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  1. Article: Wichtige Viruserkrankungen: Mumps

    Posovszky, Carsten / Michel, Detlef

    TumorDiagnostik & Therapie

    2022  Volume 43, Issue 08, Page(s) 571–572

    Language German
    Publishing date 2022-10-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2072365-9
    ISSN 1439-1279 ; 0722-219X
    ISSN (online) 1439-1279
    ISSN 0722-219X
    DOI 10.1055/a-1912-9718
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  2. Article: Wichtige Viruserkrankungen: Mumps

    Posovszky, Carsten / Michel, Detlef

    Zeitschrift für Gastroenterologie

    2021  Volume 59, Issue 12, Page(s) 1269–1270

    Language German
    Publishing date 2021-12-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 201387-3
    ISSN 1439-7803 ; 0044-2771 ; 0172-8504
    ISSN (online) 1439-7803
    ISSN 0044-2771 ; 0172-8504
    DOI 10.1055/a-1516-9163
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  3. Article ; Online: Achieving net-zero emissions targets: An analysis of long-term scenarios using an integrated assessment model.

    Dafnomilis, Ioannis / den Elzen, Michel / van Vuuren, Detlef P

    Annals of the New York Academy of Sciences

    2023  Volume 1522, Issue 1, Page(s) 98–108

    Abstract: More than 100 countries have communicated or adopted new Nationally Determined Contributions (NDCs) and net-zero target pledges. We investigate the impact on global, national, sectoral, and individual greenhouse gas emissions projections under different ... ...

    Abstract More than 100 countries have communicated or adopted new Nationally Determined Contributions (NDCs) and net-zero target pledges. We investigate the impact on global, national, sectoral, and individual greenhouse gas emissions projections under different scenarios based on the announced NDCs and net-zero pledges using the IMAGE integrated assessment model. Our results show that while the net-zero pledges, if implemented, could be an important step forward, they are still not enough to achieve the Paris Agreement goals of well below 2°C and preferably 1.5°C by the end of the century. Still, our net-zero scenarios project significant all-sector decarbonization, in particular, electricity; however, certain sectors like industry and transport prove hard to completely abate.
    MeSH term(s) Greenhouse Gases ; Climate Change ; Environment ; International Cooperation ; Environmental Policy ; Hot Temperature
    Chemical Substances Greenhouse Gases
    Language English
    Publishing date 2023-02-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 211003-9
    ISSN 1749-6632 ; 0077-8923
    ISSN (online) 1749-6632
    ISSN 0077-8923
    DOI 10.1111/nyas.14970
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  4. Article: Influenza-Diagnostik: Ist der Labortest Pflicht?

    Michel, Detlef

    Der Allgemeinarzt

    2014  Volume 36, Issue 10, Page(s) 16

    Language German
    Document type Article
    ZDB-ID 603653-3
    ISSN 0172-7249
    Database Current Contents Medicine

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  5. Article ; Online: Fast breakthrough of resistant cytomegalovirus during secondary letermovir prophylaxis in a hematopoietic stem cell transplant recipient.

    Jung, Susanne / Michel, Manuela / Stamminger, Thomas / Michel, Detlef

    BMC infectious diseases

    2019  Volume 19, Issue 1, Page(s) 388

    Abstract: Background: The compound letermovir (LMV) has recently been approved for the prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV seropositive recipients of an allogeneic hematopoietic stem cell transplant. LMV inhibits CMV ... ...

