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Article ; Online: Detection of Novel Human Astrovirus MLB1 by a Commercial Viral Gastroenteritis Multiplex Assay.

Ho, Yolanda I I / Lee, Christine W S / Wong, Ann H

2022 Volume 10, Issue 3, Page(s) e0046922

MeSH term(s)	Enterovirus Infections ; Feces ; Gastroenteritis/diagnosis ; Humans ; Infant ; Mamastrovirus/genetics
Language	English
Publishing date	2022-05-23
Publishing country	United States
Document type	Letter
ZDB-ID	2807133-5
ISSN	2165-0497 ; 2165-0497
ISSN (online)	2165-0497
ISSN	2165-0497
DOI	10.1128/spectrum.00469-22
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Article ; Online: Comparison of PneumID real-time PCR assay with Amplex eazyplex LAMP assay for laboratory diagnosis of Pneumocystis jirovecii Pneumonia.

Ng, Willy W Y / Ho, Yolanda I I / Wong, Ann H / Leung, Eddie C M / Lee, Alfred L H / Chow, Viola C Y

Medical mycology

2022

Abstract: We compared PneumID PCR with Amplex eazyplex LAMP assay for the diagnosis of Pneumocystis jirovecii pneumonia (PJP). Both assays enable accurate diagnosis of definite PJP. Cut-off cycle threshold of the PneumID assay was < 26.68 while the cut-off time-to- ...

Abstract	We compared PneumID PCR with Amplex eazyplex LAMP assay for the diagnosis of Pneumocystis jirovecii pneumonia (PJP). Both assays enable accurate diagnosis of definite PJP. Cut-off cycle threshold of the PneumID assay was < 26.68 while the cut-off time-to-positivity of the eazyplex assay was 16:02 (minutes:seconds). The positive and negative percentage agreement of eazyplex assay with PneumID assay was 75.0% and 100.0% respectively, while the overall agreement was substantial with kappa = 0.80. For both assays, establishment of cut-off values to differentiate probable PJP from colonization was not feasible as results overlapped.
Language	English
Publishing date	2022-06-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1421796-x
ISSN	1460-2709 ; 1369-3786
ISSN (online)	1460-2709
ISSN	1369-3786
DOI	10.1093/mmy/myac043
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Article ; Online: Comparison of Captia

Wong, Ann H / Ho, Yolanda I I / Tang, Kevin P S / Lai, Raymond W M

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2020 Volume 127, Page(s) 104342

Abstract: Background: Correlation of the assay cut-off values for Captia: Objective: The aim of this study was to compare the relative performance of the Captia: Study design: Correlation of the cut-off value of both assays with the immunoprotective level ... ...

Abstract	Background: Correlation of the assay cut-off values for Captia Objective: The aim of this study was to compare the relative performance of the Captia Study design: Correlation of the cut-off value of both assays with the immunoprotective level was determined with the 3rd WHO Measles IgG International Standard. One hundred clinical samples including frozen and fresh were tested with both assays. The positive percentage agreement (PPA) based on the manufacturers' interpretation and the WHO recommended immunoprotective level was compared. Results: Samples tested positive by the Captia Conclusions: Captia
MeSH term(s)	Antibodies, Viral/blood ; Humans ; Immunoassay/methods ; Immunoglobulin G/blood ; Measles/diagnosis ; Measles/immunology ; Measles virus/immunology ; Reagent Kits, Diagnostic ; Sensitivity and Specificity ; World Health Organization
Chemical Substances	Antibodies, Viral ; Immunoglobulin G ; Reagent Kits, Diagnostic
Language	English
Publishing date	2020-04-06
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2020.104342
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Zs.A 3790: Show issues

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Article ; Online: Comparison of three commercial SARS-CoV-2 assays for pooled testing of deep throat saliva for surveillance of patients attending general outpatient clinics.

Ho, Yolanda I / Wong, Ann H / Tang, Kevin P S / Wong, River C W / Leung, Eddie C M / Lai, Raymond W M

Journal of medical virology

2021 Volume 93, Issue 4, Page(s) 1917–1919

MeSH term(s)	COVID-19/diagnosis ; COVID-19 Nucleic Acid Testing ; Humans ; Nasopharynx/virology ; SARS-CoV-2/isolation & purification ; Saliva/virology ; Specimen Handling
Language	English
Publishing date	2021-01-11
Publishing country	United States
Document type	Comparative Study ; Letter
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26764
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Article ; Online: Performance evaluation of the re-standardized Abbott Architect anti-HBs assay.

