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Article ; Online: Changes in the Impacts of COVID-19 over Time on Families with Older Adults Living on Remote Islands in Japan

Naohiro Hohashi / Mikio Watanabe / Minami Taniguchi / Shiho Araki

Healthcare, Vol 11, Iss 23, p

A Study in Family Ethnographic Research

2023 Volume 3088

Abstract: Coronavirus disease 2019 (COVID-19) affected not only individuals but also families. The purpose of this study was to clarify the temporal changes in the impact of the COVID-19 pandemic on entire families with older adults susceptible to infection living ...

Abstract	Coronavirus disease 2019 (COVID-19) affected not only individuals but also families. The purpose of this study was to clarify the temporal changes in the impact of the COVID-19 pandemic on entire families with older adults susceptible to infection living on small islands in Japan over the duration of the pandemic. Family ethnographic research was conducted from 2021 to 2023, using the Concentric Sphere Family Environment Theory as the theoretical framework. Formal interviews were conducted with 20 families. In addition, data from informal interviews, participant observation and other sources were compiled into field notes. All data on the impact on the entire family were extracted and content analysis was conducted. Six categories (family internal environmental system, family system unit, micro system, macro system, supra system, and family chrono-environment system) and a total of 85 subcategories were extracted. The results show that COVID-19 exerted not only negative but also positive impacts on the entire family, and their temporal changes are clarified. The impact on families is believed to have been influenced by the family external environment, such as increases and decreases of infection cases or events that occurred outside the family. The knowledge acquired from these studies will help healthcare professionals in providing appropriate family support.
Keywords	COVID-19 ; remote island ; family with older adults ; Concentric Sphere Family Environment Theory ; family ethnographic research ; Medicine ; R
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Changes in the Impacts of COVID-19 over Time on Families with Older Adults Living on Remote Islands in Japan: A Study in Family Ethnographic Research.

Hohashi, Naohiro / Watanabe, Mikio / Taniguchi, Minami / Araki, Shiho

Healthcare (Basel, Switzerland)

2023 Volume 11, Issue 23

Abstract	Coronavirus disease 2019 (COVID-19) affected not only individuals but also families. The purpose of this study was to clarify the temporal changes in the impact of the COVID-19 pandemic on entire families with older adults susceptible to infection living on small islands in Japan over the duration of the pandemic. Family ethnographic research was conducted from 2021 to 2023, using the Concentric Sphere Family Environment Theory as the theoretical framework. Formal interviews were conducted with 20 families. In addition, data from informal interviews, participant observation and other sources were compiled into field notes. All data on the impact on the entire family were extracted and content analysis was conducted. Six categories (family internal environmental system, family system unit, micro system, macro system, supra system, and family chrono-environment system) and a total of 85 subcategories were extracted. The results show that COVID-19 exerted not only negative but also positive impacts on the entire family, and their temporal changes are clarified. The impact on families is believed to have been influenced by the family external environment, such as increases and decreases of infection cases or events that occurred outside the family. The knowledge acquired from these studies will help healthcare professionals in providing appropriate family support.
Language	English
Publishing date	2023-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare11233088
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Book ; Online: Lattice Rescoring Based on Large Ensemble of Complementary Neural Language Models

Ogawa, Atsunori / Tawara, Naohiro / Delcroix, Marc / Araki, Shoko

2023

Abstract: We investigate the effectiveness of using a large ensemble of advanced neural language models (NLMs) for lattice rescoring on automatic speech recognition (ASR) hypotheses. Previous studies have reported the effectiveness of combining a small number of ... ...

