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  1. Article ; Online: It's OK to move! Effect of a brief video on community confidence in activity despite back pain: A randomised trial.

    O'Hagan, Edel T / Traeger, Adrian C / Schabrun, Siobhan M / O'Neill, Sean / Wand, Benedict M / Cashin, Aidan G / Williams, Christopher M / Harris, Ian A / McAuley, James H

    The Journal of orthopaedic and sports physical therapy

    2024  , Page(s) 1–26

    Abstract: OBJECTIVE: ...

    Abstract OBJECTIVE:
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604640-x
    ISSN 1938-1344 ; 0190-6011
    ISSN (online) 1938-1344
    ISSN 0190-6011
    DOI 10.2519/jospt.2024.12412
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Development and measurement properties of the AxEL (attitude toward education and advice for low-back-pain) questionnaire.

    O'Hagan, Edel T / Skinner, Ian W / Jones, Matthew D / Karran, Emma L / Traeger, Adrian C / Cashin, Aidan G / Wand, Benedict M / Schabrun, Siobhan M / O'Neill, Sean / Harris, Ian A / McAuley, James H

    Health and quality of life outcomes

    2022  Volume 20, Issue 1, Page(s) 4

    Abstract: Introduction: Clinician time and resources may be underutilised if the treatment they offer does not match patient expectations and attitudes. We developed a questionnaire (AxEL-Q) to guide clinicians toward elements of first-line care that are ... ...

    Abstract Introduction: Clinician time and resources may be underutilised if the treatment they offer does not match patient expectations and attitudes. We developed a questionnaire (AxEL-Q) to guide clinicians toward elements of first-line care that are pertinent to their patients with low back pain.
    Methods: We used guidance from the COSMIN consortium to develop the questionnaire and evaluated it in a sample of people with low back pain of any duration. Participants were recruited from the community, were over 18 years and fluent in English. Statements that represented first-line care were identified. Semantic scales were used to measure attitude towards these statements. These items were combined to develop the questionnaire draft. Construct validity was evaluated with exploratory factor analysis and hypotheses testing, comparing to the Back Beliefs Questionnaire and modified Pain Self-Efficacy Questionnaire. Reliability was evaluated and floor and ceiling effects calculated.
    Results: We recruited 345 participants, and had complete data for analysis for 313 participants. The questionnaire draft was reduced to a 3-Factor questionnaire through exploratory factor analysis. Factor 1 comprised 9 items and evaluated Attitude toward staying active, Factor 2 comprised 4 items and evaluated Attitude toward low back pain being rarely caused by a serious health problem, Factor 3 comprised 4 items and evaluated Attitude toward not needing to know the cause of back pain to manage it effectively. There was a strong inverse association between each factor and the Back Beliefs Questionnaire and a moderate positive association with the modified Pain Self-Efficacy Questionnaire. Each independent factor demonstrated acceptable internal consistency; Cronbach α Factor 1 = 0.92, Factor 2 = 0.91, Factor 3 = 0.90 and adequate interclass correlation coefficients; Factor 1 = 0.71, Factor 2 = 0.73, Factor 3 = 0.79.
    Conclusion: This study demonstrates acceptable construct validity and reliability of the AxEL-Q, providing clinicians with an insight into the likelihood of patients following first-line care at the outset.
    MeSH term(s) Attitude ; Cross-Cultural Comparison ; Humans ; Low Back Pain ; Psychometrics ; Quality of Life ; Reproducibility of Results ; Surveys and Questionnaires
    Language English
    Publishing date 2022-01-10
    Publishing country England
    Document type Journal Article
    ISSN 1477-7525
    ISSN (online) 1477-7525
    DOI 10.1186/s12955-021-01908-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Development and measurement properties of the AxEL (attitude toward education and advice for low-back-pain) questionnaire

    Edel T. O’Hagan / Ian W. Skinner / Matthew D. Jones / Emma L. Karran / Adrian C. Traeger / Aidan G. Cashin / Benedict M. Wand / Siobhan M. Schabrun / Sean O’Neill / Ian A. Harris / James H. McAuley

    Health and Quality of Life Outcomes, Vol 20, Iss 1, Pp 1-

    2022  Volume 13

    Abstract: Abstract Introduction Clinician time and resources may be underutilised if the treatment they offer does not match patient expectations and attitudes. We developed a questionnaire (AxEL-Q) to guide clinicians toward elements of first-line care that are ... ...

