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Article ; Online: Long COVID-19: The Need for an Interdisciplinary Approach.

Rodriguez-Sanchez, Isabel / Rodriguez-Mañas, Leocadio / Laosa, Olga

2022 Volume 38, Issue 3, Page(s) 533–544

Abstract: Long coronavirus disease 2019 (COVID-19) is characterized by persistent COVID-19 symptoms that last for at least 2 months. In the elderly population, apart from the typical symptoms (fatigue, cough, or dyspnea), unspecific symptoms coexist (functional ... ...

Abstract	Long coronavirus disease 2019 (COVID-19) is characterized by persistent COVID-19 symptoms that last for at least 2 months. In the elderly population, apart from the typical symptoms (fatigue, cough, or dyspnea), unspecific symptoms coexist (functional deterioration, cognitive impairment, or delirium) that can mitigate the prevalence of this syndrome in this age group. Its main consequence is the functional decline, leading to sarcopenia, frailty, and disability, in addition to the nutritional and cognitive disorders. Thus, a multicomponent and individualized program (exercise, diet, cognitive stimulation) should be designed for older people with persistent COVID, where new technologies could be useful.
MeSH term(s)	Aged ; COVID-19/complications ; Frail Elderly ; Frailty ; Humans ; Sarcopenia/etiology ; Sarcopenia/prevention & control ; Post-Acute COVID-19 Syndrome
Language	English
Publishing date	2022-03-21
Publishing country	United States
Document type	Journal Article ; Review ; Systematic Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1064151-8
ISSN	1879-8853 ; 0749-0690
ISSN (online)	1879-8853
ISSN	0749-0690
DOI	10.1016/j.cger.2022.03.005
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Article ; Online: Response rates and associated factors after a multicomponent intervention in frail older adults with diabetes.

Álvarez-Bustos, Alejandro / Laosa, Olga / Marzetti, Emanuele / Carnicero, Jose Antonio / Castro-Rodriguez, Marta / Landi, Francesco / Sinclair, Alan J / Rodriguez-Mañas, Leocadio

Age and ageing

2024 Volume 53, Issue 1

Abstract: Background: Type 2 diabetes mellitus (T2DM) and frailty are associated with functional decline in older population.: Objective: To explore the individual response to a multimodal intervention on functional performance.: Design: A cluster- ... ...

Abstract	Background: Type 2 diabetes mellitus (T2DM) and frailty are associated with functional decline in older population. Objective: To explore the individual response to a multimodal intervention on functional performance. Design: A cluster-randomised multicentre clinical trial. Setting: Outpatients in hospital or primary care. Subjects: 843 (77.83 years, 50.65% men) prefrail and frail individuals ≥70 years with T2DM. Methods: Participants were allocated to usual care group (UCG) or a multicomponent intervention group (IG): 16-week progressive resistance training, seven nutritional and diabetological educational sessions and achievement of glycated haemoglobin (7-8%) and blood pressure (<150 mmHg) targets. Functional performance was assessed with the Short Physical Performance Battery (SPPB) at 1 year. We used multivariate binomial and multinomial logistic regression models to explore the effect of the IG, and adherence on the outcomes studied, in several adjusted models. Results: 53.7% in the IG versus 38.0% in the UCG improved by at least 1 point in their SPPB score [OR (95% CI): 2.07 (1.43, 2.98), P value <0.001]. Age, SPPB score and number of frailty criteria met decreased the probability of improving the SPPB score. Factors associated with worsening were pertaining to IG (decreased), age, SPPB score and the number of frailty criteria (increased). An adherence ≥84% was needed to achieve benefits, reaching the peak in the probability of improving SPPB when this was ≥85% [OR(95%CI): 2.38 (1.29, 4.79), P value 0.014]. Conclusions: Factors predicting the likelihood of improvement in a multimodal programme in pre-frail and frail older adults with diabetes are age, basal SPPB score, the number of frailty criteria and adherence.
MeSH term(s)	Male ; Aged ; Humans ; Female ; Frail Elderly ; Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/therapy ; Frailty/diagnosis ; Frailty/therapy ; Blood Pressure ; Educational Status
Language	English
Publishing date	2024-01-19
Publishing country	England
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	186788-x
ISSN	1468-2834 ; 0002-0729
ISSN (online)	1468-2834
ISSN	0002-0729
DOI	10.1093/ageing/afad253
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Article ; Online: Diabetes and frailty.

