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Article ; Online: Hypersensitivity transfusion reactions due to IgA deficiency are rare according to French hemovigilance data.

Tacquard, Charles / Boudjedir, Karim / Carlier, Monique / Muller, Jean-Yves / Gomis, Philippe / Mertes, Paul Michel

The Journal of allergy and clinical immunology

2017 Volume 140, Issue 3, Page(s) 884–885

MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Blood Safety ; Child ; Child, Preschool ; Female ; France ; Humans ; Hypersensitivity/etiology ; IgA Deficiency/complications ; Male ; Middle Aged ; Transfusion Reaction/etiology ; Young Adult
Language	English
Publishing date	2017-04-13
Publishing country	United States
Document type	Letter
ZDB-ID	121011-7
ISSN	1097-6825 ; 1085-8725 ; 0091-6749
ISSN (online)	1097-6825 ; 1085-8725
ISSN	0091-6749
DOI	10.1016/j.jaci.2017.03.029
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Article ; Online: In reply.

Laroche, Dominique / Gomis, Philippe / Malinovsky, Jean-Marc / Mertes, Paul-Michel

Anesthesiology

2015 Volume 122, Issue 3, Page(s) 714–715

MeSH term(s)	Anaphylaxis/diagnosis ; Anesthesia/adverse effects ; Drug Hypersensitivity/diagnosis ; Female ; Heart Arrest/diagnosis ; Histamine/blood ; Humans ; Male ; Shock/diagnosis ; Tryptases/blood
Chemical Substances	Histamine (820484N8I3) ; Tryptases (EC 3.4.21.59)
Language	English
Publishing date	2015-03
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	269-0
ISSN	1528-1175 ; 0003-3022
ISSN (online)	1528-1175
ISSN	0003-3022
DOI	10.1097/ALN.0000000000000585
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Article ; Online: Effect of age and care organization on sources of variation in kidney transplant waiting list registration.

Couchoud, Cécile / Bayer, Florian / Rabilloud, Muriel / Ayav, Carole / Bayat, Sahar / Bechade, Clemence / Brunet, Philippe / Gomis, Sebastien / Savoye, Emilie / Moranne, Olivier / Lobbedez, Thierry / Ecochard, Rene

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

2021 Volume 21, Issue 11, Page(s) 3608–3617

Abstract: Despite national guidelines, medical practices and kidney transplant waiting list registration policies may differ from one dialysis/transplant unit to another. Benefit risk assessment variations, especially for elderly patients, have also been described. ...

Abstract	Despite national guidelines, medical practices and kidney transplant waiting list registration policies may differ from one dialysis/transplant unit to another. Benefit risk assessment variations, especially for elderly patients, have also been described. The aim of this study was to identify sources of variation in early kidney transplant waiting list registration in France. Among 16 842 incident patients during the period 2016-2017, 4386 were registered on the kidney transplant waiting list at the start of, or during the first year after starting, dialysis (26%). We developed various log-linear mixed effect regression models on three levels: patients, dialysis networks, and transplant centers. Variability was expressed as variance from the random intercepts (± standard error). Although patient characteristics have an important impact on the likelihood of registration, the overall magnitude of variability in registration was low and shared by dialysis networks and transplant centers. Between-transplant center variability (0.23 ± 0.08) was 1.8 higher than between-dialysis network variability (0.13 ± 0.004). Older age was associated with a lower probability of registration and greater variability between networks (0.04, 0.20, & 0.93 in the 18-64, 65-74, and 75-84 age groups). Targeted interventions should focus on elderly patients and/or certain regions with greater variability in waiting list access.
MeSH term(s)	Aged ; Humans ; Kidney ; Kidney Failure, Chronic/surgery ; Kidney Transplantation ; Renal Dialysis ; Waiting Lists
Language	English
Publishing date	2021-06-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	2060594-8
ISSN	1600-6143 ; 1600-6135
ISSN (online)	1600-6143
ISSN	1600-6135
DOI	10.1111/ajt.16694
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Article ; Online: Structural and Lattice-Dynamical Properties of Tb

