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  1. Article ; Online: Metabonomics delineates allergic reactions induced by Shuang-huang-lian injection in rats using ultra performance liquid chromatography-mass spectrometry.

    Gu, Yuan-Yuan / Shi, Lang / Zhang, Dan-Dan / Huang, Xin / Chen, Da-Zhong

    Chinese journal of natural medicines

    2018  Volume 16, Issue 8, Page(s) 628–640

    Abstract: Shuang-huang-lian Injection (SHLI) is the first successfully developed drug ...

    Abstract Shuang-huang-lian Injection (SHLI) is the first successfully developed drug from traditional Chinese medicine (TCM) powder for injection, since its use for the treatment of acute respiratory tract infection, pneumonia, influenza, etc. At the same time, its allergic reactions have also emerged, which limits clinical applications. However, few scholars pay attention to the mechanism of allergic reactions. In this present study, metabonomics technology was used to explore the changes in endogenous metabolites in urine of the rat model of SHLI induced allergic reaction; we and analyzed the metabolites, metabolic pathway, and the mechanism which were closely related to the allergic reactions. The levels of serum histamine and tryptase were examined and changes in histomorphology were also observed. Based on the UPLC-Q-TOF/MS metabonomics, we carried out the pattern recognition analysis, selected potential biomarkers associated with allergic reactions, and explored the pathological mechanism for SHLI induced allergic reaction, which laid the foundation for the safety research of SHLI. Our results showed that SHLI increased the levels of serum histamine and tryptase in rats with allergic reaction; we determined 15 biomarkers in rat allergic reaction model induced by SHLI and found multiple metabolic pathways involved, such as metabolism of linolenic acid, phenylalanine, amino acid, 2-oxo acid, and purine and other metabolic pathways.
    MeSH term(s) Animals ; Biomarkers/urine ; Chromatography, High Pressure Liquid ; Drug Hypersensitivity/etiology ; Drug Hypersensitivity/urine ; Drugs, Chinese Herbal/administration & dosage ; Drugs, Chinese Herbal/adverse effects ; Histamine/urine ; Male ; Metabolomics ; Rats ; Rats, Sprague-Dawley ; Tandem Mass Spectrometry
    Chemical Substances Biomarkers ; Drugs, Chinese Herbal ; shuang-huang-lian ; Histamine (820484N8I3)
    Language English
    Publishing date 2018-09-08
    Publishing country China
    Document type Journal Article
    ZDB-ID 2192577-X
    ISSN 1875-5364 ; 2095-6975 ; 1672-3651
    ISSN (online) 1875-5364
    ISSN 2095-6975 ; 1672-3651
    DOI 10.1016/S1875-5364(18)30101-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Late Miocene palaeoflora and palaeoclimate of Lincang (China), supplementary data to: Jacques, Fr?d?ric M B; Guo, Shuang-Xing; Su, Tao; Xing, Yao-Wu; Huang, Yong-Jiang; Liu, Yu-Sheng Christopher; Ferguson, David-Kay; Zhou, Zhekun (2011): Quantitative reconstruction of the Late Miocene monsoon climates of southwest China: A case study of the Lincang flora from Yunnan Province. Palaeogeography, Palaeoclimatology, Palaeoecology, 304(3-4), 318-327

    Jacques, Fr?d?ric M B / Ferguson, David-Kay / Guo, Shuang-Xing / Huang, Yong-Jiang / Liu, Yu-Sheng Christopher / Su, Tao / Xing, Yao-Wu / Zhou, Zhekun

    2011  

    Abstract: The Miocene Lincang leaf assemblage is used in this paper as proxy data to reconstruct the palaeoclimate of southwestern Yunnan (SW China) and the evolution of monsoon intensity. Three quantitative methods were chosen for this reconstruction, i.e. Leaf ... ...

