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  1. Book: Gabriel García Márquez

    Gómez Pulido, Ignacio / Haddad, Hubert

    (Lieux de l'écrit)

    1993  

    Author's details Hubert Haddad, texte. Photographies Ignacio Gómez Pulido
    Series title Lieux de l'écrit
    Language Spanish
    Size 95 S, zahlr. Ill
    Publisher Marval
    Publishing place Paris
    Document type Book
    ISBN 2862341045 ; 9782862341040
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article: Brain organoid protocols and limitations.

    Zhao, Helen H / Haddad, Gabriel

    Frontiers in cellular neuroscience

    2024  Volume 18, Page(s) 1351734

    Abstract: Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases. Brain organoids especially open an opportunity for human brain ... ...

    Abstract Stem cell-derived organoid technology is a powerful tool that revolutionizes the field of biomedical research and extends the scope of our understanding of human biology and diseases. Brain organoids especially open an opportunity for human brain research and modeling many human neurological diseases, which have lagged due to the inaccessibility of human brain samples and lack of similarity with other animal models. Brain organoids can be generated through various protocols and mimic whole brain or region-specific. To provide an overview of brain organoid technology, we summarize currently available protocols and list several factors to consider before choosing protocols. We also outline the limitations of current protocols and challenges that need to be solved in future investigation of brain development and pathobiology.
    Language English
    Publishing date 2024-03-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2452963-1
    ISSN 1662-5102
    ISSN 1662-5102
    DOI 10.3389/fncel.2024.1351734
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book: Brain hypoxia and ischemia

    Haddad, Gabriel G.

    with special emphasis on development

    2009  

    Author's details ed. by Gabriel G. Haddad
    Keywords Hypoxia, Brain / physiopathology ; Brain Ischemia / physiopathology
    Language English
    Size XI, 343 S., [8] Bl. : zahlr. Ill., graph. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015675836
    ISBN 978-1-60327-578-1 ; 1-60327-578-9 ; 9781603275798 ; 1603275797
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 771 order for loan Magazin

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  4. Article ; Online: The Pupa Stage Is the Most Sensitive to Hypoxia in

    Stobdan, Tsering / Wen, Nicholas J / Lu-Bo, Ying / Zhou, Dan / Haddad, Gabriel G

    International journal of molecular sciences

    2024  Volume 25, Issue 2

    Abstract: Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia- ...

    Abstract Hypoxia not only plays a critical role in multiple disease conditions; it also influences the growth and development of cells, tissues and organs. To identify novel hypoxia-related mechanisms involved in cell and tissue growth, studying a precise hypoxia-sensitive time window can be an effective approach.
    MeSH term(s) Animals ; Drosophila melanogaster ; Pupa ; Drosophila ; Epigenomics ; Hypoxia
    Language English
    Publishing date 2024-01-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25020710
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Book: Genetic models in cardiorespiratory biology

    Haddad, Gabriel G.

    (Lung biology in health and disease ; 156)

    2001  

    Author's details ed. by Gabriel G. Haddad
    Series title Lung biology in health and disease ; 156
    Collection
    Keywords Models, Genetic ; Respiratory Physiology ; Cardiovascular Physiology ; Kardiovaskuläres System ; Molekulargenetik ; Vergleichende Biologie ; Atemwege
    Subject Luftwege ; Respirationstrakt ; Atmungssystem ; Atemsystem ; Apparatus respiratorius ; Herz-Kreislauf-System ; Cardiovasculäres System ; Molekulare Genetik ; Biochemische Genetik
    Language English
    Size XIX, 457 S. : Ill., graph. Darst.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT013062579
    ISBN 0-8247-0512-2 ; 978-0-8247-0512-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2001 A 3091 order for loan Magazin

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  6. Article ; Online: Peptoniphilus genitalis sp. nov. and Mobiluncus massiliensis sp. nov.: Novel Bacteria Isolated from the Vaginal Microbiome.

    Abou Chacra, Linda / Bonnet, Marion / Heredia, Mégane / Haddad, Gabriel / Armstrong, Nicholas / Alibar, Stéphane / Bretelle, Florence / Fenollar, Florence

    Current microbiology

    2024  Volume 81, Issue 4, Page(s) 97

    Abstract: The strains Marseille- ... ...

    Abstract The strains Marseille-Q7072
    MeSH term(s) Female ; Humans ; Mobiluncus ; Bacteria ; Clostridiales ; Microbiota ; DNA
    Chemical Substances DNA (9007-49-2)
    Language English
    Publishing date 2024-02-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 134238-1
    ISSN 1432-0991 ; 0343-8651
    ISSN (online) 1432-0991
    ISSN 0343-8651
    DOI 10.1007/s00284-023-03584-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1446: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A Boolean approach for novel hypoxia-related gene discovery.