Ibáñez, Jordi / Sans, Juan Ángel / Cuenca-Gotor, Vanesa / Oliva, Robert / Gomis, Óscar / Rodríguez-Hernández, Plácida / Muñoz, Alfonso / Rodríguez-Mendoza, Ulises / Velázquez, Matías / Veber, Philippe / Popescu, Catalin / Manjón, Francisco Javier

Inorganic chemistry

2020 Volume 59, Issue 14, Page(s) 9648–9666

Abstract: We report a joint experimental and theoretical investigation of the high pressure structural and vibrational properties of terbium sesquioxide ( ... ...

Abstract	We report a joint experimental and theoretical investigation of the high pressure structural and vibrational properties of terbium sesquioxide (Tb
Language	English
Publishing date	2020-06-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.0c00834
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Article ; Online: Global Sensitivity Analysis of a Cardiovascular Model for the Study of the Autonomic Response to Head-up Tilt Testing.

Calvo, Mireia / Rolle, Virginie Le / Romero, Daniel / Behar, Nathalie / Gomis, Pedro / Mabo, Philippe / Hernandez, Alfredo I

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

2018 Volume 2018, Page(s) 5458–5461

Abstract: This paper proposes the integration and analysis of a mathematical model representing the cardiovascular system and its short-term autonomic response to head-up tilt (HUT) testing. A Latin Hypercube Sampling method was applied to design an optimal ... ...

Abstract	This paper proposes the integration and analysis of a mathematical model representing the cardiovascular system and its short-term autonomic response to head-up tilt (HUT) testing. A Latin Hypercube Sampling method was applied to design an optimal experimental space, including 19 model parameters coming from the cardiovascular and baroreflex control systems. Then, a global, variance-based sensitivity analysis was applied to quantity the effects of these parameters on heart rate and systolic blood pressure. Results highlight the relevant influence of the intrinsic heart rate and the sympathetic and parasympathetic baroreflex gains on heart rate regulation, as well as the impact of left ventricle diastolic parameters on systolic blood pressure. Moreover, a significant effect of right ventricle dynamics on blood pressure was noted. These results provide valuable information for the application of such an integrated model for the analysis of the autonomic mechanisms regulating the cardiovascular response induced by postural changes. In particular, they suggest a convenient set of parameters to be identified in a subject-specific manner.
MeSH term(s)	Autonomic Nervous System ; Baroreflex ; Blood Pressure ; Heart Rate ; Models, Cardiovascular ; Tilt-Table Test
Language	English
Publishing date	2018-09-17
Publishing country	United States
Document type	Journal Article
ISSN	2694-0604
ISSN (online)	2694-0604
DOI	10.1109/EMBC.2018.8513536
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Article ; Online: Multivariate classification of Brugada syndrome patients based on autonomic response to exercise testing.

Calvo, Mireia / Romero, Daniel / Le Rolle, Virginie / Béhar, Nathalie / Gomis, Pedro / Mabo, Philippe / Hernández, Alfredo I

PloS one

2018 Volume 13, Issue 5, Page(s) e0197367

Abstract: Ventricular arrhythmias in Brugada syndrome (BS) typically occur at rest and especially during sleep, suggesting that changes in the autonomic modulation may play an important role in arrhythmogenesis. The autonomic response to exercise and subsequent ... ...

