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  1. Article ; Online: Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis.

    Gajawada, Praveen / Cetinkaya, Ayse / von Gerlach, Susanne / Kubin, Natalia / Burger, Heiko / Näbauer, Michael / Grinninger, Carola / Rolf, Andreas / Schönburg, Markus / Choi, Yeong-Hoon / Kubin, Thomas / Richter, Manfred

    International journal of molecular sciences

    2021  Volume 22, Issue 8

    Abstract: Cardiac sarcoidosis (CS) is a poorly understood disease and is characterized by the focal accumulation of immune cells, thus leading to the formation of granulomata (GL). To identify the developmental principles of fatal GL, fluorescence microscopy and ... ...

    Abstract Cardiac sarcoidosis (CS) is a poorly understood disease and is characterized by the focal accumulation of immune cells, thus leading to the formation of granulomata (GL). To identify the developmental principles of fatal GL, fluorescence microscopy and Western blot analysis of CS and control patients is presented here. CS is visualized macroscopically by positron emission tomography (PET)/ computed tomography (CT). A battery of antibodies is used to determine structural, cell cycle and inflammatory markers. GL consist of CD68
    MeSH term(s) Adult ; Apoptosis ; Aurora Kinases/metabolism ; Cardiomyopathies/metabolism ; Cardiomyopathies/pathology ; Cell Proliferation ; Cytoskeletal Proteins/metabolism ; Female ; Granuloma/metabolism ; Granuloma/pathology ; Histones/metabolism ; Humans ; Ki-67 Antigen/metabolism ; Macrophages/metabolism ; Macrophages/physiology ; Male ; Membrane Proteins/metabolism ; Microfilament Proteins/metabolism ; Middle Aged ; Myocardium/metabolism ; Oncostatin M/metabolism ; Pancreatitis-Associated Proteins/metabolism ; Sarcoidosis/metabolism ; Sarcoidosis/pathology
    Chemical Substances Cytoskeletal Proteins ; Histones ; Ki-67 Antigen ; Membrane Proteins ; Microfilament Proteins ; Pancreatitis-Associated Proteins ; REG3A protein, human ; REG3G protein, human ; ezrin ; Oncostatin M (106956-32-5) ; moesin (144131-77-1) ; radixin (144517-21-5) ; Aurora Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-04-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22084148
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book ; Online: Female Social Entrepreneurship

    Gerlach, Miriam

    Challenging boundaries and reframing gender and economic structures

    (L'AGENda)

    2021  

    Series title L'AGENda
    Keywords Gender studies: women ; gender;female entrepeneurs;Unternehmerinnen;qualitative Forschung;qualitative research;social enterprises;Sozialunternehmen;doing gender;Selbstverwirklichung;self-actualization;motivation;responsibility;Verantwortung;diversity;Diversität;Nachhaltigkeit;sustainability
    Language English
    Size 1 electronic resource (292 pages)
    Publisher Verlag Barbara Budrich
    Document type Book ; Online
    Note English
    HBZ-ID HT030376417
    ISBN 9783847425304 ; 3847425307
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  3. Article ; Online: An Observational Cerebral Magnetic Resonance Imaging Study Following 7 Days at 4554 m.

    Kühn, Sven / Gerlach, Darius / Noblé, Hans-Jürgen / Weber, Frank / Rittweger, Jörn / Jordan, Jens / Limper, Ulrich

    High altitude medicine & biology

    2019  Volume 20, Issue 4, Page(s) 407–416

    Abstract: Background: ...

    Abstract Background:
    MeSH term(s) Acclimatization ; Adult ; Altitude ; Altitude Sickness/complications ; Altitude Sickness/diagnostic imaging ; Altitude Sickness/pathology ; Brain/diagnostic imaging ; Brain/pathology ; Brain Edema/diagnostic imaging ; Brain Edema/etiology ; Brain Edema/pathology ; Female ; Humans ; Italy ; Magnetic Resonance Imaging ; Male ; Middle Aged
    Language English
    Publishing date 2019-11-14
    Publishing country United States
    Document type Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 2076262-8
    ISSN 1557-8682 ; 1527-0297
    ISSN (online) 1557-8682
    ISSN 1527-0297
    DOI 10.1089/ham.2019.0056
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Myocardial Accumulations of Reg3A, Reg3γ and Oncostatin M Are Associated with the Formation of Granulomata in Patients with Cardiac Sarcoidosis

    Praveen Gajawada / Ayse Cetinkaya / Susanne von Gerlach / Natalia Kubin / Heiko Burger / Michael Näbauer / Carola Grinninger / Andreas Rolf / Markus Schönburg / Yeong-Hoon Choi / Thomas Kubin / Manfred Richter

    International Journal of Molecular Sciences, Vol 22, Iss 4148, p

    2021  Volume 4148

    Abstract: ... of stress and inflammatory pathways in GL. High levels of oncostatin M and the Reg3A and Reg3γ chemokines ...

