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Article: Pilot study of a Spanish language measure of financial toxicity in underserved Hispanic cancer patients with low English proficiency.

Shi, Julia J / McGinnis, Gwendolyn J / Peterson, Susan K / Taku, Nicolette / Chen, Ying-Shiuan / Yu, Robert K / Wu, Chi-Fang / Mendoza, Tito R / Shete, Sanjay S / Ma, Hilary / Volk, Robert J / Giordano, Sharon H / Shih, Ya-Chen T / Nguyen, Diem-Khanh / Kaiser, Kelsey W / Smith, Grace L

Frontiers in psychology

2023 Volume 14, Page(s) 1188783

Abstract: Background: Financial toxicity (FT) reflects multi-dimensional personal economic hardships borne by cancer patients. It is unknown whether measures of FT-to date derived largely from English-speakers-adequately capture economic experiences and financial ...

Abstract	Background: Financial toxicity (FT) reflects multi-dimensional personal economic hardships borne by cancer patients. It is unknown whether measures of FT-to date derived largely from English-speakers-adequately capture economic experiences and financial hardships of medically underserved low English proficiency US Hispanic cancer patients. We piloted a Spanish language FT instrument in this population. Methods: We piloted a Spanish version of the Economic Strain and Resilience in Cancer (ENRICh) FT measure using qualitative cognitive interviews and surveys in un-/under-insured or medically underserved, low English proficiency, Spanish-speaking Hispanics (UN-Spanish, Results: UN-Spanish Hispanic participants reported high acceptability of the instrument (only 0% responded that the instrument was "very difficult to answer" and 4% that it was "very difficult to understand the questions"; 8% responded that it was "very difficult to remember resources used" and 8% that it was "very difficult to remember the burdens experienced"; and 4% responded that it was "very uncomfortable to respond"). Internal consistency of the FT measure was high (Cronbach's Conclusion: In medically underserved, uninsured Hispanic patients with cancer, comprehensive Spanish-language FT assessment in low English proficiency participants was feasible, acceptable, and internally consistent. Future studies employing tailored FT assessment and intervention should encompass the key privations and hardships in this population.
Language	English
Publishing date	2023-07-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2563826-9
ISSN	1664-1078
ISSN	1664-1078
DOI	10.3389/fpsyg.2023.1188783
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Article ; Online: CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy.

McGinnis, Gwendolyn J / Raber, Jacob

Immunotherapy

2017 Volume 9, Issue 11, Page(s) 929–941

Abstract: Following cancer treatment, patients often report behavioral and cognitive changes. Novel cancer immunotherapeutics have the potential to produce sustained cancer survivorship, meaning patients will live longer with the side effects of treatment. Given ... ...

Abstract	Following cancer treatment, patients often report behavioral and cognitive changes. Novel cancer immunotherapeutics have the potential to produce sustained cancer survivorship, meaning patients will live longer with the side effects of treatment. Given the role of inflammatory pathways in mediating behavioral and cognitive impairments seen in cancer, we aim in this review to discuss emerging evidence for the contribution of immune checkpoint blockade to exacerbate these CNS effects. We discuss ongoing studies regarding the ability of immune checkpoint inhibitors to reach the brain and how treatment responses to checkpoint inhibitors may be modulated by genetic factors. We further consider the use of preclinical tumor-models to study the role of tumor status in CNS effects of immune checkpoint inhibitors and multimodality therapy.
MeSH term(s)	Animals ; Antineoplastic Agents, Immunological/adverse effects ; Behavior/drug effects ; Central Nervous System/drug effects ; Central Nervous System/immunology ; Central Nervous System/physiopathology ; Cognition/drug effects ; Disease Models, Animal ; Drug Evaluation, Preclinical/methods ; Genetic Predisposition to Disease ; Humans ; Molecular Targeted Therapy/adverse effects ; Neoplasms/drug therapy ; Neoplasms/immunology ; Neoplasms/metabolism ; Neoplasms/pathology ; Neurotoxicity Syndromes/etiology ; Neurotoxicity Syndromes/genetics ; Neurotoxicity Syndromes/immunology ; Neurotoxicity Syndromes/psychology ; Phenotype ; Risk Assessment ; Risk Factors
Chemical Substances	Antineoplastic Agents, Immunological
Language	English
Publishing date	2017-07-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	2495964-9
ISSN	1750-7448 ; 1750-743X
ISSN (online)	1750-7448
ISSN	1750-743X
DOI	10.2217/imt-2017-0056
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Article ; Online: Association of fall rate and functional status by

McGinnis, Gwendolyn J / Holden, Sarah / Yu, Betty / Ransom, Charlton / Guidarelli, Carolyn / De, Brian / Diao, Kevin / Boyce, David / Thomas, Charles R / Winters-Stone, Kerri / Raber, Jacob

Oncotarget

2022 Volume 13, Page(s) 1259–1270

Abstract: Purpose/objectives: Cancer treatment survivors often report impaired functioning and increased falls. Not all survivors experience the same symptom burden, suggesting individual susceptibilities. : Materials and methods: Data from a subsample of a ... ...