    Stobdan, Tsering / Sahoo, Debashis / Haddad, Gabriel G

    PloS one

    2022  Volume 17, Issue 8, Page(s) e0273524

    Abstract: Hypoxia plays a major role in the etiology and pathogenesis of most of the leading causes of morbidity and mortality, whether cardiovascular diseases, cancer, respiratory diseases or stroke. Despite active research on hypoxia-signaling pathways, the ... ...

    Abstract Hypoxia plays a major role in the etiology and pathogenesis of most of the leading causes of morbidity and mortality, whether cardiovascular diseases, cancer, respiratory diseases or stroke. Despite active research on hypoxia-signaling pathways, the understanding of regulatory mechanisms, especially in specific tissues, still remain elusive. With the accessibility of thousands of potentially diverse genomic datasets, computational methods are utilized to generate new hypotheses. Here we utilized Boolean implication relationship, a powerful method to probe symmetrically and asymmetrically related genes, to identify novel hypoxia related genes. We used a well-known hypoxia-responsive gene, VEGFA, with very large human expression datasets (n = 25,955) to identify novel hypoxia-responsive candidate gene/s. Further, we utilized in-vitro analysis using human endothelial cells exposed to 1% O2 environment for 2, 8, 24 and 48 hours to validate top candidate genes. Out of the top candidate genes (n = 19), 84% genes were previously reported as hypoxia related, validating our results. However, we identified FAM114A1 as a novel candidate gene significantly upregulated in the endothelial cells at 8, 24 and 48 hours of 1% O2 environment. Additional evidence, particularly the localization of intronic miRNA and numerous HREs further support and strengthen our finding. Current results on FAM114A1 provide an example demonstrating the utility of powerful computational methods, like Boolean implications, in playing a major role in hypothesis building and discovery.
    MeSH term(s) Cell Hypoxia/genetics ; Endothelial Cells ; Genetic Association Studies ; Humans ; Hypoxia/genetics ; MicroRNAs/genetics
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-08-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0273524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Commentary: Novel Insight into the Genetic Basis of High Altitude Pulmonary Hypertension in Kyrgyz Highlanders.

    Stobdan, Tsering / Haddad, Gabriel G

    Journal of lung health and diseases

    2019  Volume 3, Issue 2, Page(s) 29–30

    Language English
    Publishing date 2019-03-19
    Publishing country United States
    Document type Journal Article ; Comment
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A Boolean approach for novel hypoxia-related gene discovery.

    Tsering Stobdan / Debashis Sahoo / Gabriel G Haddad

    PLoS ONE, Vol 17, Iss 8, p e

    2022  Volume 0273524

    Abstract: Hypoxia plays a major role in the etiology and pathogenesis of most of the leading causes of morbidity and mortality, whether cardiovascular diseases, cancer, respiratory diseases or stroke. Despite active research on hypoxia-signaling pathways, the ... ...

    Abstract Hypoxia plays a major role in the etiology and pathogenesis of most of the leading causes of morbidity and mortality, whether cardiovascular diseases, cancer, respiratory diseases or stroke. Despite active research on hypoxia-signaling pathways, the understanding of regulatory mechanisms, especially in specific tissues, still remain elusive. With the accessibility of thousands of potentially diverse genomic datasets, computational methods are utilized to generate new hypotheses. Here we utilized Boolean implication relationship, a powerful method to probe symmetrically and asymmetrically related genes, to identify novel hypoxia related genes. We used a well-known hypoxia-responsive gene, VEGFA, with very large human expression datasets (n = 25,955) to identify novel hypoxia-responsive candidate gene/s. Further, we utilized in-vitro analysis using human endothelial cells exposed to 1% O2 environment for 2, 8, 24 and 48 hours to validate top candidate genes. Out of the top candidate genes (n = 19), 84% genes were previously reported as hypoxia related, validating our results. However, we identified FAM114A1 as a novel candidate gene significantly upregulated in the endothelial cells at 8, 24 and 48 hours of 1% O2 environment. Additional evidence, particularly the localization of intronic miRNA and numerous HREs further support and strengthen our finding. Current results on FAM114A1 provide an example demonstrating the utility of powerful computational methods, like Boolean implications, in playing a major role in hypothesis building and discovery.
    Keywords Medicine ; R ; Science ; Q
    Subject code 610
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Book: Tissue oxygen deprivation

    Haddad, Gabriel G.

    from molecular to integrated function

    (Lung biology in health and disease ; 95)

    1996  

    Author's details ed. by Gabriel G. Haddad
    Series title Lung biology in health and disease ; 95
    Collection
    Keywords Cell Hypoxia / physiology ; Anoxia / physiopathology ; Anoxie ; Hypoxie ; Zelle
    Subject Sauerstoffmangel ; Anoxia
    Language English
    Size XXVI, 1085 S. : Ill., graph. Darst.
    Edition 1. print.
    Publisher Dekker
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007329897
    ISBN 0-8247-9493-1 ; 978-0-8247-9493-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 554 order for loan Magazin

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