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  1. Article ; Online: Etch characteristics of magnetic tunnel junction materials using H

    Kim, Ju Eun / Kim, Doo San / Gill, You Jung / Jang, Yun Jong / Kim, Ye Eun / Cho, Hanna / Won, Bok-Yeon / Kwon, Oik / Yoon, Kukhan / Choi, Jin-Young / Park, Jea-Gun / Yeom, Geun Young

    Nanotechnology

    2021  Volume 32, Issue 5, Page(s) 55301

    Abstract: ... such as W and TiN were etched with a reactive ion beam etching (RIBE) system using H ...

    Abstract Magnetic tunneling junction (MTJ) materials such as CoFeB, Co, Pt, MgO, and the hard mask material such as W and TiN were etched with a reactive ion beam etching (RIBE) system using H
    Language English
    Publishing date 2021-01-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/abb04e
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Rapid Visible Detection of African Swine Fever Virus Using Hybridization Chain Reaction-Sensitized Magnetic Nanoclusters and Affinity Chromatography.

    Lee, Hyo / Lee, Sojeong / Park, Chaewon / Yeom, Minjoo / Lim, Jong-Woo / Vu, Thi Thu Hang / Kim, Eunjung / Song, Daesub / Haam, Seungjoo

    Small (Weinheim an der Bergstrasse, Germany)

    2023  Volume 19, Issue 26, Page(s) e2207117

    Abstract: African swine fever virus (ASFV) is a severe and persistent threat to the global swine industry. As there are no vaccines against ASFV, there is an immense need to develop easy-to-use, cost-effective, and rapid point-of-care (POC) diagnostic platforms to ...

    Abstract African swine fever virus (ASFV) is a severe and persistent threat to the global swine industry. As there are no vaccines against ASFV, there is an immense need to develop easy-to-use, cost-effective, and rapid point-of-care (POC) diagnostic platforms to detect and prevent ASFV outbreaks. Here, a novel POC diagnostic system based on affinity column chromatography for the optical detection of ASFV is presented. This system employs an on-particle hairpin chain reaction to sensitize magnetic nanoclusters with long DNA strands in a target-selective manner, which is subsequently fed into a column chromatography device to produce quantitatively readable and colorimetric signals. The detection approach does not require expensive analytical apparatus or immobile instrumentation. The system can detect five genes constituting the ASFV whole genome with a detection limit of ≈19.8 pm in swine serum within 30 min at laboratory room temperature. With an additional pre-amplification step using polymerase chain reaction (PCR), the assay is successfully applied to detect the presence of ASFV in 30 suspected swine samples with 100% sensitivity and specificity, similar to quantitative PCR. Thus, this simple, inexpensive, portable, robust, and customizable platform for the early detection of ASFV can facilitate the timely surveillance and implementation of control measures.
    MeSH term(s) Swine ; Animals ; African Swine Fever Virus/genetics ; African Swine Fever/diagnosis ; Polymerase Chain Reaction/methods ; Chromatography, Affinity ; Sensitivity and Specificity ; Magnetic Phenomena
    Language English
    Publishing date 2023-03-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2168935-0
    ISSN 1613-6829 ; 1613-6810
    ISSN (online) 1613-6829
    ISSN 1613-6810
    DOI 10.1002/smll.202207117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Development of artificial neural networks software for arsenic adsorption from an aqueous environment

    Maurya, A.K. / Nagamani, M. / Kang, Seung Won / Yeom, Jong-Taek / Hong, Jae-Keun / Sung, Hyokyung / Park, C.H. / Uma Maheshwera Reddy, Paturi / Reddy, N.S.

    Environmental research. 2022 Jan., v. 203

    2022  

    Abstract: Arsenic contamination is a global problem, as it affects the health of millions of people. For this study, data-driven artificial neural network (ANN) software was developed to predict and validate the removal of As(V) from an aqueous solution using ... ...

    Abstract Arsenic contamination is a global problem, as it affects the health of millions of people. For this study, data-driven artificial neural network (ANN) software was developed to predict and validate the removal of As(V) from an aqueous solution using graphene oxide (GO) under various experimental conditions. A reliable model for wastewater treatment is essential in order to predict its overall performance and to provide an idea of how to control its operation. This model considered the adsorption process parameters (initial concentration, adsorbent dosage, pH, and residence time) as the input variables and arsenic removal as the only output. The ANN model predicted the adsorption efficiency with high accuracy for both training and testing datasets, when compared with the available response surface methodology (RSM) model. Based on the best model synaptic weights, user-friendly ANN software was created to predict and analyze arsenic removal as a function of adsorption process parameters. We developed various graphical user interfaces (GUI) for easy use of the developed model. Thus, a researcher can efficiently operate the software without an understanding of programming or artificial neural networks. Sensitivity analysis and quantitative estimation were carried out to study the function of adsorption process parameter variables on As(V) removal efficiency, using the GUI of the model. The model prediction shows that the adsorbent dosages, initial concentration, and pH are the most influential parameters. The efficiency was increased as the adsorbent dosages increased, decreasing with initial concentration and pH. The result show that the pH 2.0–5.0 is optimal for adsorbent efficiency (%).
    Keywords adsorbents ; adsorption ; aqueous solutions ; arsenic ; computer software ; data collection ; graphene oxide ; neural networks ; pH ; prediction ; research ; researchers ; response surface methodology ; wastewater treatment
    Language English
    Dates of publication 2022-01
    Publishing place Elsevier Inc.
    Document type Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2021.111846
    Database NAL-Catalogue (AGRICOLA)