    Abstract Abstract Introduction Clinician time and resources may be underutilised if the treatment they offer does not match patient expectations and attitudes. We developed a questionnaire (AxEL-Q) to guide clinicians toward elements of first-line care that are pertinent to their patients with low back pain. Methods We used guidance from the COSMIN consortium to develop the questionnaire and evaluated it in a sample of people with low back pain of any duration. Participants were recruited from the community, were over 18 years and fluent in English. Statements that represented first-line care were identified. Semantic scales were used to measure attitude towards these statements. These items were combined to develop the questionnaire draft. Construct validity was evaluated with exploratory factor analysis and hypotheses testing, comparing to the Back Beliefs Questionnaire and modified Pain Self-Efficacy Questionnaire. Reliability was evaluated and floor and ceiling effects calculated. Results We recruited 345 participants, and had complete data for analysis for 313 participants. The questionnaire draft was reduced to a 3-Factor questionnaire through exploratory factor analysis. Factor 1 comprised 9 items and evaluated Attitude toward staying active, Factor 2 comprised 4 items and evaluated Attitude toward low back pain being rarely caused by a serious health problem, Factor 3 comprised 4 items and evaluated Attitude toward not needing to know the cause of back pain to manage it effectively. There was a strong inverse association between each factor and the Back Beliefs Questionnaire and a moderate positive association with the modified Pain Self-Efficacy Questionnaire. Each independent factor demonstrated acceptable internal consistency; Cronbach α Factor 1 = 0.92, Factor 2 = 0.91, Factor 3 = 0.90 and adequate interclass correlation coefficients; Factor 1 = 0.71, Factor 2 = 0.73, Factor 3 = 0.79. Conclusion This study demonstrates acceptable construct validity and reliability of the AxEL-Q, providing clinicians with an ...
    Keywords Low back pain ; Questionnaire development ; Measurement properties ; First-line care ; Computer applications to medicine. Medical informatics ; R858-859.7
    Subject code 306
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: What messages predict intention to self-manage low back pain? A study of attitudes towards patient education.

    O'Hagan, Edel T / Di Pietro, Flavia / Traeger, Adrian C / Cashin, Aidan G / Hodges, Paul W / Wand, Benedict M / O'Neill, Sean / Schabrun, Siobhan M / Harris, Ian A / McAuley, James H

    Pain

    2021  Volume 163, Issue 8, Page(s) 1489–1496

    Abstract: Abstract: This observational study evaluated people's attitudes towards educational statements and tested whether this predicted intention to self-manage low back pain (LBP). People with or without LBP who were older than 18 years and fluent in written ... ...

    Abstract Abstract: This observational study evaluated people's attitudes towards educational statements and tested whether this predicted intention to self-manage low back pain (LBP). People with or without LBP who were older than 18 years and fluent in written English were recruited. Participants completed an online survey asking demographic questions and questions on the presence or absence of LBP, its duration, and intensity. We assessed attitude toward educational statements and conducted linear regression analyses to investigate the relationship between attitude toward each statement and intention to self-manage. We recruited 656 participants, n = 345 (53.6%), with LBP of varying duration. On average, participants had a positive attitude toward all statements except one; participants with chronic LBP had a negative attitude toward a statement relating to the cause of LBP. The effect of attitude on intention to self-manage was dependent on whether someone had LBP and for how long. For example, increased intention to self-manage was predicted by a positive attitude toward educational statements related to staying active (β = 0.22 [CI 0.11-0.33]) in participants without pain, statements about reassurance (β = 0.33 [CI 0.16-0.49]) for participants with acute or subacute LBP, and statements about the severity of back pain (β = 0.25 [CI 0.18-0.33]) for participants with chronic LBP. We noted differences in attitude toward educational messages and individuals' intention to self-manage LBP depending on pain duration. Self-management could be encouraged with specific reassurance in people with acute or subacute LBP and education about severity in people with chronic LBP.
    MeSH term(s) Health Knowledge, Attitudes, Practice ; Humans ; Intention ; Low Back Pain/therapy ; Patient Education as Topic ; Self-Management
    Language English
    Publishing date 2021-11-12
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 193153-2
    ISSN 1872-6623 ; 0304-3959
    ISSN (online) 1872-6623
    ISSN 0304-3959
    DOI 10.1097/j.pain.0000000000002530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Radiology of recreational drug abuse.

