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  1. Book: Advances in radiation therapy

    Guckenberger, Matthias / Combs, Stephanie / Zips, Daniel

    (Progress in Tumor Research ; Vol. 44)

    2018  

    Series title Progress in Tumor Research ; Vol. 44
    Progress in tumor research
    Collection Progress in tumor research
    Keywords Neoplasms / radiotherapy ; Radiotherapy ; Elementary Particles / therapeutic use ; Radiotherapy Planning, Computer-Assisted ; Oncology ; Radiology ; Krebs ; Strahlentherapie
    Subject Bestrahlung ; Radiotherapie ; Strahlenbehandlung ; Radioonkologie ; Carcinom ; Malignom ; Maligner Tumor ; Neoplasma ; Karzinom ; Bösartiger Tumor ; Krebserkrankung
    Subject code 610
    Language English
    Size X, 133 Seiten, Illustrationen
    Edition 1. Auflage
    Publisher Karger
    Publishing place Basel
    Publishing country Switzerland ; Germany
    Document type Book
    HBZ-ID HT019699665
    ISBN 978-3-318-06361-5 ; 3-318-06361-4 ; 9783318063622 ; 3318063622
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Uh III Zs 200 -44- verfügbar in Königswinter Königswinter

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  2. Book ; Online: Data-Based Radiation Oncology - Design of Clinical Trials

    Combs, Stephanie E. / Nuesslin, Fridtjof / Vikram, Bhadrasain / S / Kessel, Kerstin A. / Lee, Anne W.

    2018  

    Abstract: In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new ... ...

    Abstract In radiation oncology as in many other specialties clinical trials are essential to investigate new therapy approaches. Usually, preparation for a prospective clinical trial is extremely time consuming until ethics approval is obtained. To test a new treatment usually many years pass before it can be implemented in the routine care. During that time, already new interventions emerge, new drugs appear on the market, technical & physical innovations are being implemented, novel biology driven concepts are translated into clinical approaches while we are still investigating the ones from years ago. Another problem is associated with molecular diagnostics and the growing amount of tumor specific biomarkers which allows for a better stratification of patient subgroups. On the other side, this may result in a much longer time for patient recruiting and consequently in larger multicenter trials. Moreover, all of the relevant data must be readily available for treatment decision making, treatment as well as follow-up, and ultimately for trial evaluation. This challenges even more for agreed standards in data acquisition, quality and management. How could we change the way currently clinical trials are performed in a way they are safe and ethically justifiable and speed up the initiation process, so we can provide new and better treatments faster for our patients?Further, while we rely on various quantitative information handling distributed, large heterogeneous amounts of data efficiently is very important. Thus data management becomes a strong focus. A good infrastructure helps to plan, tailor and conduct clinical trials in a way they are easy and quickly analyzable.In this research topic we want to discuss new ideas for intelligent trial designs and concepts for data management
    Keywords Medicine (General) ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens
    Size 1 electronic resource (109 p.)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020099630
    ISBN 9782889454389 ; 288945438X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: Pencil beam kernel-based dose calculations on CT data for a mixed neutron-gamma fission field applying tissue correction factors.

    Sommer, Lucas B / Kampfer, Severin / Chemnitz, Tobias / Breitkreutz, Harald / Combs, Stephanie E / Wilkens, Jan J

    Physics in medicine and biology

    2024  Volume 69, Issue 4

    Abstract: Objective. ...

    Abstract Objective.
    MeSH term(s) Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted/methods ; Gamma Rays/therapeutic use ; Thromboplastin ; Neutrons ; Radiometry/methods ; Water ; Tomography, X-Ray Computed ; Monte Carlo Method ; Algorithms ; Phantoms, Imaging
    Chemical Substances Thromboplastin (9035-58-9) ; Water (059QF0KO0R)
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 208857-5
    ISSN 1361-6560 ; 0031-9155
    ISSN (online) 1361-6560
    ISSN 0031-9155
    DOI 10.1088/1361-6560/ad209b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  4. Article ; Online: Effektivität einer sequenziellen versus einer simultanen Radiochemotherapie oder alleinigen Radiotherapie bei der adjuvanten Behandlung des Zervixkarzinoms nach Hysterektomie.

    Schiller, Kilian / Combs, Stephanie E

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2021  Volume 197, Issue 8, Page(s) 746–748

    Title translation Effectiveness of sequential vs concurrent chemoradiation or radiation alone in the adjuvant treatment of cervical cancer after hysterectomy.
    MeSH term(s) Chemoradiotherapy ; Female ; Humans ; Hysterectomy ; Uterine Cervical Neoplasms
    Language German
    Publishing date 2021-05-30
    Publishing country Germany
    Document type Journal Article ; Comment
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-021-01796-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book ; Thesis: TGF-Beta-s, PACAP und die Entwicklung der sympathoadrenalen Zelllinie

    Combs, Stephanie

    2001  

    Author's details vorgelegt von Stephanie Elisabeth Combs
    Language German
    Size VI, 129 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2003
    HBZ-ID HT013725963
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 E 2276 order for loan Magazin

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  6. Article ; Online: Proton and Carbon Ion Therapy of Intracranial Gliomas.

