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Article: Experimentally Determined Hansen Solubility Parameters of Biobased and Biodegradable Polyesters.

Patel, Kush G / Maynard, Ryan K / Ferguson, Lawrence S / Broich, Michael L / Bledsoe, Joshua C / Wood, Caitlin C / Crane, Grant H / Bramhall, Jessica A / Rust, Jonathan M / Williams-Rhaesa, Amanda / Locklin, Jason J

ACS sustainable chemistry & engineering

2024 Volume 12, Issue 6, Page(s) 2386–2393

Abstract: Hansen solubility parameters (HSP) of 15 commercially relevant biobased and biodegradable polyesters were experimentally determined by applying a novel approach to the classic solubility study method. In this approach, the extent of swelling in polymer ... ...

Abstract	Hansen solubility parameters (HSP) of 15 commercially relevant biobased and biodegradable polyesters were experimentally determined by applying a novel approach to the classic solubility study method. In this approach, the extent of swelling in polymer films was determined using a simple equation based on the mass difference between swollen and nonswollen film samples to obtain normalized solvent uptake (
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ISSN	2168-0485
ISSN	2168-0485
DOI	10.1021/acssuschemeng.3c07284
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Article ; Online: Rapid and Deep Remission Induced by Blinatumomab for CD19-Positive Chronic Myeloid Leukemia in Lymphoid Blast Phase.

Patel, Shyam A / Bledsoe, Jacob R / Higgins, Anne W / Hutchinson, Lloyd / Gerber, Jonathan M

JCO precision oncology

2021 Volume 5

MeSH term(s)	Antibodies, Bispecific/therapeutic use ; Blast Crisis/drug therapy ; Humans ; Leukemia, Myelogenous, Chronic, BCR-ABL Positive/drug therapy
Chemical Substances	Antibodies, Bispecific ; blinatumomab (4FR53SIF3A)
Language	English
Publishing date	2021-07-09
Publishing country	United States
Document type	Case Reports
ISSN	2473-4284
ISSN (online)	2473-4284
DOI	10.1200/PO.21.00039
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Article ; Online: Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.

Williamson, Katrina A / Yun, Mark / Koster, Matthew J / Arment, Courtney / Patnaik, Asha / Chang, Tara W / Bledsoe, Adam C / Sae-Tia, Sutthichai / Shah, Aditya S / Samuels, Jonathan / Davis, John M / Yao, Qingping

Rheumatology (Oxford, England)

2023 Volume 63, Issue 5, Page(s) 1291–1296

Abstract: Objectives: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host ... ...

Abstract	Objectives: Whipple's disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and contributes to defence against infection and inflammatory regulation. NOD2 mutations are associated with autoinflammatory diseases. We report the association of NOD2 mutations with TW and WD for the first time. Methods: A multicentre, retrospective study of three patients with WD was conducted. Patients received extensive multidisciplinary evaluations and were cared for by the authors. NOD2 and its association with infection and inflammation were schematically represented. Results: All patients were Caucasian men and presented with years of autoinflammatory phenotypes, including recurrent fever, rash, inflammatory arthritis, gastrointestinal symptoms and elevated inflammatory markers. All patients underwent molecular testing using a gene panel for periodic fever syndromes and were identified to carry NOD2 mutations associated with NOD2-associated autoinflammatory disease. Despite initially negative gastrointestinal evaluations, repeat endoscopy with duodenal tissue biopsy ultimately confirmed WD. After initial ceftriaxone and maintenance with doxycycline and/or HCQ, symptoms were largely controlled, though mild relapses occurred in follow-up. Conclusion: Both NOD2 and TW/WD are intensively involved in monocytes/macrophages. WD is regarded as a macrophage disease. NOD2 leucin-rich repeat-associated mutations in monocytes/macrophages cause functional impairment of these cells and consequently may make the host susceptible for TW infection and WD, especially in the setting of immunosuppression.
MeSH term(s)	Humans ; Whipple Disease/genetics ; Whipple Disease/immunology ; Male ; Nod2 Signaling Adaptor Protein/genetics ; Retrospective Studies ; Mutation ; Middle Aged ; Adult ; Genetic Predisposition to Disease ; Tropheryma/genetics
Chemical Substances	Nod2 Signaling Adaptor Protein ; NOD2 protein, human
Language	English
Publishing date	2023-07-18
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't ; Case Reports
ZDB-ID	1464822-2
ISSN	1462-0332 ; 1462-0324
ISSN (online)	1462-0332
ISSN	1462-0324
DOI	10.1093/rheumatology/kead372
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Article ; Online: Regional Specialty Surgical Practice Efficiencies Gained as a Result of COVID-19.

