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  1. Article ; Online: Evaluation of rapid antigen tests based on saliva for the detection of SARS-CoV-2.

    Seitz, Tamara / Schindler, Stefanie / Winkelmeyer, Patrick / Zach, Bernhard / Wenisch, Christoph / Zoufaly, Alexander / Allerberger, Franz

    Journal of medical virology

    2021  Volume 93, Issue 7, Page(s) 4161–4162

    MeSH term(s) COVID-19 ; Emergency Service, Hospital ; Humans ; Prospective Studies ; SARS-CoV-2 ; Saliva
    Language English
    Publishing date 2021-04-13
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 752392-0
    ISSN 1096-9071 ; 0146-6615
    ISSN (online) 1096-9071
    ISSN 0146-6615
    DOI 10.1002/jmv.26983
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    Zs.A 1320: Show issues Location:
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  2. Article: Randomized controlled study to evaluate the safety and clinical impact of percutaneous auricular vagus nerve stimulation in patients with severe COVID-19.

    Seitz, Tamara / Bergmayr, Franziska / Kitzberger, Reinhard / Holbik, Johannes / Grieb, Alexander / Hind, Julian / Lucny, Felix / Tyercha, Alexander / Neuhold, Stephanie / Krenn, Claus / Wenisch, Christoph / Zoufaly, Alexander / Kaniusas, Eugenijus / Széles, József Constantin

    Frontiers in physiology

    2023  Volume 14, Page(s) 1223347

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-08-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1223347
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  3. Article ; Online: Antimicrobial and resource utilization with T2 magnetic resonance for rapid diagnosis of bloodstream infections: systematic review with meta-analysis of controlled studies.

    Giannella, Maddalena / Pankey, George A / Pascale, Renato / Miller, Valerie M / Miller, Larry E / Seitz, Tamara

    Expert review of medical devices

    2021  Volume 18, Issue 5, Page(s) 473–482

    Abstract: Objectives: ...

    Abstract Objectives:
    MeSH term(s) Aged ; Anti-Bacterial Agents/therapeutic use ; Controlled Clinical Trials as Topic ; Humans ; Intensive Care Units ; Length of Stay ; Magnetic Resonance Imaging ; Middle Aged ; Publication Bias ; Risk ; Sepsis/diagnosis ; Sepsis/diagnostic imaging ; Sepsis/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2021-06-07
    Publishing country England
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 2250857-0
    ISSN 1745-2422 ; 1743-4440
    ISSN (online) 1745-2422
    ISSN 1743-4440
    DOI 10.1080/17434440.2021.1919508
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  4. Article ; Online: Rapid Detection of Bacterial and Fungal Pathogens Using the T2MR versus Blood Culture in Patients with Severe COVID-19.

    Seitz, Tamara / Holbik, Johannes / Hind, Julian / Gibas, Georg / Karolyi, Mario / Pawelka, Erich / Traugott, Marianna / Wenisch, Christoph / Zoufaly, Alexander

    Microbiology spectrum

    2022  Volume 10, Issue 3, Page(s) e0014022

    Abstract: A high rate of bacterial and fungal superinfections was reported in critically ill patients with COVID-19. However, diagnosis can be challenging. The aim of this study is to evaluate the sensitivity and the clinical utility of the point-of-care method T2 ...

    Abstract A high rate of bacterial and fungal superinfections was reported in critically ill patients with COVID-19. However, diagnosis can be challenging. The aim of this study is to evaluate the sensitivity and the clinical utility of the point-of-care method T2 magnetic resonance (T2MR) with the gold standard: the blood culture. T2MR can potentially detect five different
    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Blood Culture ; COVID-19/diagnosis ; Candida ; Candidemia/diagnosis ; Candidemia/drug therapy ; Candidemia/microbiology ; Enterococcus faecium ; Escherichia coli ; Humans ; Magnetic Resonance Spectroscopy/methods ; Superinfection/drug therapy
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2022-06-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.00140-22
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  5. Article ; Online: Bright Luminescence by Combining Chiral [2.2]Paracyclophane with a Boron-Nitrogen-Doped Polyaromatic Hydrocarbon Building Block.