Abstract	We investigate the effectiveness of using a large ensemble of advanced neural language models (NLMs) for lattice rescoring on automatic speech recognition (ASR) hypotheses. Previous studies have reported the effectiveness of combining a small number of NLMs. In contrast, in this study, we combine up to eight NLMs, i.e., forward/backward long short-term memory/Transformer-LMs that are trained with two different random initialization seeds. We combine these NLMs through iterative lattice generation. Since these NLMs work complementarily with each other, by combining them one by one at each rescoring iteration, language scores attached to given lattice arcs can be gradually refined. Consequently, errors of the ASR hypotheses can be gradually reduced. We also investigate the effectiveness of carrying over contextual information (previous rescoring results) across a lattice sequence of a long speech such as a lecture speech. In experiments using a lecture speech corpus, by combining the eight NLMs and using context carry-over, we obtained a 24.4% relative word error rate reduction from the ASR 1-best baseline. For further comparison, we performed simultaneous (i.e., non-iterative) NLM combination and 100-best rescoring using the large ensemble of NLMs, which confirmed the advantage of lattice rescoring with iterative NLM combination. Comment: Accepted to ICASSP 2022
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing ; Computer Science - Computation and Language ; Computer Science - Sound
Subject code	410
Publishing date	2023-12-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Radiocesium mobility in different parts of the two major tree species in Fukushima.

Manaka, Takuya / Araki, Masatake G / Ohashi, Shinta / Imamura, Naohiro / Sakashita, Wataru / Ogo, Sumika / Komatsu, Masabumi / Sakata, Tadashi / Shinomiya, Yoshiki

Scientific reports

2023 Volume 13, Issue 1, Page(s) 9144

Abstract: Radiocesium ( ...

Abstract	Radiocesium (
MeSH term(s)	Trees ; Ecosystem ; Fukushima Nuclear Accident ; Radiation Monitoring ; Forests ; Cesium Radioisotopes/analysis ; Soil Pollutants, Radioactive/analysis ; Cryptomeria ; Japan
Chemical Substances	Cesium-137 (4T2E65IAR7) ; ammonium acetate (RRE756S6Q2) ; Cesium Radioisotopes ; Soil Pollutants, Radioactive
Language	English
Publishing date	2023-06-05
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-35852-8
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Article ; Online: Cortical white matter microstructural alterations underlying the impaired gamma-band auditory steady-state response in schizophrenia.

Koshiyama, Daisuke / Nishimura, Ryoichi / Usui, Kaori / Fujioka, Mao / Tada, Mariko / Kirihara, Kenji / Araki, Tsuyoshi / Kawakami, Shintaro / Okada, Naohiro / Koike, Shinsuke / Yamasue, Hidenori / Abe, Osamu / Kasai, Kiyoto

Schizophrenia (Heidelberg, Germany)

2024 Volume 10, Issue 1, Page(s) 32

Abstract: The gamma-band auditory steady-state response (ASSR), primarily generated from the auditory cortex, has received substantial attention as a potential brain marker indicating the pathophysiology of schizophrenia. Previous studies have shown reduced gamma- ... ...

Abstract	The gamma-band auditory steady-state response (ASSR), primarily generated from the auditory cortex, has received substantial attention as a potential brain marker indicating the pathophysiology of schizophrenia. Previous studies have shown reduced gamma-band ASSR in patients with schizophrenia and demonstrated correlations with impaired neurocognition and psychosocial functioning. Recent studies in clinical and healthy populations have suggested that the neural substrates of reduced gamma-band ASSR may be distributed throughout the cortices surrounding the auditory cortex, especially in the right hemisphere. This study aimed to investigate associations between the gamma-band ASSR and white matter alterations in the bundles broadly connecting the right frontal, parietal and occipital cortices to clarify the networks underlying reduced gamma-band ASSR in patients with schizophrenia. We measured the 40 Hz ASSR using electroencephalography and diffusion tensor imaging in 42 patients with schizophrenia and 22 healthy comparison subjects. The results showed that the gamma-band ASSR was positively correlated with fractional anisotropy (an index of white matter integrity) in the regions connecting the right frontal, parietal and occipital cortices in healthy subjects (β = 0.41, corrected p = 0.075, uncorrected p = 0.038) but not in patients with schizophrenia (β = 0.17, corrected p = 0.46, uncorrected p = 0.23). These findings support our hypothesis that the generation of gamma-band ASSR is supported by white matter bundles that broadly connect the cortices and that these relationships may be disrupted in schizophrenia. Our study may help characterize and interpret reduced gamma-band ASSR as a useful brain marker of schizophrenia.
Language	English
Publishing date	2024-03-12
Publishing country	Germany
Document type	Journal Article
ZDB-ID	3133210-9
ISSN	2754-6993 ; 2754-6993
ISSN (online)	2754-6993
ISSN	2754-6993
DOI	10.1038/s41537-024-00454-4
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Article ; Online: Adverse events of nivolumab plus ipilimumab versus nivolumab plus cabozantinib: a real-world pharmacovigilance study.

