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  1. Article ; Online: Correction: Study protocol for a randomised cross-over trial of Neurally adjusted ventilatory Assist for Neonates with Congenital diaphragmatic hernias: the NAN-C study.

    Poole, Grace / Harris, Christopher / Shetty, Sandeep / Dassios, Theodore / Jenkinson, Allan / Greenough, Anne

    Trials

    2024  Volume 25, Issue 1, Page(s) 109

    Language English
    Publishing date 2024-02-07
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-024-07958-5
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  2. Article ; Online: Study protocol for a randomised cross-over trial of Neurally adjusted ventilatory Assist for Neonates with Congenital diaphragmatic hernias: the NAN-C study.

    Poole, Grace / Harris, Christopher / Shetty, Sandeep / Dassios, Theodore / Jenkinson, Allan / Greenough, Anne

    Trials

    2024  Volume 25, Issue 1, Page(s) 72

    Abstract: ... NAVA to ACV.: Trial registration: NAN-C was prospectively registered on ClinicalTrials.gov ...

    Abstract Background: Neurally adjusted ventilatory assist (NAVA) is a mode of mechanical ventilation that delivers oxygen pressures in proportion to electrical signals of the diaphragm. The proportional assistance can be adjusted by the clinician to reduce the patient's work of breathing. Several case series of infants with congenital diaphragmatic hernias (CDH) have shown that NAVA may reduce oxygenation index and mean airway pressures. To date, no clinical trial has compared NAVA to standard methods of mechanical ventilation for babies with CDH.
    Methods: The aim of this dual-centre randomised cross-over trial is to compare post-operative NAVA with assist control ventilation (ACV) for infants with CDH. If eligible, infants will be enrolled for a ventilatory support tolerance trial (VSTT) to assess their suitability for randomisation. If clinically stable during the VSTT, infants will be randomised to receive either NAVA or ACV first in a 1:1 ratio for a 4-h period. The oxygenation index, respiratory severity score and cumulative sedative medication use will be measured.
    Discussion: Retrospective studies comparing NAVA to ACV in neonates with congenital diaphragmatic hernia have shown the ventilatory mode may improve respiratory parameters and benefit neonates. To our knowledge, this is the first prospective cross-over trial comparing NAVA to ACV.
    Trial registration: NAN-C was prospectively registered on ClinicalTrials.gov NCT05839340  Registered on May 2023.
    MeSH term(s) Humans ; Infant, Newborn ; Cross-Over Studies ; Hernias, Diaphragmatic, Congenital/diagnosis ; Hernias, Diaphragmatic, Congenital/therapy ; Interactive Ventilatory Support/methods ; Prospective Studies ; Randomized Controlled Trials as Topic ; Respiration, Artificial/methods ; Retrospective Studies
    Language English
    Publishing date 2024-01-20
    Publishing country England
    Document type Clinical Trial Protocol ; Journal Article
    ZDB-ID 2040523-6
    ISSN 1745-6215 ; 1468-6694 ; 1745-6215
    ISSN (online) 1745-6215
    ISSN 1468-6694 ; 1745-6215
    DOI 10.1186/s13063-023-07874-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Metal and Activating Group Free C-4 Alkylation of Isoquinolines via a Temporary Dearomatization Strategy.

    Day, Aaron J / Jenkins, Timothy C / Kischkewitz, Marvin / Christensen, Kirsten E / Poole, Darren L / Donohoe, Timothy J

    Organic letters

    2023  Volume 25, Issue 4, Page(s) 614–618

    Abstract: A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid ... as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3 ... and C-5-C-8 positions as well as allowing some variation of the vinyl ketone electrophiles ...

    Abstract A simple method for the C-4 alkylation of isoquinolines is described using benzoic acid as a nucleophilic reagent and vinyl ketones as an electrophile. The reaction shows tolerance for substitution at C-3, and C-5-C-8 positions as well as allowing some variation of the vinyl ketone electrophiles. The products contain a carbonyl that can act as a synthetic handle for further manipulations giving esters, amines, or simple alkyl products.
    Language English
    Publishing date 2023-01-23
    Publishing country United States
    Document type Journal Article
    ISSN 1523-7052
    ISSN (online) 1523-7052
    DOI 10.1021/acs.orglett.2c04149
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  4. Article ; Online: Identification of symbiosis-specific c-type cytochromes and a putative oxidase in bacteroids of

    Vargas, Carmen / Wu, Guanghui / Delgado, Maria-Jesus / Poole, Robert K / Downie, J Allan

    Microbiology (Reading, England)

    2021  Volume 142, Issue 1, Page(s) 41–46

    Abstract: Covalently bound haem proteins and cytochromes were analysed ... ...

