LIVIVO - Search results -

Search results

Result 1 - 10 of total 87

Search options

Article: Elevating the potential of CAR-T cell therapy in solid tumors: exploiting biomaterials-based delivery techniques.

Tang, Yuxiang / Yang, Xiaoyu / Hu, Hang / Jiang, Huiwen / Xiong, Wei / Mei, Heng / Hu, Yu

Frontiers in bioengineering and biotechnology

2024 Volume 11, Page(s) 1320807

Abstract: Chimeric antigen receptor (CAR) T cells exhibit promising progress in addressing hematologic malignancies. However, CAR-T therapy for solid tumors remains limited, with no FDA-approved CAR-T products available for clinical use at present. Primary reasons ...

Abstract	Chimeric antigen receptor (CAR) T cells exhibit promising progress in addressing hematologic malignancies. However, CAR-T therapy for solid tumors remains limited, with no FDA-approved CAR-T products available for clinical use at present. Primary reasons include insufficient infiltration, accumulation, tumor immunosuppression of the microenvironment, and related side effects. Single utilization of CAR-T cannot effectively overcome these unfavorable obstacles. A probable effective pathway to achieve a better CAR-T therapy effect would be to combine the benefits of biomaterials-based technology. In this article, comprehensive biomaterials strategies to break through these obstacles of CAR-T cell therapy at the tumor sites are summarized, encompassing the following aspects: 1) generating orthotopic CAR-T cells; 2) facilitating CAR-T cell trafficking; 3) stimulating CAR-T cell expansion and infiltration; 4) improving CAR-T cell activity and persistence; 5) reprogramming the immunosuppressive microenvironments. Additionally, future requirements for the development of this field, with a specific emphasis on promoting innovation and facilitating clinical translation, are thoroughly discussed.
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1320807
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Methylene-Blue-Encapsulated Metal-Organic-Framework-Based Electrochemical POCT Platform for Multiple Detection of Heavy Metal Ions in Milk.

Xiong, Huiwen / Li, Pintao / Cun, Fei / Chen, Hui / Kong, Jilie

Biosensors

2023 Volume 13, Issue 8

Abstract: Considering the high risk of heavy metal ions (HMIs) transferring through the food chain and accumulating in milk, a flexible and facile point-of-care testing (POCT) platform is urgently needed for the accurate, sensitive, and highly selective on-site ... ...

Abstract	Considering the high risk of heavy metal ions (HMIs) transferring through the food chain and accumulating in milk, a flexible and facile point-of-care testing (POCT) platform is urgently needed for the accurate, sensitive, and highly selective on-site quantification of multiple HMIs in milk. In this work, a cost-effective disk with six screen-printed electrodes (SPEs) was designed for hand-held electrochemical detection. Metal organic frameworks (MOFs) were adopted to amplify and enhance the electrochemical signals of methylene blue (MB). Using differential pulse voltammetry (DPV) methods, low limits of detection for four HMIs (Cd
MeSH term(s)	Animals ; Metal-Organic Frameworks ; Methylene Blue ; Milk ; Metals, Heavy ; Point-of-Care Testing ; Ions
Chemical Substances	Metal-Organic Frameworks ; Methylene Blue (T42P99266K) ; Metals, Heavy ; Ions
Language	English
Publishing date	2023-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662125-3
ISSN	2079-6374 ; 2079-6374
ISSN (online)	2079-6374
ISSN	2079-6374
DOI	10.3390/bios13080783
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Innovative Highly Specific Nucleic Acid Isothermal Detection Assay Based on the Polymerization-Coupled Endonuclease Activity of Prokaryotic DNA Polymerase I.

Li, Pintao / Lin, Qiuyuan / Xiong, Huiwen / Kong, Jilie / Ye, Xin / Fang, Xueen

Analytical chemistry

2023 Volume 95, Issue 42, Page(s) 15755–15762

Abstract: In this study, we developed an innovative highly specific nucleic acid isothermal detection assay based on prokaryotic DNA polymerase I with exquisitely designed fluorescent probes, achieving high sensitivity and 100% specificity within 30 min. The ... ...