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  4. Article ; Online: Risk of newly diagnosed interstitial lung disease after COVID-19 and impact of vaccination: a nationwide population-based cohort study.

    Kim, Bo-Guen / Lee, Hyun / Jeong, Cho Yun / Yeom, Sang Woo / Park, Dong Won / Park, Tai Sun / Moon, Ji-Yong / Kim, Tae-Hyung / Sohn, Jang Won / Yoon, Ho Joo / Kim, Jong Seung / Kim, Sang-Heon

    Frontiers in public health

    2024  Volume 11, Page(s) 1295457

    Abstract: Objectives: Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung disease (ILD) after COVID-19 is unclear. We aimed to determine whether COVID-19 ... ...

    Abstract Objectives: Previous studies suggested that coronavirus disease 2019 (COVID-19) could lead to pulmonary fibrosis, but the incidence of newly diagnosed interstitial lung disease (ILD) after COVID-19 is unclear. We aimed to determine whether COVID-19 increases the risk of newly diagnosed ILD and whether vaccination against COVID-19 can reduce this risk.
    Methods: This retrospective cohort study used data from the Korean National Health Insurance claim-based database. Two study groups and propensity score (PS)-matched control groups were constructed: Study 1: participants diagnosed with COVID-19 (COVID-19 cohort) and their PS-matched controls; Study 2: COVID-19 vaccinated participants (vaccination cohort) and their PS-matched controls.
    Results: In Study 1, during a median 6 months of follow-up, 0.50% of the COVID-19 cohort (300/60,518) and 0.04% of controls (27/60,518) developed newly diagnosed ILD, with an incidence of 9.76 and 0.88 per 1,000 person-years, respectively. The COVID-19 cohort had a higher risk of ILD [adjusted hazard ratio (aHR), 11.01; 95% confidence interval (CI), 7.42-16.32] than controls. In Study 2, the vaccination cohort had a lower risk of newly diagnosed ILD than controls (aHR, 0.44; 95% CI, 0.34-0.57).
    Conclusion: Using nationwide data, we demonstrated that COVID-19 was associated with a higher incidence rate of newly diagnosed ILD, but that this risk could be mitigated by COVID-19 vaccination.
    MeSH term(s) Humans ; COVID-19 Vaccines ; Cohort Studies ; Retrospective Studies ; COVID-19/epidemiology ; COVID-19/prevention & control ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/etiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2023.1295457
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: In reply: Not which forceps, but whether forceps?

    Yeom, Jong H / Oh, Mi K / Shin, Woo J / Ahn, Dae W / Jeon, Woo J / Cho, Sang Y

    Canadian journal of anaesthesia = Journal canadien d'anesthesie

    2018  Volume 65, Issue 7, Page(s) 858

    MeSH term(s) Biopsy ; Surgical Instruments
    Language English
    Publishing date 2018-03-27
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 91002-8
    ISSN 1496-8975 ; 0832-610X
    ISSN (online) 1496-8975
    ISSN 0832-610X
    DOI 10.1007/s12630-018-1115-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Development of artificial neural networks software for arsenic adsorption from an aqueous environment.

    Maurya, A K / Nagamani, M / Kang, Seung Won / Yeom, Jong-Taek / Hong, Jae-Keun / Sung, Hyokyung / Park, C H / Uma Maheshwera Reddy, Paturi / Reddy, N S

    Environmental research

    2021  Volume 203, Page(s) 111846

    Abstract: Arsenic contamination is a global problem, as it affects the health of millions of people. For this study, data-driven artificial neural network (ANN) software was developed to predict and validate the removal of As(V) from an aqueous solution using ... ...

