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Article ; Online: Off-label drug use in children over the past decade: a scoping review.

Tang, Yuyi / Li, Weiguo / Liao, Jing / Wang, Xiaoqing / Baskota, Muna / Liu, Enmei

2023 Volume 136, Issue 5, Page(s) 626–628

MeSH term(s)	Humans ; Child ; Off-Label Use
Language	English
Publishing date	2023-03-05
Publishing country	China
Document type	Review ; Letter
ZDB-ID	127089-8
ISSN	2542-5641 ; 0366-6999 ; 1002-0187
ISSN (online)	2542-5641
ISSN	0366-6999 ; 1002-0187
DOI	10.1097/CM9.0000000000001991
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Article ; Online: Off-label drug use in children over the past decade

Yuyi Tang / Weiguo Li / Jing Liao / Xiaoqing Wang / Muna Baskota / Enmei Liu / Jing Ni

Chinese Medical Journal, Vol 136, Iss 5, Pp 626-

a scoping review

2023 Volume 628

Keywords	Medicine ; R
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	Wolters Kluwer
Document type	Article ; Online
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Article: Age-related differences in IgE between childhood and adulthood allergic asthma: Analysis of NHANES 2005-2006.

Fang, Heping / Li, Juan / Ren, Luo / Liu, Enmei

The World Allergy Organization journal

2023 Volume 16, Issue 12, Page(s) 100842

Abstract: Background: Asthma exhibits varying clinical features in children and adults. However, previous studies have mainly focused on the clinical significance of immunoglobulin E (IgE) in the diagnosis and treatment of asthma, disregarding the characteristics ...

Abstract	Background: Asthma exhibits varying clinical features in children and adults. However, previous studies have mainly focused on the clinical significance of immunoglobulin E (IgE) in the diagnosis and treatment of asthma, disregarding the characteristics of IgE and its relevant factors. Objective: This study aimed to gain a better understanding of the differences in the characteristics of IgE between childhood and adulthood allergic asthma (AA). Methods: Patients with AA from the 2005 to 2006 National Health and Nutrition Examination Survey (NHANES) were divided into 3 groups based on their current age and onset age of AA: childhood AA (Group 1), childhood-onset adult AA (Group 2), and adulthood-onset AA (Group 3). Intragroup analysis and intergroup comparison were carried out, focusing on the characteristics and relevant factors of IgE, as well as the clinical relevance of total IgE (total IgE, tIgE) and allergen-specific IgE (allergen-specific IgE, sIgE). Results: A total of 424 patients were analyzed, including 187 with childhood AA, 132 with childhood-onset adult AA, and 105 with adulthood-onset AA. The concentration of tIgE was found to be higher in Group 1 (268.0, 118.0-686.0 kU/L) than in Group 2 (224.0, 78.0-494.0 kU/L) and Group 3 (165.0, 74.4-350.5 kU/L). The sensitization rates did not differ between Group 1 and Group 2 but were higher compared with Group 3, particularly for Conclusions: There are notable differences in the characteristics and environmental factors of IgE among childhood AA, childhood-onset adult AA, and adulthood-onset AA. Additionally, IgE plays a more significant role in childhood AA due to its higher concentration, fewer relevant environmental chemicals and greater clinical relevance. This may partially explain the age-related features of asthma.
Language	English
Publishing date	2023-11-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2581968-9
ISSN	1939-4551
ISSN	1939-4551
DOI	10.1016/j.waojou.2023.100842
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Article: The Effects of Combined Respiratory Muscle and Exercise Training in Children with Bronchial Asthma: A Randomised Controlled Study.

Yang, Shuhui / Zhang, Zhanmei / Liu, Yulin / Liu, Enmei / Luo, Zhengxiu

Journal of asthma and allergy

2023 Volume 16, Page(s) 293–303

Abstract: Objective: To investigate the effects of combined respiratory muscle and exercise training on inspiratory muscle strength, exercise capacity, spirometry measurements, asthma control the quality-of-life in children with asthma.: Methods: Fifty ... ...

