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  1. Article ; Online: Advancing Towards Personalized Prescription of Radiotherapy Dose.

    Citrin, Deborah / Morris, Zachary S

    Seminars in radiation oncology

    2023  Volume 33, Issue 3, Page(s) 219–220

    MeSH term(s) Humans ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted ; Prescriptions ; Radiotherapy, Intensity-Modulated
    Language English
    Publishing date 2023-07-01
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2023.03.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3654: Show issues Location:
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  2. Article ; Online: Radiation Modifiers.

    Citrin, Deborah E

    Hematology/oncology clinics of North America

    2019  Volume 33, Issue 6, Page(s) 1041–1055

    Abstract: Radiation therapy is one of the most commonly used treatments for cancer. Radiation modifiers are agents that alter tumor or normal tissue response to radiation, such as radiation sensitizers and radiation protectors. Radiation sensitizers target aspects ...

    Abstract Radiation therapy is one of the most commonly used treatments for cancer. Radiation modifiers are agents that alter tumor or normal tissue response to radiation, such as radiation sensitizers and radiation protectors. Radiation sensitizers target aspects of tumor molecular biology or physiology to enhance tumor cell killing after irradiation. Radioprotectors prevent damage of normal tissues selectively. Radiation modifiers remain largely investigational at present, with the promise that molecular characterization of tumors may enhance the capacity for successful clinical development moving forward. A variety of radiation modifiers are described.
    MeSH term(s) Antineoplastic Agents/therapeutic use ; Humans ; Neoplasms/drug therapy ; Neoplasms/radiotherapy ; Prognosis ; Radiation-Protective Agents/therapeutic use ; Radiation-Sensitizing Agents/therapeutic use
    Chemical Substances Antineoplastic Agents ; Radiation-Protective Agents ; Radiation-Sensitizing Agents
    Language English
    Publishing date 2019-09-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2019.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Methods to assess radiation-induced fibrosis in mice.

    Chung, Eun Joo / White, Ayla O / Citrin, Deborah E

    Methods in cell biology

    2023  Volume 180, Page(s) 113–126

    Abstract: Therapeutic radiation is used to treat a variety of cancers in organs and tissues throughout the body. Exposure of benign normal tissue to radiation can result in late injury in a subset of patients. Radiation induced fibrosis is one chronic, progressive ...

    Abstract Therapeutic radiation is used to treat a variety of cancers in organs and tissues throughout the body. Exposure of benign normal tissue to radiation can result in late injury in a subset of patients. Radiation induced fibrosis is one chronic, progressive late toxicity of radiation exposure that can occur in many organs and tissues, including skin and lung. Radiation fibrosis has few effective treatments. The process of radiation fibrosis is known to involve many mitogenic and immunomodulatory cytokines, inflammatory programs, and processes such as stem cell senescence. Murine models of radiation fibrosis can be used to evaluate agents that may prevent, mitigate, or treat this injury. Here, we provide a detailed protocol for the development of radiation induced dermal and pulmonary fibrosis in mice and describe protocols for the measurement of this injury in treated tissue.
    MeSH term(s) Humans ; Animals ; Mice ; Radiation Fibrosis Syndrome ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; Lung ; Skin ; Mice, Inbred C57BL
    Language English
    Publishing date 2023-03-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2023.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Exploiting the DNA Damage Response for Prostate Cancer Therapy.

    Stracker, Travis H / Osagie, Oloruntoba I / Escorcia, Freddy E / Citrin, Deborah E

    Cancers

    2023  Volume 16, Issue 1

    Abstract: Prostate cancers that progress despite androgen deprivation develop into castration-resistant prostate cancer, a fatal disease with few treatment options. In this review, we discuss the current understanding of prostate cancer subtypes and alterations in ...

    Abstract Prostate cancers that progress despite androgen deprivation develop into castration-resistant prostate cancer, a fatal disease with few treatment options. In this review, we discuss the current understanding of prostate cancer subtypes and alterations in the DNA damage response (DDR) that can predispose to the development of prostate cancer and affect its progression. We identify barriers to conventional treatments, such as radiotherapy, and discuss the development of new therapies, many of which target the DDR or take advantage of recurring genetic alterations in the DDR. We place this in the context of advances in understanding the genetic variation and immune landscape of CRPC that could help guide their use in future treatment strategies. Finally, we discuss several new and emerging agents that may advance the treatment of lethal disease, highlighting selected clinical trials.
    Language English
    Publishing date 2023-12-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers16010083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Introduction.

    Citrin, Deborah E

    Seminars in radiation oncology

    2017  Volume 27, Issue 4, Page(s) 299

    MeSH term(s) Biomarkers ; Dose Fractionation, Radiation ; Genetic Predisposition to Disease ; Humans ; Neoplasms/radiotherapy ; Radiation Injuries/etiology ; Radiation Injuries/genetics ; Radiation Injuries/therapy ; Radiation Oncology/trends ; Risk Assessment
    Chemical Substances Biomarkers
    Language English
    Publishing date 2017-09-02
    Publishing country United States
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2017.05.001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3654: Show issues Location:
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  6. Article ; Online: Radiation-induced pulmonary fibrosis: roles of therapy-induced senescence and microRNAs.

    Prasanna, Pataje G S / Aryankalayil, Molykutty / Citrin, Deborah E / Coleman, C Norman

    International journal of radiation biology

    2023  Volume 99, Issue 7, Page(s) 1027–1036

    Abstract: Purpose: Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of radiotherapy. Known mechanisms of RIPF include oxidative stress-induced activation of TGF-β with ... ...