Craig, Jason E / Martin-Krajewski, Carie A / Bledsoe, Jonathan M / Wensink, Laurie J / Crawford, Neal S / Eberhardt, Angela M / Grottke, Kara L / Helmers, Richard A

Mayo Clinic proceedings. Innovations, quality & outcomes

2021 Volume 5, Issue 4, Page(s) 693–699

Abstract: Objective: To identify opportunities for discontinuing elective and nonemergency surgical cases in a regional surgical practice in response to coronavirus disease 2019 (COVID-19).: Patients and methods: COVID-19 began to affect surgical practices ... ...

Abstract	Objective: To identify opportunities for discontinuing elective and nonemergency surgical cases in a regional surgical practice in response to coronavirus disease 2019 (COVID-19). Patients and methods: COVID-19 began to affect surgical practices across the United States in March 2020. On March 17, 2020, all elective and nonemergency surgical care was deferred to prepare the Mayo Clinic Health System sites in northwestern Wisconsin for an anticipated surge in patients with COVID-19. When the decision was made to reactivate the surgical practice, several major structural and operational changes were made to the regional surgical practice to optimize efficiencies. Results: The structural and operational changes implemented during reactivation resulted in improved utilization of surgical resources including improvement in operating room (OR) block utilization, increased available OR time, and increased case volumes. Conclusion: Surgical and procedural leaders should consider a limited-time deferral of elective surgical cases to implement widespread OR efficiency strategies. The time selected for deferral of surgical cases should target a period of historically low surgical volume to minimize disruption to patient care and impact on overall OR functions.
Language	English
Publishing date	2021-06-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	2542-4548
ISSN (online)	2542-4548
DOI	10.1016/j.mayocpiqo.2021.06.003
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Article: Prognostic Value of Multiplexed Assays of Variant Effect and Automated Patch-clamping for

O'Neill, Matthew J / Ng, Chai-Ann / Aizawa, Takanori / Sala, Luca / Bains, Sahej / Denjoy, Isabelle / Winbo, Annika / Ullah, Rizwan / Shen, Qianyi / Tan, Chek-Ying / Kozek, Krystian / Vanags, Loren R / Mitchell, Devyn W / Shen, Alex / Wada, Yuko / Kashiwa, Asami / Crotti, Lia / Dagradi, Federica / Musu, Giulia /

medRxiv : the preprint server for health sciences

2024

Abstract: Background: Long QT syndrome (LQTS) is a lethal arrhythmia condition, frequently caused by rare loss-of-function variants in the cardiac potassium channel encoded by : Objective: To test the utility of variant-specific features, including high- ... ...

Abstract	Background: Long QT syndrome (LQTS) is a lethal arrhythmia condition, frequently caused by rare loss-of-function variants in the cardiac potassium channel encoded by Objective: To test the utility of variant-specific features, including high-throughput functional data, to predict cardiac events among Methods: We quantified cell-surface trafficking of 18,323 variants in Results: Variant-specific current density (HR 0.28 [0.13-0.60]) and estimates of LQTS penetrance incorporating MAVE data (HR 3.16 [1.59-6.27]) were independently predictive of severe cardiac events when controlling for patient-specific features. Risk prediction models incorporating these data significantly improved prediction of 20 year cardiac events (AUC 0.79 [0.75-0.82]) over patient-only covariates (QTc and sex) (AUC 0.73 [0.70-0.77]). Conclusion: We show that high-throughput functional data, and other variant-specific features, meaningfully contribute to both diagnosis and prognosis of a clinically actionable monogenic disease.
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.01.24301443
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Article ; Online: Intramedullary melanotic schwannoma.

Hoover, Jason M / Bledsoe, Jonathan M / Giannini, Caterina / Krauss, William E

Rare tumors

2012 Volume 4, Issue 1, Page(s) e3

Abstract: We present a case of an intramedullary melanotic schwannoma (IMS) of the thoracic spinal cord. To our knowledge, this is the seventh reported case of an IMS of the central nervous system. Schwannomas are benign nerve sheath tumors of neural crest origin ... ...

Abstract	We present a case of an intramedullary melanotic schwannoma (IMS) of the thoracic spinal cord. To our knowledge, this is the seventh reported case of an IMS of the central nervous system. Schwannomas are benign nerve sheath tumors of neural crest origin composed entirely of well differentiated Schwann cells that typically occur in peripheral nerves. Both the intramedullary location and the melanotic component of the reported lesion make it exceedingly rare. We will present our case, theories as to the origin of these tumors, clues in radiographic identification, and current clinical follow-up recommendations.
Language	English
Publishing date	2012-01-31
Publishing country	England
Document type	Case Reports
ZDB-ID	2514363-3
ISSN	2036-3613 ; 2036-3605
ISSN (online)	2036-3613
ISSN	2036-3605
DOI	10.4081/rt.2012.e3
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Article ; Online: Regional Specialty Surgical Practice Efficiencies Gained as a Result of COVID-19

