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  1. Book ; Online: mTOR Signaling in Metabolism and Cancer

    Huang, Shile

    2020  

    Keywords Medicine ; mTOR ; histone deacetylase ; prostate cancer ; integrins ; adhesion ; invasion ; cell metabolism ; T cells ; Foxp3 ; Acute Lymphoblastic leukemia ; targeted therapy ; metabolism ; cell signalling ; mTOR signalling ; head and neck cancer ; mutant genes ; biomarkers ; targeted therapies ; clinical trials ; cancers ; inhibitors ; photodynamic therapy ; PI3K ; Akt ; skin cancers ; phytochemicals ; melanoma ; basal cell carcinoma ; squamous cell carcinoma ; Merkel cell carcinoma ; TNBC ; eribulin ; PI3K/AKT/mTOR ; everolimus ; combination ; synergy ; mTOR signaling ; tissue regeneration ; neuron ; muscle ; liver ; intestine ; hematologic malignancies ; regulatory T cells ; tumor
    Size 1 electronic resource (204 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021046454
    ISBN 9783039435548 ; 303943554X
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: mTOR Signaling in Metabolism and Cancer

    Shile Huang

    Cells, Vol 9, Iss 2278, p

    2020  Volume 2278

    Abstract: The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and ... ...

    Abstract The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases.
    Keywords mTOR ; PI3K ; Akt ; tissue regeneration ; regulatory T cells ; tumor ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2020-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: mTOR Signaling in Metabolism and Cancer.

    Huang, Shile

    Cells

    2020  Volume 9, Issue 10

    Abstract: The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and ... ...

    Abstract The mechanistic/mammalian target of rapamycin (mTOR), a serine/threonine kinase, is a central regulator for human physiological activity. Deregulated mTOR signaling is implicated in a variety of disorders, such as cancer, obesity, diabetes, and neurodegenerative diseases. The papers published in this special issue summarize the current understanding of the mTOR pathway and its role in the regulation of tissue regeneration, regulatory T cell differentiation and function, and different types of cancer including hematologic malignancies, skin, prostate, breast, and head and neck cancer. The findings highlight that targeting the mTOR pathway is a promising strategy to fight against certain human diseases.
    MeSH term(s) Epigenesis, Genetic ; Humans ; Metabolism ; Neoplasms/genetics ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/therapy ; Signal Transduction ; T-Lymphocytes, Regulatory/immunology ; TOR Serine-Threonine Kinases/metabolism ; Warburg Effect, Oncologic
    Chemical Substances TOR Serine-Threonine Kinases (EC 2.7.1.1)
    Language English
    Publishing date 2020-10-13
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells9102278
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Autophagy and Apoptosis in Rabies Virus Replication.

    Li, Saisai / Xu, Bowen / Luo, Yongwen / Luo, Jun / Huang, Shile / Guo, Xiaofeng

    Cells

    2024  Volume 13, Issue 2

    Abstract: Rabies virus (RABV) is a single-stranded negative-sense RNA virus belonging to ... ...

    Abstract Rabies virus (RABV) is a single-stranded negative-sense RNA virus belonging to the
    MeSH term(s) Animals ; Humans ; Rabies virus ; Rabies ; Apoptosis ; Autophagy ; Virus Replication
    Language English
    Publishing date 2024-01-18
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661518-6
    ISSN 2073-4409 ; 2073-4409
    ISSN (online) 2073-4409
    ISSN 2073-4409
    DOI 10.3390/cells13020183
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Liposomes for Tumor Targeted Therapy

    Shile Wang / Yanyu Chen / Jiancheng Guo / Qinqin Huang

    International Journal of Molecular Sciences, Vol 24, Iss 2643, p

    A Review

    2023  Volume 2643

    Abstract: Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include ... ...

    Abstract Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in the sustained release of the drug it carries and improved therapeutic indices. In the wake of the rapid development of nanotechnology, the studies of liposome composition have become increasingly extensive. The molecular diversity of liposome composition, which includes long-circulating PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and advanced cell membrane-coated biomimetic nanocarriers, endows their drug delivery with unique physiological functions. This review describes the composition, types and preparation methods of liposomes, and discusses their targeting strategies in cancer therapy.
    Keywords liposomes ; drug delivery systems ; cancer therapy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  6. Article ; Online: Newly synthesized Mpro inhibitors as potential oral anti-SARS-CoV-2 agents

    Lin Li / Shile Huang

    Signal Transduction and Targeted Therapy, Vol 6, Iss 1, Pp 1-

    2021  Volume 2

    Keywords Medicine ; R ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2021-03-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Newly synthesized M

    Li, Lin / Huang, Shile

    Signal transduction and targeted therapy

    2021  Volume 6, Issue 1, Page(s) 138

    MeSH term(s) Animals ; Antiviral Agents ; COVID-19 ; Humans ; Mice ; Mice, Transgenic ; Protease Inhibitors ; SARS-CoV-2
    Chemical Substances Antiviral Agents ; Protease Inhibitors
    Language English
    Publishing date 2021-03-31
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2886872-9
    ISSN 2059-3635 ; 2095-9907
    ISSN (online) 2059-3635
    ISSN 2095-9907
    DOI 10.1038/s41392-021-00560-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Liposomes for Tumor Targeted Therapy: A Review.