    Abstract Cardiac sarcoidosis (CS) is a poorly understood disease and is characterized by the focal accumulation of immune cells, thus leading to the formation of granulomata (GL). To identify the developmental principles of fatal GL, fluorescence microscopy and Western blot analysis of CS and control patients is presented here. CS is visualized macroscopically by positron emission tomography (PET)/ computed tomography (CT). A battery of antibodies is used to determine structural, cell cycle and inflammatory markers. GL consist of CD68 + , CD163 + and CD206 + macrophages surrounded by T-cells within fibrotic areas. Cell cycle markers such as phospho-histone H3, phospho-Aurora and Ki67 were moderately present; however, the phosphorylated ERM (ezrin, radixin and moesin) and Erk1/2 proteins, strong expression of the myosin motor protein and the macrophage transcription factor PU.1 indicate highly active GL. Mild apoptosis is consistent with PI3 kinase and Akt activation. Massive amounts of the IL-1R antagonist reflect a mild activation of stress and inflammatory pathways in GL. High levels of oncostatin M and the Reg3A and Reg3γ chemokines are in accordance with macrophage accumulation in areas of remodeling cardiomyocytes. We conclude that the formation of GL occurs mainly through chemoattraction and less by proliferation of macrophages. Furthermore, activation of the oncostatin/Reg3 axis might help at first to wall-off substances but might initiate the chronic development of heart failure.
    Keywords chemokine ; chemoattraction ; macrophage ; inflammation ; interleukin-1 receptor antagonist ; cell signaling ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 333 ; 610
    Language English
    Publishing date 2021-04-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Rechtsprechung. Unzureichende Aufklärung - Auswirkungen auf Krankenhausvergütung? (BSG, Urt. v. 19.3.2020 - B 1 KR 20/19 R, GesR 2020, 327 [Ls.]) m. Anm. Birgit Gerlach

    Gerlach, Birgit

    Gesundheitsrecht

    2020  Volume 19, Issue 7, Page(s) 473

    Language German
    Document type Article
    ZDB-ID 2092255-3
    ISSN 1610-1197
    Database Current Contents Medicine

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    Zs.A 6441: Show issues Location:
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  6. Book: Viel zu viel und doch zu wenig

    Gerlach, Ferdinand M. / Schmid, Raimund

    Über- und Unterversorgung in der Medizin

    2021  

    Author's details Raimund Schmid (Hrsg.) ; mit einem Geleitwort von Prof. Dr. med. Ferdinand M. Gerlach, MPH ; mit Beiträgen von Dorit Abiry, Hamburg [und vielen weiteren]
    Keywords Antibiotika-Abusus ; Apparatemedizin ; Choosing wisley ; Fehlversorgung ; Gesprächsmedizin ; Hausarztzentrierung ; IGEL-Leitstungen ; Medikamentencocktails ; Unterversorgung ; Versorgung ; Ärztehopping ; Überversorgung ; Deutschland ; Medizinische Versorgung
    Subject Gesundheitsversorgung ; Gesundheitliche Versorgung ; Patientenversorgung
    Language German
    Size XXVII, 338 Seiten, Illustrationen, Diagramme, 24 cm x 17 cm
    Edition 1. Auflage
    Publisher Elsevier ; Urban & Fischer
    Publishing place München
    Publishing country Germany
    Document type Book
    HBZ-ID HT020703392
    ISBN 978-3-437-24061-4 ; 3-437-24061-7 ; 9783437061004 ; 3437061003
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 A 573 available for loan (reading room) Lesesaal EG

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  7. Article: Praxisalltag: Welche Rolle spielt die Phytotherapie? Interview mit Prof. Dr. Ferdinand M. Gerlach

    Gerlach, Ferdinand M.

    Natura-med

    2011  Volume 26, Issue 5, Page(s) 40

    Language German
    Document type Article
    ZDB-ID 383690-3
    ISSN 0931-1513
    Database Current Contents Medicine

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    Zs.B 3224: Show issues Location:
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  8. Article: Drei Fragen an Ferdinand M. Gerlach, Institut für Allgemeinmedizin der Johann-Wolfgang-Goethe-Universität, Frankfurt am Main

    Gerlach, Ferdinand M.