Abstract	Ventricular arrhythmias in Brugada syndrome (BS) typically occur at rest and especially during sleep, suggesting that changes in the autonomic modulation may play an important role in arrhythmogenesis. The autonomic response to exercise and subsequent recovery was evaluated on 105 patients diagnosed with BS (twenty-four were symptomatic), by means of a time-frequency heart rate variability (HRV) analysis, so as to propose a novel predictive model capable of distinguishing symptomatic and asymptomatic BS populations. During incremental exercise, symptomatic patients showed higher HFnu values, probably related to an increased parasympathetic modulation, with respect to asymptomatic subjects. In addition, those extracted HRV features best distinguishing between populations were selected using a two-step feature selection approach, so as to build a linear discriminant analysis (LDA) classifier. The final features subset included one third of the total amount of extracted autonomic markers, mostly acquired during incremental exercise and active recovery, thus evidencing the relevance of these test segments in BS patients classification. The derived predictive model showed an improved performance with respect to previous works in the field (AUC = 0.92 ± 0.01; Se = 0.91 ± 0.06; Sp = 0.90 ± 0.05). Therefore, based on these findings, some of the analyzed HRV markers and the proposed model could be useful for risk stratification in Brugada syndrome.
MeSH term(s)	Adult ; Aged ; Autonomic Nervous System/physiology ; Brugada Syndrome/classification ; Brugada Syndrome/physiopathology ; Discriminant Analysis ; Exercise Test ; Female ; Heart Rate/physiology ; Humans ; Male ; Middle Aged ; Young Adult
Language	English
Publishing date	2018-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1932-6203
ISSN (online)	1932-6203
DOI	10.1371/journal.pone.0197367
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Article ; Online: Model-based analysis of the autonomic response to head-up tilt testing in Brugada syndrome.

Calvo, Mireia / Le Rolle, Virginie / Romero, Daniel / Béhar, Nathalie / Gomis, Pedro / Mabo, Philippe / Hernández, Alfredo I

Computers in biology and medicine

2018 Volume 103, Page(s) 82–92

Abstract: The etiology of Brugada syndrome (BS) is complex and multifactorial, making risk stratification in this population a major challenge. Since changes in the autonomic modulation of these patients are commonly related to arrhythmic events, we analyze in ... ...

Abstract	The etiology of Brugada syndrome (BS) is complex and multifactorial, making risk stratification in this population a major challenge. Since changes in the autonomic modulation of these patients are commonly related to arrhythmic events, we analyze in this work whether the response to head-up tilt (HUT) testing on this population may provide useful, complementary information for risk stratification. In order to perform this analysis, a coupled physiological model integrating the cardiac electrical activity, the cardiovascular system and the baroreceptors reflex control of the autonomic function, in response to HUT is proposed. A sensitivity analysis was performed, based on a screening method, evidencing the influence of cardiovascular parameters on blood pressure and of baroreflex regulation on heart rate. The most sensitive parameters have been identified on a set of 20 subjects (8 controls and 12 BS patients), so as to assess subject-specific model parameters. According to the results, controls showed an increased sympathetic modulation after tilting, as well as a reduced left ventricular contractility was observed in symptomatic, with respect to asymptomatic BS patients. These results provide new insights regarding the autonomic mechanisms regulating the cardiovascular system in BS which might be used as a complementary source of information, along with classical electrophysiological parameters, for BS risk stratification.
MeSH term(s)	Adult ; Autonomic Nervous System/physiology ; Autonomic Nervous System/physiopathology ; Baroreflex/physiology ; Blood Pressure/physiology ; Brugada Syndrome/diagnosis ; Brugada Syndrome/physiopathology ; Female ; Humans ; Male ; Middle Aged ; Models, Cardiovascular ; Posture/physiology ; Sensitivity and Specificity ; Tilt-Table Test/methods
Language	English
Publishing date	2018-10-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	127557-4
ISSN	1879-0534 ; 0010-4825
ISSN (online)	1879-0534
ISSN	0010-4825
DOI	10.1016/j.compbiomed.2018.10.007
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Article ; Online: Recursive model identification for the analysis of the autonomic response to exercise testing in Brugada syndrome.

Calvo, Mireia / Le Rolle, Virginie / Romero, Daniel / Béhar, Nathalie / Gomis, Pedro / Mabo, Philippe / Hernández, Alfredo I

Artificial intelligence in medicine

2018 Volume 97, Page(s) 98–104

Abstract: This paper proposes the integration and analysis of a closed-loop model of the baroreflex and cardiovascular systems, focused on a time-varying estimation of the autonomic modulation of heart rate in Brugada syndrome (BS), during exercise and subsequent ... ...