    Hagan, Ian G / Burney, Kashif

    Radiographics : a review publication of the Radiological Society of North America, Inc

    2007  Volume 27, Issue 4, Page(s) 919–940

    Abstract: Recreational drug abuse is increasing throughout the world. Use of these drugs may result in a diverse array of acute and chronic complications involving almost any body organ, and imaging frequently plays a vital role in detection and characterization ... ...

    Abstract Recreational drug abuse is increasing throughout the world. Use of these drugs may result in a diverse array of acute and chronic complications involving almost any body organ, and imaging frequently plays a vital role in detection and characterization of such complications. The nature of the complications depends to a large extent on the drug used, the method of administration, and the impurities associated with the drug. Radiologically demonstrable sequelae may be seen after use of opiates, cocaine, amphetamines and their derivatives such as 3,4-methylenedioxymethamphetamine ("ecstasy"), marijuana, and inhaled volatile agents including amyl nitrite ("poppers") and industrial solvents such as toluene. Cardiovascular complications include myocardial infarction, cardiomyopathy, arterial dissection, false and mycotic aneurysms, venous thromboembolic disease, and septic thrombophlebitis. Respiratory complications may involve the upper airways, lung parenchyma, pulmonary vasculature, and pleural space. Neurologic complications are most commonly due to the cerebrovascular effects of illicit drugs. Musculoskeletal complications are dominated by soft-tissue, bone, and joint infections caused by intravenous drug use. Awareness of the imaging features of recreational drug abuse is important for the radiologist because the underlying cause may not be known at presentation and because complications affecting different body systems may coexist. Intravenous drug abuse in particular should be regarded as a multisystem disease with vascular and infective complications affecting many parts of the body, often synchronously. Discovery of one complication should prompt the radiologist to search for coexisting pathologic conditions, which may alter management.
    MeSH term(s) Cardiovascular Diseases/chemically induced ; Cardiovascular Diseases/diagnostic imaging ; Humans ; Infection/diagnostic imaging ; Infection/etiology ; Lung Diseases/chemically induced ; Lung Diseases/diagnostic imaging ; Nervous System Diseases/chemically induced ; Nervous System Diseases/diagnostic imaging ; Practice Guidelines as Topic ; Practice Patterns, Physicians' ; Radiography ; Radiology/methods ; Street Drugs/poisoning ; Substance-Related Disorders/diagnostic imaging ; Substance-Related Disorders/etiology
    Chemical Substances Street Drugs
    Language English
    Publishing date 2007-07
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 603172-9
    ISSN 1527-1323 ; 0271-5333
    ISSN (online) 1527-1323
    ISSN 0271-5333
    DOI 10.1148/rg.274065103
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Psychopathic traits influence amygdala-anterior cingulate cortex connectivity during facial emotion processing.

    Ewbank, Michael P / Passamonti, Luca / Hagan, Cindy C / Goodyer, Ian M / Calder, Andrew J / Fairchild, Graeme

    Social cognitive and affective neuroscience

    2018  Volume 13, Issue 5, Page(s) 525–534

    Abstract: There is accumulating evidence that youths with antisocial behavior or psychopathic traits show deficits in facial emotion recognition, but little is known about the neural mechanisms underlying these impairments. A number of neuroimaging studies have ... ...