Abstract	Purpose/objectives: Cancer treatment survivors often report impaired functioning and increased falls. Not all survivors experience the same symptom burden, suggesting individual susceptibilities. Materials and methods: Data from a subsample of a study of fall prevention exercise in post-treatment female cancer survivors aged 50-75 years old (https://clinicaltrials.gov NCT01635413) were used to conduct a secondary data analysis. ApoE genotype was determined by serum sampling. Physical functioning, frequency of falls, and symptom burden were assessed using survey instruments. Results: Data from 126 female cancer survivors a median of 49 months out from cancer diagnosis were analyzed. ApoE4 carriers trended toward a higher fall rate at baseline ( Conclusions: APOE
MeSH term(s)	Female ; Humans ; Middle Aged ; Aged ; Cancer Survivors ; Accidental Falls/prevention & control ; Functional Status ; Apolipoproteins E/genetics ; Genotype ; Drug-Related Side Effects and Adverse Reactions ; Exercise Therapy ; Neoplasms/genetics ; Neoplasms/therapy
Chemical Substances	Apolipoproteins E
Language	English
Publishing date	2022-11-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2560162-3
ISSN	1949-2553 ; 1949-2553
ISSN (online)	1949-2553
ISSN	1949-2553
DOI	10.18632/oncotarget.28310
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Article ; Online: Barriers and Facilitators of Implementing Automated Radiotherapy Planning: A Multisite Survey of Low- and Middle-Income Country Radiation Oncology Providers.

McGinnis, Gwendolyn J / Ning, Matthew S / Beadle, Beth M / Joubert, Nanette / Shaw, William / Trauernich, Christoph / Simonds, Hannah / Grover, Surbhi / Cardenas, Carlos E / Court, Laurence E / Smith, Grace L

JCO global oncology

2022 Volume 8, Page(s) e2100431

Abstract: Purpose: Global access to radiotherapy (RT) is inequitable, with obstacles to implementing modern technologies in low- and middle- income countries (LMICs). The Radiation Planning Assistant (RPA) is a web-based automated RT planning software package ... ...

Abstract	Purpose: Global access to radiotherapy (RT) is inequitable, with obstacles to implementing modern technologies in low- and middle- income countries (LMICs). The Radiation Planning Assistant (RPA) is a web-based automated RT planning software package intended to increase accessibility of high-quality RT planning. We surveyed LMIC RT providers to identify barriers and facilitators of future RPA deployment and uptake. Methods: RT providers underwent a pilot RPA teaching session in sub-Saharan Africa (Botswana, South Africa, and Tanzania) and Central America (Guatemala). Thirty providers (30 of 33, 90.9% response rate) participated in a postsession survey. Results: Respondents included physicians (n = 10, 33%), physicists (n = 9, 30%), dosimetrists (n = 8, 27%), residents/registrars (n = 1, 3.3%), radiation therapists (n = 1, 3.3%), and administrators (n = 1, 3.3%). Overall, 86.7% expressed interest in RPA; more respondents expected that RPA would be usable in 2 years (80%) compared with now (60%). Anticipated barriers were lack of reliable internet (80%), potential subscription fees (60%), and need for functionality in additional disease sites (48%). Expected facilitators included decreased workload (80%), decreased planning time (72%), and ability to treat more patients (64%). Forty-four percent anticipated that RPA would help transition from 2-dimensional to 3-dimensional techniques and 48% from 3-dimensional to intensity-modulated radiation treatment. Of a maximum acceptability/feasibility score of 60, physicians (45.6, standard deviation [SD] = 7.5) and dosimetrists (44.3, SD = 9.1) had lower scores than the mean for all respondents (48.3, SD = 7.7) although variation in scores by roles was not significantly different ( Conclusion: These data provide an early assessment and create an initial framework to identify stakeholder needs and establish priorities to address barriers and promote facilitators of RPA deployment and uptake across global sites, as well as to tailor to needs in LMICs.
MeSH term(s)	Humans ; Income ; Poverty ; Radiation Oncology ; Surveys and Questionnaires ; Tanzania
Language	English
Publishing date	2022-05-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ISSN	2687-8941
ISSN (online)	2687-8941
DOI	10.1200/GO.21.00431
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Article: Clinical and Radiographic Presentations of COVID-19 Among Patients Receiving Radiation Therapy for Thoracic Malignancies.