    Rapp, Mario R / Leis, Wolfgang / Zinna, Francesco / Di Bari, Lorenzo / Arnold, Tamara / Speiser, Bernd / Seitz, Michael / Bettinger, Holger F

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2022  Volume 28, Issue 11, Page(s) e202104161

    Abstract: Novel BN-doped compounds based on chiral, tetrasubstituted [2.2]paracyclophane and NBN-benzo[f,g]tetracene were synthesized by Sonogashira-Hagihara coupling. Conjugated ethynyl linkers allow electronic communication between the π-electron systems through- ...

    Abstract Novel BN-doped compounds based on chiral, tetrasubstituted [2.2]paracyclophane and NBN-benzo[f,g]tetracene were synthesized by Sonogashira-Hagihara coupling. Conjugated ethynyl linkers allow electronic communication between the π-electron systems through-bond, whereas through-space interactions are provided by strong π-π overlap between the pairs of NBN-building blocks. Excellent optical and chiroptical properties in racemic and enantiopure conditions were measured, with molar absorption coefficients up to ϵ=2.04×10
    Language English
    Publishing date 2022-01-20
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202104161
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  6. Article ; Online: Whipple's disease diagnosed in a patient with suspected sarcoidosis.

    Totschnig, David / Seitz, Tamara / Zoufaly, Alexander / Hagenauer-Drektraan, Sabine / Wenisch, Christoph

    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

    2021  Volume 106, Page(s) 41–42

    Abstract: This paper presents a case of a 51-year-old patient with chronic diarrhea, weight loss, polyarthralgia, and diffuse lymphadenopathy. Laboratory work-up showed anemia, leukocytosis and thrombocytosis, and increased C-reactive protein (CRP). Due to an ... ...

    Abstract This paper presents a case of a 51-year-old patient with chronic diarrhea, weight loss, polyarthralgia, and diffuse lymphadenopathy. Laboratory work-up showed anemia, leukocytosis and thrombocytosis, and increased C-reactive protein (CRP). Due to an inconspicuous differential leukocyte count and lymph node biopsy findings showing granulomatous lymphadenopathy, sarcoidosis was initially suspected. Colonoscopy found no abnormalities and duodenal biopsies showed negative Periodic acid-Schiff stains. However, PCR testing on these biopsies revealed Tropheryma whipplei DNA. Further PCR testing of urine and cerebrospinal fluid also revealed T. whipplei DNA. The patient was treated with ceftriaxone for 2 weeks followed by trimethoprim for a year. A rapid improvement of his symptoms was seen.
    MeSH term(s) Adult ; Anti-Bacterial Agents/therapeutic use ; Biopsy ; Ceftriaxone/therapeutic use ; Humans ; Male ; Middle Aged ; Sarcoidosis/complications ; Whipple Disease/complications ; Whipple Disease/diagnosis ; Whipple Disease/drug therapy ; Whipple Disease/pathology
    Chemical Substances Anti-Bacterial Agents ; Ceftriaxone (75J73V1629)
    Language English
    Publishing date 2021-03-22
    Publishing country Canada
    Document type Case Reports
    ZDB-ID 1331197-9
    ISSN 1878-3511 ; 1201-9712
    ISSN (online) 1878-3511
    ISSN 1201-9712
    DOI 10.1016/j.ijid.2021.03.053
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    Zs.A 4516: Show issues Location:
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  7. Article ; Online: Flavonifractor plautii bloodstream infection in an asplenic patient with infectious colitis.

    Karpat, Izabella / Karolyi, Mario / Pawelka, Erich / Seitz, Tamara / Thaller, Franz / Wenisch, Christoph

    Wiener klinische Wochenschrift

    2021  Volume 133, Issue 13-14, Page(s) 724–726

    Abstract: Background: Flavonifractor plautii is a gram-positive, strictly anaerobic, rod-shaped bacterium. It belongs to the family of Clostridiales, is frequently found in the human gut microbiome and is rarely isolated in other human specimens.: Clinical ... ...