Abstract	This paper proposes the integration and analysis of a closed-loop model of the baroreflex and cardiovascular systems, focused on a time-varying estimation of the autonomic modulation of heart rate in Brugada syndrome (BS), during exercise and subsequent recovery. Patient-specific models of 44 BS patients at different levels of risk (symptomatic and asymptomatic) were identified through a recursive evolutionary algorithm. After parameter identification, a close match between experimental and simulated signals (mean error = 0.81%) was observed. The model-based estimation of vagal and sympathetic contributions were consistent with physiological knowledge, enabling to observe the expected autonomic changes induced by exercise testing. In particular, symptomatic patients presented a significantly higher parasympathetic activity during exercise, and an autonomic imbalance was observed in these patients at peak effort and during post-exercise recovery. A higher vagal modulation during exercise, as well as an increasing parasympathetic activity at peak effort and a decreasing vagal contribution during post-exercise recovery could be related with symptoms and, thus, with a worse prognosis in BS. This work proposes the first evaluation of the sympathetic and parasympathetic responses to exercise testing in patients suffering from BS, through the recursive identification of computational models; highlighting important trends of clinical relevance that provide new insights into the underlying autonomic mechanisms regulating the cardiovascular system in BS. The joint analysis of the extracted autonomic parameters and classic electrophysiological markers could improve BS risk stratification.
MeSH term(s)	Adult ; Algorithms ; Autonomic Nervous System/physiopathology ; Brugada Syndrome/physiopathology ; Computer Simulation ; Electrocardiography ; Exercise Test ; Female ; Humans ; Male ; Middle Aged
Language	English
Publishing date	2018-11-28
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645179-2
ISSN	1873-2860 ; 0933-3657
ISSN (online)	1873-2860
ISSN	0933-3657
DOI	10.1016/j.artmed.2018.11.006
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Article: Sex Differences in Autonomic Response to Exercise Testing in Patients with Brugada Syndrome.

Calvo, Mireia / Le Rolle, Virginie / Romero, Daniel / Béhar, Nathalie / Gomis, Pedro / Mabo, Philippe / Hernández, Alfredo

Advances in experimental medicine and biology

2018 Volume 1065, Page(s) 181–190

Abstract: Introduction: Cardiac events in patients with Brugada syndrome (BS) typically occur at rest and mainly during sleep, suggesting that changes in autonomic modulation play an important role in the arrhythmogenesis of the disease. Moreover, sex differences ...

Abstract	Introduction: Cardiac events in patients with Brugada syndrome (BS) typically occur at rest and mainly during sleep, suggesting that changes in autonomic modulation play an important role in the arrhythmogenesis of the disease. Moreover, sex differences in clinical manifestations of BS have been reported, identifying male patients with worse prognosis. The aim of our work was to assess and compare, according to sex, autonomic response to exercise in a clinical series including 105 BS patients. Method: Standard 12-lead electrocardiogram recordings were collected during a physical stress test divided into four phases: warm-up, incremental exercise, active recovery, and passive recovery. Spectral non-stationary heart rate variability indicators were extracted by means of a smoothed pseudo Wigner-Ville distribution approach that adapts frequency bands to respiratory information. These indicators were then averaged in non-overlapped windows of 1 min for each patient to compare groups at each minute of the physical stress test. Results: From the last minute of warm-up and until the third minute of incremental exercise, asymptomatic male patients presented significantly greater low-frequency (LF) values ([Formula: see text]: p = 0.015;[Formula: see text]: p = 0.024; [Formula: see text]: p = 0.011; [Formula: see text]: p = 0.002) than asymptomatic females. Conversely, asymptomatic women showed increased vagal modulation during the first minutes of incremental exercise ([Formula: see text]: p = 0.031; [Formula: see text]: p = 0.001). However, no significant differences were observed between symptomatic male and female patients. Conclusion: As previously reported in healthy subjects, enhanced parasympathetic and decreased sympathetic tones appear to be not only greater in women but also defensive during cardiac stress. Based on the results, asymptomatic patients presented same-sex tendencies. However, we observed that symptomatic males developed a more female-like autonomic modulation, probably related to a more protective autonomic response to exercise. These results could be a step forward toward the understanding of the autonomic function in BS along with a potential impact on risk stratification.
MeSH term(s)	Action Potentials ; Adult ; Autonomic Nervous System/physiopathology ; Brugada Syndrome/diagnosis ; Brugada Syndrome/physiopathology ; Electrocardiography ; Exercise Test ; Female ; Health Status Disparities ; Heart/innervation ; Heart Rate ; Humans ; Male ; Middle Aged ; Predictive Value of Tests ; Sex Factors ; Time Factors
Language	English
Publishing date	2018-07-27
Publishing country	United States
Document type	Comparative Study ; Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-319-77932-4_12
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Article ; Online: Population Pharmacokinetic-Pharmacodynamic Modeling of Ropivacaine in Spinal Anesthesia.

