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  1. Article ; Online: Radiotherapy for management of skin cancers in fibrodysplasia ossificans progressiva: a case report and review of the literature.

    Frew, John Antony / Kelly, Charles G

    Journal of cancer research and therapeutics

    2008  Volume 4, Issue 1, Page(s) 37–38

    Abstract: Fibrodysplasia ossificans progressiva (FOP) is a rare condition of ectopic calcification leading to increasing disability throughout life, with most patients being wheelchair bound by the age of 30. Ectopic calcification can be triggered by trauma and it ...

    Abstract Fibrodysplasia ossificans progressiva (FOP) is a rare condition of ectopic calcification leading to increasing disability throughout life, with most patients being wheelchair bound by the age of 30. Ectopic calcification can be triggered by trauma and it is therefore important to minimize biopsies and operative procedures in affected individuals. We report a 46-year-old FOP patient who was successfully treated with radiotherapy for a basal cell carcinoma. There are no previous reports in the literature on the management of skin malignancies in these patients and very limited literature on outcome following external beam radiotherapy.
    MeSH term(s) Carcinoma, Basal Cell/complications ; Carcinoma, Basal Cell/radiotherapy ; Humans ; Male ; Middle Aged ; Myositis Ossificans/complications ; Skin Neoplasms/complications ; Skin Neoplasms/radiotherapy
    Language English
    Publishing date 2008-03-11
    Publishing country India
    Document type Case Reports ; Journal Article
    ZDB-ID 2187633-2
    ISSN 1998-4138 ; 0973-1482
    ISSN (online) 1998-4138
    ISSN 0973-1482
    DOI 10.4103/0973-1482.39603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Global consensus process to establish a core dataset for hidradenitis suppurativa registries.

    Wainman, Hannah E / Chandran, Nisha S / Frew, John W / Garg, Amit / Gibbons, Angela / Gierbolini, Athena / Horvath, Barbara / Jemec, Gregor B / Kirby, Brian / Kirby, Joselyn / Lowes, Michelle A / Martorell, Antonio / McGrath, Barry M / Naik, Haley B / Oon, Hazel H / Prens, Errol / Sayed, Christopher J / Thorlacius, Linnea / Van der Zee, Hessel H /
    Villumsen, Bente / Ingram, John R

    The British journal of dermatology

    2023  Volume 190, Issue 4, Page(s) 510–518

    Abstract: Background: Several registries for hidradenitis suppurativa (HS) already exist in Europe and the USA. There is currently no global consensus on a core dataset (CDS) for these registries. Creating a global HS registry is challenging, owing to logistical ... ...

    Abstract Background: Several registries for hidradenitis suppurativa (HS) already exist in Europe and the USA. There is currently no global consensus on a core dataset (CDS) for these registries. Creating a global HS registry is challenging, owing to logistical and regulatory constraints, which could limit opportunities for global collaboration as a result of differences in the dataset collected. The solution is to encourage all HS registries to collect the same CDS of information, allowing registries to collaborate.
    Objectives: To establish a core set of items to be collected by all HS registries globally. The core set will cover demographic details, comorbidities, clinical examination findings, patient-reported outcome measures and treatments.
    Methods: Beginning in September 2022, 20 participants - including both clinicians with expertise in HS and patient advocates - from eight countries across three continents participated in a Delphi process consisting of four rounds of voting, with all participants completing each round. A list of potential items for inclusion in the core set was generated from the relevant published literature, including systematic reviews of comorbidities in HS, clinical and examination findings, and epidemiology. For disease severity and progression items, the Hidradenitis SuppuraTiva Core outcome set International Collaboration (HiSTORIC) core set and other relevant instruments were considered for inclusion. This resulted in 47 initial items. Participants were invited to suggest additional items to include during the first round. Anonymous feedback was provided to inform each subsequent round of voting to encourage consensus.
    Results: The eDelphi process established a CDS of 48 items recommended for inclusion in all HS registries globally.
    Conclusions: The routine adoption of this CDS in current and future HS registries should allow registries in different parts of the world to collaborate, enabling research requiring large numbers of participants.
    MeSH term(s) Humans ; Consensus ; Hidradenitis Suppurativa/diagnosis ; Hidradenitis Suppurativa/epidemiology ; Hidradenitis Suppurativa/therapy ; Treatment Outcome ; Delphi Technique ; Registries
    Language English
    Publishing date 2023-11-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 80076-4
    ISSN 1365-2133 ; 0007-0963
    ISSN (online) 1365-2133
    ISSN 0007-0963
    DOI 10.1093/bjd/ljad454
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [

    Liu, Longbin / Johnson, Peter D / Prime, Michael E / Khetarpal, Vinod / Lee, Matthew R / Brown, Christopher J / Chen, Xuemei / Clark-Frew, Daniel / Coe, Samuel / Conlon, Mike / Davis, Randall / Ensor, Samantha / Esposito, Simone / Moren, Anton Forsberg / Gai, Xinjie / Green, Samantha / Greenaway, Catherine / Haber, James / Halldin, Christer /
    Hayes, Sarah / Herbst, Todd / Herrmann, Frank / Heßmann, Manuela / Hsai, Ming Min / Kotey, Adrian / Mangette, John E / Mills, Matthew R / Monteagudo, Edith / Nag, Sangram / Nibbio, Martina / Orsatti, Laura / Schaertl, Sabine / Scheich, Christoph / Sproston, Joanne / Stepanov, Vladimir / Varnäs, Katarina / Varrone, Andrea / Wityak, John / Mrzljak, Ladislav / Munoz-Sanjuan, Ignacio / Bard, Jonathan A / Dominguez, Celia

    Journal of medicinal chemistry

    2021  Volume 64, Issue 16, Page(s) 12003–12021

    Abstract: The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington's disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or ... ...