Oka, Yurie / Matsumoto, Jun / Takeda, Tatsuaki / Iwata, Naohiro / Niimura, Takahiro / Ozaki, Aya Fukuma / Bekku, Kensuke / Hamano, Hirofumi / Araki, Motoo / Ishizawa, Keisuke / Zamami, Yoshito / Ariyoshi, Noritaka

International journal of clinical pharmacy

2024

Abstract: Background: No head-to-head clinical trials have compared the differences in adverse events (AEs) between nivolumab plus ipilimumab (NIVO-IPI) and nivolumab plus cabozantinib (NIVO-CABO) in the treatment of metastatic renal cell carcinoma (mRCC).: Aim! ...

Abstract	Background: No head-to-head clinical trials have compared the differences in adverse events (AEs) between nivolumab plus ipilimumab (NIVO-IPI) and nivolumab plus cabozantinib (NIVO-CABO) in the treatment of metastatic renal cell carcinoma (mRCC). Aim: We analysed the two largest real-world databases, the U.S. Food and Drug Administration Adverse Event Reporting System (FAERS) and the World Health Organization's VigiBase, to elucidate the differences in AEs between NIVO-IPI and NIVO-CABO. Method: In total, 40,376 and 38,022 records were extracted from FAERS and VigiBase, and 193 AEs were analysed. The reporting odds ratios (ROR) with 95% confidence interval were calculated using a disproportionality analysis (NIVO-CABO/NIVO-IPI). Results: The reported numbers of immune-related AEs, including myocarditis, colitis, and hepatitis, were significantly higher with NIVO-IPI (ROR = 0.18 for FAERS and 0.13 for VigiBase). Contrarily, the reported numbers of other AEs, including gastrointestinal disorders (ROR = 2.68 and 2.92) and skin and subcutaneous tissue disorders (ROR = 2.94 and 3.55), considered to be potentiated by the combination of NIVO and CABO, were higher with NIVO-CABO. Conclusion: Our findings contribute to the selection and clinical management of NIVO-IPI and NIVO-CABO, which minimizes the risk of AEs for individual patients with mRCC by considering distinctive differences in the AE profiles.
Language	English
Publishing date	2024-04-17
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2601204-2
ISSN	2210-7711 ; 2210-7703 ; 0928-1231
ISSN (online)	2210-7711
ISSN	2210-7703 ; 0928-1231
DOI	10.1007/s11096-024-01713-1
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Article ; Online: The diagnostic utility of cytology specimen in a case of EWSR1::NFATC2 sarcoma.

Takeda, Naoki / Makise, Naohiro / Kageyama, Hajime / Takahashi, Tsukasa / Katoh, Hiroshi / Odaka, Akiko / Oikawa, Mariko / Sugiyama, Takahiro / Kawana, Hidetada / Araki, Akinobu / Kinoshita, Hideyuki / Hagiwara, Yoko / Kamoda, Hiroto / Yonemoto, Tsukasa / Itami, Makiko

Virchows Archiv : an international journal of pathology

2024 Volume 484, Issue 3, Page(s) 533–538

Abstract: EWSR1::NFATC2 sarcoma, a rare round cell sarcoma constituting the majority of EWSR1::non-ETS sarcomas, has recently been defined in the latest WHO classification. To date, the cytological findings of EWSR1::NFATC2 sarcoma remain undocumented. We present ... ...

