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  1. Article ; Online: Re-irradiation for Paediatric Tumours.

    Tsang, D S / Laperriere, N J

    Clinical oncology (Royal College of Radiologists (Great Britain))

    2018  Volume 31, Issue 3, Page(s) 191–198

    Abstract: Despite best available therapy, many children with cancer develop recurrence after multimodal treatment, including initial radiation therapy. Re-irradiation is defined as the use of a second course of radiation therapy with a retreatment volume that ... ...

    Abstract Despite best available therapy, many children with cancer develop recurrence after multimodal treatment, including initial radiation therapy. Re-irradiation is defined as the use of a second course of radiation therapy with a retreatment volume that overlaps substantially with that of a previously delivered course of radiation therapy. Re-irradiation is an important part of salvage treatment for patients with recurrent ependymoma, diffuse intrinsic pontine glioma, medulloblastoma and germinoma. In patients with ependymoma, conventionally fractionated re-irradiation (1.8 Gy/day) can provide long-term disease control with low rates of high-grade toxicity. For children with progressive diffuse intrinsic pontine glioma, re-irradiation provides effective palliation of symptoms and a survival gain as compared with those treated without re-irradiation. Repeat radiation therapy that includes craniospinal irradiation, if safe to deliver, may provide long-term tumour control in patients with medulloblastoma. Patients with recurrent intracranial germinoma can be effectively salvaged with re-irradiation that includes craniospinal irradiation. Finally, the emerging role of re-irradiation in non-brainstem high-grade glioma and extracranial solid tumours requires further study regarding its efficacy and safety. When given, re-irradiation should be delivered with care so that doses to organs at risk are minimised. In all cases, re-irradiation should be considered as an option alongside, or concurrently with, other salvage treatments, including surgery or systemic therapy, to maximise the likelihood of durable disease control.
    MeSH term(s) Adolescent ; Adult ; Brain Neoplasms/radiotherapy ; Child ; Child, Preschool ; Female ; Humans ; Male ; Neoplasm Recurrence, Local/radiotherapy ; Neoplasms/radiotherapy ; Re-Irradiation/adverse effects ; Re-Irradiation/methods
    Language English
    Publishing date 2018-10-29
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1036844-9
    ISSN 1433-2981 ; 0936-6555
    ISSN (online) 1433-2981
    ISSN 0936-6555
    DOI 10.1016/j.clon.2018.10.003
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    Zs.A 2774: Show issues Location:
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  2. Article: Optimal conditions for flexible methane production in a demand-based operation of biogas plants

    Laperrière, W / B. Barry / B. Pechiné / J.P. Steyer / M. Torrijos / N. Bernet

    Bioresource technology. 2017 Dec., v. 245

    2017  

    Abstract: The aim of the presented work was to study the methane production limits and to determine optimal conditions for flexible operation of an anaerobic reactor in order to set up an operational strategy. Punctual overloads were conducted in a laboratory- ... ...

    Abstract The aim of the presented work was to study the methane production limits and to determine optimal conditions for flexible operation of an anaerobic reactor in order to set up an operational strategy. Punctual overloads were conducted in a laboratory-scale anaerobic reactor with readily biodegradable solid substrates, and the influences of overload intensity, baseload value and substrate used were investigated. A maximal daily value around 1000mL/L of reactor for methane production has been assessed. This value did not evolve significantly during experiment time, and conditioned the persistence of overloads as well as the flexibility margin on the reactor, which ranged from +25% to +140% on daily production. Results highlighted the fact that for a maximum flexibility, low organic loading rates are better to work with on this type of reactors.
    Keywords anaerobic digesters ; biodegradability ; biogas ; methane production
    Language English
    Dates of publication 2017-12
    Size p. 698-705.
    Publishing place Elsevier Ltd
    Document type Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2017.09.013
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  3. Article ; Online: Optimal conditions for flexible methane production in a demand-based operation of biogas plants.

    Laperrière, W / Barry, B / Torrijos, M / Pechiné, B / Bernet, N / Steyer, J P

    Bioresource technology

    2017  Volume 245, Issue Pt A, Page(s) 698–705

    Abstract: The aim of the presented work was to study the methane production limits and to determine optimal conditions for flexible operation of an anaerobic reactor in order to set up an operational strategy. Punctual overloads were conducted in a laboratory- ... ...