    Abstract Background: The compound letermovir (LMV) has recently been approved for the prophylaxis of cytomegalovirus (CMV) infection and disease in adult CMV seropositive recipients of an allogeneic hematopoietic stem cell transplant. LMV inhibits CMV replication by binding to the viral terminase complex. However, first cases of clinical LMV resistance have been occurred. Here we report a fast breakthrough of resistant cytomegalovirus during secondary LMV prophylaxis in a hematopoietic-cell transplant recipient.
    Case presentation: A 44-year-old male patient with acute myeloid leukemia (AML) experienced a CMV-reactivation within the first 4 weeks of allogeneic hematopoietic-cell transplantation. Administration of LMV was initiated at day + 34. Due to increasing viral loads, LMV treatment was discontinued after 8 days. The patient was then administered with valganciclovir (valGCV) until viral DNA was undetectable. Due to neutropenia, valGCV treatment was switched to LMV secondary prophylaxis. For 4 weeks, the patient maintain virologic suppression. Then, CMV viral loads increased with a fast kinetic. Genotypic testing of the viral polymerase UL54, the kinase UL97 as well as the viral terminase UL56 and UL89 revealed the mutation C325Y in UL56, which is associated with the high level LMV resistance.
    Conclusion: It is known that Letermovir is approved for prophylactic purposes. However, it may be used for some patients with CMV infection who either have failed prior therapies or are unable to tolerate other anti-CMV compounds. Particularly, the administration of LMV should be avoided in patients with detectable viral loads. When this is not possible, viral load must be routinely monitored along with UL56 genotyping. Furthermore, LMV administration at high virus loads may foster the rapid selection of resistant CMV mutants.
    MeSH term(s) Acetates/therapeutic use ; Adult ; Antiviral Agents/therapeutic use ; Cytomegalovirus/drug effects ; Cytomegalovirus/genetics ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/prevention & control ; Cytomegalovirus Infections/virology ; DNA-Directed DNA Polymerase/genetics ; Drug Resistance, Viral/drug effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Humans ; Male ; Mutation ; Quinazolines/therapeutic use ; Secondary Prevention ; Valganciclovir/therapeutic use ; Viral Load/drug effects ; Viral Proteins/genetics ; Viral Structural Proteins/genetics
    Chemical Substances Acetates ; Antiviral Agents ; Quinazolines ; UL54 protein, Human herpesvirus 5 ; UL56 protein, cytomegalovirus ; Viral Proteins ; Viral Structural Proteins ; AIC246 (1H09Y5WO1F) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Valganciclovir (GCU97FKN3R)
    Language English
    Publishing date 2019-05-08
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1471-2334
    ISSN (online) 1471-2334
    DOI 10.1186/s12879-019-4016-1
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  6. Article ; Online: Short-term reduction of dietary gluten improves metabolic-dysfunction associated steatotic liver disease: A randomised, controlled proof-of-concept study.

    Armandi, Angelo / Bespaljko, Helena / Mang, Alexander / Huber, Yvonne / Michel, Maurice / Labenz, Christian / Galle, Peter R / Neerukonda, Manjusha / Bugianesi, Elisabetta / Schuppan, Detlef / Schattenberg, Jörn M

    Alimentary pharmacology & therapeutics

    2024  Volume 59, Issue 10, Page(s) 1212–1222

    Abstract: Background: The current management of metabolic dysfunction-associated steatotic liver disease (MASLD) relies on lifestyle intervention. Prior studies have shown that nutritional wheat amylase trypsin inhibitors (ATI) activate toll-like receptor 4 on ... ...

    Abstract Background: The current management of metabolic dysfunction-associated steatotic liver disease (MASLD) relies on lifestyle intervention. Prior studies have shown that nutritional wheat amylase trypsin inhibitors (ATI) activate toll-like receptor 4 on intestinal myeloid cells to enhance intestinal and extra-intestinal inflammation, including the promotion of murine MASLD, insulin resistance and liver fibrosis.
    Aims: We aimed to assess the impact of ATI (gluten)-free diet in liver as well as metabolic parameters of biopsy-proven MASLD patients.
    Methods: We performed a 6-week, proof-of-concept 1:1 randomised controlled trial of an ATI-free diet. The controls followed a balanced diet recommended by the German Nutrition Society. We assessed changes in controlled attenuation parameter (CAP), body mass index (BMI) and homeostatic model assessment of insulin resistance (HOMA-IR). Patient-reported outcomes were assessed by the CLDQ-NASH questionnaire. Forty-five patients were consecutively enrolled (21 in the intervention arm and 24 in the control arm).
    Results: Three patients from each arm discontinued the study. In the ATI-free diet group, a significant decrease in BMI (p = 0.018), CAP (p = 0.018) and HOMA-IR (p = 0.042) was observed at 6 weeks. The mean difference in CAP between the two arms at week 6 was 30.5 dB/m (p = 0.039), with a delta significantly higher in the ATI-free diet group (p = 0.043). Only an ATI-free diet could achieve a significant improvement in CLDQ-NASH domains (p value for total scoring: 0.013).
    Conclusions: A short-term ATI-free diet leads to significant improvements in liver and metabolic parameters, as well as patient-reported outcomes with good tolerability. A larger follow-up study is justified to corroborate these findings.
    Clinical trial number: NCT04066400.
    MeSH term(s) Humans ; Female ; Male ; Middle Aged ; Insulin Resistance/physiology ; Proof of Concept Study ; Adult ; Diet, Gluten-Free ; Body Mass Index ; Fatty Liver/diet therapy ; Aged ; Glutens ; Non-alcoholic Fatty Liver Disease/diet therapy
    Chemical Substances Glutens (8002-80-0)
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 639012-2
    ISSN 1365-2036 ; 0269-2813 ; 0953-0673
    ISSN (online) 1365-2036
    ISSN 0269-2813 ; 0953-0673
    DOI 10.1111/apt.17941
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  7. Article ; Online: Resonance behavior of a compliant piezo-driven inkjet channel with an entrained microbubble.