    Abstract There is accumulating evidence that youths with antisocial behavior or psychopathic traits show deficits in facial emotion recognition, but little is known about the neural mechanisms underlying these impairments. A number of neuroimaging studies have investigated brain activity during facial emotion processing in youths with Conduct Disorder (CD) and adults with psychopathy, but few of these studies tested for group differences in effective connectivity-i.e. changes in connectivity during emotion processing. Using functional magnetic resonance imaging and psycho-physiological interaction methods, we investigated the impact of CD and psychopathic traits on amygdala activity and effective connectivity in 46 male youths with CD and 25 typically-developing controls when processing emotional faces. All participants were aged 16-21 years. Relative to controls, youths with CD showed reduced amygdala activity when processing angry or sad faces relative to neutral faces, but the groups did not significantly differ in amygdala-related effective connectivity. In contrast, psychopathic traits were negatively correlated with amygdala-ventral anterior cingulate cortex connectivity for angry vs neutral faces, but were unrelated to amygdala responses to angry or sad faces. These findings suggest that CD and psychopathic traits have differential effects on amygdala activation and functional interactions between limbic regions during facial emotion processing.
    MeSH term(s) Adolescent ; Amygdala/diagnostic imaging ; Amygdala/physiology ; Anger ; Antisocial Personality Disorder/diagnostic imaging ; Antisocial Personality Disorder/psychology ; Conduct Disorder/diagnostic imaging ; Conduct Disorder/psychology ; Emotions/physiology ; Facial Expression ; Gyrus Cinguli/diagnostic imaging ; Gyrus Cinguli/physiology ; Humans ; Magnetic Resonance Imaging ; Male ; Neural Pathways/diagnostic imaging ; Neural Pathways/physiology ; Neuropsychological Tests ; Personality Tests ; Social Perception ; Young Adult
    Language English
    Publishing date 2018-04-15
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2236933-8
    ISSN 1749-5024 ; 1749-5016
    ISSN (online) 1749-5024
    ISSN 1749-5016
    DOI 10.1093/scan/nsy019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Comparison of the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with NICE guideline CG149 in infants ≥34 weeks' gestation who developed early-onset sepsis.

    Morris, Rachel / Jones, Steve / Banerjee, Sujoy / Collinson, Andrew / Hagan, Hannah / Walsh, Hannah / Thornton, Graham / Barnard, Ian / Warren, Chris / Reid, Jennifer / Busfield, Alison / Matthes, Jean

    Archives of disease in childhood. Fetal and neonatal edition

    2020  Volume 105, Issue 6, Page(s) 581–586

    Abstract: Objective: To compare the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with National Institute for Health and Care Excellence (NICE) guideline CG149 in infants ≥34 weeks' gestation who developed ... ...

    Abstract Objective: To compare the management recommendations of the Kaiser Permanente neonatal early-onset sepsis risk calculator (SRC) with National Institute for Health and Care Excellence (NICE) guideline CG149 in infants ≥34 weeks' gestation who developed early-onset sepsis (EOS).
    Design: Retrospective multicentre study.
    Setting: Five maternity services in South West of England and Wales.
    Patients: 70 infants with EOS (<72 hours) confirmed on blood or cerebrospinal fluid culture.
    Methods: Retrospective virtual application of NICE and SRC through review of maternal and neonatal notes.
    Main outcome measure: The number of infants recommended antibiotics by 4 hours of birth.
    Results: The incidence of EOS ≥34 weeks was 0.5/1000 live births. Within 4 hours of birth, antibiotics were recommended for 39 infants (55.7%) with NICE, compared with 27 (38.6%) with SRC. The 12 infants advised early treatment by NICE but not SRC remained well, only one showing transient mild symptoms after 4 hours. Another four babies received antibiotics by 4 hours outside NICE and SRC guidance. The remaining 27 infants (38.6%) received antibiotics when symptomatic after 4 hours. Only one infant who was unwell from birth, died. Eighty-one per cent of all EOS infants were treated for clinical reasons rather than for risk factors alone.
    Conclusion: While both tools were poor in identifying EOS within 4 hours, NICE was superior to SRC in identifying asymptomatic cases. Currently, four out of five EOS have symptoms at first identification, the majority of whom present within 24 hours of birth. Antibiotic stewardship programmes using SRC should include enhanced observation for infants currently treated within NICE guidance.
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Early Diagnosis ; Humans ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases/diagnosis ; Infant, Premature, Diseases/drug therapy ; Neonatal Sepsis/diagnosis ; Neonatal Sepsis/drug therapy ; Practice Guidelines as Topic ; Retrospective Studies ; Risk Assessment/methods ; United Kingdom ; United States
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-03-13
    Publishing country England
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 2007331-8
    ISSN 1468-2052 ; 1359-2998
    ISSN (online) 1468-2052
    ISSN 1359-2998
    DOI 10.1136/archdischild-2019-317165
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The interpersonal theory of suicide: A systematic review and meta-analysis of a decade of cross-national research.