    Gesundheit und Gesellschaft : Wissenschaft

    2012  Volume 12, Issue 2, Page(s) 3

    Language German
    Document type Article
    ZDB-ID 2052876-0
    Database Current Contents Medicine

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  9. Article: Mycobacterium avium subsp. paratuberculosis-specific mpt operon expressed in M. bovis BCG as vaccine candidate.

    Heinzmann, Julia / Wilkens, Mirja / Dohmann, Karen / Gerlach, Gerald-F

    Veterinary microbiology

    2008  Volume 130, Issue 3-4, Page(s) 330–337

    Abstract: Mycobacterium (M.) avium subspecies paratuberculosis is the etiological agent of paratuberculosis ... the tuberculosis vaccine strain M. bovis BCG is considered safe and the efficacy of vaccination with M. bovis BCG ... transformants carrying foreign antigens has been shown in several studies. The mpt genes of M. avium subsp ...

    Abstract Mycobacterium (M.) avium subspecies paratuberculosis is the etiological agent of paratuberculosis (Johne's disease) in ruminants. Vaccination against paratuberculosis with an attenuated live vaccine has been shown not only to prevent or reduce disease symptoms but also to have severe side effects. In contrast, the tuberculosis vaccine strain M. bovis BCG is considered safe and the efficacy of vaccination with M. bovis BCG transformants carrying foreign antigens has been shown in several studies. The mpt genes of M. avium subsp. paratuberculosis are part of a putative pathogenicity island and have been described as possible virulence determinants. In this study we show that the mpt genes are transcribed on a single polycistronic mRNA in M. avium subsp. paratuberculosis. We cloned the entire mpt operon, transformed it into M. bovis BCG Pasteur using the integrative vector pMV306 and showed transcription and expression of the mpt genes in the M. bovis BCG transformant. In a challenge experiment with Balb/c mice we demonstrated that immunization with M. bovis BCG expressing the M. avium subsp. paratuberculosis-derived mpt operon significantly reduces amplification of M. avium subsp. paratuberculosis in liver and spleen of the host in comparison to both the mock-immunized animals as well as the M. bovis BCG-immunized control. These findings imply that immunization with M. bovis BCG transformants may constitute a new strategy in the development of an efficacious and safe vaccine against paratuberculosis.
    MeSH term(s) Animals ; BCG Vaccine/immunology ; Cloning, Molecular ; Female ; Gene Expression Regulation, Bacterial ; Genetic Engineering ; Mice ; Mice, Inbred BALB C ; Mycobacterium avium subsp. paratuberculosis/genetics ; Mycobacterium bovis/immunology ; Operon/genetics ; Operon/immunology ; Transcription, Genetic ; Tuberculosis Vaccines/immunology ; Vaccines, Synthetic
    Chemical Substances BCG Vaccine ; Tuberculosis Vaccines ; Vaccines, Synthetic
    Language English
    Publishing date 2008-08-25
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 753154-0
    ISSN 1873-2542 ; 0378-1135
    ISSN (online) 1873-2542
    ISSN 0378-1135
    DOI 10.1016/j.vetmic.2008.01.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2917: Show issues Location:
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  10. Book: Pocket Guide Neuro-/Psychopharmaka im Kindes- und Jugendalter

    Gerlach, Manfred / Warnke, Andreas

    von A - Z

    2021  

    Title variant Pocket Guide Neuro-, Psychopharmaka im Kindes- und Jugendalter
    Author's details Manfred Gerlach, Andreas Warnke
    Keywords Kinderpsychiatrie ; Jugendpsychiatrie ; Pharmakotherapie ; Psychopharmakon ; Neuropharmakon
    Subject Neurologikum ; Psychopharmaka ; Psychotrope Substanz ; Psychotropische Substanz ; Psychotherapeutikum ; Arzneimitteltherapie ; Arzneitherapie ; Medikamentöse Therapie ; Jugend ; Kind
    Language German
    Size XIX, 218 Seiten
    Edition 2. korrigierte Auflage
    Publisher Springer
    Publishing place Berlin
    Publishing country Germany
    Document type Book
    Note Zugang zu Online-Ausgabe über Code
    HBZ-ID HT020863275
    ISBN 978-3-662-62978-9 ; 9783662629796 ; 3-662-62978-X ; 3662629798
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2021 A 524 available for loan (reading room) Lesesaal EG
    Zugang zu Online-Ausgabe über Code aus lizenzrechtlichen Gründen nicht verfügbar

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