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Article: Successful IMRT and concurrent chemotherapy for a patient with intrathoracic extensive-stage small cell lung cancer.

Horio, Yoshitsugu / Tachibana, Hiroyuki / Shimizu, Junichi / Hosoda, Waki / Fujiwara, Yutaka

2022 Volume 10, Issue 4, Page(s) e0919

Abstract: Treatment of extensive-stage (ES) small cell lung cancer (SCLC) is a challenge with poor local control and dismal overall survival. Although single extrathoracic metastasis was defined as M1b according to the eighth edition of the tumour-node-metastasis ( ...

Abstract	Treatment of extensive-stage (ES) small cell lung cancer (SCLC) is a challenge with poor local control and dismal overall survival. Although single extrathoracic metastasis was defined as M1b according to the eighth edition of the tumour-node-metastasis (TNM) classification of lung cancer, M1b includes involvement of a single intrathoracic nonregional lymph node (LN) such as pericardial, internal mammary or paravertebral LNs. Here, we report a successful treated case of a 50-year-old female with ES-SCLC with right pericardial LN involvement, cT1cN3M1b (LYM). She initially received two cycles of induction chemotherapy consisting of cis-Diamminedichloroplatinum/cisplatin (CDDP) and etoposide and achieved a very good partial response. She then received curative chemoradiotherapy with intensity-modulated techniques (45 Gy in 30 fractions BID), followed by an additional cycle of chemotherapy. She is free of recurrence for more than 2.5 years.
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Case Reports
ZDB-ID	2750180-2
ISSN	2051-3380
ISSN	2051-3380
DOI	10.1002/rcr2.919
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Article: A pilot trial of an online guided self-help cognitive behavioral therapy program for bulimia nervosa and binge eating disorder in Japanese patients.

Ohsako, Noriaki / Kimura, Hiroshi / Hashimoto, Tasuku / Hosoda, Yutaka / Inaba, Yosuke / Iyo, Masaomi / Nakazato, Michiko

BioPsychoSocial medicine

2023 Volume 17, Issue 1, Page(s) 37

Abstract: Background: The purpose of this study was to develop an internet-based Guided Self-Help CBT (iGSH-CBT) for Bulimia Nervosa (BN) / Binge Eating Disorder (BED) for Japanese patients and to test its feasibility.: Methods: A single-arm feasibility study. ...

Abstract	Background: The purpose of this study was to develop an internet-based Guided Self-Help CBT (iGSH-CBT) for Bulimia Nervosa (BN) / Binge Eating Disorder (BED) for Japanese patients and to test its feasibility. Methods: A single-arm feasibility study. After baseline assessment, patients underwent a 16-week iGSH-CBT program, our Japanese adaption of the European-based Salut BN program. During the treatment period, weekly email support from trained counselors was provided. Evaluations were performed at baseline, after 8 weeks, at the end of the 16-week intervention, and at 2 months after treatment had ended. The primary outcome measure was the change in the weekly frequency of objective binging. Secondary outcomes were the change in the weekly frequency of objective purge episodes, responses on self-report questionnaires of the frequencies of binging and purging, psychopathological characteristics of eating disorders found on BITE, EDE-Q, EDI-2, HADS and EQ-5D, measurements of motivation, and completion of intervention (vs. dropout). Results: Participants were 9 female outpatients with BN (n = 5) or BED (n = 4), of whom 8 (88.9%) attended the assessment at the end of the 16-week intervention. Mean age was 28 years (SD = 7.9). Percent change of the weekly frequency of objective binging was -4.40%, and at the end of the 16-week intervention 25% of the participants had achieved symptom abstinence. Conclusions: No adverse events were observed during the treatment period and follow-up, and the implementation and operation of the program could be performed without any major problems, confirming the feasibility of iGSH-CBT for BN and BED for Japanese patients. Although no significant change was observed in the weekly frequency of objective binging, the abstinence rate from bulimic behaviors of those who completed the assessments was 25.0% at the end of treatment, and the drop-out rate was 11.1%. iGSH-CBT may be an acceptable and possibly even a preferred method of CBT delivery for Japanese patients with BN or BED, and our Japanese adaptation of Salut BN seems feasible. Trial registration: UMIN, UMIN000031962. Registered 1 April 2018 - Retrospectively registered, https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000036334.
Language	English
Publishing date	2023-11-10
Publishing country	England
Document type	Journal Article
ZDB-ID	2265705-8
ISSN	1751-0759
ISSN	1751-0759
DOI	10.1186/s13030-023-00294-1
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Article ; Online: Synthetic model ecosystem of 12 cryopreservable microbial species allowing for a noninvasive approach.