Assar, Mariam El / Laosa, Olga / Rodríguez Mañas, Leocadio

Current opinion in clinical nutrition and metabolic care

2019 Volume 22, Issue 1, Page(s) 52–57

Abstract: Purpose of review: Disability and its preceding condition, frailty, are outstanding issues for achieving healthy aging. Diabetes is a very prevalent chronic disease among older patients that favours frailty status. This review will analyse the ... ...

Abstract	Purpose of review: Disability and its preceding condition, frailty, are outstanding issues for achieving healthy aging. Diabetes is a very prevalent chronic disease among older patients that favours frailty status. This review will analyse the relationship between diabetes and frailty in the elderly and summarize the current strategies to improve physical function in diabetic older patients. Recent findings: We have analyzed the current knowledge providing insight on the relationship between frailty and diabetes in older people. Epidemiological evidences and potential mechanisms connecting diabetes with frailty in the aging process have been examined. Finally, the strategies to reduce frailty in aged population with diabetes were discussed. Summary: Current evidence reveals the high prevalence of diabetes in frail older patients, producing an additional impairment of physical performance in this population. Insulin resistance seems to contribute to this clinical manifestation which is related to the impact of diabetes on skeletal muscle function, on vascular function, and on the hormonal milieu. Exercise, nutritional and educational interventions, and less strict glycaemic control appear as the most effective strategies to reduce frailty in diabetic older people.
MeSH term(s)	Aged ; Diabetes Mellitus, Type 2/epidemiology ; Diabetes Mellitus, Type 2/physiopathology ; Diabetes Mellitus, Type 2/therapy ; Exercise ; Frail Elderly ; Frailty/complications ; Frailty/epidemiology ; Frailty/therapy ; Health Education ; Humans ; Insulin Resistance ; Muscle, Skeletal/physiopathology ; Physical Functional Performance ; Prevalence
Language	English
Publishing date	2019-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1460178-3
ISSN	1473-6519 ; 1363-1950
ISSN (online)	1473-6519
ISSN	1363-1950
DOI	10.1097/MCO.0000000000000535
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Article: A Therapeutic Vibrating Insole Device for Postural Instability in Older People with Type 2 Diabetes: A Randomized Control Study.

Bourdel-Marchasson, Isabelle / Regueme, Sophie C / Kelson, Mark / Poustis, Joël / Barralon, Pierre / Laosa, Olga / Rodriguez-Mañas, Leocadio / Sinclair, Alan J

Diabetes therapy : research, treatment and education of diabetes and related disorders

2022 Volume 13, Issue 5, Page(s) 995–1006

Abstract: Introduction: Frail older people with diabetes often present with or develop walking impairments, in part due to lower-limb sensory-motor neuropathy. Several studies suggest a possible improvement of balance control using somatosensory stimulation. We ... ...