Wong, Ann H / Ho, Yolanda I I / Lai, Raymond W M

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

2018 Volume 111, Page(s) 1–3

Abstract: Background: As defined by World Health Organization (WHO), an antibody level of ≥ 10mIU/mL to hepatitis B virus confers protection. With the launching of Abbott anti-HBs assay re-standardized to the 2: Objectives: To evaluate the performance of the ... ...

Abstract	Background: As defined by World Health Organization (WHO), an antibody level of ≥ 10mIU/mL to hepatitis B virus confers protection. With the launching of Abbott anti-HBs assay re-standardized to the 2 Objectives: To evaluate the performance of the re-standardized Abbott Architect anti-HBs assay and to determine the impact of the upward shift. Study design: A total of 52 samples, including 12 external quality assurance programme samples and 40 clinical samples were tested with both the Abbott 1 Results: Verification of the re-standardized assay with the 2 Conclusions: Final interpretation of immune status to hepatitis B was not affected by the upward shift following introduction of the new Abbott anti-HBs assay except for previously negative samples with anti-HBs levels between >5.00 to <10.00 mIU/mL.
MeSH term(s)	Hepatitis B/diagnosis ; Hepatitis B Antibodies/blood ; Hepatitis B virus/immunology ; Humans ; Reagent Kits, Diagnostic/standards ; Reference Standards ; Serologic Tests/standards ; World Health Organization
Chemical Substances	Hepatitis B Antibodies ; Reagent Kits, Diagnostic
Language	English
Publishing date	2018-12-15
Publishing country	Netherlands
Document type	Evaluation Study ; Journal Article
ZDB-ID	1446080-4
ISSN	1873-5967 ; 1386-6532
ISSN (online)	1873-5967
ISSN	1386-6532
DOI	10.1016/j.jcv.2018.12.003
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Zs.A 3790: Show issues

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Article ; Online: Use of Lumen-apposing Metal Stents for Endoscopic Drainage of Intra-abdominal Fluid Collections in Pediatric Patients.

Costa, Peter A / Ho, Sammy / Manvar, Amar / Rivas, Yolanda / Novak, Inna

Journal of pediatric gastroenterology and nutrition

2020 Volume 70, Issue 2, Page(s) 258–260

Abstract: Introduction: Intraabdominal fluid collections that previously required surgical intervention can now be drained with less invasive techniques. The use of lumen-apposing metal stents (LAMS) to treat pancreatic pseudocysts and perirectal abscesses has ... ...

Abstract	Introduction: Intraabdominal fluid collections that previously required surgical intervention can now be drained with less invasive techniques. The use of lumen-apposing metal stents (LAMS) to treat pancreatic pseudocysts and perirectal abscesses has been shown to be a safe and effective technique in adults. We aim to evaluate the indications, outcomes, and complications of the use of LAMS in pediatric patients at our institution. Methods: A retrospective chart review was performed to study patients up to 18 years of age at the Children's Hospital at Montefiore who underwent drainage of intraabdominal fluid collections with the use of LAMS. The main outcome measures were technical and clinical success and associated adverse events with LAMS placement. Results: Seven patients (2 girls) ranging from 9 to 18 years were identified. Four patients had perirectal abscess postperforated appendicitis and 3 patients had pancreatic pseudocysts. All of the patients had complete resolution of the collections, with no recurrence, and our technical and clinical success rate was 100%. Only 1 patient had mild bleeding after placement that spontaneously resolved. Discussion: Our study demonstrates the efficacy and safety of the use of LAMS for the drainage of intraabdominal fluid collections in pediatric patients, although the number of patients included is limited.
MeSH term(s)	Adult ; Child ; Drainage ; Endosonography ; Female ; Humans ; Neoplasm Recurrence, Local ; Pancreatic Pseudocyst/surgery ; Retrospective Studies ; Stents
Language	English
Publishing date	2020-01-24
Publishing country	United States
Document type	Journal Article
ZDB-ID	603201-1
ISSN	1536-4801 ; 0277-2116
ISSN (online)	1536-4801
ISSN	0277-2116
DOI	10.1097/MPG.0000000000002538
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Zs.A 1728: Show issues

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Article ; Online: Comparison of the Cepheid Xpert Xpress Flu/RSV Assay to in-house Flu/RSV triplex real-time RT-PCR for rapid molecular detection of Influenza A, Influenza B and Respiratory Syncytial Virus in respiratory specimens.

Ho, Yolanda I I / Wong, Ann H / Lai, Raymond W M

Journal of medical microbiology

2018 Volume 67, Issue 11, Page(s) 1576–1580

Abstract: This study compared the performance of the commercially available Xpert Xpress Flu/RSV assay to an in-house FluAB/RSV triplex real-time RT-PCR assay for the detection of influenza A/B viruses and respiratory syncitial virus (RSV) from both nasopharyngeal ...