    Abstract The expanded polyglutamine-containing mutant huntingtin (mHTT) protein is implicated in neuronal degeneration of medium spiny neurons in Huntington's disease (HD) for which multiple therapeutic approaches are currently being evaluated to eliminate or reduce mHTT. Development of effective and orthogonal biomarkers will ensure accurate assessment of the safety and efficacy of pharmacologic interventions. We have identified and optimized a class of ligands that bind to oligomerized/aggregated mHTT, which is a hallmark in the HD postmortem brain. These ligands are potentially useful imaging biomarkers for HD therapeutic development in both preclinical and clinical settings. We describe here the optimization of the benzo[4,5]imidazo[1,2-
    MeSH term(s) Alzheimer Disease ; Animals ; Biomarkers/metabolism ; Brain/diagnostic imaging ; Brain/metabolism ; Carbon Radioisotopes/chemistry ; Female ; Heterocyclic Compounds, 3-Ring/chemical synthesis ; Heterocyclic Compounds, 3-Ring/chemistry ; Heterocyclic Compounds, 3-Ring/pharmacokinetics ; Humans ; Huntingtin Protein/metabolism ; Macaca fascicularis ; Male ; Mice, Inbred C57BL ; Molecular Structure ; Positron-Emission Tomography ; Protein Aggregates/physiology ; Pyridines/chemical synthesis ; Pyridines/chemistry ; Pyridines/pharmacokinetics ; Radiopharmaceuticals/chemical synthesis ; Radiopharmaceuticals/chemistry ; Radiopharmaceuticals/pharmacokinetics ; Rats, Sprague-Dawley ; Structure-Activity Relationship ; Mice ; Rats
    Chemical Substances Biomarkers ; Carbon Radioisotopes ; Carbon-11 ; HTT protein, human ; Heterocyclic Compounds, 3-Ring ; Htt protein, mouse ; Htt protein, rat ; Huntingtin Protein ; Protein Aggregates ; Pyridines ; Radiopharmaceuticals
    Language English
    Publishing date 2021-08-05
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.1c00667
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: What causes hidradenitis suppurativa ?-15 years after.

    Zouboulis, Christos C / Benhadou, Farida / Byrd, Angel S / Chandran, Nisha S / Giamarellos-Bourboulis, Evangelos J / Fabbrocini, Gabriella / Frew, John W / Fujita, Hideki / González-López, Marcos A / Guillem, Philippe / Gulliver, Wayne P F / Hamzavi, Iltefat / Hayran, Yildiz / Hórvath, Barbara / Hüe, Sophie / Hunger, Robert E / Ingram, John R / Jemec, Gregor B E / Ju, Qiang /
    Kimball, Alexa B / Kirby, Joslyn S / Konstantinou, Maria P / Lowes, Michelle A / MacLeod, Amanda S / Martorell, Antonio / Marzano, Angelo V / Matusiak, Łukasz / Nassif, Aude / Nikiphorou, Elena / Nikolakis, Georgios / Nogueira da Costa, André / Okun, Martin M / Orenstein, Lauren A V / Pascual, José Carlos / Paus, Ralf / Perin, Benjamin / Prens, Errol P / Röhn, Till A / Szegedi, Andrea / Szepietowski, Jacek C / Tzellos, Thrasyvoulos / Wang, Baoxi / van der Zee, Hessel H

    Experimental dermatology

    2020  Volume 29, Issue 12, Page(s) 1154–1170

    Abstract: The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, ... ...

    Abstract The 14 authors of the first review article on hidradenitis suppurativa (HS) pathogenesis published 2008 in EXPERIMENTAL DERMATOLOGY cumulating from the 1st International Hidradenitis Suppurativa Research Symposium held March 30-April 2, 2006 in Dessau, Germany with 33 participants were prophetic when they wrote "Hopefully, this heralds a welcome new tradition: to get to the molecular heart of HS pathogenesis, which can only be achieved by a renaissance of solid basic HS research, as the key to developing more effective HS therapy." (Kurzen et al. What causes hidradenitis suppurativa? Exp Dermatol 2008;17:455). Fifteen years later, there is no doubt that the desired renaissance of solid basic HS research is progressing with rapid steps and that HS has developed deep roots among inflammatory diseases in Dermatology and beyond, recognized as "the only inflammatory skin disease than can be healed". This anniversary article of 43 research-performing authors from all around the globe in the official journal of the European Hidradenitis Suppurativa Foundation e.V. (EHSF e.V.) and the Hidradenitis Suppurativa Foundation, Inc (HSF USA) summarizes the evidence of the intense HS clinical and experimental research during the last 15 years in all aspects of the disease and provides information of the developments to come in the near future.
    MeSH term(s) Autoimmunity ; B-Lymphocytes ; Bacterial Infections/complications ; Complement C5a/metabolism ; Cytokines/metabolism ; Genotype ; Hidradenitis Suppurativa/drug therapy ; Hidradenitis Suppurativa/ethnology ; Hidradenitis Suppurativa/etiology ; Hidradenitis Suppurativa/metabolism ; Humans ; Mutation ; Pain/etiology ; Phenotype ; Pruritus/etiology ; Risk Factors ; Skin/microbiology ; Smoking/adverse effects ; T-Lymphocytes ; Transcriptome
    Chemical Substances Cytokines ; Complement C5a (80295-54-1)
    Language English
    Publishing date 2020-10-12
    Publishing country Denmark
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1130936-2
    ISSN 1600-0625 ; 0906-6705
    ISSN (online) 1600-0625
    ISSN 0906-6705
    DOI 10.1111/exd.14214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3508: Show issues Location:
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