    Abstract Covalently bound haem proteins and cytochromes were analysed in
    Language English
    Publishing date 2021-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1180712-x
    ISSN 1465-2080 ; 1350-0872
    ISSN (online) 1465-2080
    ISSN 1350-0872
    DOI 10.1099/13500872-142-1-41
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.140: Show issues Location:
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  5. Article ; Online: Rebuttal from David C. Poole.

    Poole, David C

    The Journal of physiology

    2014  Volume 592, Issue 23, Page(s) 5139

    MeSH term(s) Animals ; Capillaries/physiology ; Humans ; Muscle, Skeletal/blood supply
    Language English
    Publishing date 2014-12-01
    Publishing country England
    Document type Comment ; Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/jphysiol.2014.284596
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  6. Article: A single rapid heat stress episode does not result in prolonged elevations in salivary cortisol and C-reactive protein production in firefighters.

    Coehoorn, Cory J / Cruz, Diana / Mueller, Schaefer / Kamberov, Lilly Anne D / Danzy, Jillian / Bouchereau-Lal, Naina / Poole, Daniel / Adams, Aaron

    Journal of thermal biology

    2024  Volume 119, Page(s) 103805

    Abstract: ... and C-reactive protein production pre-RHS, post-RHS, and 24 and 48 h post-RHS exposure ... biomarkers, such as C-reactive protein. This study hypothesized that salivary cortisol and C-reactive protein ... four participants performed a steady-state treadmill protocol in an environmental chamber (35 °C; 45 ...

    Abstract In the present experiment, we evaluated the impact of rapid heat stress (RHS) on salivary cortisol and C-reactive protein production pre-RHS, post-RHS, and 24 and 48 h post-RHS exposure among firefighters. Previous research has demonstrated that RHS increases salivary cortisol during RHS and immediately post-RHS exposure. However, no research has evaluated the duration necessary to return to baseline cortisol levels following RHS. Additionally, no studies have analyzed the impact of RHS on inflammatory biomarkers, such as C-reactive protein. This study hypothesized that salivary cortisol and C-reactive protein levels would increase following RHS and then return to pre-RHS levels within 24 h post-exposure. Twenty-four participants performed a steady-state treadmill protocol in an environmental chamber (35 °C; 45% humidity) in full firefighter personal protective equipment until reaching either a core temperature (T
    MeSH term(s) Humans ; C-Reactive Protein ; Hydrocortisone ; Firefighters ; Biomarkers ; Heat-Shock Response
    Chemical Substances C-Reactive Protein (9007-41-4) ; Hydrocortisone (WI4X0X7BPJ) ; Biomarkers
    Language English
    Publishing date 2024-02-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 1498364-3
    ISSN 1879-0992 ; 0306-4565
    ISSN (online) 1879-0992
    ISSN 0306-4565
    DOI 10.1016/j.jtherbio.2024.103805
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  7. Article ; Online: Reply from George A. Brooks, Harry B. Rossiter, David C. Poole and L. Bruce Gladden.

    Brooks, George A / Rossiter, Harry B / Poole, David C / Gladden, L Bruce

    The Journal of physiology

    2021  Volume 599, Issue 5, Page(s) 1711–1712

    MeSH term(s) Anaerobic Threshold ; Oxygen Consumption ; Pulmonary Gas Exchange
    Language English
    Publishing date 2021-02-07
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP281335
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.65: Show issues Location:
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  8. Article ; Online: Comparing Hepatitis C Virus Screening in Clinics Versus the Emergency Department.

    Hluhanich, Rebecca / Ford, James S / Bruce, Devin / Chechi, Tasleem / Voong, Stephanie / Sarkar, Souvik / Poole, Patricia / Tran, Nam / May, Larissa

    The western journal of emergency medicine

    2022  Volume 23, Issue 3, Page(s) 312–317

    Abstract: ... screening programs have utility. We aimed to compare clinic-based and ED-based hepatitis C virus (HCV ... which was positive in 381 patients (45%). In an ED birth cohort sub-analysis, Hepatitis C virus Ab ...