    Abstract The aim of the presented work was to study the methane production limits and to determine optimal conditions for flexible operation of an anaerobic reactor in order to set up an operational strategy. Punctual overloads were conducted in a laboratory-scale anaerobic reactor with readily biodegradable solid substrates, and the influences of overload intensity, baseload value and substrate used were investigated. A maximal daily value around 1000mL/L of reactor for methane production has been assessed. This value did not evolve significantly during experiment time, and conditioned the persistence of overloads as well as the flexibility margin on the reactor, which ranged from +25% to +140% on daily production. Results highlighted the fact that for a maximum flexibility, low organic loading rates are better to work with on this type of reactors.
    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1065195-0
    ISSN 1873-2976 ; 0960-8524
    ISSN (online) 1873-2976
    ISSN 0960-8524
    DOI 10.1016/j.biortech.2017.09.013
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  4. Article ; Online: Rate of pachymeningeal failure following adjuvant WBRT vs SRS in patients with brain metastases.

    Gutierrez-Valencia, Enrique / Kalyvas, Aristotelis / Jamora, Kurl / Yang, Kaiyun / Lau, Ruth / Khan, Benazir / Millar, Barbara-Ann / Laperriere, Normand / Conrad, Tatiana / Berlin, Alejandro / Weiss, Jessica / Li, Xuan / Zadeh, Gelareh / Bernstein, Mark / Kongkham, Paul / Shultz, David B

    Clinical and translational radiation oncology

    2024  Volume 45, Page(s) 100723

    Abstract: Background: Stereotactic radiosurgery (SRS) has supplanted whole brain radiotherapy (WBRT) as standard-of-care adjuvant treatment following surgery for brain metastasis (BrM). Concomitant with the adoption of adjuvant SRS, a new pattern of failure ... ...

    Abstract Background: Stereotactic radiosurgery (SRS) has supplanted whole brain radiotherapy (WBRT) as standard-of-care adjuvant treatment following surgery for brain metastasis (BrM). Concomitant with the adoption of adjuvant SRS, a new pattern of failure termed "Pachymeningeal failure" (PMF) has emerged.
    Methods: We reviewed a prospective registry of 264 BrM patients; 145 and 119 were treated adjuvantly with WBRT and SRS, respectively. The Cox proportional hazards model was used to identify variables correlating to outcomes. Outcomes were calculated using the cumulative incidence (CI) method. Univariate (UVA) and multivariate analyses (MVA) were done to identify factors associated with PMF.
    Results: CI of PMF was 2 % and 18 % at 12 months, and 2 % and 23 % at 24 months for WRBT and SRS, respectively (p < 0.001)
    Conclusions: Preoperative dural contact and adjuvant SRS instead of adjuvant WBRT were associated with an increased risk of PMF. Strategies to improve pachymeningeal radiation coverage to sterilize at risk pachymeninges should be investigated.
    Language English
    Publishing date 2024-01-05
    Publishing country Ireland
    Document type Journal Article
    ISSN 2405-6308
    ISSN (online) 2405-6308
    DOI 10.1016/j.ctro.2023.100723
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  5. Article ; Online: Pituitary metastases: a case series and scoping review.

    Yang, Kaiyun / Begley, Sabrina L / Lynch, Daniel / Ye, Vincent / Saini, Jasleen / Gutierrez, Enrique / Vialet, Jaclyn / Millar, Barbara-Ann / Conrad, Tatianna / Laperriere, Normand / Bernstein, Mark / Zadeh, Gelareh / Shultz, David B / Kongkham, Paul N

    Pituitary

    2023  Volume 26, Issue 5, Page(s) 538–550

    Abstract: Purpose: To understand the natural history and optimal treatment strategy for pituitary gland metastasis.: Methods: We performed both a retrospective chart review of patients treated at our institution and a scoping review of the topic.: Results: ... ...