Hosoda, Kazufumi / Seno, Shigeto / Murakami, Naomi / Matsuda, Hideo / Osada, Yutaka / Kamiura, Rikuto / Kondoh, Michio

Bio Systems

2023 Volume 235, Page(s) 105087

Abstract: Simultaneous understanding of both population and ecosystem dynamics is crucial in an era marked by the degradation of ecosystem services. Experimental ecosystems are a powerful tool for understanding these dynamics; however, they often face technical ... ...

Abstract	Simultaneous understanding of both population and ecosystem dynamics is crucial in an era marked by the degradation of ecosystem services. Experimental ecosystems are a powerful tool for understanding these dynamics; however, they often face technical challenges, typically falling into two categories: "complex but with limited replicability microcosms" and "highly replicable but overly simplistic microcosms." Herein, we present a high-throughput synthetic microcosm system comprising 12 functionally and phylogenetically diverse microbial species. These species are axenically culturable, cryopreservable, and can be measured noninvasively via microscopy, aided by machine learning. This system includes prokaryotic and eukaryotic producers and decomposers, and eukaryotic consumers to ensure functional redundancy. Our model system exhibited key features of a complex ecosystem: (i) various positive and negative interspecific interactions, (ii) higher-order interactions beyond two-species dynamics, (iii) probabilistic dynamics leading to divergent outcomes, and (iv) stable nonlinear transitions. We identified several conditions under which at least one species from each of the three functional groups-producers, consumers, and decomposers-and one functionally redundant species, persisted for over six months. These conditions set the stage for detailed investigations in the future. Given its designability and experimental replicability, our model ecosystem offers a promising platform for deeper insights integrating both population and ecosystem dynamics.
MeSH term(s)	Ecosystem ; Prokaryotic Cells
Language	English
Publishing date	2023-11-19
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	186234-0
ISSN	1872-8324 ; 0303-2647
ISSN (online)	1872-8324
ISSN	0303-2647
DOI	10.1016/j.biosystems.2023.105087
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Article ; Online: Efficacy of awake prone positioning for severe illness coronavirus disease 2019 patients: a propensity score-adjusted cohort study.

Numata, Kenji / Kobayashi, Daiki / Hosoda, Tomohiro / Saito, Yutaka / Minoura, Ayu / Yamazaki, Satsuki / Fujitani, Shigeki

Acute medicine & surgery

2022 Volume 9, Issue 1, Page(s) e734

Abstract: Aim: Awake prone positioning (PP) in patients with coronavirus disease 2019 (COVID-19) can improve oxygenation. However, evidence showing that it can prevent intubation is lacking. This study investigated the efficacy of awake PP in patients with COVID- ... ...

Abstract	Aim: Awake prone positioning (PP) in patients with coronavirus disease 2019 (COVID-19) can improve oxygenation. However, evidence showing that it can prevent intubation is lacking. This study investigated the efficacy of awake PP in patients with COVID-19 who received remdesivir, dexamethasone, and anticoagulant therapy. Methods: This was a two-center cohort study. Patients admitted to the severe COVID-19 patient unit were included. The primary outcome was the intubation rate and secondary outcome was length of stay in the severe COVID-19 unit. After propensity score adjustment, we undertook multivariable regression to calculate the estimates of outcomes between patients who received awake PP and those who did not. Results: Overall, 108 patients were included (54 [50.0%] patients each who did and did not undergo awake PP), of whom 25 (23.2%) were intubated (with awake PP, 5 [9.3%] vs. without awake PP, 20 [37.0%]; Conclusion: Awake PP could be correlated with intubation rate in patients with COVID-19 who are receiving remdesivir, dexamethasone, and anticoagulant therapy.
Language	English
Publishing date	2022-02-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.734
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Article ; Online: Clozapine-induced myocarditis: Follow-up for 3.5 years after successful retrial.