Abstract	This study compared the performance of the commercially available Xpert Xpress Flu/RSV assay to an in-house FluAB/RSV triplex real-time RT-PCR assay for the detection of influenza A/B viruses and respiratory syncitial virus (RSV) from both nasopharyngeal aspirate (NPA) and nasopharyngeal flocked swab (NPS). A total of 20 external quality assurance (EQA) samples and 172 clinical respiratory samples were tested prospectively using both the Xpert Xpress Flu/RSV assay and the in-house FluAB/RSV triplex assay. For the EQA samples, concordance rate was 100 % when tested with both assays. For clinical samples, there was 100 % agreement between the two assays for detection of influenza A and influenza B, 96.7 % agreement for detection of RSV and 99.7 % agreement for negative results. With a shortened turnaround time and good diagnostic performance, application of the Xpert Xpress Flu/RSV assay can facilitate patient triage for prompt implementation of infection control measures and management of high-risk patients during influenza epidemics.
MeSH term(s)	Biological Assay ; DNA Primers/genetics ; Humans ; Influenza A virus/genetics ; Influenza A virus/isolation & purification ; Influenza B virus/genetics ; Influenza B virus/isolation & purification ; Influenza, Human/diagnosis ; Influenza, Human/virology ; Molecular Diagnostic Techniques/instrumentation ; Molecular Diagnostic Techniques/methods ; Multiplex Polymerase Chain Reaction/methods ; Nasopharynx/virology ; Real-Time Polymerase Chain Reaction/instrumentation ; Real-Time Polymerase Chain Reaction/methods ; Respiratory Syncytial Virus Infections/diagnosis ; Respiratory Syncytial Virus Infections/virology ; Respiratory Syncytial Viruses/genetics ; Respiratory Syncytial Viruses/isolation & purification ; Sensitivity and Specificity
Chemical Substances	DNA Primers
Language	English
Publishing date	2018-09-12
Publishing country	England
Document type	Comparative Study ; Journal Article
ZDB-ID	218356-0
ISSN	1473-5644 ; 0022-2615
ISSN (online)	1473-5644
ISSN	0022-2615
DOI	10.1099/jmm.0.000841
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Zs.A 634: Show issues

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Article ; Online: A Novel Liver-targeted Testosterone Therapy for Sarcopenia in Androgen Deprived Men With Prostate Cancer.

Rhee, Handoo / Navaratnam, Anojan / Oleinikova, Irina / Gilroy, Deborah / Scuderi, Yolanda / Heathcote, Peter / Nguyen, Tuan / Wood, Simon / Ho, Ken K Y

Journal of the Endocrine Society

2021 Volume 5, Issue 9, Page(s) bvab116

Abstract: Objective: Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone ... ...

Abstract	Objective: Androgen deprivation therapy (ADT) reduces muscle and bone mass, increasing frailty in men with prostate cancer. The liver mediates the whole body anabolic effects of testosterone. Based on first-pass metabolism, liver-targeted testosterone treatment (LTTT) entails oral delivery of a small dose of testosterone that does not raise peripheral blood testosterone levels. LTTT reduces blood urea and stimulates protein anabolism in hypogonadal men and postmenopausal women. We investigated whether LTTT prevents loss of lean and bone mass during ADT. Method: A 6-month, double-blind, placebo-controlled study of testosterone 40 mg/day in 50 men. Primary outcome measures were lean mass and bone mineral content (BMC). Testosterone, urea and prostate-specific antigen (PSA) were monitored. Patients were withdrawn if PSA exceeded 4 ng/mL. Results: 42 patients completed the study. Mean (95% CI) testosterone rose during LTTT but not placebo treatment [∆ 2.2 (1.3-3.0) Conclusion: LTTT shows promise as a simple therapy for preventing sarcopenia and bone loss during ADT. LTTT may induce reversible PSA rise in some patients. Further studies are required to optimize LTTT dose in ADT. LTTT has potential application in other catabolic states in men and women.
Language	English
Publishing date	2021-06-19
Publishing country	United States
Document type	Journal Article
ISSN	2472-1972
ISSN (online)	2472-1972
DOI	10.1210/jendso/bvab116
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Article ; Online: Rapid adaptation and continuous performance evaluation of SARS-CoV-2 envelope gene (E-gene) real-time RT-PCR assays to support the hospital surge in test demand.

Ho, Yolanda I I / Wong, Ann H / Leung, Eddie C M / Wong, River C W / Lai, Raymond W M

Journal of medical virology

2020 Volume 93, Issue 3, Page(s) 1824–1827

Abstract: We describe the timely adaption of both published WHO E-gene protocol and commercially available LightMix Modular E-gene assay to the test platform (ABI 7900 Fast real-time analyzer and TaqMan Fast One-step Virus Master Mix) available in an accredited ... ...