Djerada, Zoubir / Feliu, Catherine / Cazaubon, Yoann / Smati, Faouzi / Gomis, Philippe / Guerrot, Dominique / Charbit, Beny / Fernandes, Olivier / Malinovsky, Jean-Marc

Clinical pharmacokinetics

2018 Volume 57, Issue 9, Page(s) 1135–1147

Abstract: Background: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown.: Objective: The aim of this study was to assess the relationship between plasma ropivacaine ... ...

Abstract	Background: Ropivacaine is frequently used in spinal anesthesia but the relationship between plasma concentrations and sensory block level remains unknown. Objective: The aim of this study was to assess the relationship between plasma ropivacaine concentrations and effects during spinal anesthesia. Methods: Sixty patients aged between 18 and 82 years were included in this study after providing written informed consent. Patients were randomly assigned to receive intrathecal administration of ropivacaine 15, 20 or 25 mg. Blood samples were drawn to determine ropivacaine concentrations, and sensory blockade was assessed using pinprick testing. Ropivacaine plasma concentrations and sensory block level were analyzed using a nonlinear mixed-effects modeling approach with Monolix 4.2.2. Uncertainty of parameters was estimated by bootstrapping. Results: Overall, 216 plasma ropivacaine values and 407 sensory block-related data were available for pharmacokinetic-pharmacodynamic (PK-PD) model evaluation. A two-compartment open model connected to a spinal compartment was selected to describe the PKs of ropivacaine. Sensory block modeling was performed using a sigmoid E Conclusions: This first population PK-PD model for ropivacaine in spinal anesthesia confirms the relationship between plasma ropivacaine concentrations and effect. We also clarify the relationship between the spread of sensory block level and dose, age and, for the first time, weight. Study registration: This study was approved by the Reims University Hospital Ethics Committee (protocol: PHRC-2005; registered at Agence Nationale de Sécurité du Médicament et des Produits de Santé ANSM: D60890). This was an open, prospective, monocentric study conducted in the University Hospital of Reims (France).
MeSH term(s)	Adolescent ; Adult ; Age Factors ; Aged ; Aged, 80 and over ; Anesthesia, Spinal/methods ; Anesthetics, Local/blood ; Anesthetics, Local/pharmacokinetics ; Anesthetics, Local/pharmacology ; Dose-Response Relationship, Drug ; Humans ; Injections, Spinal ; Middle Aged ; Models, Biological ; Prospective Studies ; Ropivacaine/blood ; Ropivacaine/pharmacokinetics ; Ropivacaine/pharmacology ; Young Adult
Chemical Substances	Anesthetics, Local ; Ropivacaine (7IO5LYA57N)
Language	English
Publishing date	2018-03-14
Publishing country	Switzerland
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	197627-8
ISSN	1179-1926 ; 0312-5963
ISSN (online)	1179-1926
ISSN	0312-5963
DOI	10.1007/s40262-017-0617-2
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