    Abstract Arsenic contamination is a global problem, as it affects the health of millions of people. For this study, data-driven artificial neural network (ANN) software was developed to predict and validate the removal of As(V) from an aqueous solution using graphene oxide (GO) under various experimental conditions. A reliable model for wastewater treatment is essential in order to predict its overall performance and to provide an idea of how to control its operation. This model considered the adsorption process parameters (initial concentration, adsorbent dosage, pH, and residence time) as the input variables and arsenic removal as the only output. The ANN model predicted the adsorption efficiency with high accuracy for both training and testing datasets, when compared with the available response surface methodology (RSM) model. Based on the best model synaptic weights, user-friendly ANN software was created to predict and analyze arsenic removal as a function of adsorption process parameters. We developed various graphical user interfaces (GUI) for easy use of the developed model. Thus, a researcher can efficiently operate the software without an understanding of programming or artificial neural networks. Sensitivity analysis and quantitative estimation were carried out to study the function of adsorption process parameter variables on As(V) removal efficiency, using the GUI of the model. The model prediction shows that the adsorbent dosages, initial concentration, and pH are the most influential parameters. The efficiency was increased as the adsorbent dosages increased, decreasing with initial concentration and pH. The result show that the pH 2.0-5.0 is optimal for adsorbent efficiency (%).
    MeSH term(s) Adsorption ; Arsenic ; Humans ; Hydrogen-Ion Concentration ; Kinetics ; Neural Networks, Computer ; Software ; Water Pollutants, Chemical/analysis
    Chemical Substances Water Pollutants, Chemical ; Arsenic (N712M78A8G)
    Language English
    Publishing date 2021-08-06
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2021.111846
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: High-throughput genetic engineering tools for regulating gene expression in a microbial cell factory.

    Yeom, Jinho / Park, Jong Seong / Jung, Seung-Woon / Lee, Sumin / Kwon, Hyukjin / Yoo, Seung Min

    Critical reviews in biotechnology

    2021  Volume 43, Issue 1, Page(s) 82–99

    Abstract: With the rapid advances in biotechnological tools and strategies, microbial cell factory-constructing strategies have been established for the production of value-added compounds. However, optimizing the tradeoff between the biomass, yield, and titer ... ...

    Abstract With the rapid advances in biotechnological tools and strategies, microbial cell factory-constructing strategies have been established for the production of value-added compounds. However, optimizing the tradeoff between the biomass, yield, and titer remains a challenge in microbial production. Gene regulation is necessary to optimize and control metabolic fluxes in microorganisms for high-production performance. Various high-throughput genetic engineering tools have been developed for achieving rational gene regulation and genetic perturbation, diversifying the cellular phenotype and enhancing bioproduction performance. In this paper, we review the current high-throughput genetic engineering tools for gene regulation. In particular, technological approaches used in a diverse range of genetic tools for constructing microbial cell factories are introduced, and representative applications of these tools are presented. Finally, the prospects for high-throughput genetic engineering tools for gene regulation are discussed.
    MeSH term(s) Metabolic Engineering ; Biotechnology ; Gene Expression Regulation ; Biomass ; Gene Expression
    Language English
    Publishing date 2021-12-26
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1042364-3
    ISSN 1549-7801 ; 0738-8551
    ISSN (online) 1549-7801
    ISSN 0738-8551
    DOI 10.1080/07388551.2021.2007351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Kinetic stability modulation of polymeric nanoparticles for enhanced detection of influenza virus

    Park, Chaewon / Lim, Jong-Woo / Park, Geunseon / Kim, Hyun-Ouk / Lee, Sojeong / Kwon, Yuri H / Kim, Seong-Eun / Yeom, Minjoo / Na, Woonsung / Song, Daesub / Kim, Eunjung / Haam, Seungjoo

    Journal of materials chemistry. B

    2021  Volume 9, Issue 47, Page(s) 9658–9669

    Abstract: Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for ... ...

    Abstract Specific interactions between viruses and host cells provide essential insights into material science-based strategies to combat emerging viral diseases. pH-triggered viral fusion is ubiquitous to multiple viral families and is important for understanding the viral infection cycle. Inspired by this process, virus detection has been achieved using nanomaterials with host-mimetic membranes, enabling interactions with amphiphilic hemagglutinin fusion peptides of viruses. Most research has been on designing functional nanoparticles with fusogenic capability for virus detection, and there has been little exploitation of the kinetic stability to alter the ability of nanoparticles to interact with viral membranes and improve their sensing performance. In this study, a homogeneous fluorescent assay using self-assembled polymeric nanoparticles (PNPs) with tunable responsiveness to external stimuli is developed for rapid and straightforward detection of an activated influenza A virus. Dissociation of PNPs induced by virus insertion can be readily controlled by varying the fraction of hydrophilic segments in copolymers constituting PNPs, giving rise to fluorescence signals within 30 min and detection of various influenza viruses, including H9N2, CA04(H1N1), H4N6, and H6N8. Therefore, the designs demonstrated in this study propose underlying approaches for utilizing engineered PNPs through modulation of their kinetic stability for direct and sensitive identification of infectious viruses.
    MeSH term(s) Animals ; Carbocyanines/chemistry ; Chickens ; Eggs/virology ; Fluorescence Resonance Energy Transfer/methods ; Fluorescent Dyes/chemistry ; Influenza A virus/isolation & purification ; Influenza A virus/metabolism ; Limit of Detection ; Membrane Fusion/drug effects ; Membranes, Artificial ; Nanoparticles/chemistry ; Peptides/chemical synthesis ; Peptides/chemistry ; Peptides/metabolism ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethylene Glycols/metabolism ; Viral Fusion Proteins/metabolism
    Chemical Substances Carbocyanines ; Fluorescent Dyes ; Membranes, Artificial ; Peptides ; Viral Fusion Proteins ; polyleucine (25248-98-0) ; Polyethylene Glycols (3WJQ0SDW1A) ; 3,3'-dioctadecylindocarbocyanine (40957-95-7) ; 3,3'-dioctadecyloxacarbocyanine (68006-80-4)
    Language English
    Publishing date 2021-12-08
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb01847g
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Genome-wide association study of the response of patients with diabetic macular edema to intravitreal Anti-VEGF injection.