Abstract	EWSR1::NFATC2 sarcoma, a rare round cell sarcoma constituting the majority of EWSR1::non-ETS sarcomas, has recently been defined in the latest WHO classification. To date, the cytological findings of EWSR1::NFATC2 sarcoma remain undocumented. We present the case of a 25-year-old man with a history of polyostotic fibrous dysplasia in the right leg, referred to our hospital with left thigh pain. Cytological findings included metachromasia, minimally pleomorphic round cells, and eosinophilic infiltration. There was no precursor fibrous dysplasia and the initial diagnosis was undifferentiated pleomorphic sarcoma. Following histologic review, we successfully performed immunocytochemistry and fluorescence in situ hybridization (FISH) on archival cytology specimens. The tumor cells were positive for NKX2-2, NKX3-1, and PAX7 and showed amplified 5' single signals of EWSR1 gene. Reverse transcriptase-polymerase chain reaction revealed an in-frame fusion of EWSR1 and NFATC2. This report describes the cytological features of EWSR1::NFATC2 sarcoma and highlights the diagnostic utility of archival cytology specimens.
MeSH term(s)	Adult ; Humans ; Male ; Cytology ; Diagnosis, Differential ; In Situ Hybridization, Fluorescence ; NFATC Transcription Factors/genetics ; Oncogene Proteins, Fusion/genetics ; RNA-Binding Protein EWS/genetics ; Sarcoma/diagnosis ; Sarcoma/genetics ; Transcription Factors/genetics
Chemical Substances	EWSR1 protein, human ; NFATC Transcription Factors ; NFATC2 protein, human ; Oncogene Proteins, Fusion ; RNA-Binding Protein EWS ; Transcription Factors ; NFATc2-EWSR1 fusion protein, human
Language	English
Publishing date	2024-03-14
Publishing country	Germany
Document type	Case Reports ; Journal Article
ZDB-ID	1184867-4
ISSN	1432-2307 ; 0945-6317
ISSN (online)	1432-2307
ISSN	0945-6317
DOI	10.1007/s00428-024-03784-x
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Article ; Online: Radiocesium mobility in different parts of the two major tree species in Fukushima

Takuya Manaka / Masatake G. Araki / Shinta Ohashi / Naohiro Imamura / Wataru Sakashita / Sumika Ogo / Masabumi Komatsu / Tadashi Sakata / Yoshiki Shinomiya

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 13

Abstract: Abstract Radiocesium (137Cs) released in the Fukushima Dai-ichi Nuclear Power Plant accident is still cycling in the forest ecosystem. We examined the mobility of 137Cs in the external parts—leaves/needles, branches, and bark—of the two major tree ... ...

Abstract	Abstract Radiocesium (137Cs) released in the Fukushima Dai-ichi Nuclear Power Plant accident is still cycling in the forest ecosystem. We examined the mobility of 137Cs in the external parts—leaves/needles, branches, and bark—of the two major tree species in Fukushima, Japanese cedar (Cryptomeria japonica) and konara oak (Quercus serrata). This variable mobility will likely lead to spatial heterogeneity of 137Cs and difficulty in predicting its dynamics for decades. We conducted leaching experiments on these samples by using ultrapure water and ammonium acetate. In Japanese cedar, the 137Cs percentage leached from current-year needles was 26–45% (ultrapure water) and 27–60% (ammonium acetate)—similar to those from old needles and branches. In konara oak, the 137Cs percentage leached from leaves was 47–72% (ultrapure water) and 70–100% (ammonium acetate)—comparable to those from current-year and old branches. Relatively poor 137Cs mobility was observed in the outer bark of Japanese cedar and in organic layer samples from both species. Comparison of the results from corresponding parts revealed greater 137Cs mobility in konara oak than in Japanese cedar. We suggest that more active cycling of 137Cs occurs in konara oak.
Keywords	Medicine ; R ; Science ; Q
Subject code	580
Language	English
Publishing date	2023-06-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
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Article ; Online: Diagnostic Utility of a New Assay for Thyroid Stimulating Immunoglobulins in Graves' Disease and Thyroid Eye Disease.