Abstract	In this study, we developed an innovative highly specific nucleic acid isothermal detection assay based on prokaryotic DNA polymerase I with exquisitely designed fluorescent probes, achieving high sensitivity and 100% specificity within 30 min. The fluorescent nucleic acid probe was designed and constructed based on the specific flap cleavage endonuclease activity of prokaryotic DNA polymerase I (including the
MeSH term(s)	DNA Polymerase I ; Polymerization ; Nucleic Acid Amplification Techniques ; DNA ; Endonucleases ; Sensitivity and Specificity
Chemical Substances	DNA Polymerase I (EC 2.7.7.7) ; DNA (9007-49-2) ; Endonucleases (EC 3.1.-)
Language	English
Publishing date	2023-10-12
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03261
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 4033: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Combined effects of amoxicillin and copper on nitrogen transformation and the microbial mechanisms during aerobic composting of cow manure.

Su, Ya / Xiong, Jinpeng / Fang, Chen / Qu, Huiwen / Han, Lujia / He, Xueqin / Huang, Guangqun

Journal of hazardous materials

2023 Volume 455, Page(s) 131569

Abstract: Pollutants in livestock manure have a compound effect during aerobic composting, but research to date has focused more on single factors. This study investigated the effects of adding amoxicillin (AMX), copper (Cu) and both (ACu) on nitrogen ... ...

Abstract	Pollutants in livestock manure have a compound effect during aerobic composting, but research to date has focused more on single factors. This study investigated the effects of adding amoxicillin (AMX), copper (Cu) and both (ACu) on nitrogen transformation and the microbial mechanisms in cow manure aerobic composting with wheat straw. In this study, compared with CK, AMX, Cu, and ACu increased NH
MeSH term(s)	Animals ; Cattle ; Amoxicillin/pharmacology ; Manure ; Copper ; Composting ; Nitrogen ; Soil
Chemical Substances	Amoxicillin (804826J2HU) ; Manure ; Copper (789U1901C5) ; Nitrogen (N762921K75) ; Soil
Language	English
Publishing date	2023-05-06
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2023.131569
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Nitrogen evolution during membrane-covered aerobic composting: Interconversion between nitrogen forms and migration pathways.

Xiong, Jinpeng / Zhuo, Qianting / Su, Ya / Qu, Huiwen / He, Xueqin / Han, Lujia / Huang, Guangqun

Journal of environmental management

2023 Volume 345, Page(s) 118727

Abstract: Aerobic composting is a promising technology for converting manure into organic fertilizer with low capital investment and easy operation. However, the large nitrogen losses in conventional aerobic composting impede its development. Interconversion of ... ...

Abstract	Aerobic composting is a promising technology for converting manure into organic fertilizer with low capital investment and easy operation. However, the large nitrogen losses in conventional aerobic composting impede its development. Interconversion of nitrogen species was studied during membrane-covered aerobic composting (MCAC) and conventional aerobic composting, and solid-, liquid-, and gas-phase nitrogen migration pathways were identified by performing nitrogen balance measurements. During the thermophilic phase, nitrogenous organic matter degradation and therefore NH
MeSH term(s)	Nitrogen/analysis ; Composting ; Soil ; Environmental Pollutants ; Manure
Chemical Substances	Nitrogen (N762921K75) ; Soil ; Environmental Pollutants ; Manure
Language	English
Publishing date	2023-07-31
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118727
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7556: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article: Development of short-target primers for species identification in biological studies of Carnivora.

Liu, Huiwen / Wang, Dan / Zhang, Chenglin / Pu, Tianchun / Xiong, Lijuan / Wei, Fuwen / Hu, Yibo

Ecology and evolution

2023 Volume 13, Issue 5, Page(s) e10135

Abstract: Noninvasive genetic sampling greatly facilitates studies on the genetics, ecology, and conservation of threatened species. Species identification is often a prerequisite for noninvasive sampling-based biological studies. Due to the low quantity and ... ...