Abstract	Objective: To investigate the effects of combined respiratory muscle and exercise training on inspiratory muscle strength, exercise capacity, spirometry measurements, asthma control the quality-of-life in children with asthma. Methods: Fifty children with asthma, who were treated in children's hospital of Chongqing medical university in Chongqing between May and December 2021, were selected and randomly divided into a rehabilitation group and a control group by using a random number table. The control group was given routine drug treatment and health education while the rehabilitation group received a combination of respiratory muscle and exercise training on the basis of control group. Results: After three months of treatment, the maximum inspiratory pressure, level of asthma control and quality-of-life in the rehabilitation group were significantly improved when compared with those in the control group (P<0.05); there were no significant differences in the 6-minute walking test and spirometry measurements (P>0.05). After three months of treatment, all outcome indicators in the rehabilitation group were significantly improved when compared to those before treatment (P<0.05). The mean value of maximum inspiratory pressure and some indices of spirometry measurements in the control group were significantly improved when compared to those before treatment (P<0.05). Conclusion: Combining respiratory muscle and exercise training on the basis of the routine drug treatment and health education significantly improved inspiratory muscle strength, the level of asthma control and the quality-of-life in children with asthma. More research is needed to explore its role in asthma in the future.
Language	English
Publishing date	2023-03-15
Publishing country	New Zealand
Document type	Case Reports ; Clinical Trial
ZDB-ID	2494877-9
ISSN	1178-6965
ISSN	1178-6965
DOI	10.2147/JAA.S398108
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Article ; Online: Andrographolide exerts anti-respiratory syncytial virus activity by up-regulating heme oxygenase-1 independent of interferon responses in human airway epithelial cells.

Che, Siyi / Zhou, Na / Liu, Ying / Xie, Jun / Liu, Enmei

Molecular biology reports

2023 Volume 50, Issue 5, Page(s) 4261–4272

Abstract: Background: Respiratory syncytial virus (RSV) is the leading cause of mortality and morbidity in children under the age of five. Despite this, there is still a lack of safe and effective vaccines and antiviral agents for clinical use. Andrographolide ... ...

Abstract	Background: Respiratory syncytial virus (RSV) is the leading cause of mortality and morbidity in children under the age of five. Despite this, there is still a lack of safe and effective vaccines and antiviral agents for clinical use. Andrographolide exerts antiviral functions against a variety of viruses, but whether (and how) it exerts antiviral effects on RSV remains unclear. Methods and results: In vitro RSV infection models using A549 and 16HBE cell lines were established, and the effects of andrographolide on RSV were analyzed via RSV N gene load and proinflammatory cytokine levels. The RNA transcriptome was sequenced, and data were analyzed by R software. Andrographolide-related target genes were extracted via network pharmacology using online databases. Lentiviral transfection was applied to knockdown the heme oxygenase-1 gene (Hmox1, HO-1). Results showed that andrographolide suppressed RSV replication and attenuated subsequent inflammation. Network pharmacology and RNA sequencing analysis indicated that the hub gene HO-1 may play a pivotal role in the anti-RSV effects of andrographolide. Furthermore, andrographolide exerted antiviral effects against RSV partially by inducing HO-1 but did not activate the antiviral interferon response. Conclusion: Our findings demonstrated that andrographolide exerted anti-RSV activity by up-regulating HO-1 expression in human airway epithelial cells, providing novel insights into potential therapeutic targets and drug repurposing in RSV infection.
MeSH term(s)	Child ; Humans ; Antiviral Agents/pharmacology ; Epithelial Cells/metabolism ; Heme Oxygenase-1/drug effects ; Heme Oxygenase-1/genetics ; Interferons/drug effects ; Interferons/metabolism ; Respiratory Syncytial Virus Infections/drug therapy ; Respiratory Syncytial Virus Infections/metabolism ; Respiratory Syncytial Virus, Human/genetics ; Respiratory Syncytial Virus, Human/pathogenicity ; Diterpenes/pharmacology ; Diterpenes/therapeutic use
Chemical Substances	andrographolide (410105JHGR) ; Antiviral Agents ; Heme Oxygenase-1 (EC 1.14.14.18) ; Interferons (9008-11-1) ; Diterpenes
Language	English
Publishing date	2023-03-14
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	186544-4
ISSN	1573-4978 ; 0301-4851
ISSN (online)	1573-4978
ISSN	0301-4851
DOI	10.1007/s11033-023-08346-z
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Article ; Online: CXCL12/CXCR4 Axis is Involved in the Recruitment of NK Cells by HMGB1 Contributing to Persistent Airway Inflammation and AHR During the Late Stage of RSV Infection.

Chen, Sisi / Tang, Wei / Yu, Guangyuan / Tang, Zhengzhen / Liu, Enmei

Journal of microbiology (Seoul, Korea)

2023 Volume 61, Issue 4, Page(s) 461–469

Abstract: We previously showed that both high-mobility group box-1 (HMGB1) and natural killer (NK) cells contribute to respiratory syncytial virus (RSV)-induced persistent airway inflammation and airway hyperresponsiveness (AHR). Meanwhile, Chemokine (C-X-C motif) ...