    Hong, Eun Hee / Yeom, Hoseok / Yu, Hyo Seon / Park, Jong Eun / Shin, Yong Un / Bang, So-Young / Cho, Heeyoon

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 22527

    Abstract: Diabetic macular edema (DME), a complication of diabetes mellitus, is a leading cause of adult-onset blindness worldwide. Recently, intravitreal anti-VEGF injection has been used as a first-line treatment. This study analyzed the association between the ... ...

    Abstract Diabetic macular edema (DME), a complication of diabetes mellitus, is a leading cause of adult-onset blindness worldwide. Recently, intravitreal anti-VEGF injection has been used as a first-line treatment. This study analyzed the association between the genetic profile of patients with DME and their response to treatment. Intravitreal anti-VEGF injections were administered monthly for three months to Korean patients diagnosed with DME, who were classified into two groups depending on whether they responded to anti-VEGF therapy or showed recurrence within six months. Peripheral blood samples were used for genetic analyses. Genome-wide association analysis results sowed that the genes DIRC3 on chromosome 2 (rs16857280, p = 1.2 × 10
    MeSH term(s) Adult ; Humans ; Macular Edema/drug therapy ; Macular Edema/genetics ; Macular Edema/diagnosis ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/genetics ; Diabetic Retinopathy/complications ; Ranibizumab ; Angiogenesis Inhibitors/therapeutic use ; Genome-Wide Association Study ; Vascular Endothelial Growth Factor A/genetics ; Intravitreal Injections ; Tomography, Optical Coherence/adverse effects ; Retrospective Studies ; Diabetes Mellitus/drug therapy
    Chemical Substances Ranibizumab (ZL1R02VT79) ; Angiogenesis Inhibitors ; Vascular Endothelial Growth Factor A
    Language English
    Publishing date 2022-12-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-26048-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Chiral Diketopyrrolopyrrole-Based Conjugated Polymers with Intramolecular Rotation-Isomeric Conformation Asymmetry for Near-Infrared Circularly Polarized Light-Sensing Organic Phototransistors.

    Han, Hyemi / Choi, Jong Ho / Ahn, Jongtae / Lee, Hanna / Choi, Changsoon / Jung, Wookjin / Yeom, Jihyeon / Hwang, Do Kyung / Sung, Bong June / Lim, Jung Ah

    ACS applied materials & interfaces

    2023  

    Abstract: Recent advances in chiral nanomaterials interacting with circularly polarized (CP) light open new expectations for optoelectronics in various research fields such as quantum- and biology-related technology. To fully utilize the great potential of chiral ... ...

    Abstract Recent advances in chiral nanomaterials interacting with circularly polarized (CP) light open new expectations for optoelectronics in various research fields such as quantum- and biology-related technology. To fully utilize the great potential of chiral optoelectronic devices, the development of chiral optoelectronic devices that function in the near-infrared (NIR) region is required. Herein, we demonstrate a NIR-absorbing, chiroptical, low-band-gap polymer semiconductor for high-performance NIR CP light phototransistors. A newly synthesized diketopyrrolopyrrole-based donor-acceptor-type chiral π-conjugated polymer with an asymmetric alkyl side chain exhibits strong chiroptical activity in a wavelength range of 700-1000 nm. We found that the attachment of an enantiomerically pure stereogenic alkyl substituent to the π-conjugated chromophore backbone led to strong chiroptical activity through symmetry breaking of the π-conjugation of the backbone in a molecular rotational motion while maintaining the coplanar backbone conformation for efficient charge transport. The NIR CP light-sensing phototransistors based on a chiral π-conjugated polymer photoactive single channel layer exhibit a high photoresponsivity of 26 A W
    Language English
    Publishing date 2023-11-30
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c13976
    Database MEDical Literature Analysis and Retrieval System OnLINE

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