    Abstract Background: Flavonifractor plautii is a gram-positive, strictly anaerobic, rod-shaped bacterium. It belongs to the family of Clostridiales, is frequently found in the human gut microbiome and is rarely isolated in other human specimens.
    Clinical presentation: We report a case of a bloodstream infection with Flavonifractor plautii following infectious colitis in a 24-year-old asplenic woman with beta thalassemia. The patient presented to our department with diarrhea, fever, and lower abdominal pain for over 1 month. F. plautii was the only organism isolated from blood cultures.
    Results: The antimicrobial resistance pattern showed in vitro sensitivity to all antimicrobials used for treatment; however, in vivo treatment with amoxicillin and clavulanic acid failed. After switching to meropenem and metronidazole the patient rapidly recovered.
    Conclusion: Asplenia and a damaged intestinal wall might have favored the bloodstream infection. We found similarities in attributes of the affected patients and in treatment patterns between our case and the only three other published case reports.
    MeSH term(s) Adult ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Clostridiales ; Colitis/diagnosis ; Colitis/drug therapy ; Female ; Gastrointestinal Microbiome ; Humans ; Young Adult
    Language English
    Publishing date 2021-05-27
    Publishing country Austria
    Document type Case Reports ; Journal Article
    ZDB-ID 200462-8
    ISSN 1613-7671 ; 0043-5325 ; 0300-5178
    ISSN (online) 1613-7671
    ISSN 0043-5325 ; 0300-5178
    DOI 10.1007/s00508-021-01877-0
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    Zs.A 902: Show issues Location:
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  8. Article ; Online: Is the T2 magnetic resonance imaging Candida panel a suitable alternative to the SeptiFast for the rapid diagnosis of candidemia in routine clinical practice?

    Camp, Iris / Füszl, Astrid / Selitsch, Brigitte / Kröckel, Ivonne / Kovac, Katharina / Wahrmann, Martin / Steinlechner, Barbara / Weber, Johannes / Schellongowski, Peter / Zauner, Christian / Sengölge, Guerkan / Seitz, Tamara / Zoufaly, Alexander / Ströbele, Barbara / Fuchs, Stefan / Lass-Flörl, Cornelia / Burgmann, Heinz / Kundi, Michael / Willinger, Birgit

    Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases

    2024  

    Abstract: Objectives: The diagnosis of invasive Candida infection remains challenging because of tests with slow turnaround times or mediocre performance. T2magnetic resonance imaging is a new diagnostic tool. We investigated the diagnostic accuracy of the ... ...

    Abstract Objectives: The diagnosis of invasive Candida infection remains challenging because of tests with slow turnaround times or mediocre performance. T2magnetic resonance imaging is a new diagnostic tool. We investigated the diagnostic accuracy of the T2Candida panel (T2) in comparison with blood culture (BC) and the SeptiFast (SF) for the detection of five different Candida species among high-risk intensive care unit patients with suspected candidemia.
    Methods: We analysed blood samples collected from patients with suspected candidemia (177 samples from 138 patients) from August 2018 to April 2020. Blood samples were collected and analysed concurrently by BC, SF, and T2Candida. Subsequently, based on clinical and microbiological findings, patient samples were assigned to specific risk categories (proven, probable, and no candidemia).
    Results: Twenty-two samples from 17 patients were classified as proven candidemia, and 15 samples from 14 patients were classified as probable candidemia. A sensitivity of 68.2% (95% CI, 45-86%) was observed for the BC and the SF, and a sensitivity of 63.6% (95% CI, 41-83%) was observed for the T2 when only cases with proven candidemia were evaluated. For proven and probable candidemia, the sensitivity was 40.5% (95% CI, 23-58%) for BC, 81.1% (95% CI, 65-92%) for SF, and 73.0% (95% CI, 56-86%) for T2.
    Discussion: The diagnostic performance of SF and T2 was similar. For samples with proven/probable candidemia, SF and T2 had a higher sensitivity compared to BC. Used in conjunction with other diagnostic methods, T2 can replace the no longer available SF for the diagnosis of candidemia, enabling the timely initiation of targeted antifungal therapy.
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 1328418-6
    ISSN 1469-0691 ; 1470-9465 ; 1198-743X
    ISSN (online) 1469-0691
    ISSN 1470-9465 ; 1198-743X
    DOI 10.1016/j.cmi.2024.02.024
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  9. Article ; Online: The Role of Bacterial and Fungal Superinfection in Critical COVID-19.