Abstract	Noninvasive genetic sampling greatly facilitates studies on the genetics, ecology, and conservation of threatened species. Species identification is often a prerequisite for noninvasive sampling-based biological studies. Due to the low quantity and quality of genomic DNA from noninvasive samples, high-performance short-target PCR primers are necessary for DNA barcoding applications. The order Carnivora is characterized by an elusive habit and threatened status. In this study, we developed three pairs of short-target primers for identifying Carnivora species. The COI279 primer pair was suitable for samples with better DNA quality. The COI157a and COI157b primer pairs performed well for noninvasive samples and reduced the interference of nuclear mitochondrial pseudogenes (numts). COI157a could effectively identify samples from Felidae, Canidae, Viverridae, and Hyaenidae, while COI157b could be applied to samples from Ursidae, Ailuridae, Mustelidae, Procyonidae, and Herpestidae. These short-target primers will facilitate noninvasive biological studies and efforts to conserve Carnivora species.
Language	English
Publishing date	2023-05-25
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.10135
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Unveiling the hidden pathways: Exploring astrocytes as a key target for depression therapy.

Liu, Ying / Chen, Lu / Lin, Lin / Xu, Caijuan / Xiong, Yifan / Qiu, Huiwen / Li, Xinyu / Li, Sixin / Cao, Hui

Journal of psychiatric research

2024 Volume 174, Page(s) 101–113

Abstract: Depressive disorders are widely debilitating psychiatric disease. Despite the considerable progress in the field of depression therapy, extensive research spanning many decades has failed to uncover pathogenic pathways that might aid in the creation of ... ...

Abstract	Depressive disorders are widely debilitating psychiatric disease. Despite the considerable progress in the field of depression therapy, extensive research spanning many decades has failed to uncover pathogenic pathways that might aid in the creation of long-acting and rapid-acting antidepressants. Consequently, it is imperative to reconsider existing approaches and explore other targets to improve this area of study. In contemporary times, several scholarly investigations have unveiled that persons who have received a diagnosis of depression, as well as animal models employed to study depression, demonstrate a decrease in both the quantity as well as density of astrocytes, accompanied by alterations in gene expression and morphological attributes. Astrocytes rely on a diverse array of channels and receptors to facilitate their neurotransmitter transmission inside tripartite synapses. This study aimed to investigate the potential processes behind the development of depression, specifically focusing on astrocyte-associated neuroinflammation and the involvement of several molecular components such as connexin 43, potassium channel Kir4.1, aquaporin 4, glutamatergic aspartic acid transporter protein, SLC1A2 or GLT-1, glucocorticoid receptors, 5-hydroxytryptamine receptor 2B, and autophagy, that localized on the surface of astrocytes. The study also explores novel approaches in the treatment of depression, with a focus on astrocytes, offering innovative perspectives on potential antidepressant medications.
Language	English
Publishing date	2024-04-11
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2024.04.003
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui I Zs.243: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Nitrogen evolution during membrane-covered aerobic composting: Interconversion between nitrogen forms and migration pathways

Xiong, Jinpeng / Zhuo, Qianting / Su, Ya / Qu, Huiwen / He, Xueqin / Han, Lujia / Huang, Guangqun