    Abstract The Miocene Lincang leaf assemblage is used in this paper as proxy data to reconstruct the palaeoclimate of southwestern Yunnan (SW China) and the evolution of monsoon intensity. Three quantitative methods were chosen for this reconstruction, i.e. Leaf Margin Analysis (LMA), Climate Leaf Analysis Multivariate Program (CLAMP), and the Coexistence Approach (CA). These methods, however, yield inconsistent results, particularly for the precipitation, as also shown in European and other East Asian Cenozoic floras. The wide range of the reconstructed climatic parameters includes the Mean Annual Temperature (MAT) of 18.5-24.7 ?C and the Mean Annual Precipitation (MAP) of 1213-3711 mm. Compared with the modern Lincang climate (MAT, 17.3 ?C; MAP, 1178.7 mm), the Miocene climate is slightly warmer, wetter and has a higher temperature seasonality. A detailed comparison on the palaeoclimatic variables with the coeval Late Miocene Xiaolongtan flora from the eastern part of Yunnan allows us to investigate the development and interactions of both South Asian and East Asian monsoons during the Late Miocene in southwest China, now under strong influence of these monsoon systems. Our results suggest that the monsoon climate has already been established in southwest Yunnan during the Late Miocene. Furthermore, our results support that both Southeast Asian and East Asian monsoons co-occurred in Yunnan during the Late Miocene.
    Language English
    Dates of publication 2011-9999
    Size Online-Ressource
    Publisher PANGAEA - Data Publisher for Earth & Environmental Science
    Publishing place Bremen/Bremerhaven
    Document type Book ; Online
    Note This dataset is supplement to doi:10.1016/j.palaeo.2010.04.014
    DOI 10.1594/PANGAEA.758946
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  3. Article ; Online: Understanding complex mirror-image flowers - a commentary on: 'The enantiostylous floral polymorphism of Barberetta aurea (Haemodoraceae) facilitates wing pollination by syrphid flies'.

    Huang, Shuang-Quan

    Annals of botany

    2023  Volume 132, Issue 6, Page(s) viii–x

    MeSH term(s) Animals ; Pollination ; Flowers/genetics ; Reproduction ; Diptera ; Seeds
    Language English
    Publishing date 2023-10-25
    Publishing country England
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1461328-1
    ISSN 1095-8290 ; 0305-7364
    ISSN (online) 1095-8290
    ISSN 0305-7364
    DOI 10.1093/aob/mcad157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Regarding a recently published Meta-analysis on moxibustion for lumbar disc herniation.

    Kaiyu, Huang / Shuang, Liang

    Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan

    2023  Volume 43, Issue 6, Page(s) 1056

    MeSH term(s) Humans ; Moxibustion ; Intervertebral Disc Displacement/therapy ; Acupuncture Therapy ; Lumbar Vertebrae
    Language English
    Publishing date 2023-09-30
    Publishing country China
    Document type Journal Article
    ZDB-ID 603186-9
    ISSN 2589-451X ; 0254-6272 ; 0255-2922
    ISSN (online) 2589-451X ; 0254-6272
    ISSN 0255-2922
    DOI 10.19852/j.cnki.jtcm.2023.06.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: Comprehensive analysis based on glycolytic and glutaminolytic pathways signature for predicting prognosis and immunotherapy in ovarian cancer.

    Zhang, Zihui / Huang, Yuqin / Li, Shuang / Hong, Li

    Journal of Cancer

    2024  Volume 15, Issue 2, Page(s) 383–400

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-01-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 2573318-7
    ISSN 1837-9664
    ISSN 1837-9664
    DOI 10.7150/jca.88359
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The complete mitochondrial genome of small narrow-mouthed frog,

    Huang, Shuang / Huang, Yan

    Mitochondrial DNA. Part B, Resources

    2022  Volume 7, Issue 6, Page(s) 1186–1188

    Abstract: The complete mitochondrial genome (mtDNA) ... ...