    Abstract Purpose: To understand the natural history and optimal treatment strategy for pituitary gland metastasis.
    Methods: We performed both a retrospective chart review of patients treated at our institution and a scoping review of the topic.
    Results: The retrospective review identified seven patients with an average age of 59.6 years. Primary histologies included breast cancer (4), melanoma (1), renal cell carcinoma (1), and sarcoma (1). Two patients had anterior pituitary endocrine dysfunction, one of whom was the only patient with visual symptoms. All patients were treated with radiosurgery and two also underwent surgical resection. Overall survival ranged from 6.5 to 117 months. Literature review identified 166 patients from 71 studies. The most common primary cancer was lung (27.7%), followed by breast (18.7%) and renal (14.5%) cancer. 107 presented with endocrine dysfunction, including 41 cases of diabetes insipidus and 55 cases of hypopituitarism. 110 presented with visual compromise. 107 patients received radiotherapy, 96 underwent surgical resection and 44 received systemic chemotherapy/immunotherapy. Surgery was significantly associated with an increased likelihood of vision improvement and a decreased likelihood of endocrine normalization. Radiographic regression predicted visual improvement. Median overall survival was 9.9 months (range: 0.2-96).
    Conclusions: This scoping review showed that both radiosurgery and surgical resection have been frequently used to treat pituitary metastases with good response. Vision improvement is more likely to happen following surgical resection, likely at the expense of endocrine dysfunction. Despite treatment and radiographic response, patient survival remains less than a year.
    MeSH term(s) Humans ; Middle Aged ; Retrospective Studies ; Pituitary Neoplasms/surgery ; Carcinoma, Renal Cell ; Diabetes Insipidus ; Radiosurgery ; Kidney Neoplasms/pathology ; Kidney Neoplasms/surgery ; Treatment Outcome
    Language English
    Publishing date 2023-09-12
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1385151-2
    ISSN 1573-7403 ; 1386-341X
    ISSN (online) 1573-7403
    ISSN 1386-341X
    DOI 10.1007/s11102-023-01349-w
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    Zs.A 6139: Show issues Location:
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  6. Article ; Online: Anatomical and surgical characteristics correlate with pachymeningeal failure in patients with brain metastases after neurosurgical resection and adjuvant stereotactic radiosurgery.

    Kalyvas, Aristotelis / Gutierrez-Valencia, Enrique / Lau, Ruth / Ye, Xiang Y / O'Halloran, Philip J / Mohan, Nilesh / Wong, Christine / Millar, Barbara-Ann / Laperriere, Normand / Conrad, Tatiana / Berlin, Alejandro / Bernstein, Mark / Zadeh, Gelareh / Shultz, David B / Kongkham, Paul

    Journal of neuro-oncology

    2023  Volume 163, Issue 1, Page(s) 269–279

    Abstract: ... Graded Prognostic Assessment (GPA) index (HR 2.4, p < 0.001), absence of prior radiation therapy (HR N ...

    Abstract Purpose: Neurosurgery (NS) is an essential modality for large brain metastases (BM). Postoperative stereotactic radiosurgery (SRS) is the standard of care adjuvant treatment. Pachymeningeal failure (PMF) is a newly described entity, distinct from classical leptomeningeal failure (LMF), that is uniquely observed in postoperative patients treated with adjuvant SRS. We sought to identify risk factors for PMF in patients treated with NS + SRS.
    Methods: From a prospective registry (2009 to 2021), we identified all patients treated with NS + SRS. Clinical, imaging, pathological, and treatment factors were analyzed. PMF incidence was evaluated using a competing risks model.
    Results: 144 Patients were identified. The median age was 62 (23-90). PMF occurred in 21.5% (31/144). Female gender [Hazard Ratio (HR) 2.65, p = 0.013], higher Graded Prognostic Assessment (GPA) index (HR 2.4, p < 0.001), absence of prior radiation therapy (HR N/A, p = 0.018), controlled extracranial disease (CED) (HR 3.46, p = 0.0038), and pia/dura contact (PDC) (HR 3.30, p = 0.0053) were associated with increased risk for PMF on univariate analysis. In patients with PDC, wider target volumes correlated with reduced risk of PMF. Multivariate analysis indicated PDC (HR 3.51, p = 0.0053), piecemeal resection (HR 2.38, p = 0.027), and CED (HR 3.97, p = 0.0016) independently correlated with PMF risk. PMF correlated with reduced OS (HR 2.90, p < 0.001) at a lower rate compared to LMF (HR 10.15, p < 0.001).
    Conclusion: PMF correlates with tumor PDC and piecemeal resection in patients treated with NS + SRS. For unclear reasons, it is also associated with CED. In tumors with PDC, wider dural radiotherapy coverage was associated with a lower risk of PMF.
    MeSH term(s) Humans ; Male ; Female ; Brain Neoplasms/radiotherapy ; Brain Neoplasms/secondary ; Brain Neoplasms/surgery ; Radiosurgery ; Postoperative Complications ; Adult ; Middle Aged ; Aged ; Aged, 80 and over ; Treatment Outcome ; Meningeal Neoplasms/radiotherapy ; Meningeal Neoplasms/secondary
    Language English
    Publishing date 2023-05-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04325-3
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    Zs.A 1825: Show issues Location:
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  7. Article ; Online: Time to dismiss boost? Outcomes of children with localized and metastatic germinoma.