Samson, Pamela / Ning, Matthew S / Shaverdian, Narek / Shepherd, Annemarie F / Gomez, Daniel R / McGinnis, Gwendolyn J / Nitsch, Paige L / Chmura, Steven / O'Reilly, Michael S / Lee, Percy / Chang, Joe Y / Robinson, Clifford / Lin, Steven H

Advances in radiation oncology

2020 Volume 5, Issue 4, Page(s) 700–704

Keywords	covid19
Language	English
Publishing date	2020-05-11
Publishing country	United States
Document type	Case Reports
ISSN	2452-1094
ISSN	2452-1094
DOI	10.1016/j.adro.2020.04.020
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Article ; Online: Contemporary image-guided cervical cancer brachytherapy: Consensus imaging recommendations from the Society of Abdominal Radiology and the American Brachytherapy Society.

Jacobsen, Megan C / Beriwal, Sushil / Dyer, Brandon A / Klopp, Ann H / Lee, Susanna I / McGinnis, Gwendolyn J / Robbins, Jessica B / Rauch, Gaiane M / Sadowski, Elizabeth A / Simiele, Samantha J / Stafford, R Jason / Taunk, Neil K / Yashar, Catheryn M / Venkatesan, Aradhana M

Brachytherapy

2022 Volume 21, Issue 4, Page(s) 369–388

Abstract: Purpose: To present recommendations for the use of imaging for evaluation and procedural guidance of brachytherapy for cervical cancer patients.: Methods: An expert panel comprised of members of the Society of Abdominal Radiology Uterine and Ovarian ... ...

Abstract	Purpose: To present recommendations for the use of imaging for evaluation and procedural guidance of brachytherapy for cervical cancer patients. Methods: An expert panel comprised of members of the Society of Abdominal Radiology Uterine and Ovarian Cancer Disease Focused Panel and the American Brachytherapy Society jointly assessed the existing literature and provide data-driven guidance on imaging protocol development, interpretation, and reporting. Results: Image-guidance during applicator implantation reduces rates of uterine perforation by the tandem. Postimplant images may be acquired with radiography, computed tomography (CT), or magnetic resonance imaging (MRI), and CT or MRI are preferred due to a decrease in severe complications. Pre-brachytherapy T2-weighted MRI may be used as a reference for contouring the high-risk clinical target volume (HR-CTV) when CT is used for treatment planning. Reference CT and MRI protocols are provided for reference. Conclusions: Image-guided brachytherapy in locally advanced cervical cancer is essential for optimal patient management. Various imaging modalities, including orthogonal radiographs, ultrasound, computed tomography, and magnetic resonance imaging, remain integral to the successful execution of image-guided brachytherapy.
MeSH term(s)	Brachytherapy/methods ; Consensus ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Radiology ; Radiotherapy Planning, Computer-Assisted ; Tomography, X-Ray Computed/methods ; Uterine Cervical Neoplasms/diagnostic imaging ; Uterine Cervical Neoplasms/pathology ; Uterine Cervical Neoplasms/radiotherapy
Language	English
Publishing date	2022-06-18
Publishing country	United States
Document type	Journal Article
ZDB-ID	2098608-7
ISSN	1873-1449 ; 1538-4721
ISSN (online)	1873-1449
ISSN	1538-4721
DOI	10.1016/j.brachy.2022.04.005
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Article: Massive hemorrhage following definitive esophageal chemoradiation: teaching case of a fatal aortoesophageal fistula and lessons learned.

McGinnis, Gwendolyn J / Holland, John M / Thomas, Charles R / Nabavizadeh, Nima

Clinical case reports

2017 Volume 5, Issue 12, Page(s) 2074–2079

Abstract: Esophageal self-expandable metal stents and radiotherapy are valuable in combination for palliation and definitive treatment of esophageal cancer. However, risk of aortoesophageal fistula is significant in patients with evidence of malignant aortic ... ...