    Seitz, Tamara / Holbik, Johannes / Grieb, Alexander / Karolyi, Mario / Hind, Julian / Gibas, Georg / Neuhold, Stephanie / Zoufaly, Alexander / Wenisch, Christoph

    Viruses

    2022  Volume 14, Issue 12

    Abstract: Background: The range of reported rates of bacterial and fungal superinfections in patients with a severe course of COVID-19 is wide, suggesting a lack of standardised reporting.: Methods: The rates of bacterial and fungal superinfection were ... ...

    Abstract Background: The range of reported rates of bacterial and fungal superinfections in patients with a severe course of COVID-19 is wide, suggesting a lack of standardised reporting.
    Methods: The rates of bacterial and fungal superinfection were assessed using predefined criteria to differentiate between infection and contamination.
    Results: Overall, 117 patients admitted to the Intensive Care Unit due to severe COVID-19 were included. Overall, 55% of patients developed a superinfection and 13.6% developed a fungal superinfection (5.9% candidemia and 7.7% CAPA). The rate of ventilator-associated pneumonia was 65.2%. If superinfection was detected, the length of hospital stay was significantly longer and the mortality was especially increased if candidemia was detected. An increased risk of superinfection was observed in patients with pre-existing diabetes mellitus or chronic heart failure. The presence of immunomodulating therapy did not seem to have an impact on the frequency of superinfections.
    Conclusion: Increased awareness of high superinfection rates, fungal infections in particular, in patients suffering from severe COVID-19 is necessary.
    MeSH term(s) Humans ; COVID-19/complications ; Superinfection ; Candidemia ; Hospitalization ; Length of Stay
    Language English
    Publishing date 2022-12-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2516098-9
    ISSN 1999-4915 ; 1999-4915
    ISSN (online) 1999-4915
    ISSN 1999-4915
    DOI 10.3390/v14122785
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  10. Article ; Online: Longitudinal viscosity of blood plasma for rapid COVID-19 prognostics

    Illibauer, Jennifer / Clodi-Seitz, Tamara / Zoufaly, Alexander / Aberle, Judith H. / Weninger, Wolfgang J. / Foedinger, Manuela / Elsayad, Kareem

    medRxiv

    Abstract: Blood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV colloquially refers to the shear viscosity, there is a second viscosity component--the bulk viscosity--that describes the irreversible fluid compressibility on short ... ...

    Abstract Blood Plasma Viscosity (PV) is an established biomarker for numerous diseases. While PV colloquially refers to the shear viscosity, there is a second viscosity component--the bulk viscosity--that describes the irreversible fluid compressibility on short time scales. The bulk viscosity is acutely sensitive to solid-like suspensions, and obtainable via the longitudinal viscosity from acoustic attenuation measurements. Whether it has diagnostic value remains unexplored yet may be pertinent given the association of diverse pathologies with the formation of plasma suspensions, such as fibrin-microstructures in COVID-19 and long-COVID. Here we show that the longitudinal PV measured using Brillouin Light Scattering (BLS) can serve as a proxy for the shear PV of blood plasma, and exhibits a temperature dependence consistent with increased suspension concentrations in severe COVID-patient plasma. Our results open a new avenue for PV diagnostics based on the longitudinal PV, and show that BLS can provide a means for its clinical implementation.
    Keywords covid19
    Language English
    Publishing date 2023-10-15
    Publisher Cold Spring Harbor Laboratory Press
    Document type Article ; Online
    DOI 10.1101/2023.10.13.23297016
    Database COVID19

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