    Wang, Shile / Chen, Yanyu / Guo, Jiancheng / Huang, Qinqin

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include ... ...

    Abstract Liposomes, the most widely studied nano-drug carriers in drug delivery, are sphere-shaped vesicles consisting of one or more phospholipid bilayers. Compared with traditional drug delivery systems, liposomes exhibit prominent properties that include targeted delivery, high biocompatibility, biodegradability, easy functionalization, low toxicity, improvements in the sustained release of the drug it carries and improved therapeutic indices. In the wake of the rapid development of nanotechnology, the studies of liposome composition have become increasingly extensive. The molecular diversity of liposome composition, which includes long-circulating PEGylated liposomes, ligand-functionalized liposomes, stimuli-responsive liposomes, and advanced cell membrane-coated biomimetic nanocarriers, endows their drug delivery with unique physiological functions. This review describes the composition, types and preparation methods of liposomes, and discusses their targeting strategies in cancer therapy.
    MeSH term(s) Humans ; Liposomes/therapeutic use ; Drug Delivery Systems ; Neoplasms/drug therapy ; Drug Carriers/therapeutic use ; Nanotechnology/methods
    Chemical Substances Liposomes ; Drug Carriers
    Language English
    Publishing date 2023-01-31
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Reposition of the Fungicide Ciclopirox for Cancer Treatment.

    Huang, Zhu / Huang, Shile

    Recent patents on anti-cancer drug discovery

    2021  Volume 16, Issue 2, Page(s) 122–135

    Abstract: Background: Ciclopirox (CPX), a broad-spectrum fungicide, has been widely used to treat fungal infection on the skin and nails for decades. Recent preclinical and clinical studies have shown that CPX also possesses promising anticancer activity.: ... ...

    Abstract Background: Ciclopirox (CPX), a broad-spectrum fungicide, has been widely used to treat fungal infection on the skin and nails for decades. Recent preclinical and clinical studies have shown that CPX also possesses promising anticancer activity.
    Objective: The objective of this study is to summarize the patents, the pharmacological and toxicological properties, the anticancer activity, and the mechanisms of action of CPX and its derivatives as anticancer agents.
    Methods: PubMed and Google using the keywords "ciclopirox", "cancer or tumor" and "patent" were searched, and the identified literature was reviewed.
    Results: Pharmacological and toxicological profiles from preclinical and clinical studies support that systemic administration of CPX and its derivatives is feasible and safe for cancer treatment. CPX exerts its anticancer activity by inhibiting cell proliferation, inducing apoptosis, suppressing cell migration and invasion, and inhibiting angiogenesis and lymphangiogenesis. Mechanistically, CPX impacts the expression or activities of multiple signaling molecules or pathways, such as ribonucleotide reductase, Myc, DJ-1, Wnt/β-catenin, DOHH/eIF5A/PEAK1, VEGFR-3/ERK1/2, ATR/Chk1/Cdc25A, and AMPK/TSC/mTORC1. Most of these effects are attributed to iron chelation by CPX. Five patents have been retrieved: four patents on the development of CPX prodrugs to improve the water solubility and bioavailability of CPX, and one patent on the methods of bladder cancer treatment with CPX, CPX-O, or a CPX prodrug.
    Conclusion: CPX has a great potential to be repositioned for cancer therapy.
    MeSH term(s) Animals ; Antifungal Agents/administration & dosage ; Antifungal Agents/adverse effects ; Antifungal Agents/pharmacology ; Antineoplastic Agents/administration & dosage ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/pharmacology ; Biological Availability ; Cell Proliferation/drug effects ; Ciclopirox/administration & dosage ; Ciclopirox/adverse effects ; Ciclopirox/pharmacology ; Drug Repositioning ; Humans ; Neoplasms/drug therapy ; Neoplasms/pathology ; Patents as Topic ; Solubility
    Chemical Substances Antifungal Agents ; Antineoplastic Agents ; Ciclopirox (19W019ZDRJ)
    Language English
    Publishing date 2021-02-12
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 2250820-X
    ISSN 2212-3970 ; 1574-8928
    ISSN (online) 2212-3970
    ISSN 1574-8928
    DOI 10.2174/1574892816666210211090845
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6393: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Cu-doped polypyrrole hydrogel with tumor catalyst activity for NIR-II thermo-radiotherapy.

    Wang, Shile / Fei, Haotian / Ma, Yuhong / Zhu, Daoming / Zhang, Hongtao / Li, Xiang / Huang, Qinqin

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1225937

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-07-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1225937
    Database MEDical Literature Analysis and Retrieval System OnLINE

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