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  1. Article ; Online: Xiaoqing: A Q&A model for glaucoma based on LLMs.

    Xue, Xiaojuan / Zhang, Deshiwei / Sun, Chengyang / Shi, Yiqiao / Wang, Rongsheng / Tan, Tao / Gao, Peng / Fan, Sujie / Zhai, Guangtao / Hu, Menghan / Wu, Yue

    Computers in biology and medicine

    2024  Volume 174, Page(s) 108399

    Abstract: ... glaucoma patients. We introduce Xiaoqing, a Natural Language Processing (NLP) model specifically tailored ... glaucoma-related questions in simplified Chinese to three medical NLP models (Xiaoqing LLMs, HuaTuo, Ivy ... patients and non-patients interacting with Xiaoqing, collecting and analyzing their questions and feedback ...

    Abstract Glaucoma is one of the leading cause of blindness worldwide. Individuals affected by glaucoma, including patients and their family members, frequently encounter a deficit in dependable support beyond the confines of clinical environments. Seeking advice via the internet can be a difficult task due to the vast amount of disorganized and unstructured material available on these sites, nevertheless. This research explores how Large Language Models (LLMs) can be leveraged to better serve medical research and benefit glaucoma patients. We introduce Xiaoqing, a Natural Language Processing (NLP) model specifically tailored for the glaucoma field, detailing its development and deployment. To evaluate its effectiveness, we conducted two forms of experiments: comparative and experiential. In the comparative analysis, we presented 22 glaucoma-related questions in simplified Chinese to three medical NLP models (Xiaoqing LLMs, HuaTuo, Ivy GPT) and two general models (ChatGPT-3.5 and ChatGPT-4), covering a range of topics from basic glaucoma knowledge to treatment, surgery, research, management standards, and patient lifestyle. Responses were assessed for informativeness and readability. The experiential experiment involved glaucoma patients and non-patients interacting with Xiaoqing, collecting and analyzing their questions and feedback on the same criteria. The findings demonstrated that Xiaoqing notably outperformed the other models in terms of informativeness and readability, suggesting that Xiaoqing is a significant advancement in the management and treatment of glaucoma in China. We also provide a Web-based version of Xiaoqing, allowing readers to directly experience its functionality. The Web-based Xiaoqing is available at https://qa.glaucoma-assistant.com//qa.
    Language English
    Publishing date 2024-04-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 127557-4
    ISSN 1879-0534 ; 0010-4825
    ISSN (online) 1879-0534
    ISSN 0010-4825
    DOI 10.1016/j.compbiomed.2024.108399
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 653: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Coordination Environment Engineering to Regulate the Adsorption Strength of Intermediates in Single Atom Catalysts for High-performance CO

    Wang, Maohuai / Kong, Lingyan / Lu, Xiaoqing / Wu, Chi-Man Lawrence

    Small (Weinheim an der Bergstrasse, Germany)

    2024  , Page(s) e2310339

    Abstract: The modulation of the coordination environment of single atom catalysts (SACs) plays a vital role in promoting ... ...

    Abstract The modulation of the coordination environment of single atom catalysts (SACs) plays a vital role in promoting CO
    Language English
    Publishing date 2024-01-31
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202310339
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  3. Article ; Online: Alignment-Based Adversarial Training (ABAT) for Improving the Robustness and Accuracy of EEG-Based BCIs.

    Chen, Xiaoqing / Wang, Ziwei / Wu, Dongrui

    IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society

    2024  Volume PP

    Abstract: Machine learning has achieved great success in electroencephalogram (EEG) based brain-computer interfaces (BCIs). Most existing BCI studies focused on improving the decoding accuracy, with only a few considering the adversarial security. Although many ... ...

    Abstract Machine learning has achieved great success in electroencephalogram (EEG) based brain-computer interfaces (BCIs). Most existing BCI studies focused on improving the decoding accuracy, with only a few considering the adversarial security. Although many adversarial defense approaches have been proposed in other application domains such as computer vision, previous research showed that their direct extensions to BCIs degrade the classification accuracy on benign samples. This phenomenon greatly affects the applicability of adversarial defense approaches to EEG-based BCIs. To mitigate this problem, we propose alignment-based adversarial training (ABAT), which performs EEG data alignment before adversarial training. Data alignment aligns EEG trials from different domains to reduce their distribution discrepancies, and adversarial training further robustifies the classification boundary. The integration of data alignment and adversarial training can make the trained EEG classifiers simultaneously more accurate and more robust. Experiments on five EEG datasets from two different BCI paradigms (motor imagery classification, and event related potential recognition), three convolutional neural network classifiers (EEGNet, ShallowCNN and DeepCNN) and three different experimental settings (offline within-subject cross-block/-session classification, online cross-session classification, and pre-trained classifiers) demonstrated its effectiveness. It is very intriguing that adversarial attacks, which are usually used to damage BCI systems, can be used in ABAT to simultaneously improve the model accuracy and robustness.
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1166307-8
    ISSN 1558-0210 ; 1063-6528 ; 1534-4320
    ISSN (online) 1558-0210
    ISSN 1063-6528 ; 1534-4320
    DOI 10.1109/TNSRE.2024.3391936
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4726: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Detailed mechanism study of volatile organic compound decomposition and oxidation removal based on a ReaxFF MD method.