    Chu, Carol / Buchman-Schmitt, Jennifer M / Stanley, Ian H / Hom, Melanie A / Tucker, Raymond P / Hagan, Christopher R / Rogers, Megan L / Podlogar, Matthew C / Chiurliza, Bruno / Ringer, Fallon B / Michaels, Matthew S / Patros, Connor H G / Joiner, Thomas E

    Psychological bulletin

    2017  Volume 143, Issue 12, Page(s) 1313–1345

    Abstract: Over the past decade, the interpersonal theory of suicide has contributed to substantial advances in the scientific and clinical understanding of suicide and related conditions. The interpersonal theory of suicide posits that suicidal desire emerges when ...

    Abstract Over the past decade, the interpersonal theory of suicide has contributed to substantial advances in the scientific and clinical understanding of suicide and related conditions. The interpersonal theory of suicide posits that suicidal desire emerges when individuals experience intractable feelings of perceived burdensomeness and thwarted belongingness and near-lethal or lethal suicidal behavior occurs in the presence of suicidal desire and capability for suicide. A growing number of studies have tested these posited pathways in various samples; however, these findings have yet to be evaluated meta-analytically. This paper aimed to (a) conduct a systematic review of the unpublished and published, peer-reviewed literature examining the relationship between interpersonal theory constructs and suicidal thoughts and behaviors, (b) conduct meta-analyses testing the interpersonal theory hypotheses, and (c) evaluate the influence of various moderators on these relationships. Four electronic bibliographic databases were searched through the end of March, 2016: PubMed, Medline, PsycINFO, and Web of Science. Hypothesis-driven meta-analyses using random effects models were conducted using 122 distinct unpublished and published samples. Findings supported the interpersonal theory: the interaction between thwarted belongingness and perceived burdensomeness was significantly associated with suicidal ideation; and the interaction between thwarted belongingness, perceived burdensomeness, and capability for suicide was significantly related to a greater number of prior suicide attempts. However, effect sizes for these interactions were modest. Alternative configurations of theory variables were similarly useful for predicting suicide risk as theory-consistent pathways. We conclude with limitations and recommendations for the interpersonal theory as a framework for understanding the suicidal spectrum. (PsycINFO Database Record
    MeSH term(s) Humans ; Internationality ; Interpersonal Relations ; Models, Psychological ; Psychological Theory ; Suicidal Ideation ; Suicide/psychology
    Language English
    Publishing date 2017-10-26
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 1321-3
    ISSN 1939-1455 ; 0033-2909
    ISSN (online) 1939-1455
    ISSN 0033-2909
    DOI 10.1037/bul0000123
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Cortical thickness, surface area, and folding alterations in male youths with conduct disorder and varying levels of callous-unemotional traits.

    Fairchild, Graeme / Toschi, Nicola / Hagan, Cindy C / Goodyer, Ian M / Calder, Andrew J / Passamonti, Luca

    NeuroImage. Clinical

    2015  Volume 8, Page(s) 253–260

    Abstract: Purpose: Previous studies have reported changes in gray matter volume in youths with conduct disorder (CD), although these differences are difficult to interpret as they may have been driven by alterations in cortical thickness, surface area (SA), or ... ...