Jason E. Craig, MBA / Carie A. Martin-Krajewski, MHA, BSN / Jonathan M. Bledsoe, MD / Laurie J. Wensink, MSN, MBA, RN / Neal S. Crawford, MBA, BSN / Angela M. Eberhardt, MBA, BSN / Kara L. Grottke, BS / Richard A. Helmers, MD

Mayo Clinic Proceedings: Innovations, Quality & Outcomes, Vol 5, Iss 4, Pp 693-

2021 Volume 699

Abstract: Objective: To identify opportunities for discontinuing elective and nonemergency surgical cases in a regional surgical practice in response to coronavirus disease 2019 (COVID-19). Patients and Methods: COVID-19 began to affect surgical practices across ... ...

Abstract	Objective: To identify opportunities for discontinuing elective and nonemergency surgical cases in a regional surgical practice in response to coronavirus disease 2019 (COVID-19). Patients and Methods: COVID-19 began to affect surgical practices across the United States in March 2020. On March 17, 2020, all elective and nonemergency surgical care was deferred to prepare the Mayo Clinic Health System sites in northwestern Wisconsin for an anticipated surge in patients with COVID-19. When the decision was made to reactivate the surgical practice, several major structural and operational changes were made to the regional surgical practice to optimize efficiencies. Results: The structural and operational changes implemented during reactivation resulted in improved utilization of surgical resources including improvement in operating room (OR) block utilization, increased available OR time, and increased case volumes. Conclusion: Surgical and procedural leaders should consider a limited-time deferral of elective surgical cases to implement widespread OR efficiency strategies. The time selected for deferral of surgical cases should target a period of historically low surgical volume to minimize disruption to patient care and impact on overall OR functions.
Keywords	Medicine (General) ; R5-920
Subject code	616
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Integration of Genomic Sequencing Drives Therapeutic Targeting of PDGFRA in T-Cell Acute Lymphoblastic Leukemia/Lymphoblastic Lymphoma.

Paolino, Jonathan / Dimitrov, Boris / Apsel Winger, Beth / Sandoval-Perez, Angelica / Rangarajan, Amith Vikram / Ocasio-Martinez, Nicole / Tsai, Harrison K / Li, Yuting / Robichaud, Amanda L / Khalid, Delan / Hatton, Charlie / Gillani, Riaz / Polonen, Petri / Dilig, Anthony / Gotti, Giacomo / Kavanagh, Julia / Adhav, Asmani A / Gow, Sean / Tsai, Jonathan /

Clinical cancer research : an official journal of the American Association for Cancer Research

2023 Volume 29, Issue 22, Page(s) 4613–4626

Abstract: Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to ...

Abstract	Purpose: Patients with relapsed or refractory T-cell acute lymphoblastic leukemia (T-ALL) or lymphoblastic lymphoma (T-LBL) have limited therapeutic options. Clinical use of genomic profiling provides an opportunity to identify targetable alterations to inform therapy. Experimental design: We describe a cohort of 14 pediatric patients with relapsed or refractory T-ALL enrolled on the Leukemia Precision-based Therapy (LEAP) Consortium trial (NCT02670525) and a patient with T-LBL, discovering alterations in platelet-derived growth factor receptor-α (PDGFRA) in 3 of these patients. We identified a novel mutation in PDGFRA, p.D842N, and used an integrated structural modeling and molecular biology approach to characterize mutations at D842 to guide therapeutic targeting. We conducted a preclinical study of avapritinib in a mouse patient-derived xenograft (PDX) model of FIP1L1-PDGFRA and PDGFRA p.D842N leukemia. Results: Two patients with T-ALL in the LEAP cohort (14%) had targetable genomic alterations affecting PDGFRA, a FIP1-like 1 protein/PDGFRA (FIP1L1-PDGFRA) fusion and a novel mutation in PDGFRA, p.D842N. The D842N mutation resulted in PDGFRA activation and sensitivity to tested PDGFRA inhibitors. In a T-ALL PDX model, avapritinib treatment led to decreased leukemia burden, significantly prolonged survival, and even cured a subset of mice. Avapritinib treatment was well tolerated and yielded clinical benefit in a patient with refractory T-ALL. Conclusions: Refractory T-ALL has not been fully characterized. Alterations in PDGFRA or other targetable kinases may inform therapy for patients with refractory T-ALL who otherwise have limited treatment options. Clinical genomic profiling, in real time, is needed for fully informed therapeutic decision making.
MeSH term(s)	Humans ; Child ; Animals ; Mice ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/drug therapy ; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma/genetics ; Receptor, Platelet-Derived Growth Factor alpha/genetics ; Mutation ; Receptor Protein-Tyrosine Kinases/genetics ; Precursor Cell Lymphoblastic Leukemia-Lymphoma ; T-Lymphocytes
Chemical Substances	Receptor, Platelet-Derived Growth Factor alpha (EC 2.7.10.1) ; Receptor Protein-Tyrosine Kinases (EC 2.7.10.1)
Language	English
Publishing date	2023-09-19
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1225457-5
ISSN	1557-3265 ; 1078-0432
ISSN (online)	1557-3265
ISSN	1078-0432
DOI	10.1158/1078-0432.CCR-22-2562
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Zs.A 4223: Show issues

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Article ; Online: Refractory cerebrospinal fluid rhinorrhea secondary to occult superior vena cava syndrome and benign intracranial hypertension: diagnosis and management.