    Wang, Shuo / Wu, Xiaoqing / Chen, Xiaozhen

    RSC advances

    2024  Volume 14, Issue 9, Page(s) 5863–5874

    Abstract: Volatile organic compounds (VOCs) are typical air pollutants as well as gaseous wastes that contain energy. Utilization and disposition of VOCs is currently an important research hotspot in the field of atmospheric environment. In this paper, the thermal ...

    Abstract Volatile organic compounds (VOCs) are typical air pollutants as well as gaseous wastes that contain energy. Utilization and disposition of VOCs is currently an important research hotspot in the field of atmospheric environment. In this paper, the thermal cracking and oxidation reaction processes of typical VOCs components were modelled and analyzed by combining molecular dynamics and detailed reaction mechanisms, focusing on the effects of temperature, oxygen and other conditions on the conversion of VOCs. The results of molecular dynamics studies show that improving temperature and reaction time benefit the decomposition of VOCs. High temperatures under an inert atmosphere can sufficiently crack the VOCs themselves, but other by-products are generated, which in turn cause secondary pollution. The activation energies derived by ReaxFF-MD calculation are 328 kJ mol
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra08122b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Curtius-Type Rearrangement of Sulfinyl Azides: A Matrix Isolation and Computational Study.

    Wu, Zhuang / Zeng, Xiaoqing

    The journal of physical chemistry. A

    2022  Volume 126, Issue 27, Page(s) 4367–4375

    Abstract: The highly unstable methyl sulfinyl azide, ... ...

    Abstract The highly unstable methyl sulfinyl azide, CH
    Language English
    Publishing date 2022-06-30
    Publishing country United States
    Document type Journal Article
    ISSN 1520-5215
    ISSN (online) 1520-5215
    DOI 10.1021/acs.jpca.2c02469
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  6. Article ; Online: Effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on root surfaces and patient complaints.

    You, Xiaoqing / Wu, Xiaohong / Chen, Shiwei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 6601

    Abstract: Tooth wear and pain are the primary concerns of patients undergoing periodontal scaling. The aims of this study were to compare the effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on tooth surface ... ...

    Abstract Tooth wear and pain are the primary concerns of patients undergoing periodontal scaling. The aims of this study were to compare the effects of a new magnetostrictive ultrasonic scaler and a traditional piezoelectric ultrasonic scaler on tooth surface roughness and calculus removal and to determine their impacts on patient discomfort during supragingival cleaning. This article had two parts: an in vitro study and a clinical study. In the in vitro study, thirty teeth with subgingival calculus were randomly assigned to two scaling treatment groups: magnetostrictive scalers (n = 15) and piezoelectric scalers (n = 15). Surface roughness measurements were taken at baseline and after scaling, and the root samples were visualised by SEM after scaling. Additionally, a single-centre randomised split-mouth clinical trial was conducted. Eighty-five participants diagnosed with chronic gingivitis or periodontitis were randomly assigned to receive supragingival scaling. The magnetostrictive scaler was used in half of the mouths (n = 85), and the piezoelectric scaler was used in the other half of the mouths (n = 85). Data on pain, noise, and vibration were collected using a VAS questionnaire, and the operating time was recorded. In both in vitro and clinical studies, magnetostrictive scalers were reported to be more effective than piezoelectric scalers in removing dental deposits (P < 0.05). Additionally, the root surface after scaling with the magnetostrictive scaler was smoother than that after scaling with the piezoelectric scaler in the in vitro study (P = 0.02). SEM examination also revealed that fewer dental materials were lost after instrumentation with the magnetostrictive scaler than after instrumentation with the piezoelectric scaler. Piezoelectric scalers caused less discomfort to patients in terms of pain, noise, and vibration than magnetostrictive scalers (P < 0.05). According to this clinical study, the magnetostrictive scaler caused more discomfort during supragingival scaling than the piezoelectric scaler. Moreover, the magnetostrictive scaler was also more efficient and produced a smoother root surface with less material loss after scaling than the piezoelectric scaler, as demonstrated in the in vitro study.
    MeSH term(s) Humans ; Ultrasonics ; Tooth ; Tooth Root ; Pain ; Ultrasonic Therapy ; Calculi
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Randomized Controlled Trial ; Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-57037-7
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  7. Article ; Online: Integrating spatial-temporal soundscape mapping with landscape indicators for effective conservation management and planning of a protected area.