Otsuka, Yuji / Idemoto, Keita / Hosoda, Yutaka / Imamura, Yukitsugu / Aoki, Tsutomu

Journal of general and family medicine

2019 Volume 20, Issue 3, Page(s) 114–117

Abstract: Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine-induced ... ...

Abstract	Schizophrenia patients have significantly lower life expectancy than the general population. Clozapine is the most effective antipsychotic to reduce the mortality rate in these patients. Here, we report a schizophrenic patient with clozapine-induced myocarditis and successful retrial. In the first trial, clozapine was discontinued due to myocarditis. In the second trial, the titration rate was slower, and sodium valproate was not coadministered with clozapine. The patient has not developed myocarditis over 3.5 years of observation. It may be possible to take clozapine for a long time even after clozapine-induced myocarditis, and thus improve the life expectancy of schizophrenia patients.
Language	English
Publishing date	2019-02-27
Publishing country	Japan
Document type	Case Reports
ISSN	2189-7948
ISSN (online)	2189-7948
DOI	10.1002/jgf2.239
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Article ; Online: Intensive care burden of COVID-19 in tertiary care hospitals during the first year of outbreak in Kawasaki City, Japan: A retrospective cohort study.

Hosoda, Tomohiro / Hamada, Shota / Numata, Kenji / Saito, Yutaka / Yamazaki, Satsuki / Minoura, Ayu / Sakamoto, Mitsuo / Fujitani, Shigeki

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

2022 Volume 28, Issue 5, Page(s) 678–683

Abstract: Introduction: This study aimed to describe the changes in the intensive care burden of coronavirus disease 2019 (COVID-19) during the first year of outbreak in Japan.: Methods: This retrospective cohort study included COVID-19 patients who received ... ...

Abstract	Introduction: This study aimed to describe the changes in the intensive care burden of coronavirus disease 2019 (COVID-19) during the first year of outbreak in Japan. Methods: This retrospective cohort study included COVID-19 patients who received mechanical ventilation (MV) support in two designated hospitals for critical patients in Kawasaki City. We compared the lengths of MV and stay in the intensive care unit (ICU) or high care unit (HCU) according to the three epidemic waves. We calculated in-hospital mortality rates in patients with or without MV. Results: The median age of the sample was 65.0 years, and 22.7% were women. There were 37, 29, and 62 patients in the first (W1), second (W2), and third waves (W3), respectively. Systemic steroids, remdesivir, and prone positioning were more frequent in W2 and W3. The median length of MV decreased from 18.0 days in W1 to 13.0 days in W3 (P = 0.019), and that of ICU/HCU stay decreased from 22.0 days in W1 to 15.5 days in W3 (P = 0.027). The peak daily number of patients receiving MV support was higher at 18 patients in W1, compared to 8 and 15 patients in W2 and W3, respectively. The mortality rate was 23.4%, which did not significantly change (P = 0.467). Conclusions: The lengths of MV and ICU/HCU stay per patient decreased over time. Despite an increase in the number of COVID-19 patients who received MV in W3, this study may indicate that the intensive care burden during the study period did not substantially increase.
MeSH term(s)	Aged ; COVID-19/epidemiology ; Critical Care ; Disease Outbreaks ; Female ; Humans ; Intensive Care Units ; Japan/epidemiology ; Respiration, Artificial ; Retrospective Studies ; SARS-CoV-2 ; Tertiary Care Centers
Language	English
Publishing date	2022-02-09
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1355399-9
ISSN	1437-7780 ; 1341-321X
ISSN (online)	1437-7780
ISSN	1341-321X
DOI	10.1016/j.jiac.2022.01.022
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Zs.A 5236: Show issues

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Article ; Online: Retraction: Transcriptome analysis reveals a role for the endothelial ANP-GC-A signaling in interfering with pre-metastatic niche formation by solid cancers.