Bledsoe, Jonathan M / Moore, Eric J / Link, Michael J

Skull base : official journal of North American Skull Base Society ... [et al.

2009 Volume 19, Issue 4, Page(s) 279–285

Abstract: Objective: This study is designed to describe the association between benign intracranial hypertension (BIH) and spontaneous cerebrospinal fluid (CSF) rhinorrhea and address the effect of extracranial venous flow dynamics on intracranial pressure (ICP).! ...

Abstract	Objective: This study is designed to describe the association between benign intracranial hypertension (BIH) and spontaneous cerebrospinal fluid (CSF) rhinorrhea and address the effect of extracranial venous flow dynamics on intracranial pressure (ICP). Methods: We present a 58-year-old woman with refractory spontaneous CSF rhinorrhea who was later found to have superior vena cava syndrome. The patient had undergone two prior transnasal endoscopic repair attempts. In retrospect, a preoperative magnetic resonance venogram (MRV) suggested very prolonged cerebral transit time, despite otherwise normal intracranial venous anatomy. Results: The CSF leak was repaired through a bifrontal craniotomy. The intraoperative and postoperative course was complicated due to the patient's significant comorbidities. She ultimately made a good recovery and has not had any further CSF rhinorrhea in more than 2 years of follow-up. Conclusions: Refractory, spontaneous CSF leak must prompt aggressive investigation for multiple causes of elevated ICP. A cerebral transit time can be obtained from scout imaging when a magnetic resonance angiogram or MRV is performed, and this may disclose elevated ICP if it is prolonged. If endoscopic transnasal repair fails, craniotomy and direct suture repair and autologous tissue reinforcement of the skull base may prove successful and durable, even if BIH persists.
Language	English
Publishing date	2009-12-29
Publishing country	United States
Document type	Case Reports
ZDB-ID	2043690-7
ISSN	1532-0065 ; 1531-5010
ISSN (online)	1532-0065
ISSN	1531-5010
DOI	10.1055/s-0028-1115326
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Zs.A 3425: Show issues

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Article: Using NDVI to measure precipitation in semi-arid landscapes

Birtwistle, Amy N / Brian Bledsoe / Jonathan M. Friedman / Melinda Laituri

Elsevier Ltd Journal of arid environments. 2016 Aug., v. 131

2016

Abstract: Measuring precipitation in semi-arid landscapes is important for understanding the processes related to rainfall and run-off; however, measuring precipitation accurately can often be challenging especially within remote regions where precipitation ... ...

Abstract	Measuring precipitation in semi-arid landscapes is important for understanding the processes related to rainfall and run-off; however, measuring precipitation accurately can often be challenging especially within remote regions where precipitation instruments are scarce. Typically, rain-gauges are sparsely distributed and research comparing rain-gauge and RADAR precipitation estimates reveal that RADAR data are often misleading, especially for monsoon season convective storms. This study investigates an alternative way to map the spatial and temporal variation of precipitation inputs along ephemeral stream channels using Normalized Difference Vegetation Index (NDVI) derived from Landsat Thematic Mapper imagery. NDVI values from 26 years of pre- and post-monsoon season Landsat imagery were derived across Yuma Proving Ground (YPG), a region covering 3,367 km2 of semiarid landscapes in southwestern Arizona, USA. The change in NDVI from a pre-to post-monsoon season image along ephemeral stream channels explained 73% of the variance in annual monsoonal precipitation totals from a nearby rain-gauge. In addition, large seasonal changes in NDVI along channels were useful in determining when and where flow events have occurred.
Keywords	dry environmental conditions ; Landsat ; landscapes ; monsoon season ; normalized difference vegetation index ; radar ; rain ; rain gauges ; runoff ; seasonal variation ; storms ; stream channels ; thematic maps ; variance ; Arizona
Language	English
Dates of publication	2016-08
Size	p. 15-24.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	428507-4
ISSN	1095-922X ; 0140-1963
ISSN (online)	1095-922X
ISSN	0140-1963
DOI	10.1016/j.jaridenv.2016.04.004
Database	NAL-Catalogue (AGRICOLA)

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Z 6073: Show issues

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