    Abstract Purpose: Previous studies have reported changes in gray matter volume in youths with conduct disorder (CD), although these differences are difficult to interpret as they may have been driven by alterations in cortical thickness, surface area (SA), or folding. The objective of this study was to use surface-based morphometry (SBM) methods to compare male youths with CD and age and sex-matched healthy controls (HCs) in cortical thickness, SA, and folding. We also tested for structural differences between the childhood-onset and adolescence-onset subtypes of CD and performed regression analyses to assess for relationships between CD symptoms and callous-unemotional (CU) traits and SBM-derived measures.
    Methods: We acquired structural neuroimaging data from 20 HCs and 36 CD participants (18 with childhood-onset CD and 18 with adolescence-onset CD) and analyzed the data using FreeSurfer.
    Results: Relative to HCs, youths with CD showed reduced cortical thickness in the superior temporal gyrus, reduced SA in the orbitofrontal cortex (OFC), and increased cortical folding in the insula. There were no significant differences between the childhood-onset and adolescence-onset CD subgroups in cortical thickness or SA, but several frontal and temporal regions showed increased cortical folding in childhood-onset relative to adolescence-onset CD participants. Both CD subgroups also showed increased cortical folding relative to HCs. CD symptoms were negatively correlated with OFC SA whereas CU traits were positively correlated with insula folding.
    Conclusions: Cortical thinning in the superior temporal gyrus may contribute to the social cognitive impairments displayed by youths with CD, whereas reduced OFC SA may lead to impairments in emotion regulation and reward processing in youths with CD. The increased cortical folding observed in the insula may reflect a maturational delay in this region and could mediate the link between CU traits and empathy deficits. Altered cortical folding was observed in childhood-onset and adolescence-onset forms of CD.
    MeSH term(s) Adolescent ; Adult ; Age of Onset ; Antisocial Personality Disorder/pathology ; Cerebral Cortex/growth & development ; Cerebral Cortex/pathology ; Conduct Disorder/pathology ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Young Adult
    Language English
    Publishing date 2015-04-30
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701571-3
    ISSN 2213-1582 ; 2213-1582
    ISSN (online) 2213-1582
    ISSN 2213-1582
    DOI 10.1016/j.nicl.2015.04.018
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  10. Article ; Online: Atypical neural responses during face processing in female adolescents with conduct disorder.

    Fairchild, Graeme / Hagan, Cindy C / Passamonti, Luca / Walsh, Nicholas D / Goodyer, Ian M / Calder, Andrew J

    Journal of the American Academy of Child and Adolescent Psychiatry

    2014  Volume 53, Issue 6, Page(s) 677–687.e5

    Abstract: Objective: Conduct disorder (CD) in females is associated with negative adult outcomes including mental health problems and personality disorders. Although recent neuroimaging studies have reported changes in neural activity during facial emotion ... ...

    Abstract Objective: Conduct disorder (CD) in females is associated with negative adult outcomes including mental health problems and personality disorders. Although recent neuroimaging studies have reported changes in neural activity during facial emotion processing in males with CD or callous-unemotional (CU) traits, there have been no neuroimaging studies specifically assessing females with CD. We addressed this gap by investigating whether female adolescents with CD show atypical neural activation when processing emotional or neutral faces.
    Method: We acquired functional magnetic resonance imaging (fMRI) data from 20 female adolescents with CD and 20 female control participants while they viewed angry, sad, and neutral faces.
    Results: An omnibus group (CD, control) by facial emotion (angry, sad, neutral) analysis of variance (ANOVA) revealed main effects of facial emotion in superior temporal cortex, fusiform gyrus, ventrolateral prefrontal cortex and insula, and main effects of group in medial orbitofrontal cortex (OFC) and right anterior insula. Female participants with CD showed reduced medial OFC and increased anterior insula responses relative to healthy controls. There were no significant group × facial emotion interactions. Lifetime CD symptoms were negatively correlated with amygdala, superior temporal cortex, fusiform gyrus, and dorsolateral prefrontal cortex activity for the contrast "all-faces versus fixation." CU traits were negatively correlated with fusiform gyrus activity for the contrast sad versus neutral faces.
    Conclusion: Females with CD showed atypical neural activation during the processing of all facial expressions, irrespective of valence. Our results demonstrate that severity of CD symptoms and CU traits is important in explaining abnormal patterns of neural activity.
    MeSH term(s) Adolescent ; Amygdala/physiopathology ; Cerebral Cortex/physiopathology ; Conduct Disorder/physiopathology ; Emotions/physiology ; Facial Expression ; Female ; Humans ; Magnetic Resonance Imaging
    Language English
    Publishing date 2014-03-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2014.02.009
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