    Combs, Stephanie E

    Progress in neurological surgery

    2018  Volume 32, Page(s) 57–65

    Abstract: In comparison to photon irradiation, particle therapy of cancer performed either with protons or with carbon ions, offers the advantage of their distinct physical characteristics, and through delivery of high linear energy transfer (LET) particles, ... ...

    Abstract In comparison to photon irradiation, particle therapy of cancer performed either with protons or with carbon ions, offers the advantage of their distinct physical characteristics, and through delivery of high linear energy transfer (LET) particles, exploits greater relative biological effectiveness (RBE). There is strong rationale for applying such treatment in patients with intracranial gliomas. In cases of low-grade tumors, the main benefits may be related to potential decrease of long-term morbidity, whereas in cases of high-grade neoplasms, the use of modalities with greater RBE may lead to better tumor control and improve patient survival. Nevertheless, to date, there are no convincing data that confirm the superior effects of particle therapy (either with protons or carbon ions) in comparison to advanced photon fractionated radiotherapy (FRT) in patients with either newly diagnosed or recurrent intracranial gliomas. Therefore, the real clinical benefit of such treatment should be evaluated further in prospective clinical trials.
    MeSH term(s) Brain Neoplasms/radiotherapy ; Glioma/radiotherapy ; Heavy Ion Radiotherapy/methods ; Humans ; Outcome Assessment (Health Care) ; Proton Therapy/methods
    Language English
    Publishing date 2018-07-10
    Publishing country Switzerland
    Document type Journal Article ; Review
    ISSN 1662-3924 ; 0079-6492
    ISSN (online) 1662-3924
    ISSN 0079-6492
    DOI 10.1159/000469680
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Brustkrebs in der letzten Lebensphase: Stellenwert der palliativen Strahlentherapie

    Borm, Kai J. / Asadpour, Rebecca / Combs, Stephanie E.

    Senologie - Zeitschrift für Mammadiagnostik und -therapie

    2023  Volume 20, Issue 02, Page(s) 138–140

    Language German
    Publishing date 2023-06-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2174147-5
    ISSN 1611-647X ; 1611-6453
    ISSN (online) 1611-647X
    ISSN 1611-6453
    DOI 10.1055/a-2079-8243
    Database Thieme publisher's database

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6562: Show issues Location:
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  8. Article ; Online: Development of a PTV margin for preclinical irradiation of orthotopic pancreatic tumors derived from a well-known recipe for humans.

    Kampfer, Severin / Dobiasch, Sophie / Combs, Stephanie E / Wilkens, Jan J

    Zeitschrift fur medizinische Physik

    2023  

    Abstract: In human radiotherapy a safety margin (PTV margin) is essential for successful irradiation and is usually part of clinical treatment planning. In preclinical radiotherapy research with small animals, most uncertainties and inaccuracies are present as ... ...

    Abstract In human radiotherapy a safety margin (PTV margin) is essential for successful irradiation and is usually part of clinical treatment planning. In preclinical radiotherapy research with small animals, most uncertainties and inaccuracies are present as well, but according to the literature a margin is used only scarcely. In addition, there is only little experience about the appropriate size of the margin, which should carefully be investigated and considered, since sparing of organs at risk or normal tissue is affected. Here we estimate the needed margin for preclinical irradiation by adapting a well-known human margin recipe from van Herck et al. to the dimensions and requirements of the specimen on a small animal radiation research platform (SARRP). We adjusted the factors of the described formula to the specific challenges in an orthotopic pancreatic tumor mouse model to establish an appropriate margin concept. The SARRP was used with its image-guidance irradiation possibility for arc irradiation with a field size of 10 × 10 mm
    Language English
    Publishing date 2023-05-22
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1104517-6
    ISSN 1876-4436 ; 0939-3889 ; 0040-5973
    ISSN (online) 1876-4436
    ISSN 0939-3889 ; 0040-5973
    DOI 10.1016/j.zemedi.2023.03.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3525: Show issues Location:
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  9. Article ; Online: Happy birthday, Klaus-Rüdiger! Heartfelt appreciation on the occasion of the 80th birthday of Professor Klaus-Rüdiger Trott.

    Combs, Stephanie E / Atkinson, Michael J

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2020  Volume 196, Issue 8, Page(s) 747–748

    MeSH term(s) Germany ; History, 20th Century ; History, 21st Century ; Humans ; London ; Radiation Oncology/history ; Radiobiology/history
    Language English
    Publishing date 2020-07-15
    Publishing country Germany
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-020-01668-y
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  10. Article ; Online: [Target volume reduction by

    Bernhardt, Denise / Combs, Stephanie E

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al

    2020  Volume 196, Issue 8, Page(s) 743–746

    Title translation Zielvolumenreduktion durch
    MeSH term(s) Carcinoma, Non-Small-Cell Lung ; Fluorodeoxyglucose F18 ; Humans ; Lung Neoplasms ; Positron Emission Tomography Computed Tomography ; Positron-Emission Tomography ; Radiopharmaceuticals ; Reference Standards
    Chemical Substances Radiopharmaceuticals ; Fluorodeoxyglucose F18 (0Z5B2CJX4D)
    Language German
    Publishing date 2020-06-06
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 84983-2
    ISSN 1439-099X ; 0179-7158 ; 0039-2073
    ISSN (online) 1439-099X
    ISSN 0179-7158 ; 0039-2073
    DOI 10.1007/s00066-020-01643-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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