    Abstract The complete mitochondrial genome (mtDNA) of
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2090293
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: The Utility of

    Zhang, Yun / Hu, Yuxiao / Zhao, Shuang / Huang, Rong

    Clinical Medicine Insights. Oncology

    2024  Volume 18, Page(s) 11795549231225419

    Abstract: Background: Following changes in primary tumor (T) and lymph node (N) staging for nasopharyngeal carcinoma (NPC) in the : Methods: A total of 435 NPC patients underwent : Results: There were significant differences between all parameters relative ... ...

    Abstract Background: Following changes in primary tumor (T) and lymph node (N) staging for nasopharyngeal carcinoma (NPC) in the
    Methods: A total of 435 NPC patients underwent
    Results: There were significant differences between all parameters relative to the primary tumor but no significant differences in any parameter relative to the LNM and T stages. Higher mean values of TGN
    Conclusions: Our findings suggest that metabolic parameters are useful indicators of tumor invasiveness and LNM based on the Eighth Edition manual. Compared with volume-dependent parameters, TGN
    Language English
    Publishing date 2024-02-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2577877-8
    ISSN 1179-5549
    ISSN 1179-5549
    DOI 10.1177/11795549231225419
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Two new species of

    Song, Shuang / Li, Meng / Huang, Jun-En / Liu, Fang

    MycoKeys

    2023  Volume 96, Page(s) 113–126

    Abstract: ... ...

    Abstract Scolecobasidium
    Language English
    Publishing date 2023-03-29
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2630648-7
    ISSN 1314-4049 ; 1314-4049
    ISSN (online) 1314-4049
    ISSN 1314-4049
    DOI 10.3897/mycokeys.96.100621
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A rare case of intravenous leiomyomatosis extending to inferior vena cava.

    Dai, Dong-Qin / Wang, Shuang-Lu / Xiao, Dan / Huang, Zhi-Cheng / Tang, Guang-Cai

    The American journal of the medical sciences

    2024  

    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Letter
    ZDB-ID 82078-7
    ISSN 1538-2990 ; 0002-9629
    ISSN (online) 1538-2990
    ISSN 0002-9629
    DOI 10.1016/j.amjms.2024.03.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: GMean-a semi-supervised GRU and K-mean model for predicting the TF binding site.

    Chuah, Chai Wen / He, Wanxian / Huang, De-Shuang

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 2539

    Abstract: The transcription factor binding site is a deoxyribonucleic acid sequence that binds to transcription factors. Transcription factors are proteins that regulate the transcription gene. Abnormal turnover of transcription factors can lead to uncontrolled ... ...

    Abstract The transcription factor binding site is a deoxyribonucleic acid sequence that binds to transcription factors. Transcription factors are proteins that regulate the transcription gene. Abnormal turnover of transcription factors can lead to uncontrolled cell growth. Therefore, discovering the relationships between transcription factors and deoxyribonucleic acid sequences is an important component of bioinformatics research. Numerous deep learning and machine learning language models have been developed to accomplish these tasks. Our goal in this work is to propose a GMean model for predicting unlabelled deoxyribonucleic acid sequences. The GMean model is a hybrid model with a combination of gated recurrent unit and K-mean clustering. The GMean model is developed in three phases. The labelled and unlabelled data are processed based on k-mers and tokenization. The labelled data is used for training. The unlabelled data are used for testing and prediction. The experimental data consists of deoxyribonucleic acid experimental of GM12878, K562 and HepG2. The experimental results show that GMean is feasible and effective in predicting deoxyribonucleic acid sequences, as the highest accuracy is 91.85% in predicting K562 and HepG2. This is followed by the prediction of the sequence between GM12878 and K562 with an accuracy of 89.13%. The lowest accuracy is the prediction of the sequence between HepG2 and GM12828, which is 88.80%.
    MeSH term(s) Binding Sites ; Protein Binding ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Computational Biology ; DNA/metabolism
    Chemical Substances Transcription Factors ; DNA (9007-49-2)
    Language English
    Publishing date 2024-01-30
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-52933-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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