    Foo, Jen Chun / Yaman Bajin, Inci / Marushchak, Oksana / McKeown, Tara / Bouffet, Eric / Tsang, Derek S / Laperriere, Norman / Dirks, Peter / Drake, James / Ertl-Wagner, Birgit / Bartels, Ute

    Journal of neuro-oncology

    2023  Volume 162, Issue 2, Page(s) 443–448

    Abstract: ... suprasellar (n = 11), pineal (n = 10), bifocal (n = 3) and basal ganglia (n = 1) while 4 children had ... by either ventricular irradiation (VI) (23.4 Gy) (n = 23), whole brain (WBI) (23.4 Gy) (n = 5) or craniospinal radiation ... CSI) (23.4 Gy) (n = 1). Two children, who had localized disease at presentation and received VI after ...

    Abstract Purpose: To determine long-term outcomes of a cohort of children with germinoma treated with chemotherapy and radiation therapy without primary tumor boost even in the absence of complete response to chemotherapy METHODS: This retrospective study analyzed the outcome of patients with germinoma consecutively diagnosed and treated at a tertiary care center from January 2000 to December 2021. MRIs were reviewed by two radiologists, blinded to patient data. Tumor location at diagnosis, tumor response to chemotherapy and at completion of radiation therapy and site of relapse were assessed. Tumor response was assessed radiologically by determining the tumor size and response on diffusion-weighted imaging, in addition to biochemical, cytological parameters and neurological status.
    Results: Of 46 pediatric germinoma patients, 29 children (14 male; median age 12.8 years) received no primary tumor boost. Median follow-up was 63 months (range 9-187 months). Twenty-five children had localized disease and tumor location was suprasellar (n = 11), pineal (n = 10), bifocal (n = 3) and basal ganglia (n = 1) while 4 children had metastatic disease at presentation. All patients completed multi-agent chemotherapy followed by either ventricular irradiation (VI) (23.4 Gy) (n = 23), whole brain (WBI) (23.4 Gy) (n = 5) or craniospinal radiation (CSI) (23.4 Gy) (n = 1). Two children, who had localized disease at presentation and received VI after chemotherapy, relapsed 9 months and 32 months after completion of treatment respectively. No patient had a local relapse. Location of relapse was distant, outside (n = 1) and out- and inside (n = 1) the irradiation field. Five-year progression free survival (PFS) was 91% and overall survival (OS) was 100%.
    Conclusions: In this case series, excellent 5-year PFS and OS rates were achieved with chemotherapy followed by radiation therapy of 23.4 Gy delivered without primary tumor boost. No local relapse was observed despite omitting primary tumor boost in patients with localized and metastatic germinoma.
    MeSH term(s) Child ; Humans ; Male ; Retrospective Studies ; Brain Neoplasms/therapy ; Brain Neoplasms/drug therapy ; Neoplasm Recurrence, Local/pathology ; Germinoma/therapy ; Germinoma/drug therapy ; Brain/pathology ; Radiotherapy Dosage ; Follow-Up Studies
    Language English
    Publishing date 2023-04-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-023-04307-5
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  8. Article ; Conference proceedings: Pituitary Metastases: A Case Series and Scoping Review

    Yang, Kaiyun / Begley, Sabrina / Lynch, Daniel / Ye, Vincent / Saini, Jasleen / Gutiérrez-Valencia, Enrique / Vialet, Jaclyn / Millar, Barbara-Ann / Conrad, Tatianna / Laperriere, Normand / Bernstein, Mark / Zadeh, Gelareh / Shultz, David / Kongkham, Paul

    Journal of Neurological Surgery Part B: Skull Base

    2024  Volume 85, Issue S 01

    Event/congress 33rd Annual Meeting North American Skull Base Society, Atlanta Marriott Marquis Atlanta, Georgia, United States, 2024-02-16
    Language English
    Publishing date 2024-02-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 2654269-9
    ISSN 2193-634X ; 2193-6331
    ISSN (online) 2193-634X
    ISSN 2193-6331
    DOI 10.1055/s-0044-1780166
    Database Thieme publisher's database

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  9. Article ; Online: Novel and Engineered Type II CRISPR Systems from Uncultivated Microbes with Broad Genome Editing Capability.

    Alexander, Lisa M / Aliaga Goltsman, Daniela S / Liu, Jason / Lin, Jyun-Liang / Temoche-Diaz, Morayma M / Laperriere, Sarah M / Neerincx, Andreas / Bednarski, Christien / Knyphausen, Philipp / Cohnen, Andre / Albers, Justine / Gonzalez-Osorio, Liliana / Fregoso Ocampo, Rodrigo / Oki, Jennifer / Devoto, Audra E / Castelle, Cindy J / Lamothe, Rebecca C / Cost, Gregory J / Butterfield, Cristina N /
    Thomas, Brian C / Brown, Christopher T

    The CRISPR journal

    2023  Volume 6, Issue 3, Page(s) 261–277

    Abstract: Type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 nucleases have been extensively used in biotechnology and therapeutics. However, many applications are not possible owing to the size, targetability, and potential off-target ...