Abstract	Introduction: Frail older people with diabetes often present with or develop walking impairments, in part due to lower-limb sensory-motor neuropathy. Several studies suggest a possible improvement of balance control using somatosensory stimulation. We undertook a novel randomized control trial, the aim of which was to observe whether use of this device for 1 month improves walking speed as measured in the 10-m fast walking speed test standardized to body size at month 1 (M1) (FWS). Secondary outcomes were the differences between intervention (VS) and control (C) in the 10-m normal walking speed test, step length, short physical performance battery, timed up and go test, and posturographic measures. Methods: Subjects were aged ≥ 70 years and had had type 2 diabetes for at least 2 years. The intervention (VS) at home consisted of 22-min daily vibrating sequences with noise intensity set at 90% of the tactile threshold for each foot. The same device was used in group C but noise was set to 0. Compliance was retrieved from the device. Results: Among 56 subjects, 27 were in the VS group and 29 in the C group; 35 subjects were frail, 15 were prefrail ,and 6 were non-frail. Bilateral neuropathy was present in 17 subjects. More than half of sessions were done in 36 subjects with no discernible difference according to intervention. At M1 there were no discernible differences in FWS between the groups [VS: 0.96 (0.53) cm s Conclusion: In a cohort of frail, prefrail, or non-frail older subjects with diabetes, a 1-month intervention using a vibrating insole device did not alter measures of walking speed and related measures. Larger studies with longer term and different stimulation protocols are required to test this hypothesis more fully.
Language	English
Publishing date	2022-03-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2566702-6
ISSN	1869-6961 ; 1869-6953
ISSN (online)	1869-6961
ISSN	1869-6953
DOI	10.1007/s13300-022-01246-8
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Article: Drug Induced Liver Injury in Geriatric Patients Detected by a Two-Hospital Prospective Pharmacovigilance Program: A Comprehensive Analysis Using the Roussel Uclaf Causality Assessment Method.

Pedraza, Laura / Laosa, Olga / Rodríguez-Mañas, Leocadio / Gutiérrez-Romero, Diego F / Frías, Jesús / Carnicero, José Antonio / Ramírez, Elena

Frontiers in pharmacology

2021 Volume 11, Page(s) 600255

Abstract: Background/aim: ...

Abstract	Background/aim:
Language	English
Publishing date	2021-02-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.600255
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Article: Amino Acid Profiles in Older Adults with Frailty: Secondary Analysis from MetaboFrail and BIOSPHERE Studies.

Calvani, Riccardo / Picca, Anna / Rodriguez-Mañas, Leocadio / Tosato, Matteo / Coelho-Júnior, Hélio José / Biancolillo, Alessandra / Laosa, Olga / Gervasoni, Jacopo / Primiano, Aniello / Santucci, Lavinia / Giampaoli, Ottavia / Bourdel-Marchasson, Isabelle / Regueme, Sophie C / Sinclair, Alan J / Urbani, Andrea / Landi, Francesco / Gambassi, Giovanni / Marini, Federico / Marzetti, Emanuele

Metabolites

2023 Volume 13, Issue 4

Abstract: An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with ... ...

Abstract	An altered amino acid metabolism has been described in frail older adults which may contribute to muscle loss and functional decline associated with frailty. In the present investigation, we compared circulating amino acid profiles of older adults with physical frailty and sarcopenia (PF&S,
Language	English
Publishing date	2023-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo13040542
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Article ; Online: Rapid Assessment at Hospital Admission of Mortality Risk From COVID-19: The Role of Functional Status.

Laosa, Olga / Pedraza, Laura / Álvarez-Bustos, Alejandro / Carnicero, Jose A / Rodriguez-Artalejo, Fernando / Rodriguez-Mañas, Leocadio

Journal of the American Medical Directors Association

2020 Volume 21, Issue 12, Page(s) 1798–1802.e2

Abstract: Objective: To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19.: Design: Prospective cohort study.: Setting: Public university hospital (Madrid).: ... ...