Abstract	We previously showed that both high-mobility group box-1 (HMGB1) and natural killer (NK) cells contribute to respiratory syncytial virus (RSV)-induced persistent airway inflammation and airway hyperresponsiveness (AHR). Meanwhile, Chemokine (C-X-C motif) ligand 12 (CXCL12) and its specific receptor (chemokine receptor 4, CXCR4) play important roles in recruitment of immune cells. CXCL12 has been reported to form a complex with HMGB1 that binds to CXCR4 and increases inflammatory cell migration. The relationship between HMGB1, NK cells and chemokines in RSV-infected model remains unclear. An anti-HMGB1 neutralizing antibody and inhibitor of CXCR4 (AMD3100) was administered to observe changes of NK cells and airway disorders in nude mice and BALB/c mice. Results showed that the mRNA expression and protein levels of HMGB1 were elevated in late stage of RSV infection and persistent airway inflammation and AHR were diminished after administration of anti-HMGB1 antibodies, with an associated significant decrease in CXCR4
MeSH term(s)	Mice ; Animals ; Chemokine CXCL12/genetics ; Chemokine CXCL12/metabolism ; Mice, Nude ; Respiratory Syncytial Virus Infections ; Killer Cells, Natural/metabolism ; Respiratory Syncytial Virus, Human ; Inflammation
Chemical Substances	plerixafor (S915P5499N) ; Chemokine CXCL12
Language	English
Publishing date	2023-02-13
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2012399-1
ISSN	1976-3794 ; 1225-8873
ISSN (online)	1976-3794
ISSN	1225-8873
DOI	10.1007/s12275-023-00018-8
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Zs.A 5211: Show issues

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Article ; Online: Barriers and facilitators to guideline for the management of pediatric off-label use of drugs in China: a qualitative descriptive study.

Meng, Min / Hu, Jiale / Liu, Xiao / Tian, Min / Lei, Wenjuan / Liu, Enmei / Han, Zhu / Li, Qiu / Chen, Yaolong

BMC health services research

2024 Volume 24, Issue 1, Page(s) 435

Abstract: Background: Despite being a global public health concern, there is a research gap in analyzing implementation strategies for managing off-label drug use in children. This study aims to understand professional health managers' perspectives on ... ...

Abstract	Background: Despite being a global public health concern, there is a research gap in analyzing implementation strategies for managing off-label drug use in children. This study aims to understand professional health managers' perspectives on implementing the Guideline in hospitals and determine the Guideline's implementation facilitators and barriers. Methods: Pediatric directors, pharmacy directors, and medical department directors from secondary and tertiary hospitals across the country were recruited for online interviews. The interviews were performed between June 27 and August 25, 2022. The Consolidated Framework for Implementation Research (CFIR) was adopted for data collection, data analysis, and findings interpretation to implement interventions across healthcare settings. Results: Individual interviews were conducted with 28 healthcare professionals from all over the Chinese mainland. Key stakeholders in implementing the Guideline for the Management of Pediatric Off-Label Use of Drugs in China (2021) were interviewed to identify 57 influencing factors, including 27 facilitators, 29 barriers, and one neutral factor, based on the CFIR framework. The study revealed the complexity of the factors influencing managing children's off-label medication use. A lack of policy incentives was the key obstacle in external settings. The communication barrier between pharmacists and physicians was the most critical internal barrier. Conclusion: To our knowledge, this study significantly reduces the implementation gap in managing children's off-label drug use. We provided a reference for the standardized management of children's off-label use of drugs.
MeSH term(s)	Humans ; Child ; Off-Label Use ; Qualitative Research ; Health Personnel ; Pharmacists ; Delivery of Health Care
Language	English
Publishing date	2024-04-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2050434-2
ISSN	1472-6963 ; 1472-6963
ISSN (online)	1472-6963
ISSN	1472-6963
DOI	10.1186/s12913-024-10860-0
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Article ; Online: Andrographolide Attenuates RSV-induced Inflammation by Suppressing Apoptosis and Promoting Pyroptosis after Respiratory Syncytial Virus Infection In Vitro.

Che, Siyi / Xie, Xiaohong / Lin, Jilei / Liu, Ying / Xie, Jun / Liu, Enmei

Combinatorial chemistry & high throughput screening

2023

Abstract: Background: Respiratory syncytial virus (RSV), which is the predominant viral pathogen responsible for causing acute lower respiratory tract infections in children, currently lacks specific therapeutic drugs. Despite andrographolide's demonstrated ... ...