    Reinten, Hans / Jethani, Yogesh / Fraters, Arjan / Jeurissen, Roger / Lohse, Detlef / Versluis, Michel / Segers, Tim

    The Journal of the Acoustical Society of America

    2022  Volume 151, Issue 4, Page(s) 2545

    Abstract: Microbubbles entrained in a piezo-driven drop-on-demand printhead disturb the acoustics of the microfluidic ink channel and, thereby, the jetting behavior. Here, the resonance behavior of an ink channel as a function of the microbubble size and number of ...

    Abstract Microbubbles entrained in a piezo-driven drop-on-demand printhead disturb the acoustics of the microfluidic ink channel and, thereby, the jetting behavior. Here, the resonance behavior of an ink channel as a function of the microbubble size and number of bubbles is studied through theoretical modeling and experiments. The system is modeled as a set of two coupled harmonic oscillators: one corresponds to the compliant ink channel and the other corresponds to the microbubble. The predicted and measured eigenfrequencies are in excellent agreement. It was found that the resonance frequency is independent of the bubble size as long as the compliance of the bubble dominates over that of the piezo actuator. An accurate description of the eigenfrequency of the coupled system requires the inclusion of the increased inertance of the entrained microbubble due to confinement. It is shown that the inertance of a confined bubble can be accurately obtained by using a simple potential flow approach. The model is further validated by the excellent agreement between the modeled and measured microbubble resonance curves. The present work, therefore, provides physical insight into the coupled dynamics of a compliant ink channel with an entrained microbubble.
    Language English
    Publishing date 2022-04-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 219231-7
    ISSN 1520-8524 ; 0001-4966
    ISSN (online) 1520-8524
    ISSN 0001-4966
    DOI 10.1121/10.0009784
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  8. Article ; Online: Net-zero emission targets for major emitting countries consistent with the Paris Agreement

    Heleen L. van Soest / Michel G. J. den Elzen / Detlef P. van Vuuren

    Nature Communications, Vol 12, Iss 1, Pp 1-

    2021  Volume 9

    Abstract: Over 100 countries have set or are considering net-zero emissions targets. Here, the authors show that a country’s potential for negative emissions and methodological issues affect when countries can reach net-zero, calling for clear internationally ... ...

    Abstract Over 100 countries have set or are considering net-zero emissions targets. Here, the authors show that a country’s potential for negative emissions and methodological issues affect when countries can reach net-zero, calling for clear internationally agreed definitions and accounting methods.
    Keywords Science ; Q
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Net-zero emission targets for major emitting countries consistent with the Paris Agreement.

    van Soest, Heleen L / den Elzen, Michel G J / van Vuuren, Detlef P

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 2140

    Abstract: Over 100 countries have set or are considering net-zero emissions or neutrality targets. However, most of the information on emissions neutrality (such as timing) is provided for the global level. Here, we look at national-level neutrality-years based on ...

    Abstract Over 100 countries have set or are considering net-zero emissions or neutrality targets. However, most of the information on emissions neutrality (such as timing) is provided for the global level. Here, we look at national-level neutrality-years based on globally cost-effective 1.5 °C and 2 °C scenarios from integrated assessment models. These results indicate that domestic net zero greenhouse gas and CO
    Language English
    Publishing date 2021-04-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-22294-x
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  10. Article ; Online: Evaporation-Induced Crystallization of Surfactants in Sessile Multicomponent Droplets.

    Li, Yaxing / Salvator, Valentin / Wijshoff, Herman / Versluis, Michel / Lohse, Detlef

    Langmuir : the ACS journal of surfaces and colloids

    2020  Volume 36, Issue 26, Page(s) 7545–7552

    Abstract: Surfactants have been widely studied and used in controlling droplet evaporation. In this work, we observe and study the crystallization of sodium dodecyl sulfate (SDS) within an evaporating glycerol-water mixture droplet. The crystallization is induced ... ...

    Abstract Surfactants have been widely studied and used in controlling droplet evaporation. In this work, we observe and study the crystallization of sodium dodecyl sulfate (SDS) within an evaporating glycerol-water mixture droplet. The crystallization is induced by the preferential evaporation of water, which decreases the solubility of SDS in the mixture. As a consequence, the crystals shield the droplet surface and cease the evaporation. The universality of the evaporation characteristics for a range of droplet sizes is revealed by applying a diffusion model, extended by Raoult's law. To describe the nucleation and growth of the crystals, we employ the 2-dimensional crystallization model of Weinberg [
    Language English
    Publishing date 2020-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c01169
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