Abstract	Objective: To evaluate the role of functional status along with other used clinical factors on the occurrence of death in patients hospitalized with COVID-19. Design: Prospective cohort study. Setting: Public university hospital (Madrid). Participants and methods: A total of 375 consecutive patients with COVID-19 infection, admitted to a Public University Hospital (Madrid) between March 1 and March 31, 2020, were included in the Prospective Cohort study. Death was the main outcome. The main variable was disability in activities of daily living (ADL) assessed with the Barthel Index. Covariates included sex, age, severity index (Quick Sequential Organ Failure Assessment, qSOFA), polypharmacy (≥5 drugs in the month before admission), and comorbidity (≥3 diseases). Multivariable logistic regression was used to identify risk factors for adverse outcomes. Estimated model coefficients served to calculate the expected probability of death for a selected combination of 5 variables: Barthel Index, sex, age, comorbidities, and severity index (qSOFA). Results: Mean age was 66 years (standard deviation 15.33), and there were 207 (55%) men. Seventy-four patients died (19.8%). Mortality was associated with low Barthel Index (odds ratio per 5-point decrease 1.11, 95% confidence interval 1.03-1.20), male sex (0.23, 0.11-0.47), age (1.07, 1.03-1.10), and comorbidity (2.15, 1.08-4.30) but not with qSOFA (1.29, 0.87-1.93) or polypharmacy (1.54, 0.77-3.08). Calculated mortality risk ranged from 0 to 0.78. Conclusions and implications: Functional status predicts death in hospitalized patients with COVID-19. Combination of 5 variables allows to predict individual probability of death. These findings provide useful information for the decision-making process and management of patients.
MeSH term(s)	Aged ; Aged, 80 and over ; COVID-19 ; Female ; Functional Status ; Hospital Mortality ; Hospitalization ; Humans ; Male ; Pandemics ; Prospective Studies ; Risk Assessment ; Risk Factors ; SARS-CoV-2 ; Spain/epidemiology
Keywords	covid19
Language	English
Publishing date	2020-10-08
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2020.10.002
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Article: Superiority of a Novel Multifunctional Amorphous Hydrogel Containing

Verdú-Soriano, José / de Cristino-Espinar, Marisol / Luna-Morales, Silvia / Dios-Guerra, Caridad / Caballero-Villarraso, Javier / Moreno-Moreno, Paloma / Casado-Díaz, Antonio / Berenguer-Pérez, Miriam / Guler-Caamaño, Ipek / Laosa-Zafra, Olga / Rodríguez-Mañas, Leocadio / Lázaro-Martínez, José Luis

Journal of clinical medicine

2022 Volume 11, Issue 5

Abstract: This 8-week, multicenter, randomized, active-controlled, observer-blinded clinical trial was designed to demonstrate the accelerating effect on wound healing of the novel Olea europaea leaf extract hydrogel (EHO-85) by comparing it to a widely used ... ...

Abstract	This 8-week, multicenter, randomized, active-controlled, observer-blinded clinical trial was designed to demonstrate the accelerating effect on wound healing of the novel Olea europaea leaf extract hydrogel (EHO-85) by comparing it to a widely used amorphous hydrogel. Results showed that EHO-85 significantly accelerated wound healing, regardless of ulcer etiology (pressure, venous leg or diabetic foot) and prognosis, doubling the median wound area reduction compared with a reference amorphous hydrogel (79.4% vs. 39.7%; difference: −39.7%, 95% CI: −71.1 to −21.3%; p < 0.001). The intention-to-treat analysis was conducted on 195 patients from 23 Spanish health centers/nursing homes. This novel treatment balances the ulcer microenvironment by modulating reactive oxygen species and pH. These actions complement the moistening and barrier functions inherent to amorphous hydrogels, whilst also conferring EHO-85 its documented granulation formation and pain relief properties. Furthermore, efficacy was achieved safely and in a cost-efficient manner due to its multi-dose format, which reduced the amount of product needed by 85.8% over 8 weeks compared to single-use hydrogel. The present randomized controlled trial is a relevant milestone in evidence-based practice for being the first to demonstrate (i) the effectiveness of an amorphous hydrogel in accelerating wound healing and (ii) the superiority of a specific hydrogel over another.
Language	English
Publishing date	2022-02-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11051260
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Article ; Online: Two-Year Follow-up of a Multimodal Intervention on Functional Capacity and Muscle Power in Frail Patients With Type 2 Diabetes.