Abstract	We describe the timely adaption of both published WHO E-gene protocol and commercially available LightMix Modular E-gene assay to the test platform (ABI 7900 Fast real-time analyzer and TaqMan Fast One-step Virus Master Mix) available in an accredited tertiary hospital laboratory with an on-going evaluation to ensure the provision of quality service within the time constraint. The LightMix Modular E-gene was slightly more sensitive when compared to the WHO E-gene, both analytically and diagnostically. The assay was recommended for screening of SARS-CoV-2 infection. With the availability of technically competent staff through continuous training, the provision of round-the-clock service is feasible despite the test is of high complexity. The thermal cycling duration of the adapted LightMix E-gene and WHO E-gene is shortened by half and one hour respectively and allows the number of runs to double when 24-h round-the-clock service is provided. An increase in testing capacity could support surges in testing demand, which is essential to control the current SARS-CoV-2 pandemic, to prevent potential overwhelming of the healthcare system, and to optimize utilization of the isolation beds.
MeSH term(s)	COVID-19/diagnosis ; COVID-19/virology ; COVID-19 Testing/methods ; Clinical Laboratory Techniques/methods ; Coronavirus Envelope Proteins/genetics ; Genes, env/genetics ; Hospitals ; Humans ; Pandemics/prevention & control ; RNA, Viral/genetics ; Real-Time Polymerase Chain Reaction/methods ; Reverse Transcriptase Polymerase Chain Reaction/methods ; SARS-CoV-2/genetics ; Sensitivity and Specificity
Chemical Substances	Coronavirus Envelope Proteins ; RNA, Viral ; envelope protein, SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-11-22
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26660
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Article ; Online: AAV9:PKP2 improves heart function and survival in a Pkp2-deficient mouse model of arrhythmogenic right ventricular cardiomyopathy.

Wu, Iris / Zeng, Aliya / Greer-Short, Amara / Aycinena, J Alex / Tefera, Anley E / Shenwai, Reva / Farshidfar, Farshad / Van Pell, Melissa / Xu, Emma / Reid, Chris / Rodriguez, Neshel / Lim, Beatriz / Chung, Tae Won / Woods, Joseph / Scott, Aquilla / Jones, Samantha / Dee-Hoskins, Cristina / Gutierrez, Carolina G / Madariaga, Jessie /

Robinson, Kevin / Hatter, Yolanda / Butler, Renee / Steltzer, Stephanie / Ho, Jaclyn / Priest, James R / Song, Xiaomei / Jing, Frank / Green, Kristina / Ivey, Kathryn N / Hoey, Timothy / Yang, Jin / Yang, Zhihong Jane

Communications medicine

2024 Volume 4, Issue 1, Page(s) 38

Abstract: Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the ... ...

Abstract	Background: Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a familial cardiac disease associated with ventricular arrhythmias and an increased risk of sudden cardiac death. Currently, there are no approved treatments that address the underlying genetic cause of this disease, representing a significant unmet need. Mutations in Plakophilin-2 (PKP2), encoding a desmosomal protein, account for approximately 40% of ARVC cases and result in reduced gene expression. Methods: Our goal is to examine the feasibility and the efficacy of adeno-associated virus 9 (AAV9)-mediated restoration of PKP2 expression in a cardiac specific knock-out mouse model of Pkp2. Results: We show that a single dose of AAV9:PKP2 gene delivery prevents disease development before the onset of cardiomyopathy and attenuates disease progression after overt cardiomyopathy. Restoration of PKP2 expression leads to a significant extension of lifespan by restoring cellular structures of desmosomes and gap junctions, preventing or halting decline in left ventricular ejection fraction, preventing or reversing dilation of the right ventricle, ameliorating ventricular arrhythmia event frequency and severity, and preventing adverse fibrotic remodeling. RNA sequencing analyses show that restoration of PKP2 expression leads to highly coordinated and durable correction of PKP2-associated transcriptional networks beyond desmosomes, revealing a broad spectrum of biological perturbances behind ARVC disease etiology. Conclusions: We identify fundamental mechanisms of PKP2-associated ARVC beyond disruption of desmosome function. The observed PKP2 dose-function relationship indicates that cardiac-selective AAV9:PKP2 gene therapy may be a promising therapeutic approach to treat ARVC patients with PKP2 mutations.
Language	English
Publishing date	2024-03-18
Publishing country	England
Document type	Journal Article
ISSN	2730-664X
ISSN (online)	2730-664X
DOI	10.1038/s43856-024-00450-w
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