Nojiri, Takashi / Arai, Miki / Suzuki, Yutaka / Kumazoe, Motofumi / Tokudome, Takeshi / Miura, Koichi / Hino, Jun / Hosoda, Hiroshi / Miyazato, Mikiya / Okumura, Meinoshin / Kawaoka, Shinpei / Kangawa, Kenji

Oncotarget

2022 Volume 13, Page(s) 551–552

Abstract: This retracts the article DOI: 10.18632/oncotarget.18032.]. ...

Abstract	[This retracts the article DOI: 10.18632/oncotarget.18032.].
Language	English
Publishing date	2022-03-24
Publishing country	United States
Document type	Retraction of Publication
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28223
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Article ; Online: Establishment of a Japanese version of the Sick, Control, One Stone, Fat, and Food (SCOFF) questionnaire for screening eating disorders in university students.

Hosoda, Yutaka / Ohtani, Toshiyuki / Hanazawa, Hisashi / Tanaka, Mami / Kimura, Hiroshi / Ohsako, Noriaki / Hashimoto, Tasuku / Kobori, Osamu / Iyo, Masaomi / Nakazato, Michiko

BMC research notes

2021 Volume 14, Issue 1, Page(s) 142

Abstract: Objective: This study aimed to validate the Sick, Control, One stone, Fat, and Food (SCOFF) questionnaire in relation to the Eating Disorders Examination Questionnaire (EDE-Q) and to examine the appropriateness of a question concerning weight loss among ...

Abstract	Objective: This study aimed to validate the Sick, Control, One stone, Fat, and Food (SCOFF) questionnaire in relation to the Eating Disorders Examination Questionnaire (EDE-Q) and to examine the appropriateness of a question concerning weight loss among Japanese university students. The psychometric properties of the two Japanese versions were determined among 649 Japanese college students. The original version (SCOFF-O) employed the original item 3, whereas the revised version (SCOFF-2.5) modified the item to "Have you recently lost more than 2.5 kg within three months?" Validity was tested relative to EDE-Q. Results: The test-retest reliabilities of SCOFF-O and SCOFF-2.5 were 0.52 and 0.57, while the correlations of SCOFF-O and SCOFF-2.5 with EDE-Q were r = 0.53 and r = 0.56. The sensitivity and specificity of SCOFF-O were 65.2 and 89.7, and those of SCOFF-2.5 were 69.5 and 86.5, respectively. There were significant correlations between the question concerning losing 2.5 kg and the EDE-Q subscales. The Japanese version of SCOFF-2.5 is an appropriate tool for the early screening of eating disorders among Japanese university students.
MeSH term(s)	Adolescent ; Adult ; Feeding and Eating Disorders/diagnosis ; Feeding and Eating Disorders/psychology ; Female ; Humans ; Japan ; Male ; Psychometrics/methods ; Reproducibility of Results ; Sensitivity and Specificity ; Students/psychology ; Surveys and Questionnaires/standards ; Universities ; Weight Loss
Language	English
Publishing date	2021-04-16
Publishing country	England
Document type	Journal Article
ZDB-ID	2413336-X
ISSN	1756-0500 ; 1756-0500
ISSN (online)	1756-0500
ISSN	1756-0500
DOI	10.1186/s13104-021-05549-0
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Article ; Online: Ifenprodil tartrate treatment of adolescents with post-traumatic stress disorder: A double-blind, placebo-controlled trial.

Sasaki, Tsuyoshi / Hashimoto, Kenji / Niitsu, Tomihisa / Hosoda, Yutaka / Oda, Yasunori / Shiko, Yuki / Ozawa, Yoshihito / Kawasaki, Yohei / Kanahara, Nobuhisa / Shiina, Akihiro / Hashimoto, Tasuku / Suzuki, Takaaki / Sugawara, Takeshi / Hanaoka, Hideki / Iyo, Masaomi

Psychiatry research

2022 Volume 311, Page(s) 114486

Abstract: Background: Several lines of evidence suggest that glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptor plays a role in certain behavioral manifestations common to Post-Traumatic Stress Disorder (PTSD). Ifenprodil tartrate is a ... ...