    Abstract Type II Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-Cas9 nucleases have been extensively used in biotechnology and therapeutics. However, many applications are not possible owing to the size, targetability, and potential off-target effects associated with currently known systems. In this study, we identified thousands of CRISPR type II effectors by mining an extensive, genome-resolved metagenomics database encompassing hundreds of thousands of microbial genomes. We developed a high-throughput pipeline that enabled us to predict tracrRNA sequences, to design single guide RNAs, and to demonstrate nuclease activity
    MeSH term(s) Animals ; Gene Editing ; CRISPR-Cas Systems/genetics ; CRISPR-Associated Protein 9/genetics ; CRISPR-Associated Protein 9/metabolism ; Biotechnology ; RNA, Guide, CRISPR-Cas Systems ; Mammals/genetics ; Mammals/metabolism
    Chemical Substances CRISPR-Associated Protein 9 (EC 3.1.-) ; RNA, Guide, CRISPR-Cas Systems
    Language English
    Publishing date 2023-06-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3017891-5
    ISSN 2573-1602 ; 2573-1599
    ISSN (online) 2573-1602
    ISSN 2573-1599
    DOI 10.1089/crispr.2022.0090
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  10. Article ; Online: Factors correlating with survival following adjuvant or definitive radiosurgery for large brain metastases.

    Gutiérrez-Valencia, Enrique / Kalyvas, Aristotelis / Villafuerte, Conrad J / Millar, Barbara-Ann / Laperriere, Normand / Conrad, Tatiana / Berlin, Alejandro / Weiss, Jessica / Zadeh, Gelareh / Bernstein, Mark / Kongkham, Paul / Shultz, David B

    Neuro-oncology

    2022  Volume 24, Issue 11, Page(s) 1925–1934

    Abstract: Background: We sought to identify variates correlating with overall survival (OS) in patients treated with surgery (S) plus adjuvant stereotactic radiosurgery (SRS) versus definitive SRS for large (>4 cc) brain metastases (BrM).: Methods: We used ... ...

    Abstract Background: We sought to identify variates correlating with overall survival (OS) in patients treated with surgery (S) plus adjuvant stereotactic radiosurgery (SRS) versus definitive SRS for large (>4 cc) brain metastases (BrM).
    Methods: We used univariate (UVA) and multivariate analyses (MVA) to identify survival correlates among eligible patients identified from a prospective registry and compared definitive SRS to S+ adjuvant SRS cohorts using propensity score-matched analysis (PSMA). Secondary outcomes were measured using the cumulative incidence (CI) method.
    Results: We identified 364 patients; 127 and 237 were treated with S+SRS and definitive SRS, respectively. On UVA, SRS alone [HR1.73 (1.35,2.22) P < .001), BrM quantity [HR 1.13 (1.06-1.22) (P < .001)]; performance status (PS) [HR 2.78 (1.73-4.46) (P < .001)]; extracranial disease (ECD) [HR 1.82 (1.37,2.40) (P < .001)]; and receipt of systemic treatment after BrM therapy, [HR 0.58 (0.46-073) (P < .001)] correlated with OS. On MVA, SRS alone [HR 1.81 (1.19,2.74) (P < .0054)], SRS target volume [HR 1.03 (1.01,1.06) (P < .0042)], and receipt of systemic treatment [HR 0.68 (0.50,0.93) (P < .015)] correlated with OS. When PSMA was used to balance ECD, BrM quantity, PS, and SRS target volume, SRS alone remained correlated with worsened OS [HR 1.62 (1.20-2.19) (P = 0.0015)]. CI of local failure requiring resection at 12 months was 3% versus 7% for S+SRS and SRS cohorts, respectively [(HR 2.04 (0.89-4.69) (P = .091)]. CI of pachymeningeal failure at 12 months was 16% versus 0% for S+SRS and SRS.
    Conclusion: SRS target volume, receipt of systemic therapies, and treatment with S+SRS instead of definitive SRS correlated with improved survival in patients with large BrM.
    MeSH term(s) Humans ; Radiosurgery/methods ; Retrospective Studies ; Brain Neoplasms/secondary ; Incidence ; Multivariate Analysis
    Language English
    Publishing date 2022-04-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 2028601-6
    ISSN 1523-5866 ; 1522-8517
    ISSN (online) 1523-5866
    ISSN 1522-8517
    DOI 10.1093/neuonc/noac106
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