    Abstract Purpose: Progressive, irreversible radiation-induced pulmonary fibrosis (RIPF) is a clinically significant intermediate- to a late-occurring side effect of radiotherapy. Known mechanisms of RIPF include oxidative stress-induced activation of TGF-β with activation of SMAD signaling, TNF-α elaboration, and activation of the Angiotensin Converting Enzyme (ACE) mediated production of angiotensin II with resulting activation of profibrotic cytokine signaling and vasoconstriction. The pioneering work of John Moulder, to whom this paper is dedicated, and several of his colleagues demonstrated that inhibiting the conversion of ACE with drugs such as Captopril, Enalapril, and Losartan can ameliorate radiation fibrosis in various tissues. While this work led several groups to probe mechanism-based pharmacological mitigation of RIPF, in this article, we explore and discuss the roles of microRNAs (miRNA) and therapy-induced senescence (TIS) in the pathogenesis of and potential biomarkers for RIPF.
    Conclusion: Our analysis of the published literature in the last decade on RIPF, miRNA, and TIS identifies TIS as a mechanism in the onset and progression of RIPF, which is regulated through several miRNAs. This work may lead to the discovery and development of the next generation of miRNA therapeutics and/or the repurposing of approved pharmaceutical agents and the development of early biomarker panels to predict RIPF.
    MeSH term(s) Humans ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/genetics ; MicroRNAs/genetics ; Radiation Fibrosis Syndrome ; Lung/pathology ; Radiation Injuries/pathology ; Fibrosis
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2023-02-15
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3065-x
    ISSN 1362-3095 ; 0020-7616 ; 0955-3002
    ISSN (online) 1362-3095
    ISSN 0020-7616 ; 0955-3002
    DOI 10.1080/09553002.2023.2177768
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ue I Zs.280: Show issues Location:
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  7. Article ; Online: Recent Developments in Radiotherapy.

    Citrin, Deborah E

    The New England journal of medicine

    2017  Volume 377, Issue 11, Page(s) 1065–1075

    MeSH term(s) Cellular Senescence/radiation effects ; Humans ; Immunity/radiation effects ; Neoplasms/diagnostic imaging ; Neoplasms/radiotherapy ; Positron Emission Tomography Computed Tomography ; Radiation Dosage ; Radiotherapy/adverse effects ; Radiotherapy/methods ; Radiotherapy/trends ; Radiotherapy Planning, Computer-Assisted/methods ; Radiotherapy, Conformal
    Language English
    Publishing date 2017-09-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra1608986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Short-Term Screening Assays for the Identification of Therapeutics for Cancer.

    Citrin, Deborah E

    Cancer research

    2016  Volume 76, Issue 12, Page(s) 3443–3445

    MeSH term(s) Cytological Techniques/history ; Cytological Techniques/methods ; History, 20th Century ; Humans ; Neoplasms/history ; Neoplasms/pathology ; Neoplasms/therapy ; Tetrazolium Salts
    Chemical Substances 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2H-tetrazolium bromide ; Tetrazolium Salts
    Language English
    Publishing date 2016-07-08
    Publishing country United States
    Document type Historical Article ; Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-16-1299
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The clinical manifestations and molecular pathogenesis of radiation fibrosis.

    Fijardo, Mackenzie / Kwan, Jennifer Yin Yee / Bissey, Pierre-Antoine / Citrin, Deborah E / Yip, Kenneth W / Liu, Fei-Fei

    EBioMedicine

    2024  Volume 103, Page(s) 105089

    Abstract: Advances in radiation techniques have enabled the precise delivery of higher doses of radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the incidence of radiation toxicities has declined, and will likely continue to ... ...

    Abstract Advances in radiation techniques have enabled the precise delivery of higher doses of radiotherapy to tumours, while sparing surrounding healthy tissues. Consequently, the incidence of radiation toxicities has declined, and will likely continue to improve as radiotherapy further evolves. Nonetheless, ionizing radiation elicits tissue-specific toxicities that gradually develop into radiation-induced fibrosis, a common long-term side-effect of radiotherapy. Radiation fibrosis is characterized by an aberrant wound repair process, which promotes the deposition of extensive scar tissue, clinically manifesting as a loss of elasticity, tissue thickening, and organ-specific functional consequences. In addition to improving the existing technologies and guidelines directing the administration of radiotherapy, understanding the pathogenesis underlying radiation fibrosis is essential for the success of cancer treatments. This review integrates the principles for radiotherapy dosimetry to minimize off-target effects, the tissue-specific clinical manifestations, the key cellular and molecular drivers of radiation fibrosis, and emerging therapeutic opportunities for both prevention and treatment.
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2024.105089
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7090: Show issues Location:
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  10. Article ; Online: Biology of Radiation-Induced Lung Injury.

    Roy, Soumyajit / Salerno, Kilian E / Citrin, Deborah E

    Seminars in radiation oncology

    2021  Volume 31, Issue 2, Page(s) 155–161

    Abstract: Radiation-induced lung injury encompasses radiation-induced pneumonitis, inflammation of the lung which may manifest as a dose-limiting acute or subacute toxicity, and radiation-induced lung fibrosis, a late effect of lung exposure to radiation. This ... ...

    Abstract Radiation-induced lung injury encompasses radiation-induced pneumonitis, inflammation of the lung which may manifest as a dose-limiting acute or subacute toxicity, and radiation-induced lung fibrosis, a late effect of lung exposure to radiation. This review aims to highlight developments in molecular radiation biology of radiation-induced lung injury and their implications in clinical practice.
    MeSH term(s) Humans ; Lung ; Lung Injury/etiology ; Lung Injury/pathology ; Pulmonary Fibrosis/etiology ; Pulmonary Fibrosis/pathology ; Radiation Pneumonitis/etiology ; Radiobiology
    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2020.11.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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