Abstract	Esophageal self-expandable metal stents and radiotherapy are valuable in combination for palliation and definitive treatment of esophageal cancer. However, risk of aortoesophageal fistula is significant in patients with evidence of malignant aortic invasion. Use of thoracic endovascular repair may represent an approach to early intervention in high-risk patients.
Language	English
Publishing date	2017-11-07
Publishing country	England
Document type	Case Reports
ZDB-ID	2740234-4
ISSN	2050-0904
ISSN	2050-0904
DOI	10.1002/ccr3.1239
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Article ; Online: New Pulmonary Infiltrates Observed on Computed Tomography-Based Image Guidance for Radiotherapy Warrant Diagnostic Workup for Coronavirus Disease 2019.

Warren, Graham W / Lim, Vun-Sin / Chowdhary, Mudit / Marwaha, Gaurav / Abd Elbadee, Osama Mostafa / Kirakli, Esra Korkmaz / Billiet, Charlotte / Marin, Alexandra Giraldo / Ramos, Monica / Suppli, Morten Hiul / McGinnis, Gwendolyn J / Adjei, Alex A

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2021 Volume 16, Issue 11, Page(s) 1946–1951

Abstract: ... the United States. Results and imaging from the patients reported by Suppli et al. and McGinnis et al. were included ...

Abstract	Introduction: Screening for coronavirus disease 2019 (COVID-19) exposure, coupled with engaged decision making to prioritize cancer treatment in parallel with reducing risk of exposure and infection, is crucial in the management of COVID-19 during cancer treatment. After two reported case studies of imaging findings during daily computed tomography (CT)-based image-guided radiotherapy (RT) scans, a call for submission of anonymized case reports was published with the objective of rapidly determining if there was a correlation between the onset of new pulmonary infiltrates found during RT and COVID-19. We hereby report the results of the aggregate analysis. Methods: Data of deidentified case reports for patients who developed biochemically confirmed COVID-19 during RT were submitted through an online portal. Information requested included a patient's sex, age, cancer diagnosis and treatment, and COVID-19 diagnosis and outcome. Coplanar CT-based imaging was requested to reveal the presence or absence of ground-glass opacities or infiltrates. Results: A total of seven reports were submitted from Turkey, Spain, Belgium, Egypt, and the United States. Results and imaging from the patients reported by Suppli et al. and McGinnis et al. were included for a total of nine patients for analysis. All patients were confirmed COVID-19 positive using polymerase chain reaction-based methods or nasopharyngeal swabs. Of the nine patients analyzed, abnormalities consistent with ground-glass opacities or infiltrates were observed in eight patients. Conclusions: This is the largest case series revealing the potential use of CT-based image guidance during RT as a tool for identifying patients who need further workup for COVID-19. Considerations for reviewing image guidance for new pulmonary infiltrates and immediate COVID-19 testing in patients who develop new infiltrates even without COVID-19 symptoms are strongly encouraged.
MeSH term(s)	COVID-19 ; COVID-19 Testing ; Humans ; Lung ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/radiotherapy ; SARS-CoV-2 ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-06-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2021.06.005
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Article ; Online: Rapid Detection of Asymptomatic Coronavirus Disease 2019 by Computed Tomography Image Guidance for Stereotactic Ablative Radiotherapy.

McGinnis, Gwendolyn J / Ning, Matthew S / Nitsch, Paige L / O'Reilly, Michael S / McAleer, Mary Frances / Koong, Albert C / Chang, Joe Y

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer

2020 Volume 15, Issue 6, Page(s) 1085–1087

MeSH term(s)	Betacoronavirus/isolation & purification ; COVID-19 ; COVID-19 Testing ; Clinical Laboratory Techniques/methods ; Coronavirus Infections/diagnosis ; Coronavirus Infections/diagnostic imaging ; Coronavirus Infections/epidemiology ; Coronavirus Infections/virology ; Female ; Humans ; Image-Guided Biopsy/methods ; Incidence ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery ; Lung Neoplasms/virology ; Middle Aged ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/diagnostic imaging ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/virology ; Prognosis ; Radiosurgery/methods ; SARS-CoV-2 ; Tomography, X-Ray Computed/methods
Keywords	covid19
Language	English
Publishing date	2020-04-17
Publishing country	United States
Document type	Case Reports
ZDB-ID	2432037-7
ISSN	1556-1380 ; 1556-0864
ISSN (online)	1556-1380
ISSN	1556-0864
DOI	10.1016/j.jtho.2020.04.007
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Article: Rapid Detection of Asymptomatic Coronavirus Disease 2019 by Computed Tomography Image Guidance for Stereotactic Ablative Radiotherapy

McGinnis, Gwendolyn J / Ning, Matthew S / Nitsch, Paige L / O039, / Reilly, Michael S / McAleer, Mary Frances / Koong, Albert C / Chang, Joe Y

J Thorac Oncol

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #72074
Database	COVID19

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