    Xu, Xiaoqing / Baydur, Caner / Feng, Jingjie / Wu, Chengzhao

    Journal of environmental management

    2024  Volume 356, Page(s) 120555

    Abstract: Protected areas (PAs) possess generous biodiversity, making them great potential for human and wildlife well-being. Nevertheless, rising anthropogenic sounds may pose a serious challenge and threat to the habitats. Therefore, understanding the acoustic ... ...

    Abstract Protected areas (PAs) possess generous biodiversity, making them great potential for human and wildlife well-being. Nevertheless, rising anthropogenic sounds may pose a serious challenge and threat to the habitats. Therefore, understanding the acoustic environments of PAs and implementing proper conservation strategies are essential for maintaining species richness within the territory. In this study, we investigate the spatial-temporal variations of soundscape distribution in the Dashanbao Protected Area (DPA) of China, ultimately discussing the planning and management strategies. Firstly, to systematically analyse the spatial-temporal soundscape distribution of the reserve, we generated single and multi-acoustic source maps by classifying geographical, biological, and anthropogenic sounds. In the region, we installed 35 recording points and collected sounds using the synchronic recording method. Secondly, we conducted Spearman correlation analyses to examine the relationships between the sound sources and i) temporal variations, ii) landscape feature indicators. Thirdly, we identified the dominant sound sources in the region and their conflict areas through the cross-analysis module of Grass Geographic Information Systems (GIS). Finally, we provided sound control strategies by discussing landscape indicators and land-use management policies. The results show that even though there is conservation planning in the DPA, anthropogenic sounds dominate in certain parts of the reserve depending on diurnal and seasonal cycles. This reveals deficiencies in the DPA's current planning concerning the soundscape and highlights the effectiveness of spatial-temporal mapping. Additionally, our correlation analyses demonstrate that landscape feature indicators can represent how sound environment is affected by landscape. The patch diversity (PD), landscape shape index (LSI), Shannon's Diversity Index (SHDI), woodland, shrubland, and water distance (WD) were identified as the primary predictors for both biological and anthropogenic sounds. None of the indicators exhibited a significant positive or negative correlation with geological sounds. Consequently, to enhance and conserve the acoustic quality of the region, spatial-temporal mapping with landscape indicators can be employed in the management and planning processes.
    MeSH term(s) Humans ; Animals ; Ecosystem ; Biodiversity ; Forests ; Animals, Wild ; Geography ; Conservation of Natural Resources/methods
    Language English
    Publishing date 2024-03-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 184882-3
    ISSN 1095-8630 ; 0301-4797
    ISSN (online) 1095-8630
    ISSN 0301-4797
    DOI 10.1016/j.jenvman.2024.120555
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7556: Show issues

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  8. Article: Aqueous Extract of

    Li, Xiaoqing / Lin, Yilin / Jiang, Yiqi / Wu, Binbin / Yu, Yigang

    Foods (Basel, Switzerland)

    2022  Volume 11, Issue 10

    Abstract: Phyllanthus ... ...

    Abstract Phyllanthus emblica
    Language English
    Publishing date 2022-05-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704223-6
    ISSN 2304-8158
    ISSN 2304-8158
    DOI 10.3390/foods11101491
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  9. Article ; Online: Homocysteine Facilitates the Formation of Carotid Atherosclerotic Plaque Through Inflammatory and Noninflammatory Mechanisms.

    Zhang, Qiang / Wu, Chunxi / Tan, Xiaoqing / Li, Can / Liu, Ying / Hu, Shixia

    Metabolic syndrome and related disorders

    2024  

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-02-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2151220-6
    ISSN 1557-8518 ; 1540-4196
    ISSN (online) 1557-8518
    ISSN 1540-4196
    DOI 10.1089/met.2023.0293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Advanced glycation end products regulate the receptor of AGEs epigenetically.

    Wu, Xiaoqing / Shi, Xuanren / Chen, Xiaoyong / Yin, Zhanhai

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1062229

    Abstract: Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE-RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However, ...

    Abstract Advanced glycation end-products (AGEs) can boost their receptor of AGE (RAGE) expression through the downstream signaling pathway to facilitate AGE-RAGE interaction. In this regulation process, the primary signaling pathways are NF-κB and STAT3. However, the inhibition of these transcription factors cannot completely block the upregulation of RAGE, which indicates AGEs may also impact RAGE expression
    Language English
    Publishing date 2023-02-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1062229
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