Stan, Marius Nicolae / Algeciras-Schimnich, Alicia / Murthy, Vishakantha / Thapa, Prabin / Araki, Naohiro

Thyroid : official journal of the American Thyroid Association

2021 Volume 32, Issue 2, Page(s) 170–176

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Adult ; Aged ; Biological Assay ; Cohort Studies ; Cross-Sectional Studies ; Female ; Graves Disease/diagnosis ; Graves Ophthalmopathy/diagnosis ; Humans ; Immunoglobulins, Thyroid-Stimulating/isolation & purification ; Male ; Middle Aged
Chemical Substances	Immunoglobulins, Thyroid-Stimulating
Language	English
Publishing date	2021-12-31
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1086044-7
ISSN	1557-9077 ; 1050-7256
ISSN (online)	1557-9077
ISSN	1050-7256
DOI	10.1089/thy.2021.0299
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Zs.A 3307: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Metastasizing aneurysmal dermatofibroma initially diagnosed as angiosarcoma confirmed by CD63::PRKCD fusion gene detection with nanopore sequencing.

Takeda, Naoki / Makise, Naohiro / Lin, Jason / Kageyama, Hajime / Oikawa, Mariko / Sugiyama, Takahiro / Kawana, Hidetada / Araki, Akinobu / Tuskanishi, Toshinori / Kinoshita, Hideyuki / Hagiwara, Yoko / Kamoda, Hiroto / Motoi, Toru / Yonemoto, Tsukasa / Kawazu, Masahito / Itami, Makiko

Genes, chromosomes & cancer

2024 Volume 63, Issue 5, Page(s) e23246

Abstract: Dermatofibroma (DF) is a benign tumor that forms pedunculated lesions ranging in size from a few millimeters to 2 cm, usually affecting the extremities and trunks of young adults. Histopathologically, DF is characterized by the storiform proliferation of ...

Abstract	Dermatofibroma (DF) is a benign tumor that forms pedunculated lesions ranging in size from a few millimeters to 2 cm, usually affecting the extremities and trunks of young adults. Histopathologically, DF is characterized by the storiform proliferation of monomorphic fibroblast-like spindle cells. In addition to neoplastic cells, secondary elements such as foamy histiocytes, Touton-type giant cells, lymphoplasmacytes, and epidermal hyperplasia are characteristic histological features. Several histological variants, including atypical, cellular, aneurysmal, and lipidized variants, have been reported; cases with variant histologies are sometimes misdiagnosed as sarcomas. We present a case of metastasizing aneurysmal DF that was initially diagnosed as an angiosarcoma on biopsy. A 26-year-old woman was referred to our hospital with a gradually enlarging subcutaneous mass in her lower left leg. Positron emission tomography-computed tomography revealed high fluorodeoxyglucose uptake not only in the tumor but also in the left inguinal region. On biopsy, ERG and CD31-positive atypical spindle cells proliferated in slit-like spaces with extravasation, leading to the diagnosis of angiosarcoma. Histology of the wide-resection specimen was consistent with DF, and lymph node metastasis was also observed. Nanopore DNA sequencing detected CD63::PRKCD fusion and copy number gain, although CD63 was not included in the target region of adaptive sampling. This report highlights the importance of recognizing the unusual clinical, radiological, and pathological features of DF to avoid misdiagnosis, and the potential diagnostic utility of nanopore sequencer.
MeSH term(s)	Humans ; Female ; Adult ; Hemangiosarcoma/genetics ; Hemangiosarcoma/diagnosis ; Hemangiosarcoma/pathology ; Histiocytoma, Benign Fibrous/genetics ; Histiocytoma, Benign Fibrous/diagnosis ; Histiocytoma, Benign Fibrous/pathology ; Nanopore Sequencing ; Tetraspanin 30/genetics ; Tetraspanin 30/metabolism ; Skin Neoplasms/genetics ; Skin Neoplasms/pathology ; Skin Neoplasms/diagnosis ; Oncogene Proteins, Fusion/genetics
Language	English
Publishing date	2024-05-15
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	1018988-9
ISSN	1098-2264 ; 1045-2257
ISSN (online)	1098-2264
ISSN	1045-2257
DOI	10.1002/gcc.23246
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