Abstract	Background: Respiratory syncytial virus (RSV), which is the predominant viral pathogen responsible for causing acute lower respiratory tract infections in children, currently lacks specific therapeutic drugs. Despite andrographolide's demonstrated effectiveness against various viral infections, its effects on RSV infection remain unclear. Methods: In this study, RSV infection and andrographolide-intervened A549 cell lines were used. The virus load of RSV and the levels of IL-6 and IL-8 in the cell supernatant were quantified. The potential targets of andrographolide in the treatment of RSV-infected airway epithelial cells were analyzed using the Gene Expression Omnibus (GEO) database and the PharmMapper Database, and the changes in mRNA expression of these target genes were measured. To further illustrate the effect of andrographolide on the death pattern of RSV-infected airway epithelial cells, Annexin V-FITC/PI apoptosis assays and Western blotting were conducted. Results: Andrographolide decreased the viral load and attenuated IL-6 and IL-8 levels in cell supernatant post-RSV infection. A total of 25 potential targets of andrographolide in the treatment of RSV-infected airway epithelial cells were discovered, and CASP1, CCL5, JAK2, and STAT1 were identified as significant players. Andrographolide noticeably suppressed the increased mRNA expressions of these genes post-RSV infection as well as IL-1β. The flow cytometry analysis demonstrated that andrographolide alleviated apoptosis in RSV-infected cells. Additionally, RSV infection decreased the protein levels of caspase-1, cleaved caspase-1, cleaved IL-1β, N-terminal of GSDMD, and Bcl-2. Conversely, andrographolide increased their levels. Conclusion: These results suggest that andrographolide may reduce RSV-induced inflammation by suppressing apoptosis and promoting pyroptosis in epithelial cells, leading to effective viral clearance.
Language	English
Publishing date	2023-11-07
Publishing country	United Arab Emirates
Document type	Journal Article
ZDB-ID	2064785-2
ISSN	1875-5402 ; 1386-2073
ISSN (online)	1875-5402
ISSN	1386-2073
DOI	10.2174/0113862073256465231024075452
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Article: Why multisystem inflammatory syndrome in children has been less commonly described in Asia?

Li, Weiguo / Tang, Yuyi / Shi, Yuan / Chen, Yaolong / Liu, Enmei

Translational pediatrics

2020 Volume 9, Issue 6, Page(s) 873–875

Language	English
Publishing date	2020-01-23
Publishing country	China
Document type	Journal Article
ZDB-ID	2901309-4
ISSN	2224-4344 ; 2224-4344 ; 2224-4336
ISSN (online)	2224-4344
ISSN	2224-4344 ; 2224-4336
DOI	10.21037/tp-20-151
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Article ; Online: A case-control study of the relationship between early-life environmental exposure and childhood asthma

DENG Yuntian / XIONG Wenkui / ZHU Rui / LIU Enmei / LI Xuemei / ZHONG Zhaohui

Shanghai Jiaotong Daxue xuebao. Yixue ban, Vol 43, Iss 1, Pp 44-

2023 Volume 51

Abstract: Objective·To explore the potential impact of early-life environmental exposure on childhood asthma in Chongqing, China.Methods·A case-control study was designed. The cases with asthma diagnosis were enrolled from outpatients of the respiratory medicine ... ...

Abstract	Objective·To explore the potential impact of early-life environmental exposure on childhood asthma in Chongqing, China.Methods·A case-control study was designed. The cases with asthma diagnosis were enrolled from outpatients of the respiratory medicine departments and the healthy children without history of asthma were enrolled from health check-up clinics of the child health care departments in two tertiary children's hospitals in Chongqing from September 2020 to January 2022. The children in the two groups had all lived in Chongqing since birth and their home addresses had not changed before they were 3 years old. A self-developed “Children's Early-Life Environment Survey” was used to collect general personal data, family information, child health status, birth history, and indoor environment from birth to 3 years old (second-hand smoke, dampness and mold points in bedroom, seen cockroaches in bedroom, bedroom cleaning frequency, air conditioning and air purifier use, and decoration). Based on the home address information before 3 years old, annual particular matter 2.5 (PM2.5) exposure levels were estimated by using a high spatiotemporal resolution model. Univariate and multivariate Logistic regression models were used to analyze the early-life environmental factors affecting the development of childhood asthma. The risk factors which were statistically significant in univariate Logistic regression or had clinical significance were included in the multivariate model.Results·A total of 220 asthma cases and 636 healthy control children were enrolled. The mean age of the asthma cases and the controls were (7.4±2.1) and (7.6±2.1) years old, respectively. There were no statistically significant differences in age, gender, gestational age, birth weight, mode of delivery, family size, annual family income, maternal education level and living space per person. Multivariate Logistic regression analysis showed that early-life bedroom dampness and mold exposure [odds ratio (OR)=2.155, 95% confidence interval (CI) ...
Keywords	asthma ; child ; early-life ; environment ; particular matter 2.5 (pm2.5) ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2023-01-01T00:00:00Z
Publisher	Editorial Office of Journal of Shanghai Jiao Tong University (Medical Science)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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