
Language	English
Publishing date	2023-05-23
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15112873
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