Abstract	Background: Several lines of evidence suggest that glutamatergic neurotransmission via the N-methyl-D-aspartate (NMDA) receptor plays a role in certain behavioral manifestations common to Post-Traumatic Stress Disorder (PTSD). Ifenprodil tartrate is a neuroprotective agent that binds to the GluN2B subunit of the NMDA receptor. The aim of this study is to confirm whether ifenprodil tartrate is effective in the adolescent PTSD patients. Methods: This is a randomized, double-blind, placebo-controlled trial. Ten adolescent (13 to 18 years old) PTSD patients were randomized into two arms: placebo (n = 4), 40 mg/day ifenprodil tartrate (n = 6) for 4 weeks. All of the patients were assessed by IES-R-J (Primary outcome measure), TSCC-J, CDRS-R, DSRS-C-J and CGI-I. Results: A comparison of baseline IES-R-J total scores and 4-week end-point scores showed a mild trend of improvement (p = 0.0895) and the difference score was -9.314. A comparison of baseline scores and 2-week intermediate-point scores showed that IES-R-J hyperarousal subscores and TSCC-J subscores (dissociation subscores, sexual concerns subscores) improved significantly. A comparison of baseline TSCC-J sexual concerns subscores and 4-week end-point scores improved significantly. Conclusions: Our study may prove to be an short-term effective alternative safe treatment for adolescent patients with PTSD.
MeSH term(s)	Adolescent ; Double-Blind Method ; Humans ; Piperidines/therapeutic use ; Stress Disorders, Post-Traumatic/drug therapy ; Treatment Outcome
Chemical Substances	Piperidines ; ifenprodil (R8OE3P6O5S)
Language	English
Publishing date	2022-02-25
Publishing country	Ireland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	445361-x
ISSN	1872-7123 ; 1872-7506 ; 0925-4927 ; 0165-1781
ISSN (online)	1872-7123 ; 1872-7506
ISSN	0925-4927 ; 0165-1781
DOI	10.1016/j.psychres.2022.114486
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Article ; Online: An Inappropriate Shock Case Early after Implantation of a Subcutaneous Cardiac Defibrillator by Subcutaneous Entrapped Air.

Taguchi, Yuka / Ishikawa, Toshiyuki / Matsumoto, Katsumi / Ogino, Yutaka / Matsushita, Hirooki / Iguchi, Kohei / Hosoda, Junya

International heart journal

2018 Volume 59, Issue 2, Page(s) 417–419

Abstract: A 17-year-old woman was resuscitated from cardiac arrest due to ventricular fibrillation and was diagnosed with concealed long QT syndrome. She underwent subcutaneous implantable cardiac defibrillator (S-ICD) implantation at our hospital. The device ... ...

Abstract	A 17-year-old woman was resuscitated from cardiac arrest due to ventricular fibrillation and was diagnosed with concealed long QT syndrome. She underwent subcutaneous implantable cardiac defibrillator (S-ICD) implantation at our hospital. The device electrogram immediately after implantation was normal. Four days after implantation, she received an inappropriate shock. The device interrogation revealed a continuous baseline shift and frequent oversensing for low amplitude signals, followed by a shock. A chest radiograph in the orthogonal view showed entrapped subcutaneous air surrounding the distal electrode. Entrapped subcutaneous air can cause inappropriate shocks in the early period after S-ICD implantation.
MeSH term(s)	Adolescent ; Defibrillators, Implantable/adverse effects ; Equipment Failure ; Female ; Humans ; Long QT Syndrome/physiopathology ; Long QT Syndrome/therapy ; Subcutaneous Emphysema/diagnosis ; Subcutaneous Emphysema/etiology ; Time Factors ; Ventricular Fibrillation/physiopathology ; Ventricular Fibrillation/therapy
Language	English
Publishing date	2018-03-30
Publishing country	Japan
Document type	Case Reports ; Journal Article
ZDB-ID	2187806-7
ISSN	1349-3299 ; 1349-2365
ISSN (online)	1349-3299
ISSN	1349-2365
DOI	10.1536/ihj.17-117
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