    Abstract Introduction: New evidence suggests that emergency department (ED)-based infectious diseases screening programs have utility. We aimed to compare clinic-based and ED-based hepatitis C virus (HCV) screening programs within a single health system, to identify key differences in HCV antibody (Ab) positivity and chronic HCV, as well as population demographics.
    Methods: In the clinic-based program, adults in the birth cohort (born 1945-1965) were screened for HCV. In the ED-based program, non-targeted HCV screening of all adults was conducted. We included patients screened between June 2019-June 2020. Patients were screened for anti-HCV Ab, and positive results were followed by HCV viral load (VL) testing. Our primary outcomes were seroprevalence of HCV Ab and HCV VL.
    Results: There were 1,296 and 12,778 patients screened for HCV in the clinics and the ED, respectively. In the clinic setting, 13 patients (1%) screened positive for HCV Ab and nine (69%) completed VL testing, which was positive in one patient (11%). In the ED, 1,053 patients (8%) screened positive for HCV Ab and 847 (80%) underwent reflex VL testing, which was positive in 381 patients (45%). In an ED birth cohort sub-analysis, Hepatitis C virus Ab seroprevalence was 15% (675/4521).
    Conclusion: In this study of patients in a single healthcare system, ED-based HCV screening was higher yield than clinic-based screening.
    MeSH term(s) Adult ; Emergency Service, Hospital ; Hepacivirus ; Hepatitis C/diagnosis ; Hepatitis C/epidemiology ; Hepatitis C Antibodies ; Humans ; Mass Screening/methods ; Seroepidemiologic Studies
    Chemical Substances Hepatitis C Antibodies
    Language English
    Publishing date 2022-03-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2375700-0
    ISSN 1936-9018 ; 1936-9018
    ISSN (online) 1936-9018
    ISSN 1936-9018
    DOI 10.5811/westjem.2021.11.53870
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  9. Article ; Online: On the origins and conceptual frameworks of natural plasticity-Lessons from single-cell models in C. elegans.

    Lambert, Julien / Lloret-Fernández, Carla / Laplane, Lucie / Poole, Richard J / Jarriault, Sophie

    Current topics in developmental biology

    2021  Volume 144, Page(s) 111–159

    Abstract: ... of these new frameworks we describe here an atlas of natural plasticity of cell identity in C. elegans ...

    Abstract How flexible are cell identities? This problem has fascinated developmental biologists for several centuries and can be traced back to Abraham Trembley's pioneering manipulations of Hydra to test its regeneration abilities in the 1700s. Since the cell theory in the mid-19th century, developmental biology has been dominated by a single framework in which embryonic cells are committed to specific cell fates, progressively and irreversibly acquiring their differentiated identities. This hierarchical, unidirectional and irreversible view of cell identity has been challenged in the past decades through accumulative evidence that many cell types are more plastic than previously thought, even in intact organisms. The paradigm shift introduced by such plasticity calls into question several other key traditional concepts, such as how to define a differentiated cell or more generally cellular identity, and has brought new concepts, such as distinct cellular states. In this review, we want to contribute to this representation by attempting to clarify the conceptual and theoretical frameworks of cell plasticity and identity. In the context of these new frameworks we describe here an atlas of natural plasticity of cell identity in C. elegans, including our current understanding of the cellular and molecular mechanisms at play. The worm further provides interesting cases at the borderlines of cellular plasticity that highlight the conceptual challenges still ahead. We then discuss a set of future questions and perspectives arising from the studies of natural plasticity in the worm that are shared with other reprogramming and plasticity events across phyla.
    MeSH term(s) Animals ; Caenorhabditis elegans ; Cell Plasticity
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ISSN 1557-8933 ; 0070-2153
    ISSN (online) 1557-8933
    ISSN 0070-2153
    DOI 10.1016/bs.ctdb.2021.03.004
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  10. Article: Critical Remarks on the "Plea of Insanity," &c.

    Poole, Richard

    Journal of psychological medicine and mental pathology (London, England : 1848)

    2017  Volume 8, Issue 30, Page(s) 266–281

    Language English
    Publishing date 2017-09-14
    Publishing country England
    Document type Journal Article
    Database MEDical Literature Analysis and Retrieval System OnLINE

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