Izquierdo, Mikel / Laosa, Olga / Cadore, Eduardo L / Abizanda, Pedro / Garcia-Garcia, Francisco J / Hornillos, Mercedes / López-Pavón, Ignacio / Sinclair, Alan J / Rodríguez-Mañas, Leocadio

Journal of the American Medical Directors Association

2021 Volume 22, Issue 9, Page(s) 1906–1911

Abstract: Objectives: To analyze the effects of a program composed of resistance training and nutritional interventions on functional capacity, maximal strength, and power output after 2 years of follow-up, including 2 periods of 16 weeks of intervention followed ...

Abstract	Objectives: To analyze the effects of a program composed of resistance training and nutritional interventions on functional capacity, maximal strength, and power output after 2 years of follow-up, including 2 periods of 16 weeks of intervention followed by several weeks of intervention cessation in frail patients with type 2 diabetes. Design: MIDPOW is a substudy of a multicenter, multimodal intervention composed of resistance training combined with a structured diabetes and nutritional education program in frail and prefrail older people with type 2 diabetes (MID-Frail). Setting and participants: This study recruited 52 participants (mean age: 79 ± 5.6, 63% women), with type 2 diabetes mellitus, frail or prefrail using Fried's frailty phenotype. Methods: Primary outcomes of this substudy were Short Physical Performance Battery (SPPB) and maximal power output at 30% and 80% of 1RM. Results: Each set of 16 weeks of intervention resulted in significant improvements in SPPB performance by a mean of 36.1% at week 18 (P < .001) and 10.2% at week 68 (P < .05). Maximal power output improvements at 30% and 80% of the 1RM ranged from 45.2% to 57.2% at week 18 (P < .01-.001); and no significant changes were observed after the second period of intervention. After 2 years of follow-up, the SPPB and maximal power values observed remained significantly higher than the baseline. Conclusions and implications: Resistance training combined with nutritional program improved SPPB, maximal strength, and power output in older frail patients with diabetes. These improvements were maintained above the basal levels after several weeks of intervention cessation during a 2-year follow-up.
MeSH term(s)	Aged ; Aged, 80 and over ; Diabetes Mellitus, Type 2/therapy ; Female ; Follow-Up Studies ; Frail Elderly ; Frailty ; Humans ; Male ; Muscle Strength ; Muscles
Language	English
Publishing date	2021-07-12
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2171030-2
ISSN	1538-9375 ; 1525-8610
ISSN (online)	1538-9375
ISSN	1525-8610
DOI	10.1016/j.jamda.2021.06.022
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Article ; Online: Economic evaluation of a multimodal intervention in pre-frail and frail older people with diabetes mellitus: the MID-FRAIL project.

Peña-Longobardo, Luz María / Oliva-Moreno, Juan / Zozaya, Neboa / Aranda-Reneo, Isaac / Trapero-Bertran, Marta / Laosa, Olga / Sinclair, Alan / Rodríguez-Mañas, Leocadio

Expert review of pharmacoeconomics & outcomes research

2020 Volume 21, Issue 1, Page(s) 111–118

Abstract: ... ...

Abstract	Background
MeSH term(s)	Aged ; Aged, 80 and over ; Cost-Benefit Analysis ; Delivery of Health Care/economics ; Delivery of Health Care/statistics & numerical data ; Diabetes Mellitus, Type 2/economics ; Diabetes Mellitus, Type 2/therapy ; Europe ; Female ; Frail Elderly ; Frailty/economics ; Frailty/epidemiology ; Health Care Costs/statistics & numerical data ; Humans ; Male ; Quality-Adjusted Life Years
Language	English
Publishing date	2020-05-25
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2208481-2
ISSN	1744-8379 ; 1473-7167
ISSN (online)	1744-8379
ISSN	1473-7167
DOI	10.1080/14737167.2020.1766970
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