Journal of Environmental Management. 2023 Nov., v. 345 p.118727-

2023

Abstract	Aerobic composting is a promising technology for converting manure into organic fertilizer with low capital investment and easy operation. However, the large nitrogen losses in conventional aerobic composting impede its development. Interconversion of nitrogen species was studied during membrane-covered aerobic composting (MCAC) and conventional aerobic composting, and solid-, liquid-, and gas-phase nitrogen migration pathways were identified by performing nitrogen balance measurements. During the thermophilic phase, nitrogenous organic matter degradation and therefore NH₃ production were faster during MCAC than uncovered composting. However, the water films inside and outside the membrane decreased NH₃ release by 13.92%–22.91%. The micro-positive pressure environment during MCAC decreased N₂O production and emission by 20.35%–27.01%. Less leachate was produced and therefore less nitrogen and other pollutants were released during MCAC than uncovered composting. The nitrogen succession patterns during MCAC and uncovered composting were different and NH₄⁺ storage in organic nitrogen fractions was better facilitated during MCAC than uncovered composting. Overall, MCAC decreased total nitrogen losses by 33.24%–50.07% and effectively decreased environmental pollution and increased the nitrogen content of the produced compost.
Keywords	composts ; economic investment ; environmental management ; evolution ; leachates ; nitrogen balance ; organic nitrogen ; pollution ; total nitrogen ; Interconversion pathways ; Membrane-covered aerobic composting ; Nitrogen fractions ; Nitrogen migration
Language	English
Dates of publication	2023-11
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.118727
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 7556: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Development of short‐target primers for species identification in biological studies of Carnivora

Huiwen Liu / Dan Wang / Chenglin Zhang / Tianchun Pu / Lijuan Xiong / Fuwen Wei / Yibo Hu

Ecology and Evolution, Vol 13, Iss 5, Pp n/a-n/a (2023)

2023

Abstract: Abstract Noninvasive genetic sampling greatly facilitates studies on the genetics, ecology, and conservation of threatened species. Species identification is often a prerequisite for noninvasive sampling‐based biological studies. Due to the low quantity ... ...

Abstract	Abstract Noninvasive genetic sampling greatly facilitates studies on the genetics, ecology, and conservation of threatened species. Species identification is often a prerequisite for noninvasive sampling‐based biological studies. Due to the low quantity and quality of genomic DNA from noninvasive samples, high‐performance short‐target PCR primers are necessary for DNA barcoding applications. The order Carnivora is characterized by an elusive habit and threatened status. In this study, we developed three pairs of short‐target primers for identifying Carnivora species. The COI279 primer pair was suitable for samples with better DNA quality. The COI157a and COI157b primer pairs performed well for noninvasive samples and reduced the interference of nuclear mitochondrial pseudogenes (numts). COI157a could effectively identify samples from Felidae, Canidae, Viverridae, and Hyaenidae, while COI157b could be applied to samples from Ursidae, Ailuridae, Mustelidae, Procyonidae, and Herpestidae. These short‐target primers will facilitate noninvasive biological studies and efforts to conserve Carnivora species.
Keywords	Carnivora ; COI ; noninvasive sample ; species identification ; Ecology ; QH540-549.5
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	Wiley
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Innovative Highly Specific Nucleic Acid Isothermal Detection Assay Based on the Polymerization-Coupled Endonuclease Activity of Prokaryotic DNA Polymerase I

Li, Pintao / Lin, Qiuyuan / Xiong, Huiwen / Kong, Jilie / Ye, Xin / Fang, Xueen

Analytical Chemistry. 2023 Oct. 12, v. 95, no. 42 p.15755-15762

2023

Abstract	In this study, we developed an innovative highly specific nucleic acid isothermal detection assay based on prokaryotic DNA polymerase I with exquisitely designed fluorescent probes, achieving high sensitivity and 100% specificity within 30 min. The fluorescent nucleic acid probe was designed and constructed based on the specific flap cleavage endonuclease activity of prokaryotic DNA polymerase I (including the Bst, Bsu, Bsm, and Klenow DNA polymerases). The flap endonuclease activity depends on the length of the flap DNA and polymerization activity, which greatly reduces the false-positive rate caused by primer dimerization. This robust assay was also validated by the detection of rotavirus with great specificity and sensitivity. It could be a great alternative to qPCR in the field of point-of-care detection of pathogens.
Keywords	DNA ; DNA-directed DNA polymerase ; analytical chemistry ; dimerization ; fluorescence ; point-of-care systems ; polymerization
Language	English
Dates of publication	2023-1012
Size	p. 15755-15762.
Publishing place	American Chemical Society
Document type	Article ; Online
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.3c03261
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 4' 52/94: Show issues
Z 2.9: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED